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Veröffentlichungsdatum
Anzahl der Publikationen: 10
2022
Willems, Sabine; Marschner, Julian A.; Kilu, Whitney; Faudone, Giuseppe; Busch, Romy; Duensing‐Kropp, Silke; Heering, Jan und Merk, Daniel
(30. Juni 2022):
Nurr1 Modulation Mediates Neuroprotective Effects of Statins.
In: Advanced Science, Bd. 9, Nr. 18
[PDF, 4MB]
Willems, Sabine; Mueller, Marcel; Ohrndorf, Julia; Heering, Jan; Proschak, Ewgenij und Merk, Daniel
(2022):
Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries.
In: Chemmedchem, Bd. 17, Nr. 8, e202200026
Zaienne, Daniel; Arifi, Silvia; Marschner, Julian A.; Heering, Jan und Merk, Daniel
(2022):
Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR-1) Reveals Inverse NOR-1 Agonists.
In: Chemmedchem, Bd. 17, Nr. 16, e202200259
Arifi, Silvia; Zaienne, Daniel; Heering, Jan; Wein, Thomas; Zhubi, Rezart; Chaikuad, Apirat; Knapp, Stefan; Marschner, Julian A. und Merk, Daniel
(2022):
Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
In: Bioorganic Chemistry, Bd. 129, 106164
Faudone, Giuseppe; Zhubi, Rezart; Celik, Fatih; Knapp, Stefan; Chaikuad, Apirat; Heering, Jan und Merk, Daniel
(2022):
Design of a Potent TLX Agonist by Rational Fragment Fusion.
In: Journal of Medicinal Chemistry, Bd. 65, Nr. 3: S. 2288-2296
Ehrler, Johanna H. M.; Brunst, Steffen; Tjaden, Amelie; Kilu, Whitney; Heering, Jan; Hernandez-Olmos, Victor; Krommes, Andre; Kramer, Jan S.; Steinhilber, Dieter; Schubert-Zsilavecz, Manfred; Müller, Susanne; Merk, Daniel und Proschak, Ewgenij
(2022):
Compilation and evaluation of a fatty acid mimetics screening library.
In: Biochemical Pharmacology, Bd. 204, 115191
Heering, Jan; Jores, Nathalie; Kilu, Whitney; Schallmayer, Espen; Peelen, Evelyn; Muehler, Andreas; Kohlhof, Hella; Vitt, Daniel; Linhard, Verena; Gande, Santosh L.; Chaikuad, Apirat; Sreeramulu, Sridhar; Schwalbe, Harald und Merk, Daniel
(2022):
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.
In: ACS Chemical Biology, Bd. 17, Nr. 11: S. 3159-3168
2021
Faudone, Giuseppe; Kilu, Whitney; Ni, Xiaomin; Chaikuad, Apirat; Sreeramulu, Sridhar; Heitel, Pascal; Schwalbe, Harald; Knapp, Stefan; Schubert-Zsilavecz, Manfred; Heering, Jan und Merk, Daniel
(2021):
The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines.
In: ACS Pharmacology & Translational Science, Bd. 4, Nr. 6: S. 1794-1807
Zaienne, Daniel; Willems, Sabine; Schierle, Simone; Heering, Jan und Merk, Daniel
(2021):
Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.
In: Journal of Medicinal Chemistry, Bd. 64, Nr. 20: S. 15126-15140
2020
Hinnah, Konstantin; Willems, Sabine; Morstein, Johannes; Heering, Jan; Hartrampf, Felix W. W.; Broichhagen, Johannes; Leippe, Philipp; Merk, Daniel und Trauner, Dirk
(2020):
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma).
In: Journal of Medicinal Chemistry, Bd. 63, Nr. 19: S. 10908-10920