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Anzahl der Publikationen: 38
Zeitschriftenartikel
Erben, Amelie; Hoerning, Marcel; Hartmann, Bastian; Becke, Tanja; Eisler, Stephan A.; Southan, Alexander; Cranz, Severine; Hayden, Oliver; Kneidinger, Nikolaus; Königshoff, Melanie; Lindner, Michael; Tovar, Guenter E. M.; Burgstaller, Gerald; Clausen-Schaumann, Hauke; Sudhop, Stefanie und Heymann, Michael
(2020):
Precision 3D-Printed Cell Scaffolds Mimicking Native Tissue Composition and Mechanics.
In: Advanced Healthcare Materials, Bd. 9, Nr. 24, 2000918
Vladar, Eszter K. und Königshoff, Melanie
(2020):
Noncanonical Wnt planar cell polarity signaling in lung development and disease.
In: Biochemical Society Transactions, Bd. 48, Nr. 1: S. 231-243
Strunz, Maximilian; Simon, Lukas M.; Ansari, Meshal; Kathiriya, Jaymin J.; Angelidis, Ilias; Mayr, Christoph H.; Tsidiridis, George; Lange, Marius; Mattner, Laura F.; Yee, Min; Ogar, Paulina; Sengupta, Arunima; Kukhtevich, Igor; Schneider, Robert; Zhao, Zhongming; Voss, Carola; Stoeger, Tobias; Neumann, Jens H. L.; Hilgendorff, Anne; Behr, Jürgen; O'Reilly, Michael; Lehmann, Mareike; Burgstaller, Gerald; Königshoff, Melanie; Chapman, Harold A.; Theis, Fabian J. und Schiller, Herbert B.
(2020):
Alveolar regeneration through a Krt8+transitional stem cell state that persists in human lung fibrosis.
In: Nature Communications, Bd. 11, Nr. 1, 3559
[PDF, 11MB]
Lehmann, Mareike; Hu, Qianjiang; Hu, Yan; Hafner, Kathrin; Costa, Rita; Berg, Anastasia van den und Königshoff, Melanie
(2020):
Chronic WNT/beta-catenin signaling induces cellular senescence in lung epithelial cells.
In: Cellular Signalling, Bd. 70, 109588
De Santis, Martina M.; Alsafadi, Hani N.; Tas, Sinem; Bolukbas, Deniz A.; Prithiviraj, Sujeethkumar; Da Silva, Iran A. N.; Mittendorfer, Margareta; Ota, Chiharu; Stegmayr, John; Daoud, Fatima; Königshoff, Melanie; Sward, Karl; Wood, Jeffery A.; Tassieri, Manlio; Bourgine, Paul E.; Lindstedt, Sandra; Mohlin, Sofie und Wagner, Darcy E.
(2020):
Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue.
In: Advanced Materials, Bd. 33, Nr. 3, 2005476
Ulke, Henrik M.; Mutze, Kathrin; Lehmann, Mareike; Wagner, Darcy E.; Heinzelmann, Katharina; Guenther, Andreas; Eickelberg, Oliver und Königshoff, Melanie
(2019):
The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis.
In: American Journal of Respiratory Cell and Molecular Biology, Bd. 61, Nr. 6: S. 713-726
Distler, Jörg H. W.; Gyoerfi, Andrea-Hermina; Ramanujam, Meera; Whitfield, Michael L.; Königshoff, Melanie und Lafyatis, Robert
(2019):
Shared and distinct mechanisms of fibrosis.
In: Nature Reviews Rheumatology, Bd. 15, Nr. 12: S. 705-730
Ng-Blichfeldt, John-Poul; de Jong, Tristan; Kortekaas, Rosa K.; Wu, Xinhui; Lindner, Michael; Guryev, Victor; Hiemstra, Pieter S.; Stolk, Jan; Königshoff, Melanie und Gosens, Reinoud
(2019):
TGF-beta activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.
In: American Journal of Physiology-Lung Cellular and Molecular Physiology, Bd. 317, Nr. 1:
L14-L28
Gerckens, Michael; Alsafadi, Hani N.; Wagner, Darcy E.; Lindner, Michael; Burgstaller, Gerald und Königshoff, Melanie
(2019):
Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling.
