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Anzahl der Publikationen: 14
Zeitschriftenartikel
Pfizer, Jose; Assfalg-Machleidt, Irmgard; Machleidt, Werner und Schaschke, Norbert
(2008):
Inhibition of human μ-calpain by conformationally constrained calpastatin peptides.
In: Biological Chemistry, Bd. 389, Nr. 1: S. 83-90
[PDF, 216kB]
Fernández-Montalván, Amaury; Assfalg-Machleidt, Irmgard; Pfeiler, Dietmar; Fritz, Hans; Jochum, Marianne und Machleidt, Werner
(2006):
μ-calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation.
In: Biological Chemistry, Bd. 387, Nr. 5: S. 617-627
[PDF, 226kB]
Krol, Janna; Sato, Sumito; Rettenberger, Peter; Assfalg-Machleidt, Irmgard; Schmitt, Manfred; Magdolen, Viktor und Magdolen, Ulla
(2003):
Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems.
In: Biological Chemistry, Bd. 384, Nr. 7: S. 1085-1096
[PDF, 313kB]
Hoffmann, D.; Assfalg-Machleidt, Irmgard; Nitschko, H.; Helm, K. von der; Koszinowski, U. und Machleidt, Werner
(2003):
Rapid enzymatic test for phenotypic HIV protease drug resistance.
In: Biological Chemistry, Bd. 384, Nr. 7: S. 1109-1117
[PDF, 128kB]
Gil-Parrado, S.; Assfalg-Machleidt, Irmgard; Fiorino, F.; Deluca, D.; Pfeiler, D.; Schaschke, N.; Moroder, L. und Machleidt, Werner
(2003):
Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin.
In: Biological Chemistry, Bd. 384, Nr. 3: S. 395-402
[PDF, 128kB]
Schaschke, Norbert; Deluca, Dominga; Assfalg-Machleidt, Irmgard; Höhneke, Clara; Sommerhoff, Christian P. und Machleidt, Werner
(2002):
Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin.
In: Biological Chemistry, Bd. 383, Nr. 5: S. 849-852
[PDF, 121kB]
Gabrijelcic-Geiger, Dusica; Mentele, Reinhard; Meisel, Barbara; Hinz, Heide; Assfalg-Machleidt, Irmgard; Machleidt, Werner; Möller, Achim und Auerswald, Ennes A.
(2001):
Human μ-calpain: Simple isolation from erythrocytes and characterization of autolysis fragments.
In: Biological Chemistry, Bd. 382, Nr. 12: S. 1733-1737
[PDF, 188kB]
García Diaz, Beatriz; Gross, Stefan; Assfalg-Machleidt, Irmgard; Pfeiler, Dietmar; Gollmitzer, Nicole; Gabrijelcic-Geiger, Dusica; Stubbs, Milton T.; Fritz, Hans; Auerswald, Ennes A. und Machleidt, Werner
(2001):
Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain.
In: Biological Chemistry, Bd. 382, Nr. 1: S. 97-107
[PDF, 219kB]
Machleidt, W.; Assfalg-Machleidt, Irmgard; Jochum, Marianne; Jänicke, F. und Schmitt, M.
(1992):
Lysosomal cysteine proteinases as mediators of inflammation and tumor spread. Control of their extracellular proteolytic activity.
In: Fibronolysis, Bd. 6, Nr. Sup.4: S. 125-129
[PDF, 1MB]
Billing, A.; Fröhlich, D.; Assfalg-Machleidt, Irmgard; Machleidt, W. und Jochum, Marianne
(1991):
Proteolysis of defensive proteins in peritonitis exudate. Pathobiochemical aspects and therapeutical approach.
In: Biomedica biochimica acta, Bd. 50, Nr. 4-6: S. 399-402
[PDF, 794kB]
Assfalg-Machleidt, Irmgard; Jochum, Marianne; Nast-Kolb, Dieter; Siebeck, Matthias; Billing, Arend; Joka, Theo; Rothe, Gregor; Valet, Günter; Zauner, Rita; Scheuber, Heinz- Peter und Machleidt, Werner
(1990):
Cathepsin B - indicator for the release of lysosomal cyasteine proteinases in severe trauma and inflammation.
In: Biological chemistry Hoppe-Seyler, Bd. 371, Nr. Supple: S. 211-222
[PDF, 1MB]
Assfalg-Machleidt, Irmgard; Jochum, Marianne; Klaubert, W.; Inthorn, D. und Machleidt, W.
(1988):
Enzymatically active cathepsin B dissociating from its inhibitor complexes is elevated in blood plasma of patients wih septic shock and some malignant tumors.
In: Biological chemistry Hoppe-Seyler, Bd. 369, Nr. Suppl.: S. 263-269
Buchbeitrag
Machleidt, W.; Assfalg-Machleidt, Irmgard; Billing, A.; Fröhlich, D.; Jochum, Marianne; Joka, T. und Nast-Kolb, Dieter
(1993):
The role of lysosomal cysteine proteinases as markers of macrophage activation and as non-specific mediators of inflammation.
In: Faist, E.; Meakins, J. und Schildberg, F. W. (Hrsg.):
Host Defence Dysfunction in Trauma, Shock and Sepsis. Berlin, Heidelberg: Springer. S. 459-463
[PDF, 1MB]
Konferenzbeitrag
Jochum, Marianne; Assfalg-Machleidt, Irmgard; Inthorn, D.; Nast-Kolb, Dieter; Waydhas, Christian und Fritz, Hans
(1990):
Leukozytäre Proteinasen und Hämostasestörung bei der Sepsis.
32. Hamburger Symposium über Blutgerinnung, Hamburg, 26. - 27. Mai 1989.
Tilsner, Volkmar (Hrsg.):
In: Infektion, Entzündung und Blutgerinnung,
S. 241-254
[PDF, 1MB]