Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) F-18-Radiopharmaceuticals

Gower-Fry, Lexi; Kronemann, Travis; Dorian, Andreas; Pu, Yinglan; Jaworski, Carolin; Waengler, Carmen; Bartenstein, Peter; Beyer, Leonie; Lindner, Simon; Jurkschat, Klaus; Waengler, Bjoern; Bailey, Justin J. und Schirrmacher, Ralf (2021): Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) F-18-Radiopharmaceuticals. In: Pharmaceuticals, Bd. 14, Nr. 7, 701

Abstract

The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of F-18-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [F-18]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [F-18]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch