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Keidel, Leonie F.; Zwingelberg, Sarah; Schworm, Benedikt; Luft, Nikolaus; Herold, Tina; Priglinger, Siegfried G. and Siedlecki, Jakob (2021): Pachychoroid disease and its association with retinal vein occlusion: a case-control study. In: Scientific Reports, Vol. 11, No. 1, 19854

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The development of a retinal vein occlusion (RVO) is multifactorial. This study investigates pachychoroid as a risk factor for RVO or as an entity sharing common pathophysiology with RVO. A database screening at the University Eye Hospital, Ludwig-Maximilian University Munich, Germany was performed for patients diagnosed with central or branch RVO (CRVO/BRVO). In every patient a complete ophthalmologic examination was performed, including posterior segment enhanced depth spectral domain optical coherence tomography (EDI-SD-OCT). The SD-OCT scans of respective partner eyes without history of RVO were compared to an age- and refraction-matched, randomly recruited normal control group. In total, 312 eyes of 312 patients were included in this study, with 162 eyes in the RVO and 150 eyes in the control group. A significantly higher subfoveal choroidal thickness (SFCT) was found in the RVO (310.3 +/- 72.5 (94 to 583) mu m) as compared to the control group (237.0 +/- 99.0 (62 to 498);p < 0.00001). Moreover, the RVO group showed a significantly higher prevalence of a symptomatic pachychoroid (22 vs. 9 eyes;odds ratio: 2.46;95 CI: 1.10 to 5.53;p = 0.029). Since pachychoroid disease represents a bilateral entity, it might be a risk factor for RVO, or share risk factors with RVO.

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