Preconditioning increases brain resistance against acute brain injury via neuroinflammation modulation

Gao, Pan; Tang, Sicheng; Chen, Hanmin; Zhou, Xiangyue; Ou, Yibo; Shen, Ronghua und He, Yue (2021): Preconditioning increases brain resistance against acute brain injury via neuroinflammation modulation. In: Experimental Neurology, Bd. 341, 113712

Abstract

Acute brain injury (ABI) is a broad concept mainly comprised of sudden parenchymal brain injury. Acute brain injury outcomes are dependent not only on the severity of the primary injury, but the delayed secondary injury that subsequently follows as well. These are both taken into consideration when determining the patient's prognosis. Growing clinical and experimental evidence demonstrates that preconditioning, a prophylactic approach in which the brain is exposed to various pre-injury stressors, can induce varying degrees of tolerance against the impact of the ABI by modulating neuroinflammation. In this review, we will summarize the pathophysiology of ABI, and discuss the involved mechanisms of neuroinflammation in ABI, as well as existing experimental and clinical studies demonstrating the efficacy of preconditioning methods in various types of ABI by modulating neuroinflammation.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0014-4886
• Sprache: Englisch