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Veröffentlichungsdatum
Anzahl der Publikationen: 40
2022
Dhawan, Umesh Kumar; Margraf, Andreas; Lech, Maciej und Subramanian, Manikandan
(2022):
Hypercholesterolemia promotes autoantibody production and a lupus-like pathology via decreased DNase-mediated clearance of DNA.
In: Journal of Cellular and Molecular Medicine, Bd. 26, Nr. 20: S. 5267-5276
Lorenz, Georg; Shen, Yuli; Hausinger, Renate Ilona; Scheid, Caroline; Eckermann, Marie; Hornung, Sophia; Cardoso, Joana; Lech, Maciej; Ribeiro, Andrea; Haller, Bernhard; Holzmann-Littig, Christopher; Steubl, Dominik; Braunisch, Matthias C.; Günthner, Roman; Poschenrieder, Andreas; Freitag, Britt; Weber, Mario; Luppa, Peter; Heemann, Uwe und Schmaderer, Christoph
(2022):
A randomized prospective cross over study on the effects of medium cut-off membranes on T cellular and serologic immune phenotypes in hemodialysis.
In: Scientific Reports, Bd. 12, Nr. 1, 16419
Wadowska, Marta; Dobosz, Ewelina; Golda, Anna; Bryzek, Danuta; Lech, Maciej; Fu, Mingui und Koziel, Joanna
(2022):
MCP-Induced Protein 1 Participates in Macrophage-Dependent Endotoxin Tolerance.
In: Journal of Immunology, Bd. 209, Nr. 7: S. 1348-1358
Ribeiro, Andrea; Dobosz, Ewelina; Krill, Moritz; Köhler, Paulina; Wadowska, Marta; Steiger, Stefanie; Schmaderer, Christoph; Koziel, