Logo Logo
Switch Language to German

Kruechten, Ricarda von; Lorbeer, Roberto; Schuppert, Christopher; Storz, Corinna; Mujaj, Blerim; Schulz, Holger; Kauczor, Hans-Ulrich; Peters, Annette; Bamberg, Fabian; Karrasch, Stefan and Schlett, Christopher L. (2021): Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study. In: Scientific Reports, Vol. 11, No. 1, 16173

Full text not available from 'Open Access LMU'.


To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3 +/- 9.2 years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (ss = - 0.14, p = 0.01), early diastolic filling rate (ss = - 0.11, p = 0.04), and LV/RV stroke volume (ss = - 0.14, p = 0.01;ss = - 0.11, p = 0.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT.

Actions (login required)

View Item View Item