Cobalt-Catalyzed Preparation of N -Heterocyclic Organozinc Reagents from the Corresponding Heteroaryl Chlorides

Kremsmair, Alexander; Graßl, Simon; Seifert, Christoph J. B.; Godineau, Edouard and Knochel, Paul (2021): Cobalt-Catalyzed Preparation of N -Heterocyclic Organozinc Reagents from the Corresponding Heteroaryl Chlorides. In: Synthesis-Stuttgart, Vol. 53, No. 21: pp. 4068-4074

Abstract

Various substituted and unsubstituted N-heteroaryl chlorides have been converted into their corresponding organozinc species using zinc dust in the presence of zinc pivalate and 10% CoCl (2) in benzonitrile at 25 degrees C. The resulting heteroarylzinc reagents were obtained in 43-98% yield within 9-48 h and reacted with a broad range of electrophiles, leading to the functionalized heteroarenes.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 0039-7881
• Language: English