In: Jove-Journal of Visualized Experiments, Nr. 144, e58437
Ng-Blichfeldt, John-Poul; Schrik, Anneke; Kortekaas, Rosa K.; Noordhoek, Jacobien A.; Heijink, Irene H.; Hiemstra, Pieter S.; Stolk, Jan; Königshoff, Melanie und Gosens, Reinoud
(2018):
Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
In: Ebiomedicine, Bd. 36: S. 461-474
[PDF, 4MB]
Zhang, Wei; Ohno, Shinji; Steer, Beatrix; Klee, Stephan; Staab-Weijnitz, Claudia A.; Wagner, Darcy; Lehmann, Mareike; Stoeger, Tobias; Königshoff, Melanie und Adler, Heiko
(2018):
S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis.
In: Frontiers in Immunology, Bd. 9, 1216
[PDF, 4MB]
Skronska-Wasek, Wioletta; Gosens, Reinoud; Königshoff, Melanie und Baarsma, Hoeke Abele
(2018):
WNT receptor signalling in lung physiology and pathology.
In: Pharmacology & Therapeutics, Bd. 187: S. 150-166
Martin-Medina, Aina; Lehmann, Mareike; Burgy, Olivier; Hermann, Sarah; Baarsma, Hoeke A.; Wagner, Darcy E.; De Santis, Martina M.; Ciolek, Florian; Hofer, Thomas P.; Frankenberger, Marion; Aichler, Michaela; Lindner, Michael; Gesierich, Wolfgang; Günther, Andreas; Walch, Axel; Coughlan, Christina; Wolters, Paul; Lee, Joyce S.; Behr, Jürgen und Königshoff, Melanie
(2018):
Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis.
In: American Journal of Respiratory and Critical Care Medicine, Bd. 198, Nr. 12: S. 1527-1538
Burgstaller, Gerald; Sengupta, Arunima; Vierkotten, Sarah; Preissler, Gerhard; Lindner, Michael; Behr, Jürgen; Königshoff, Melanie und Eickelberg, Oliver
(2018):
Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures.
In: American Journal of Physiology-Lung Cellular and Molecular Physiology, Bd. 314, Nr. 5:
L708-L723
Lehmann, Mareike; Buhl, Lara; Alsafadi, Hani N.; Klee, Stephan; Hermann, Sarah; Mutze, Kathrin; Ota, Chiharu; Lindner, Michael; Behr, Jürgen; Hilgendorff, Anne; Wagner, Darcy E. und Königshoff, Melanie
(2018):
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis.
In: Respiratory Research
19:175
[PDF, 3MB]
Mümmler, Carlo; Burgy, Olivier; Hermann, Sarah; Mutze, Kathrin; Günther, Andreas und Königshoff, Melanie
(2018):
Cell-specific expression of runt-related transcription factor 2 contributes to pulmonary fibrosis.
In: FASEB Journal, Bd. 32, Nr. 2: S. 703-716
Heinzelmann, Katharina; Lehmann, Mareike; Gerckens, Michael; Noskovicova, Nina; Frankenberger, Marion; Lindner, Michael; Hatz, Rudolf; Behr, Jürgen; Hilgendorff, Anne; Königshoff, Melanie und Eickelberg, Oliver
(2018):
Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis.
In: American Journal of Physiology-Lung Cellular and Molecular Physiology, Bd. 315, Nr. 5:
L682-L696
Ota, Chiharu; Ng-Blichfeldt, John-Poul; Korfei, Martina; Alsafadi, Hani N.; Lehmann, Mareike; Skronska-Wasek, Wioletta; Santis, Martina M. de; Günther, Andreas; Wagner, Darcy E. und Königshoff, Melanie
(2018):
Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis.
In: Scientific Reports, Bd. 8, 12983
[PDF, 8MB]
Mossina, Alessandra; Lukas, Christina; Merl-Pham, Juliane; Uhl, Franziska E.; Mutze, Kathrin; Schamberger, Andrea; Staab-Weijnitz, Claudia; Jia, Jie; Yildirim, Ali Ö.; Königshoff, Melanie; Hauck, Stefanie M.; Eickelberg, Oliver und Meiners, Silke
(2017):
Cigarette smoke alters the secretome of lung epithelial cells.
In: Proteomics, Bd. 17, Nr. 43132, 1600243
Hofmann, Katharina; Fiedler, Susanne; Vierkotten, Sarah; Weber, Jonas; Klee, Stephan; Jia, Jie; Zwickenpflug, Wolfgang; Flockerzi, Veit; Storch, Ursula; Yildirim, Ali Önder; Gudermann, Thomas; Königshoff, Melanie und Dietrich, Alexander
(2017):
Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis.
