Abstract
Primary treatment of cervical cancer should include as few therapy modalities as possible. An optimal diagnostic algorithm-including an estimation of local (cervix), loco-regional (lymph nodes), and distant disease spread-should be adhered to maintain the latter principle. Surgery alone is sufficient in most cases of early-stage disease. In locally advanced disease, one must meticulously evaluate whether surgery alone will be sufficient, or whether risk factors will be present after surgery and adjuvant radio-chemotherapy will be indicated. If this is anticipated, primary combined, simultaneous radio-chemotherapy should be performed. In metastatic disease, platinum-based chemotherapy with paclitaxel and bevacizumb is the standard regimen and is associated with prolonged overall survival. Newest data indicate high efficacy for checkpoint-inhibitor therapy with cemiplimab in patients with recurrent disease after platinum-based chemotherapy.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine |
| Subjects: | 600 Technology > 610 Medicine and health |
| ISSN: | 0017-5994 |
| Language: | German |
| Item ID: | 99196 |
| Date Deposited: | 05. Jun 2023, 15:30 |
| Last Modified: | 17. Oct 2023, 15:00 |
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