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Veröffentlichungsdatum
Anzahl der Publikationen: 32
2024
Strohm, Lea; Daiber, Andreas; Ubbens, Henning; Krishnankutty, Roopesh; Oelze, Matthias; Kuntic, Marin; Hahad, Omar; Klein, Veronique; Hoefer, Imo E.; von Kriegsheim, Alex; Kleinert, Hartmut; Atzler, Dorothee; Lurz, Philipp; Weber, Christian; Wild, Philipp S.; Muenzel, Thomas; Knosalla, Christoph; Lutgens, Esther und Daub, Steffen
(2024):
Role of inflammatory signaling pathways involving the CD40-CD40L-TRAF cascade in diabetes and hypertension-insights from animal and human studies.
In: Basic Research in Cardiology
[PDF, 2MB]
Doering, Yvonne; van der Vorst, Emiel P. C.; Yan, Yi; Neideck, Carlos; Blanchet, Xavier; Jansen, Yvonne; Kemmerich, Manuela; Bayasgalan, Soyolmaa; Peters, Linsey J. F.; Hristov, Michael; Bidzhekov, Kiril; Yin, Changjun; Zhang, Xi; Leberzammer, Julian; Li, Ya; Park, Inhye; Kral, Maria; Nitz, Katrin; Parma, Laura; Gencer, Selin; Habenicht, Andreas J. R.; Faussner, Alexander; Teupser, Daniel; Monaco, Claudia; Holdt, Lesca; Megens, Remco T. A.; Atzler, Dorothee; Santovito, Donato; von Hundelshausen, Philipp und Weber, Christian
(2024):
Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis.
In: Nature Cardiovascular Research, Bd. 3, Nr. 2
[PDF, 21MB]
Vos, Winnie G.; van Os, Bram W.; den Toom, Myrthe; Beckers, Linda; van Roomen, Cindy P. A. A.; van Tiel, Claudia M.; Mohapatra, Bhopal C.; Band, Hamid; Nitz, Katrin; Weber, Christian; Atzler, Dorothee; de Winther, Menno P. J.; Bosmans, Laura A.; Lutgens, Esther und Seijkens, Tom T. P.
(2024):
T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation.
In: Frontiers in Immunology, Bd. 15, 1297893
[PDF, 3MB]
2023
van Os, Bram W 
ORCID: https://orcid.org/0000-0002-2327-0527; Vos, Winnie G; Bosmans, Laura A; van Tiel, Claudia M; Lith, Sanne C; den Toom, Myrthe S; Beckers, Linda; Levels, Johannes H M; van Wouw, Suzanne A E; Zelcer, Noam; Zaal, Esther A; Berkers, Celia R; van der Lest, Chris H A; Helms, J Bernd; Weber, Christian ORCID: https://orcid.org/0000-0003-4610-8714; Atzler, Dorothee; de Winther, Menno P J; Baardman, Jeroen; Lutgens, Esther und Ketelhuth, Daniel FJ
(2023):
Hyperlipidaemia elicits an atypical, T helper 1–like CD4+ T-cell response: a key role for very low-density lipoprotein.
In: European Heart Journal Open, Bd. 3, Nr. 2
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-2327-0527; Vos, Winnie G; Bosmans, Laura A; van Tiel, Claudia M; Lith, Sanne C; den Toom, Myrthe S; Beckers, Linda; Levels, Johannes H M; van Wouw, Suzanne A E; Zelcer, Noam; Zaal, Esther A; Berkers, Celia R; van der Lest, Chris H A; Helms, J Bernd; Weber, Christian ORCID: https://orcid.org/0000-0003-4610-8714; Atzler, Dorothee; de Winther, Menno P J; Baardman, Jeroen; Lutgens, Esther und Ketelhuth, Daniel FJ
(2023):
Hyperlipidaemia elicits an atypical, T helper 1–like CD4+ T-cell response: a key role for very low-density lipoprotein.
