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Anzahl der Publikationen: 46

Zeitschriftenartikel

Calbiac, Hortense de ORCID logoORCID: https://orcid.org/0000-0002-6246-0833; Renault, Solène; Haouy, Grégoire; Jung, Vincent; Roger, Kevin; Zhou, Qihui; Campanari, Maria-Letizia; Chentout, Loïc; Demy, Doris Lou; Marian, Anca; Goudin, Nicolas; Edbauer, Dieter ORCID logoORCID: https://orcid.org/0000-0002-7186-4653; Guerrera, Chiara; Ciura, Sorana und Kabashi, Edor (2024): Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects. In: Autophagy, Bd. 20, Nr. 10: S. 2164-2185 [PDF, 5MB]

Hu, Yiying; Hruscha, Alexander; Pan, Chenchen; Schifferer, Martina; Schmidt, Michael K.; Nuscher, Brigitte ORCID logoORCID: https://orcid.org/0009-0000-4661-0742; Giera, Martin; Kostidis, Sarantos; Burhan, Özge; Bebber, Frauke van; Edbauer, Dieter ORCID logoORCID: https://orcid.org/0000-0002-7186-4653; Arzberger, Thomas; Haass, Christian ORCID logoORCID: https://orcid.org/0000-0002-4869-1627 und Schmid, Bettina ORCID logoORCID: https://orcid.org/0000-0001-8043-7269 (2024): Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits. In: Molecular Neurodegeneration, Bd. 19, 50 [PDF, 6MB]

Reich, Marvin ORCID logoORCID: https://orcid.org/0000-0002-4567-0994; Simon, Matthew J. ORCID logoORCID: https://orcid.org/0000-0002-0065-6486; Polke, Beate; Paris, Iñaki ORCID logoORCID: https://orcid.org/0000-0002-3887-0277; Werner, Georg ORCID logoORCID: https://orcid.org/0000-0001-5328-3049; Schrader, Christian; Spieth, Lena; Davis, Sonnet S. ORCID logoORCID: https://orcid.org/0000-0001-7189-1427; Robinson, Sophie ORCID logoORCID: https://orcid.org/0000-0003-1261-1370; de Melo, Gabrielly Lunkes ORCID logoORCID: https://orcid.org/0009-0002-1342-3080; Schlaphoff, Lennart ORCID logoORCID: https://orcid.org/0000-0001-8043-4025; Buschmann, Katrin; Berghoff, Stefan ORCID logoORCID: https://orcid.org/0000-0002-3794-7295; Logan, Todd ORCID logoORCID: https://orcid.org/0000-0003-2081-782X; Nuscher, Brigitte ORCID logoORCID: https://orcid.org/0009-0000-4661-0742; de Weerd, Lis ORCID logoORCID: https://orcid.org/0000-0002-3641-1851; Edbauer, Dieter ORCID logoORCID: https://orcid.org/0000-0002-7186-4653; Simons, Mikael ORCID logoORCID: https://orcid.org/0000-0001-5329-192X; Suh, Jung H. ORCID logoORCID: https://orcid.org/0000-0001-8119-326X; Sandmann, Thomas ORCID logoORCID: https://orcid.org/0000-0002-6601-8890; Kariolis, Mihalis S. ORCID logoORCID: https://orcid.org/0000-0003-2067-4013; DeVos, Sarah L. ORCID logoORCID: https://orcid.org/0000-0003-0921-1763; Lewcock, Joseph W. ORCID logoORCID: https://orcid.org/0000-0003-3012-7881; Paquet, Dominik ORCID logoORCID: https://orcid.org/0000-0003-2065-1639; Capell, Anja ORCID logoORCID: https://orcid.org/0000-0003-3118-911X; Di Paolo, Gilbert ORCID logoORCID: https://orcid.org/0000-0003-1032-1265 und Haass, Christian ORCID logoORCID: https://orcid.org/0000-0002-4869-1627 (2024): Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. In: Science Translational Medicine, Bd. 16, Nr. 750

Caldi Gomes, Lucas ORCID logoORCID: https://orcid.org/0000-0003-4959-2169; Hänzelmann, Sonja ORCID logoORCID: https://orcid.org/0000-0003-4953-0101; Hausmann, Fabian ORCID logoORCID: https://orcid.org/0000-0001-6110-5824; Khatri, Robin ORCID logoORCID: https://orcid.org/0009-0006-5311-1718; Oller, Sergio; Parvaz, Mojan; Tzeplaeff, Laura ORCID logoORCID: https://orcid.org/0009-0003-7643-3232; Pasetto, Laura; Gebelin, Marie; Ebbing, Melanie; Holzapfel, Constantin; Columbro, Stefano Fabrizio; Scozzari, Serena; Knöferle, Johanna; Cordts, Isabell; Demleitner, Antonia F.; Deschauer, Marcus; Dufke, Claudia; Sturm, Marc; Zhou, Qihui; Zelina, Pavol; Sudria-Lopez, Emma; Haack, Tobias B. ORCID logoORCID: https://orcid.org/0000-0001-6033-4836; Streb, Sebastian ORCID logoORCID: https://orcid.org/0000-0002-9095-6596; Kuzma-Kozakiewicz, Magdalena; Edbauer, Dieter ORCID logoORCID: https://orcid.org/0000-0002-7186-4653; Pasterkamp, R. Jeroen ORCID logoORCID: https://orcid.org/0000-0003-1631-6440; Laczko, Endre ORCID logoORCID: https://orcid.org/0000-0003-0271-3971; Rehrauer, Hubert ORCID logoORCID: https://orcid.org/0000-0001-7612-9394; Schlapbach, Ralph; Carapito, Christine ORCID logoORCID: https://orcid.org/0000-0002-0079-319X; Bonetto, Valentina ORCID logoORCID: https://orcid.org/0000-0003-0456-2054; Bonn, Stefan und Lingor, Paul (2024): Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target. In: Nature Communications, Bd. 15, 4893 [PDF, 4MB]

Shojaei, Monireh; Zhou, Qihui; Palumbo, Giovanna; Schaefer, Rebecca; Kaskinoro, Janne; Vehmaan-Kreula, Pirjo; Bartenstein, Peter; Brendel, Matthias ORCID logoORCID: https://orcid.org/0000-0002-9247-2843; Edbauer, Dieter und Lindner, Simon ORCID logoORCID: https://orcid.org/0009-0007-4379-4436 (2024): Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia. In: ACS Pharmacology & Translational Science, Bd. 7, Nr. 5: S. 1404-1414 [PDF, 8MB]

Hipke, Katrin; Pitter, Bettina; Hruscha, Alexander; van Bebber, Frauke; Modic, Miha; Bansal, Vikas; Lewandowski, Sebastian A.; Orozco, Denise; Edbauer, Dieter; Bonn, Stefan; Haass, Christian; Pohl, Ulrich; Montanez, Eloi und Schmid, Bettina (2023): Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. In: Frontiers in Cell and Developmental Biology, Bd. 11, 1169962 [PDF, 3MB]

Jülg, Julia ORCID logoORCID: https://orcid.org/0000-0002-2973-1275; Edbauer, Dieter und Behrends, Christian ORCID logoORCID: https://orcid.org/0000-0002-9184-7607 (2023): C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains. In: EMBO reports, Bd. 24, Nr. 8 [PDF, 2MB]

Riemenschneider, Henrick; Simonetti, Francesca; Sheth, Udit; Katona, Eszter; Roth, Stefan; Hutten, Saskia; Farny, Daniel; Michaelsen, Meike; Nuscher, Brigitte; Schmidt, Michael K.; Flatley, Andrew; Schepers, Aloys; da Silva, Lara Gruijs A.; Zhou, Qihui; Klopstock, Thomas; Liesz, Arthur; Arzberger, Thomas; Herms, Jochen; Feederle, Regina; Gendron, Tania F.; Dormann, Dorothee und Edbauer, Dieter (2023): Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo. In: Acta Neuropathologica Communications, Bd. 11, Nr. 1, 112 [PDF, 6MB]

Strohm, Laura; Hu, Zehan; Suk, Yongwon; Rühmkorf, Alina; Sternburg, Erin; Gattringer, Vanessa; Riemenschneider, Henrick; Berutti, Riccardo; Graf, Elisabeth; Weishaupt, Jochen H. ORCID logoORCID: https://orcid.org/0000-0002-3399-9784; Brill, Monika S.; Harbauer, Angelika B.; Dormann, Dorothee; Dengjel, Jörn; Edbauer, Dieter und Behrends, Christian (1. Juli 2022): Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants. In: Life Science Alliance, Bd. 5, Nr. 11 [PDF, 6MB]

