Cytotoxic Activities of Bis-cyclometalated Rhodium(III) and Iridium(III) Complexes Containing 2,2 '-Biphenyldiamine

Graf, Marion; Böttcher, Hans-Christian; Metzler-Nolte, Nils; Sünkel, Karlheinz; Thavalingam, Sugina und Czerwieniec, Rafal (2021): Cytotoxic Activities of Bis-cyclometalated Rhodium(III) and Iridium(III) Complexes Containing 2,2 '-Biphenyldiamine. In: Zeitschrift für Anorganische und Allgemeine Chemie, Bd. 647, Nr. 5: S. 519-524

Abstract

The synthesis and characterization of new bis-cyclometalated complex salts [M(ptpy)(2)(2,2'-biphenyldiamine)]PF6 (M=Rh, 1;M=Ir, 2;ptpy=2-(p-tolyl)pyridinato) are described. Compounds 1 and 2 were obtained by bridge-splitting reactions of [{M(mu-Cl)(ptpy)(2)}(2)] (M=Rh or Ir) with 2,2'-biphenyldiamine in CH2Cl2/MeOH/H2O mixtures. The molecular structure of compound 2 in the crystal was confirmed by single-crystal X-ray diffraction. 2 crystallized from dichloromethane/methanol/n-heptane in the monoclinic space group P2(1)/(n). The cytotoxic activities of both new compounds were examined and evaluated. Compound 1 and 2 exhibit significant cytotoxicity against human cancer cell lines with the IC50 values in the low micromolar range.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0044-2313
• Sprache: Englisch