Cobalt-Catalyzed Preparation of N -Heterocyclic Organozinc Reagents from the Corresponding Heteroaryl Chlorides

Kremsmair, Alexander; Graßl, Simon; Seifert, Christoph J. B.; Godineau, Edouard und Knochel, Paul (2021): Cobalt-Catalyzed Preparation of N -Heterocyclic Organozinc Reagents from the Corresponding Heteroaryl Chlorides. In: Synthesis-Stuttgart, Bd. 53, Nr. 21: S. 4068-4074

Abstract

Various substituted and unsubstituted N-heteroaryl chlorides have been converted into their corresponding organozinc species using zinc dust in the presence of zinc pivalate and 10% CoCl (2) in benzonitrile at 25 degrees C. The resulting heteroarylzinc reagents were obtained in 43-98% yield within 9-48 h and reacted with a broad range of electrophiles, leading to the functionalized heteroarenes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0039-7881
• Sprache: Englisch