Gallo, Jean-Marc und Edbauer, Dieter (2022): A perturbed network in neurodegeneration. In: Science, Bd. 378, Nr. 6615: S. 28-29

da Silva, Lara A. Gruijs; Simonetti, Francesca; Hutten, Saskia; Riemenschneider, Henrick; Sternburg, Erin L.; Pietrek, Lisa M.; Gebel, Jakob; Doetsch, Volker; Edbauer, Dieter; Hummer, Gerhard; Stelzl, Lukas S. und Dormann, Dorothee (2022): Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation. In: EMBO Journal, Bd. 41, Nr. 8, e108443 [PDF, 6MB]

Riemenschneider, Henrick; Guo, Qiang; Bader, Jakob; Frottin, Frederic; Farny, Daniel; Kleinberger, Gernot; Haass, Christian; Mann, Matthias; Hartl, F. Ulrich; Baumeister, Wolfgang; Hipp, Mark S.; Meissner, Felix; Fernandez-Busnadiego, Ruben und Edbauer, Dieter (2022): Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. In: EMBO Reports, Bd. 23, Nr. 6, e53890 [PDF, 1MB]

Czuppa, Mareike; Dhingra, Ashutosh; Zhou, Qihui; Schludi, Carina; Koenig, Laura; Scharf, Elisabeth; Farny, Daniel; Dalmia, Anupriya; Taeger, Joachim; Castillo-Lizardo, Melissa; Katona, Eszter; Mori, Kohji; Aumer, Tina; Schelter, Florian; Mueller, Markus; Carell, Thomas; Kalliokoski, Tuomo; Messinger, Josef; Rizzu, Patrizia; Heutink, Peter und Edbauer, Dieter (2022): Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G(4)C(2))(n) expression in C9orf72 ALS/FTD. In: Cell Reports, Bd. 39, Nr. 10, 110913 [PDF, 3MB]

Nuebling, Georg S.; Prix, Catharina; Brendel, Matthias; Beyer, Leonie; Wlasich, Elisabeth; Loosli, Sandra; Barthel, Henryk; Sabri, Osama; Bartenstein, Peter; Voeglein, Jonathan; Danek, Adrian; Rominger, Axel; Edbauer, Dieter; Haass, Christian und Levin, Johannes (2021): Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease. In: Neurobiology of Aging, Bd. 103 [PDF, 472kB]

Wagner, Matias; Lorenz, Georg; Volk, Alexander E.; Brunet, Theresa; Edbauer, Dieter; Berutti, Riccardo; Zhao, Chen; Anderl-Straub, Sarah; Bertram, Lars; Danek, Adrian ORCID logoORCID: https://orcid.org/0000-0001-8857-5383; Deschauer, Marcus; Dill, Veronika; Fassbender, Klaus; Fliessbach, Klaus; Goetze, Katharina S.; Jahn, Holger; Kornhuber, Johannes; Landwehrmeyer, Bernhard; Lauer, Martin; Obrig, Hellmuth; Prudlo, Johannes; Schneider, Anja; Schroeter, Matthias L.; Uttner, Ingo; Vukovich, Ruth; Wiltfang, Jens; Winkler, Andrea S.; Zhou, Qihui; Ludolph, Albert C.; Oexle, Konrad; Otto, Markus; Diehl-Schmid, Janine und Winkelmann, Juliane (2021): Clinico-genetic findings in 509 frontotemporal dementia patients. In: Molecular Psychiatry, Bd. 26, Nr. 10: S. 5824-5832 [PDF, 1MB]

Mori, Kohji; Gotoh, Shiho; Yamashita, Tomoko; Uozumi, Ryota; Kawabe, Yuya; Tagami, Shinji; Kamp, Frits; Nuscher, Brigitte; Edbauer, Dieter; Haass, Christian; Nagai, Yoshitaka und Ikeda, Manabu (2021): The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene. In: Journal of Biological Chemistry, Bd. 297, Nr. 4, 101120 [PDF, 2MB]

