Cross-sectional and prospective relationships of endogenous progestogens and estrogens with glucose metabolism in men and women: a KORA F4/FF4 Study

Lau, Lina Hui Ying; Nano, Jana; Cecil, Alexander; Schederecker, Florian; Rathmann, Wolfgang; Prehn, Cornelia; Zeller, Tanja; Lechner, Andreas; Adamski, Jerzy; Peters, Annette und Thorand, Barbara (2021): Cross-sectional and prospective relationships of endogenous progestogens and estrogens with glucose metabolism in men and women: a KORA F4/FF4 Study. In: BMJ Open Diabetes Research & Care, Bd. 9, Nr. 1, e001951

Abstract

Introduction Relationships between endogenous female sex hormones and glycemic traits remain understudied, especially in men. We examined whether endogenous 17 alpha-hydroxyprogesterone (17-OHP), progesterone, estradiol (E2), and free estradiol (fE2) were associated with glycemic traits and glycemic deterioration. Research design and methods 921 mainly middle-aged and elderly men and 390 perimenopausal/postmenopausal women from the German population-based Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort study were followed up for a median of 6.4 years. Sex hormones were measured at baseline using mass spectrometry. We calculated regression coefficients (beta) and ORs with 95% CIs using multivariable-adjusted linear and logistic regression models for Z-standardized hormones and glycemic traits or glycemic deterioration (ie, worsening of categorized glucose tolerance status), respectively. Results In the cross-sectional analysis (n=1222 men and n=594 women), in men, 17-OHP was inversely associated with 2h-glucose (2hG) (beta=-0.067, 95% CI -0.120 to -0.013) and fasting insulin (beta=-0.074, 95% CI -0.118 to -0.030), and positively associated with Quantitative Insulin Sensitivity Check Index (QUICKI) (beta=0.061, 95% CI 0.018 to 0.105). Progesterone was inversely associated with fasting insulin (beta=-0.047, 95% CI -0.088 to -0.006) and positively associated with QUICKI (beta=0.041, 95% CI 0.001 to 0.082). E2 was inversely associated with fasting insulin (beta=-0.068, 95% CI -0.116 to -0.020) and positively associated with QUICKI (beta=0.059, 95% CI 0.012 to 0.107). fE2 was positively associated with glycated hemoglobin (HbA(1c)) (beta=0.079, 95% CI 0.027 to 0.132). In women, 17-OHP was positively associated with fasting glucose (FG) (beta=0.068, 95% CI 0.014 to 0.123). fE2 was positively associated with FG (beta=0.080, 95% CI 0.020 to 0.141) and HbA(1c) (beta=0.121, 95% CI 0.062 to 0.180). In the sensitivity analyses restricted to postmenopausal women, we observed a positive association between 17-OHP and glycemic deterioration (OR=1.518, 95% CI 1.033 to 2.264). Conclusions Inter-relations exist between female sex hormones and glucose-related traits among perimenopausal/postmenopausal women and insulin-related traits among men. Endogenous progestogens and estrogens appear to be involved in glucose homeostasis not only in women but in men as well. Further well-powered studies assessing causal associations between endogenous female sex hormones and glycemic traits are warranted.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch