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Anzahl der Publikationen: 14
Zeitschriftenartikel
Geisslinger, Franz; Müller, Martin; Chao, Yu-Kai; Grimm, Christian; Vollmar, Angelika M. und Bartel, Karin
(1. August 2022):
Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function.
In: Cell Death & Disease, Bd. 13, Nr. 8
[PDF, 5MB]
Siow, Wei Xiong; Kabiri, Yaschar; Tang, Rachel; Chao, Yu-Kai; Plesch, Eva; Eberhagen, Carola; Flenkenthaler, Florian; Froehlich, Thomas; Bracher, Franz; Grimm, Christian; Biel, Martin; Zischka, Hans; Vollmar, Angelika M. und Bartel, Karin
(2022):
Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.
In: Journal of Cell Science, Bd. 135, Nr. 6, jcs259455
Netcharoensirisuk, Ponsawan; Abrahamian, Carla; Tang, Rachel; Chen, Cheng-Chang; Rosato, Anna Scotto; Beyers, Wyatt; Chao, Yu-Kai; Filippini, Antonio; Di Pietro, Santiago; Bartel, Karin; Biel, Martin; Vollmar, Angelika M.; Umehara, Kaoru; De-Eknamkul, Wanchai und Grimm, Christian
(2021):
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
In: Scientific reports, Bd. 11, Nr. 1, 8515
[PDF, 4MB]
Böck, Julia; Krogsaeter, Einar; Passon, Marcel; Chao, Yu-Kai; Sharma, Sapna; Grallert, Harald; Peters, Annette und Grimm, Christian
(2021):
Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect.
In: PLOS Genetics 17(1), e1009236
In: PLOS Genetics 17(1), e1009236
Müller, Martin; Gerndt, Susanne; Chao, Yu-Kai; Zisis, Themistoklis; Ong, Nam Phuong Nguyen; Gerwien, Aaron; Urban, Nicole; Müller, Christoph; Gegenfurtner, Florian A.; Geisslinger, Franz; Ortler, Carina; Chen, Cheng-Chang; Zahler, Stefan; Biel, Martin; Schäfer, Michael; Grimm, Christian; Bracher, Franz; Vollmar, Angelika M. und Bartel, Karin
(2021):
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth.
In: Cell Chemical Biology, Bd. 28, Nr. 8:
1119-
Spix, Barbara; Chao, Yu-Kai; Abrahamian, Carla; Chen, Cheng-Chang und Grimm, Christian
(Februar 2020):
TRPML Cation Channels in Inflammation and Immunity.
In: Frontiers in Immunology, Bd. 11, 225: S. 1-9
[PDF, 747kB]
Weber, Jonas; Rajan, Suhasini; Schremmer, Christian; Chao, Yu-Kai; Krasteva-Christ, Gabriela; Kannler, Martina; Yildirim, Ali Onder; Brosien, Monika; Schredelseker, Johann; Weissmann, Norbert; Grimm, Christian; Gudermann, Thomas und Dietrich, Alexander
(2020):
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
In: Jci Insight, Bd. 5, Nr. 20, e134464
Gerndt, Susanne; Chen, Cheng-Chang; Chao, Yu-Kai; Yuan, Yu; Burgstaller, Sandra; Rosato, Anna Scotto; Krogsaeter, Einar; Urban, Nicole; Jacob, Katharina; Ong, Nam Phuong Nguyen; Miller, Meghan T.; Keller, Marco; Vollmar, Angelika M.; Gudermann, Thomas; Zierler, Susanna; Schredelseker, Johann; Schaefer, Michael; Biel, Martin; Malli, Roland; Wahl-Schott, Christian; Bracher, Franz; Patel, Sandip und Grimm, Christian
(2020):
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
In: eLife, Bd. 9, e54712
[PDF, 4MB]
Villella, Valeria R.; Venerando, Andrea; Cozza, Giorgio; Esposito, Speranza; Ferrari, Eleonora; Monzani, Romina; Spinella, Mara C.; Oikonomou, Vasilis; Renga, Giorgia; Tosco, Antonella; Rossin, Federica; Guido, Stefano; Silano, Marco; Garaci, Enrico; Chao, Yu-Kai; Grimm, Christian; Luciani, Alessandro; Romani, Luigina; Piacentini, Mauro; Raia, Valeria; Kroemer, Guido und Maiuri, Luigi
(2019):
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.
In: EMBO Journal, Bd. 38, Nr. 2, e100101
Chao, Yu-Kai; Schludi, Verena; Chen, Cheng-Chang; Butz, Elisabeth; Nguyen, O. N. Phuong; Müller, Martin; Krüger, Jens; Kammerbauer, Claudia; Ben-Johny, Manu; Vollmar, Angelika M.; Berking, Carola; Biel, Martin; Wahl-Schott, Christian A. und Grimm, Christian
(2017):
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 114, Nr. 41, E8595-E8602
Chen, Cheng-Chang; Cang, Chunlei; Fenske, Stefanie; Butz, Elisabeth; Chao, Yu-Kai; Biel, Martin; Ren, Dejian; Wahl-Schott, Christian und Grimm, Christian
(2017):
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.
In: Nature Protocols, Bd. 12, Nr. 8: S. 1639-1658
Chen, Cheng-Chang; Butz, Elisabeth S.; Chao, Yu-Kai; Grishchuk, Yulia; Becker, Lars; Heller, Stefan; Slaugenhaupt, Susan A.; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian
(2017):
Small Molecules for Early Endosome-Specific Patch Clamping.
In: Cell Chemical Biology, Bd. 24, Nr. 7: S. 907-916
Nguyen, Ong Nam Phuong; Grimm, Christian; Schneider, Lina S.; Chao, Yu-Kai; Atzberger, Carina; Bartel, Karin; Watermann, Anna; Ulrich, Melanie; Mayr, Doris; Wahl-Schott, Christian; Biel, Martin und Vollmar, Angelika M.
(2017):
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.
In: Cancer Research, Bd. 77, Nr. 6: S. 1427-1438
Beck, Simon; Henß, Lisa; Weidner, Tatjana; Herrmann, Jennifer; Müller, Rolf; Chao, Yu-Kai; Grimm, Christian; Weber, Christopher; Sliva, Katja und Schnierle, Barbara S.
(2016):
Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library.
In: Antiviral Research, Bd. 132: S. 85-91