Heindl, Steffanie; Ricci, Alessio; Carofiglio, Olga; Zhou, Qihui; Arzberger, Thomas; Lenart, Nikolett; Franzmeier, Nicolai; Hortobagyi, Tibor; Nelson, Peter T.; Stowe, Ann M.; Denes, Adam; Edbauer, Dieter und Liesz, Arthur (2021): Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. In: Journal of Experimental Medicine, Bd. 218, Nr. 8, e20202411 [PDF, 3MB]

Abo-Rady, Masin; Kalmbach, Norman; Pal, Arun; Schludi, Carina; Janosch, Antje; Richter, Tanja; Freitag, Petra; Bickle, Marc; Kahlert, Anne-Karin; Petri, Susanne; Stefanov, Stefan; Glass, Hannes; Staege, Selma; Just, Walter; Bhatnagar, Rajat; Edbauer, Dieter; Hermann, Andreas; Wegner, Florian und Sterneckert, Jared L. (2020): Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins. In: Stem Cell Reports, Bd. 14, Nr. 3: S. 390-405 [PDF, 19MB]

Khosravi, Bahram; LaClair, Kathrine D.; Riemenschneider, Henrick; Zhou, Qihui; Frottin, Frederic; Mareljic, Nikola; Czuppa, Mareike; Farny, Daniel; Hartmann, Hannelore; Michaelsen, Meike; Arzberger, Thomas; Hartl, F. Ulrich; Hipp, Mark S. und Edbauer, Dieter (2020): Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD. In: EMBO Journal, Bd. 39, Nr. 8, e102811 [PDF, 2MB]

Werner, Georg; Damme, Markus; Schludi, Martin; Gnoerich, Johannes; Wind, Karin; Fellerer, Katrin; Wefers, Benedikt; Wurst, Wolfgang; Edbauer, Dieter; Brendel, Matthias; Haass, Christian und Capell, Anja (2020): Loss ofTMEM106B potentiates lysosomal andFTLD-like pathology in progranulin-deficient mice. In: EMBO Reports, Bd. 21, Nr. 10, e50241 [PDF, 4MB]

Hutten, Saskia; Usluer, Sinem; Bourgeois, Benjamin; Simonetti, Francesca; Odeh, Hana M.; Fare, Charlotte M.; Czuppa, Mareike; Hruska-Plochan, Marian; Hofweber, Mario; Polymenidou, Magdalini; Shorter, James; Edbauer, Dieter; Madl, Tobias und Dormann, Dorothee (2020): Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions. In: Cell Reports, Bd. 33, Nr. 12, 108538 [PDF, 3MB]

LaClair, Katherine D.; Zhou, Qihui; Michaelsen, Meike; Wefers, Benedikt; Brill, Monika S.; Janjic, Aleksandar; Rathkolb, Birgit; Farny, Daniel; Cygan, Mikolaj; de Angelis, Martin Hrabe; Wurst, Wolfgang; Neumann, Manuela; Enard, Wolfgang; Misgeld, Thomas; Arzberger, Thomas und Edbauer, Dieter (2020): Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. In: Acta Neuropathologica, Bd. 140, Nr. 2: S. 121-142 [PDF, 8MB]

Diehl-Schmid, Janine; Licata, Abigail; Goldhardt, Oliver; Foerstl, Hans; Yakushew, Igor; Otto, Markus; Anderl-Straub, Sarah; Beer, Ambros; Ludolph, Albert Christian; Landwehrmeyer, Georg Bernhard; Levin, Johannes; Danek, Adrian; Fliessbach, Klaus; Spottke, Annika; Fassbender, Klaus; Lyros, Epameinondas; Prudlo, Johannes; Krause, Bernd Joachim; Volk, Alexander; Edbauer, Dieter; Schroeter, Matthias Leopold; Drzezga, Alexander; Kornhuber, Johannes; Lauer, Martin; Ackl, Nibal; Arnim, Christine V.; Brumberg, Joachim; Gaertner, Florian; Jahn, Holger; Kasper, Elisabeth; Kassubek, Jan; Prix, Catharina; Riedl, Lina; Rossmeier, Carola; Schönecker, Sonja; Semler, Elisa; Teipel, Stefan; Westerteicher, Christine; Wlasich, Elisabeth und Grimmer, Timo (2019): FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations. In: Translational Psychiatry, Bd. 9, 54 [PDF, 1MB]