In: European Heart Journal Open, Bd. 3, Nr. 2
[PDF, 2MB]
2022
Nitz, Katrin; Lacy, Michael; Bianchini, Mariaelvy; Wichapong, Kanin; Kücükgöze, Irem Avcilar; Bonfiglio, Cecilia A.; Migheli, Roberta; Wu, Yuting; Burger, Carina; Li, Yuanfang; Forne, Ignasi; Ammar, Constantin; Janjic, Aleksandar; Mohanta, Sarajo; Duchene, Johan; Heemskerk, Johan W. M.; Megens, Remco T. A.; Schwedhelm, Edzard; Huveneers, Stephan; Lygate, Craig A.; Santovito, Donato; Zimmer, Ralf; Imhof, Axel; Weber, Christian; Lutgens, Esther und Atzler, Dorothee
(2022):
The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function.
In: Circulation Research, Bd. 131, Nr. 8: S. 701-712
Bosmans, Laura A.; Tiel, Claudia M. van; Aarts, Suzanne A. B. M.; Willemsen, Lisa; Baardman, Jeroen; Os, Bram W. van; Toom, Myrthe den; Beckers, Linda; Ahern, David J.; Levels, Johannes H. M.; Jongejan, Aldo; Moerland, Perry D.; Verberk, Sanne G. S.; Bossche, Jan van den; Winther, Menno M. P. J. de; Weber, Christian; Atzler, Dorothee; Monaco, Claudia; Gerdes, Norbert; Shami, Annelie und Lutgens, Esther
(2022):
Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state.
In: Cardiovascular Research, Bd. 119, Nr. 5: S. 1146-1160
[PDF, 1MB]
Kleist, Christine J.; Choe, Chi-Un; Atzler, Dorothee; Schoenhoff, Mirjam; Böger, Rainer; Schwedhelm, Edzard und Wicha, Sebastian G.
(2022):
Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction.
In: Amino Acids, Bd. 54, Nr. 6: S. 889-896
2021
Yola, Ibrahim Musa ORCID: https://orcid.org/0000-0002-2898-9792; Moser, Carlee; Duncan, Meredith S. ORCID: https://orcid.org/0000-0001-6922-8503; Schwedhelm, Edzard; Atzler, Dorothee; Maas, Renke; Hannemann, Juliane; Boeger, Rainer H.; Vasan, Ramachandran S. ORCID: https://orcid.org/0000-0001-7357-5970 und Xanthakis, Vanessa ORCID: https://orcid.org/0000-0002-7352-621X
(2021):
Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study.
In: PLOS One 16(9), e0254577 [PDF, 746kB]
ORCID: https://orcid.org/0000-0002-2898-9792; Moser, Carlee; Duncan, Meredith S. ORCID: https://orcid.org/0000-0001-6922-8503; Schwedhelm, Edzard; Atzler, Dorothee; Maas, Renke; Hannemann, Juliane; Boeger, Rainer H.; Vasan, Ramachandran S. ORCID: https://orcid.org/0000-0001-7357-5970 und Xanthakis, Vanessa ORCID: https://orcid.org/0000-0002-7352-621X
(2021):
Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study.
In: PLOS One 16(9), e0254577 [PDF, 746kB]
Lacy, Michael; Buerger, Christina; Shami, Annelie; Ahmadsei, Maiwand; Winkels, Holger; Nitz, Katrin; Tiel, Claudia M. van; Seijkens, Tom T. P.; Kusters, Pascal J. H.; Karshovka, Ela; Prange, Koen H. M.; Wu, Yuting; Brouns, Sanne L. N.; Unterlugauer, Sigrid; Kuijpers, Marijke J. E.; Reiche, Myrthe E.; Steffens, Sabine; Edsfeldt, Andreas; Megens, Remco T. A.; Heemskerk, Johan W. M.; Goncalves, Isabel; Weber, Christian; Gerdes, Norbert; Atzler, Dorothee und Lutgens, Esther
(2021):
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.
In: Nature Communications, Bd. 12, Nr. 1, 3754
[PDF, 3MB]
Bosmans, Laura A.; Shami, Annelie; Atzler, Dorothee; Weber, Christian; Goncalves, Isabel und Lutgens, Esther
(2021):
Glucocorticoid induced TNF receptor family-related protein (GITR)-A novel driver of atherosclerosis.
In: Vascular Pharmacology, Bd. 139, 106884
[PDF, 1MB]
2020
Gencer, Selin; Lacy, Michael; Atzler, Dorothee; Vorst, Emiel P. C. van der; Döring, Yvonne und Weber, Christian
(2020):
Immunoinflammatory, Thrombohaemostatic, and Cardiovascular Mechanisms in COVID-19.
In: Thrombosis and Haemostasis, Bd. 120, Nr. 12: S. 1629-1641
Shami, Annelie; Atzler, Dorothee; Bosmans, Laura A.; Winkels, Holger; Meiler, Svenja; Lacy, Michael; Tiel, Claudia van; Megens, Remco Ta; Nitz, Katrin; Baardman, Jeroen; Kusters, Pascal; Seijkens, Tom; Buerger, Christina; Janjic, Aleksandar; Riccardi, Carlo; Edsfeldt, Andreas; Monaco, Claudia; Daemen, Mat; Winther, Menno P. J. de; Nilsson, Jan; Weber, Christian; Gerdes, Norbert; Goncalves, Isabel und Lutgens, Esther
(2020):
Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
In: European Heart Journal, Bd. 41, Nr. 31: S. 2938-2948
Niekerk, Elandi van; Botha Le Roux, Shani; Atzler, Dorothee; Schwedhelm, Edzard; Boeger, Rainer H.; Rooyen, Johannes M. van; Moss, Sarah J. und Mels, Catharina M. C.
(2020):
Blood pressure and nitric oxide synthesis capacity in physically active and inactive groups: the SABPA study.
In: Journal of Human Hypertension, Bd. 35, Nr. 4: S. 325-333
2019
Cordts, Kathrin; Grzybowski, Ricarda; Lezius, Susanne; Lueneburg, Nicole; Atzler, Dorothee; Neu, Axel; Hornig, Soeke; Boeger, Rainer H.; Gerloff, Christian; Magnus, Tim; Thomalla, Götz; Schwedhelm, Edzard; Grant, Peter J. und Choe, Chi-un
(2019):
Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies.
In: Journal of the Neurological Sciences, Bd. 397: S. 156-161
Lacy, Michael; Atzler, Dorothee; Liu, Rongqi; de Winther, Menno; Weber, Christian und Lutgens, Esther
(2019):
Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis.
In: Pharmacology & Therapeutics, Bd. 193: S. 50-62
Seijkens, Tom T. P.; Poels, Kikkie; Meiler, Svenja; van Tiel, Claudia M.; Kusters, Pascal J. H.; Reiche, Myrthe; Atzler, Dorothee; Winkels, Holger; Tjwa, Marc; Poelman, Hessel; Slutter, Bram; Kuiper, Johan; Gijbels, Marion; Kuivenhoven, Jan Albert; Matic, Ljubica Perisic; Paulsson-Berne, Gabrielle; Hedin, Ulf; Hansson, Goran K.; Nicolaes, Gerry A. F.; Daemen, Mat J. A. P.; Weber, Christian; Gerdes, Norbert; de Winther, Menno P. J. und Lutgens, Esther
(2019):
Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8(+) T cell-mediated macrophage death.
In: European Heart Journal, Bd. 40, Nr. 4
Nitz, Katrin; Lacy, Michael und Atzler, Dorothee
(2019):
Amino Acids and Their Metabolism in Atherosclerosis.
