2020 WHO Classification of Female Genital Tumors

Höhn, Anne Kathrin; Brambs, Christine E.; Hiller, Grit Gesine Ruth; May, Doris; Schmoeckel, Elisa and Horn, Lars-Christian (2021): 2020 WHO Classification of Female Genital Tumors. In: Geburtshilfe und Frauenheilkunde, Vol. 81, No. 10: pp. 1145-1153

Abstract

The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading;however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0016-5751
• Language: English