Parhizkar, Samira; Arzberger, Thomas; Brendel, Matthias; Kleinberger, Gernot; Deussing, Maximilian; Focke, Carola; Nuscher, Brigitte; Xiong, Monica; Ghasemigharagoz, Alireza; Katzmarski, Natalie; Krasemann, Susanne; Lichtenthaler, Stefan F.; Müller, Stephan A.; Colombo, Alessio; Monasor, Laura Sebastian; Tahirovic, Sabina; Herms, Jochen; Willem, Michael; Pettkus, Nadine; Butovsky, Oleg; Bartenstein, Peter; Edbauer, Dieter; Rominger, Axel; Ertuerk, Ali; Grathwohl, Stefan A.; Neher, Jonas J.; Holtzman, David M.; Meyer-Luehmann, Melanie und Haass, Christian (2019): Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. In: Nature Neuroscience, Bd. 22, Nr. 2 [PDF, 6MB]

Pottier, Cyril; Ren, Yingxue; Perkerson, Ralph B.; Baker, Matt; Jenkins, Gregory D.; Blitterswijk, Marka van; DeJesus-Hernandez, Mariely; van Rooij, Jeroen G. J.; Murray, Melissa E.; Christopher, Elizabeth; McDonnell, Shannon K.; Fogarty, Zachary; Batzler, Anthony; Tian, Shulan; Vicente, Cristina T.; Matchett, Billie; Karydas, Anna M.; Hsiung, Ging-Yuek Robin; Seelaar, Harro; Mol, Merel O.; Finger, Elizabeth C.; Graff, Caroline; Oijerstedt, Linn; Neumann, Manuela; Heutink, Peter; Synofzik, Matthis; Wilke, Carlo; Prudlo, Johannes; Rizzu, Patrizia; Simon-Sanchez, Javier; Edbauer, Dieter; Roeber, Sigrun; Diehl-Schmid, Janine; Evers, Bret M.; King, Andrew; Mesulam, M. Marsel; Weintraub, Sandra; Geula, Changiz; Bieniek, Kevin F.; Petrucelli, Leonard; Ahern, Geoffrey L.; Reiman, Eric M.; Woodruff, Bryan K.; Caselli, Richard J.; Huey, Edward D.; Farlow, Martin R.; Grafman, Jordan; Mead, Simon; Grinberg, Lea T.; Spina, Salvatore; Grossman, Murray; Irwin, David J.; Lee, Edward B.; Suh, EunRan; Snowden, Julie; Mann, David; Ertekin-Taner, Nilufer; Uitti, Ryan J.; Wszolek, Zbigniew K.; Josephs, Keith A.; Parisi, Joseph E.; Knopman, David S.; Petersen, Ronald C.; Hodges, John R.; Piguet, Olivier; Geier, Ethan G.; Yokoyama, Jennifer S.; Rissman, Robert A.; Rogaeva, Ekaterina; Keith, Julia; Zinman, Lorne; Tartaglia, Maria Carmela; Cairns, Nigel J.; Cruchaga, Carlos; Ghetti, Bernardino; Kofler, Julia; Lopez, Oscar L.; Beach, Thomas G.; Arzberger, Thomas; Herms, Jochen; Honig, Lawrence S.; Vonsattel, Jean Paul; Halliday, Glenda M.; Kwok, John B.; White, Charles L.; Gearing, Marla; Glass, Jonathan; Rollinson, Sara; Pickering-Brown, Stuart; Rohrer, Jonathan D.; Trojanowski, John Q.; Van Deerlin, Vivianna; Bigio, Eileen H.; Troakes, Claire; Al-Sarraj, Safa; Asmann, Yan; Miller, Bruce L.; Graff-Radford, Neill R.; Boeve, Bradley F.; Seeley, William W.; Mackenzie, Ian R. A.; van Swieten, John C.; Dickson, Dennis W.; Biernacka, Joanna M. und Rademakers, Rosa (2019): Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. In: Acta Neuropathologica, Bd. 137, Nr. 6: S. 879-899 [PDF, 1MB]