In: Arteriosclerosis Thrombosis and Vascular Biology, Bd. 39, Nr. 3: S. 319-330
Centa, Monica; Jin, Hong; Hofste, Lisa; Hellberg, Sanna; Busch, Albert; Baumgartner, Roland; Verzaal, Nienke J.; Enoksson, Sara Lind; Matic, Ljubica Perisic; Boddul, Sanjay; Atzler, Dorothee; Li, Daniel Y.; Sun, Changyan; Hansson, Goran K.; Ketelhuth, Daniel F. J.; Hedin, Ulf; Wermeling, Fredrik; Lutgens, Esther; Binder, Christoph J.; Maegdesfessel, Lars und Malin, Stephen G.
(2019):
Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
In: Circulation, Bd. 139, Nr. 21: S. 2466-2482
Bianchini, Mariaelvy; Duchene, Johan; Santovito, Donato; Schloss, Maximilian J.; Evrard, Maximilien; Winkels, Holger; Aslani, Maria; Mohanta, Sarajo K.; Horckmans, Michael; Blanchet, Xavier; Lacy, Michael; Hundelshausen, Philipp von; Atzler, Dorothee; Habenicht, Andreas; Gerdes, Norbert; Pelisek, Jaroslav; Ng, Lai Guan; Steffens, Sabine; Weber, Christian und Megens, Remco T. A.
(2019):
PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function.
In: Science Immunology, Bd. 4, Nr. 36, eaar3054
Bollenbach, Alexander; Cordts, Kathrin; Hanff, Erik; Atzler, Dorothee; Choe, Chi-un; Schwedhelm, Edzard und Tsikas, Dimitrios
(2019):
Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans.
In: Analytical Biochemistry, Bd. 577: S. 59-66
Hackler, Eddie; Lew, Jeanney; Gore, M. Odette; Ayers, Colby R.; Atzler, Dorothee; Khera, Amit; Rohatgi, Anand; Lewis, Alana; Neeland, Ian; Omland, Torbjorn und de Lemos, James A.
(2019):
Racial Differences in Cardiovascular Biomarkers in the General Population.
In: Journal of the American Heart Association, Bd. 8, Nr. 18, e012729
[PDF, 708kB]
Lutgens, Esther; Atzler, Dorothee; Döring, Yvonne; Duchene, Johan; Steffens, Sabine und Weber, Christian
(2019):
Immunotherapy for cardiovascular disease.
In: European Heart Journal, Bd. 40, Nr. 48
2018
Schönhoff, Mirjam; Weineck, Gabriele; Hoppe, Julia; Hornig, Rinke; Cordts, Kathrin; Atzler, Dorothee; Gerloff, Christian; Boeger, Rainer; Neu, Axel; Schwedhelm, Edzard und Choe, Chi-Un
(2018):
Cognitive performance of 20 healthy humans supplemented with L-homoarginine for 4 weeks.
In: Journal of Clinical Neuroscience, Bd. 50: S. 237-241
Seijkens, Tom T. P.; Tiel, Claudia M. van; Kusters, Pascal J. H.; Atzler, Dorothee; Soehnlein, Oliver; Zarzycka, Barbara; Aarts, Suzanne A. B. M.; Lameijer, Marnix; Gijbels, Marion J.; Beckers, Linda; Toom, Myrthe den; Slutter, Bram; Kuiper, Johan; Duchene, Johan; Aslani, Maria; Megens, Remco T. A.; Veer, Cornelis van 't; Kooij, Gijs; Schrijver, Roy; Hoeksema, Marten A.; Boon, Louis; Fay, Francois; Tang, Jun; Baxter, Samantha; Jongejan, Aldo; Moerland, Perry D.; Vriend, Gert; Bleijlevens, Boris; Fisher, Edward A.; Duivenvoorden, Raphael; Gerdes, Norbert; Winther, Menno P. J. de; Nicolaes, Gerry A.; Mulder, Willem J. M.; Weber, Christian und Lutgens, Esther
(2018):
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.