In: Biochimica et Biophysica Acta-Molecular Basis of Disease, Bd. 1863, Nr. 2: S. 560-568
Poobalasingam, Thanushiyan; Yates, Laura L.; Walker, Simone A.; Pereira, Miguel; Gross, Nina Y.; Ali, Akmol; Kolatsi-Joannou, Maria; Jarvelin, Marjo-Riitta; Pekkanen, Juha; Papakrivopoulou, Eugenia; Long, David A.; Griffiths, Mark; Wagner, Darcy; Königshoff, Melanie; Hind, Matthew; Minelli, Cosetta; Lloyd, Clare M. und Dean, Charlotte H.
(2017):
Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.
In: Disease Models & Mechanisms, Bd. 10, Nr. 4: S. 409-423
Milger, Katrin; Yu, Yingyan; Brudy, Eva; Irmler, Martin; Skapenko, Alla; Mayinger, Michael; Lehmann, Mareike; Beckers, Johannes; Reichenberger, Frank; Behr, Jürgen; Eickelberg, Oliver; Königshoff, Melanie und Krauss-Etschmann, Susanne
(2017):
Pulmonary CCR2(+)CD4(+) T cells are immune regulatory and attenuate lung fibrosis development.
In: Thorax, Bd. 72, Nr. 11: S. 1007-1020
[PDF, 9MB]
Costa, Rita und Königshoff, Melanie
(2017):
Linking Wnt Signaling to Mucosal Inflammation.
In: American Journal of Respiratory Cell and Molecular Biology, Bd. 56, Nr. 5: S. 551-552
Brandsma, Corry-Anke; Vries, Maaike de; Costa, Rita; Woldhuis, Roy R.; Königshoff, Melanie und Timens, Wim
(2017):
Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
In: European Respiratory Review, Bd. 26, Nr. 146, 170073
Dietz, Katharina; Jimenez, Marta de los Reyes; Gollwitzer, Eva S.; Chaker, Adam M.; Zissler, Ulrich M.; Radmark, Olof P.; Baarsma, Höke A.; Königshoff, Melanie; Schmidt-Weber, Carsten B.; Marsland, Benjamin J. und Esser-von Bieren, Julia
(2017):
Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways.
In: Journal of Allergy and Clinical Immunology, Bd. 139, Nr. 4: S. 1343-1354
Voigt, Cornelia; May, Peter; Gottschlich, Adrian; Markota, Anamarija; Wenk, Daniel; Gerlach, Inga; Voigt, Sebastian; Stathopoulos, Georgios T.; Arendt, Kristina A. M.; Heise, Constanze; Rataj, Felicitas; Janssen, Klaus-Peter; Königshoff, Melanie; Winter, Hauke; Himsl, Isabelle; Thasler, Wolfgang E.; Schnurr, Max; Rothenfußer, Simon; Endres, Stefan und Kobold, Sebastian
(2017):
Cancer cells induce interleukin-22 production from memory CD4(+) T cells via interleukin-1 to promote tumor growth.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 114, Nr. 49: S. 12994-12999
Liu, Xueping; Baarsma, Hoeke Abele; Thiam, Chung Hwee; Montrone, Corinna; Brauner, Barbara; Fobo, Gisela; Heier, Julia-Sophie; Duscha, Sven; Königshoff, Melanie; Angeli, Veronique; Ruepp, Andreas und Campillos, Monica
(2016):
Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens.
In: Cell Chemical Biology, Bd. 23, Nr. 10: S. 1302-1313
Bardou, Olivier; Menou, Awen; Francois, Charlene; Duitman, Jan Willem; Thüsen, Jan H. von der; Borie, Raphael; Sales, Katiuchia Uzzun; Mutze, Kathrin; Castier, Yves; Sage, Edouard; Liu, Ligong; Bugge, Thomas H.; Fairlie, David P.; Königshoff, Melanie; Crestani, Bruno und Borensztajn, Keren S.
(2016):
Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.
In: American Journal of Respiratory and Critical Care Medicine, Bd. 193, Nr. 8: S. 847-860
Fernandez, Isis E.; Amarie, Oana V.; Mutze, Kathrin; Königshoff, Melanie; Yildirim, Ali Önder und Eickelberg, Oliver
(2016):
Systematic phenotyping and correlation of biomarkers with lung function and histology in lung fibrosis.