Nihei, Yoshihiro; Mori, Kohji; Werner, Georg; Arzberger, Thomas; Zhou, Qihui; Khosravi, Barham; Japtok, Julia; Hermann, Andreas; Sommacal, Andreas; Weber, Markus; Kamp, Frits; Nuscher, Brigitte; Edbauer, Dieter und Haass, Christian (2019): Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3. In: Acta Neuropathologica, Bd. 139, Nr. 1: S. 99-118 [PDF, 3MB]

Zhou, Qihui; Mareljic, Nikola; Michaelsen, Meike; Parhizkar, Samira; Heindl, Steffanie; Nuscher, Brigitte; Farny, Daniel; Czuppa, Mareike; Schludi, Carina; Graf, Alexander; Krebs, Stefan; Blum, Helmut; Feederle, Regina; Roth, Stefan; Haass, Christian; Arzberger, Thomas; Liesz, Arthur und Edbauer, Dieter (2019): Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. In: EMBO Molecular Medicine, e10919 [PDF, 969kB]

Frick, Petra; Sellier, Chantal; Mackenzie, Ian R. A.; Cheng, Chieh-Yu; Tahraoui-Bories, Julie; Martinat, Cecile; Pasterkamp, R. Jeroen; Prudlo, Johannes; Edbauer, Dieter; Oulad-Abdelghani, Mustapha; Feederle, Regina; Charlet-Berguerand, Nicolas und Neumann, Manuela (2018): Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers. In: Acta Neuropathologica Communications 6:72 [PDF, 3MB]

Guo, Qiang; Lehmer, Carina; Martinez-Sanchez, Antonio; Rudack, Till; Beck, Florian; Hartmann, Hannelore; Perez-Berlanga, Manuela; Frottin, Frederic; Hipp, Mark S.; Hartl, F. Ulrich; Edbauer, Dieter; Baumeister, Wolfgang und Fernandez-Busnadiego, Ruben (2018): In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. In: Cell, Bd. 172, Nr. 4: S. 696-705

Lehmer, Carina; Schludi, Martin H.; Ransom, Linnea; Greiling, Johanna; Junghaenel, Michaela; Exner, Nicole; Riemenschneider, Henrick; Zee, Julie van der; Broeckhoven, Christine van; Weydt, Patrick; Heneka, Michael T. und Edbauer, Dieter (2018): A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS. In: EMBO Molecular Medicine, Bd. 10, Nr. 6 [PDF, 2MB]

Hartmann, Hannelore; Hornburg, Daniel; Czuppa, Mareike; Bader, Jakob; Michaelsen, Meike; Farny, Daniel; Arzberger, Thomas; Mann, Matthias; Meissner, Felix und Edbauer, Dieter (2018): Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity. In: Life Science Alliance, Bd. 1, Nr. 2, e201800070 [PDF, 3MB]

Schönecker, Sonja; Neuhofer, Christiane; Otto, Markus; Ludolph, Albert; Kassubek, Jan; Landwehrmeyer, Bernhard; Anderl-Straub, Sarah; Semler, Elisa; Diehl-Schmid, Janine; Prix, Catharina; Vollmar, Christian; Fortea, Juan; Huppertz, Hans-Jürgen; Arzberger, Thomas; Edbauer, Dieter; Feddersen, Berend; Dieterich, Marianne; Schröter, Matthias L.; Volk, Alexander E.; Fliessbach, Klaus; Schneider, Anja; Kornhuber, Johannes; Maler, Manuel; Prudlo, Johannes; Jahn, Holger; Böckh-Behrens, Tobias; Danek, Adrian; Klopstock, Thomas und Levin, Johannes (2018): Atrophy in the Thalamus But Not Cerebellum Is Specific for C9orf72 FTD and ALS Patients - An Atlas-Based Volumetric MRI Study. In: Frontiers in Aging Neuroscience, Bd. 10, 45 [PDF, 1MB]

Ohki, Yu; Wenninger-Weinzierl, Andrea; Hruscha, Alexander; Asakawa, Kazuhide; Kawakami, Koichi; Haass, Christian ORCID logoORCID: https://orcid.org/0000-0002-4869-1627; Edbauer, Dieter und Schmid, Bettina (2017): Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration. In: Molecular Neurodegeneration 12:6 [PDF, 1MB]

