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Kremsmair, Alexander; Harenberg, Johannes H.; Schwärzer, Kuno; Hess, Andreas and Knochel, Paul (2021): Preparation and reactions of polyfunctional magnesium and zinc organometallics in organic synthesis. In: Chemical Science, Vol. 12, No. 17: pp. 6011-6019

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Polyfunctional organometallics of magnesium and zinc are readily prepared from organic halides via a direct metal insertion in the presence of LiCl or a Br/Mg-exchange using iPrMgCl center dot LiCl (turbo-Grignard) or related reagents. Alternatively, such functionalized organometallics are prepared by metalations with TMP-bases (TMP = 2,2,6,6-tetramethylpiperidyl). The scope of these methods is described as well as applications in new Co- or Fe-catalyzed cross-couplings or aminations. It is shown that the use of a continous flow set-up considerably expands the field of applications of these methods and further allows the preparation of highly reactive organosodium reagents.

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