In: American Journal of Physiology: Lung Cellular and Molecular Physiology, Bd. 310, Nr. 10:
L919-L927
Ge, Lingyin; Habiel, David M.; Hansbro, Phil M.; Kim, Richard Y.; Gharib, Sina A.; Edelman, Jeffery D.; Königshoff, Melanie; Parimon, Tanyalak; Brauer, Rena; Huang, Ying; Allen, Jenieke; Jiang, Dianhua; Kurkciyan, Adrianne A.; Mizuno, Takako; Stripp, Barry R.; Noble, Paul W.; Hogaboam, Cory M. und Chen, Peter
(2016):
miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways.
In: Jci insight, Bd. 1, Nr. 20, e90301
Kammerl, Ilona E.; Dann, Angela; Mossina, Alessandra; Brech, Dorothee; Lukas, Christina; Vosyka, Oliver; Nathan, Petra; Conlon, Thomas M.; Wagner, Darcy E.; Overkleeft, Hermen S.; Prasse, Antje; Rosas, Ivan O.; Straub, Tobias; Krauss-Etschmann, Susanne; Königshoff, Melanie; Preissler, Gerhard; Winter, Hauke; Lindner, Michael; Hatz, Rudolf; Behr, Jürgen; Heinzelmann, Katharina; Yildirim, Ali Ö.; Noessner, Elfriede; Eickelberg, Oliver und Meiners, Silke
(2016):
Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease.
In: American Journal of Respiratory and Critical Care Medicine, Bd. 193, Nr. 11: S. 1230-1241
Spanjer, Anita I. R.; Baarsma, Hoeke A.; Oostenbrink, Lisette M.; Jansen, Sepp R.; Kuipers, Christine C.; Lindner, Michael; Postma, Dirkje S.; Meurs, Herman; Heijink, Irene H.; Gosens, Reinoud und Königshoff, Melanie
(2016):
TGF-beta-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.
In: FASEB Journal, Bd. 30, Nr. 5: S. 1823-1835
Banon-Maneus, E.; Rovira, J.; Ramirez-Bajo, M. J.; Moya-Rull, D.; Hierro-Garcia, N.; Takenaka, S.; Diekmann, F.; Eickelberg, Oliver; Königshoff, Melanie und Campistol, J. M.
(2014):
Wnt Pathway Activation in Long Term Remnant Rat Model.
In: Biomed Research International, Bd. 2014, 324713
[PDF, 2MB]
Jenkins, Gisli; Blanchard, Andrew; Borok, Zea; Bradding, Peter; Ehrhardt, Carsten; Fisher, Andrew; Hirani, Nik; Johnson, Simon; Königshoff, Melanie; Maher, Toby M.; Millar, Ann; Parfrey, Helen; Scotton, Chris; Tetley, Terry; Thickett, David und Wolters, Paul
(Februar 2012):
In search of the fibrotic epithelial cell: opportunities for a collaborative network.
In: Thorax, Bd. 67, Nr. 2: S. 179-182
[PDF, 103kB]
Mittal, Rashmi A.; Hammel, Markus; Schwarz, Johannes; Heschl, Katharina M.; Bretschneider, Nancy; Flemmer, Andreas W.; Herber-Jonat, Susanne; Königshoff, Melanie; Eickelberg, Oliver und Holzinger, Andreas
(2012):
SFTA2 - a novel secretory peptide highly expressed in the lung - is modulated by lipopolysaccharide but not hyperoxia.
In: PLOS ONE 7(6), e40011 [PDF, 1MB]
In: PLOS ONE 7(6), e40011 [PDF, 1MB]
Königshoff, Melanie
(2011):
Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity.
In: Respiration, Nr. 5: S. 353-358
[PDF, 175kB]
Königshoff, Melanie; Dumitrascu, Rio; Udalov, Sergey; Amarie, Oana Veronica; Reiter, Rudolf; Grimminger, Friedrich; Seeger, Werner; Schermuly, Ralph Theo und Eickelberg, Oliver
(2010):
Increased expression of 5-hydroxytryptamine(2A/B) receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention.
In: Thorax, Bd. 65, Nr. 11: S. 949-955
[PDF, 1MB]
Jayachandran, A.; Königshoff, Melanie; Yu, H.; Rupniewska, E.; Hecker, M.; Klepetko, W.; Seeger, W. und Eickelberg, O.
(2009):
SNAI transcription factors mediate epithelial--mesenchymal transition in lung fibrosis.
In: Thorax, Bd. 64, Nr. 12: S. 1053-1061
[PDF, 2MB]