Schludi, Martin H.; Becker, Lore; Garrett, Lillian; Gendron, Tania F.; Zhou, Qihui; Schreiber, Franziska; Popper, Bastian; Dimou, Leda; Strom, Tim M.; Winkelmann, Juliane; Thaden, Anne von; Rentzsch, Kristin; May, Stephanie; Michaelsen, Meike; Schwenk, Benjamin M.; Tan, Jing; Schoser, Benedikt; Dieterich, Marianne; Petrucelli, Leonard; Hölter, Sabine M.; Wurst, Wolfgang; Fuchs, Helmut; Gailus-Durner, Valerie; Hrabe de Angelis, Martin; Klopstock, Thomas; Arzberger, Thomas und Edbauer, Dieter (2017): Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. In: Acta Neuropathologica, Bd. 134, Nr. 2: S. 241-254

Lehmer, Carina; Öckl, Patrick; Weishaupt, Jochen H.; Volk, Alexander E.; Diehl-Schmid, Janine; Schröter, Matthias L.; Lauer, Martin; Kornhuber, Johannes; Levin, Johannes; Fassbender, Klaus; Landwehrmeyer, Bernhard; Schludi, Martin H.; Arzberger, Thomas; Kremmer, Elisabeth; Flatley, Andrew; Feederle, Regina; Steinacker, Petra; Weydt, Patrick; Ludolph, Albert C.; Edbauer, Dieter und Otto, Markus (2017): Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD. In: Embo Molecular Medicine, Bd. 9, Nr. 7: S. 859-868

Zhou, Qihui; Lehmer, Carina; Michaelsen, Meike; Mori, Kohji; Alterauge, Dominik; Baumjohann, Dirk; Schludi, Martin H.; Greiling, Johanna; Farny, Daniel; Flatley, Andrew; Feederle, Regina; May, Stephanie; Schreiber, Franziska; Arzberger, Thomas; Kuhm, Christoph; Klopstock, Thomas; Hermann, Andreas; Haass, Christian ORCID logoORCID: https://orcid.org/0000-0002-4869-1627 und Edbauer, Dieter (2017): Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins. In: Embo Molecular Medicine, Bd. 9, Nr. 5: S. 687-702

Khosravi, Bahram; Hartmann, Hannelore; May, Stephanie; Möhl, Christoph; Ederle, Helena; Michaelsen, Meike; Schludi, Martin H.; Dormann, Dorothee und Edbauer, Dieter (2017): Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD. In: Human Molecular Genetics, Bd. 26, Nr. 4: S. 790-800 [PDF, 1MB]

Jiang, Jie; Zhu, Qiang; Gendron, Tania F.; Saberi, Shahram; McAlonis-Downes, Melissa; Seelman, Amanda; Stauffer, Jennifer E.; Jafar-nejad, Paymaan; Drenner, Kevin; Schulte, Derek; Chun, Seung; Sun, Shuying; Ling, Shuo-Chien; Myers, Brian; Engelhardt, Jeffery; Katz, Melanie; Baughn, Michael; Platoshyn, Oleksandr; Marsala, Martin; Watt, Andy; Heyser, Charles J.; Ard, M. Colin; Muynck, Louis de; Daughrity, Lillian M.; Swing, Deborah A.; Tessarollo, Lino; Jung, Chris J.; Delpoux, Arnaud; Utzschneider, Daniel T.; Hedrick, Stephen M.; Jong, Pieter J. de; Edbauer, Dieter; Damme, Philip van; Petrucelli, Leonard; Shaw, Christopher E.; Bennett, C. Frank; Da Cruz, Sandrine; Ravits, John; Rigo, Frank; Cleveland, Don W. und Lagier-Tourenne, Clotilde (2016): Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. In: Neuron, Bd. 90, Nr. 3: S. 535-550

Suárez-Calvet, Marc; Neumann, Manuela; Arzberger, Thomas; Abou-Ajram, Claudia; Funk, Eva; Hartmann, Hannelore; Edbauer, Dieter; Kremmer, Elisabeth; Göbl, Christoph; Resch, Moritz; Bourgeois, Benjamin; Madl, Tobias; Reber, Stefan; Jutzi, Daniel; Ruepp, Marc-David; Mackenzie, Ian R. A.; Ansorge, Olaf; Dormann, Dorothee und Haass, Christian ORCID logoORCID: https://orcid.org/0000-0002-4869-1627 (2016): Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. In: Acta Neuropathologica, Bd. 131, Nr. 4: S. 587-604

Schwenk, Benjamin M.; Hartmann, Hannelore; Serdaroglu, Alperen; Schludi, Martin H.; Hornburg, Daniel; Meissner, Felix; Orozco, Denise; Colombo, Alessio; Tahirovic, Sabina; Michaelsen, Meike; Schreiber, Franziska; Haupt, Simone; Peitz, Michael; Bruestle, Oliver; Küpper, Clemens; Klopstock, Thomas; Otto, Markus; Ludolph, Albert C.; Arzberger, Thomas; Kuhn, Peer-Hendrik und Edbauer, Dieter (2016): TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. In: Embo Journal, Bd. 35, Nr. 21: S. 2350-2370

Gijselinck, Ilse; Mossevelde, Sara van; Zee, Julie van der; Sieben, Anne; Engelborghs, Sebastiaan; Bleecker, Jan de; Ivanoiu, Adrian; Deryck, O.; Edbauer, Dieter; Zhang, M.; Heeman, Bavo; Bäumer, Veerle; Broeck, M. van den; Mattheijssens, Maria; Peeters, K.; Rogaeva, E.; Jonghe, Peter de; Cras, Patrick; Martin, Jean-Jacques; Deyn, Peter Paul de; Cruts, Marc und Broeckhoven, Christine van (2016): The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter. In: Molecular Psychiatry, Bd. 21, Nr. 8: S. 1112-1124

Zhang, Yong-Jie; Gendron, Tania F.; Grima, Jonathan C.; Sasaguri, Hiroki; Jansen-West, Karen; Xu, Ya-Fei; Katzman, Rebecca B.; Gass, Jennifer; Murray, Melissa E.; Shinohara, Mitsuru; Lin, Wen-Lang; Garrett, Aliesha; Stankowski, Jeannette N.; Daughrity, Lillian; Tong, Jimei; Perkerson, Emilie A.; Yue, Mei; Chew, Jeannie; Castanedes-Casey, Monica; Kurti, Aishe; Wang, Zizhao S.; Liesinger, Amanda M.; Baker, Jeremy D.; Jiang, Jie; Lagier-Tourenne, Clotilde; Edbauer, Dieter; Cleveland, Don W.; Rademakers, Rosa; Boylan, Kevin B.; Bu, Guojun; Link, Christopher D.; Dickey, Chad A.; Rothstein, Jeffrey D.; Dickson, Dennis W.; Fryer, John D. und Petrucelli, Leonard (2016): C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. In: Nature Neuroscience, Bd. 19, Nr. 5: S. 668-677

Edbauer, Dieter und Haass, Christian ORCID logoORCID: https://orcid.org/0000-0002-4869-1627 (2016): An amyloid-like cascade hypothesis for C9orf72 ALS/FTD. In: Current Opinion in Neurobiology, Bd. 36: S. 99-106

Fleck, Daniel; Voss, Matthias; Brankatschk, Ben; Giudici, Camilla; Hampel, Heike; Schwenk, Benjamin; Edbauer, Dieter; Fukumori, Akio; Steiner, Harald; Kremmer, Elisabeth; Haug-Kröper, Martina; Rossner, Moritz J.; Fluhrer, Regina; Willem, Michael und Haass, Christian ORCID logoORCID: https://orcid.org/0000-0002-4869-1627 (2016): Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases. In: Journal of Biological Chemistry, Bd. 291, Nr. 1: S. 318-333

Mori, Kohji; Nihei, Yoshihiro; Arzberger, Thomas; Zhou, Qihui; Mackenzie, Ian R.; Hermann, Andreas; Hanisch, Frank; Kamp, Frits; Nuscher, Brigitte; Orozco, Denise; Edbauer, Dieter und Haass, Christian ORCID logoORCID: https://orcid.org/0000-0002-4869-1627 (2016): Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition. In: Embo Reports, Bd. 17, Nr. 9: S. 1314-1325

Banzhaf-Strathmann, Julia und Edbauer, Dieter (2014): Good guy or bad guy: the opposing roles of microRNA 125b in cancer. In: Cell Communication and Signaling 12:30 [PDF, 1MB]

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