In: Journal of the American College of Cardiology, Bd. 71, Nr. 5: S. 527-542
Faller, Kiterie M. E.; Atzler, Dorothee; McAndrew, Debra J.; Zervou, Sevasti; Whittington, Hannah J.; Simon, Jillian N.; Aksentijevic, Dunja; ten Hove, Michiel; Choe, Chi-un; Isbrandt, Dirk; Casadei, Barbara; Schneider, Jürgen E.; Neubauer, Stefan und Lygate, Craig A.
(2018):
Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.
In: Cardiovascular Research, Bd. 114, Nr. 3: S. 417-430
Baldassarri, Flavia; Schwedhelm, Edzard; Atzler, Dorothee; Boeger, Rainer H.; Cordts, Kathrin; Haller, Bernhard; Pressler, Axel; Müller, Stephan; Suchy, Christiane; Wachter, Rolf; Duengen, Hans-Dirk; Hasenfuss, Gerd; Pieske, Burkert; Halle, Martin; Edelmann, Frank und Duvinage, Andre
(2018):
Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction.
In: Biomarkers, Bd. 23, Nr. 6: S. 540-550
Bahls, Martin; Atzler, Dorothee; Markus, Marcello R. P.; Friedrich, Nele; Boeger, Rainer H.; Völzke, Henry; Felix, Stephan B.; Schwedhelm, Edzard und Dörr, Marcus
(2018):
Low-Circulating Homoarginine is Associated with Dilatation and Decreased Function of the Left Ventricle in the General Population.
In: Biomolecules, Bd. 8, Nr. 3, 63
[PDF, 388kB]
Niekamp, Christoph; Atzler, Dorothee; Ojeda, Francisco M.; Sinning, Christoph R.; Lackner, Karl J.; Boeger, Rainer H.; Munzel, Thomas; Beutel, Manfred E.; Schmidtmann, Irene; Pfeiffer, Norbert; Leuschner, Anja; Blankenberg, Stefan; Wild, Philipp S.; Zeller, Tanja; Schwedhelm, Edzard und Schnabel, Renate B.
(2018):
Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the CommunityThe Gutenberg Health Study.
In: Biomolecules, Bd. 8, Nr. 3, 86
[PDF, 738kB]
2017
Atzler, Dorothee; McAndrew, Debra J.; Cordts, Kathrin; Schneider, Jürgen E.; Zervou, Sevasti; Schwedhelm, Edzard; Neubauer, Stefan und Lygate, Craig A.
(2017):
Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.
In: Circulation, Bd. 135, Nr. 4: S. 400-402
[PDF, 71kB]
Xu, Xin; Zhang, Ping; Kwak, Dongmin; Fassett, John; Yue, Wenhui; Atzler, Dorothee; Hu, Xinli; Liu, Xiaohong; Wang, Huan; Lu, Zhongbing; Guo, Haipeng; Schwedhelm, Edzard; Böger, Rainer H.; Chen, Peijie und Chen, Yingjie
(2017):
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
In: Basic Research in Cardiology, Bd. 112, Nr. 5, 55
Kusters, Pascal; Seijkens, Tom; Bürger, Christina; Legein, Bart; Winkels, Holger; Gijbels, Marion; Barthels, Christian; Bennett, Remy; Beckers, Linda; Atzler, Dorothee; Biessen, Erik; Brocker, Thomas; Weber, Christian; Gerdes, Norbert und Lutgens, Esther
(2017):
Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption.
In: American Journal of Pathology, Bd. 187, Nr. 12: S. 2912-2919
2016
Atzler, Dorothee; Schönhoff, Mirjam; Cordts, Kathrin; Ortland, Imke; Hoppe, Julia; Hummel, Friedhelm C.; Gerloff, Christian; Jaehde, Ulrich; Jagodzinski, Annika; Böger, Rainer H.; Choe, Chi-un und Schwedhelm, Edzard
(2016):
Oral supplementation with L-homoarginine in young volunteers.
In: British Journal of Clinical Pharmacology, Bd. 82, Nr. 6: S. 1477-1485