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Kabacinski, Piotr; Romanelli, Marco; Ponkkonen, Eveliina; Jaiswal, Vishal Kumar; Carell, Thomas; Garavelli, Marco; Cerullo, Giulio and Conti, Irene (2021): Unified Description of Ultrafast Excited State Decay Processes in Epigenetic Deoxycytidine Derivatives. In: Journal of Physical Chemistry Letters, Vol. 12, No. 45: pp. 11070-11077

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Abstract

Epigenetic DNA modifications play a fundamental role in modulating gene expression and regulating cellular and developmental biological processes, thereby forming a second layer of information in DNA. The epigenetic 2 '-deoxycytidine modification 5-methyl-2 '-deoxycytidine, together with its enzymatic oxidation products (5-hydroxymethyl-2 '-deoxycytidine, 5-formyl-2 '-deoxycytidine, and 5-carboxyl-2 '-deoxycytidine), are closely related to deactivation and reactivation of DNA transcription. Here, we combine sub-30-fs transient absorption spectroscopy with high-level correlated multiconfigurational CASPT2/MM computational methods, explicitly including the solvent, to obtain a unified picture of the photophysics of deoxycytidine-derived epigenetic DNA nucleosides. We assign all the observed time constants and identify the excited state relaxation pathways, including the competition of intersystem crossing and internal conversion for 5-formyl-2 '-deoxycytidine and ballistic decay to the ground state for 5-carboxy-2 '-deoxycytidine. Our work contributes to shed light on the role of epigenetic derivatives in DNA photodamage as well as on their possible therapeutic use.

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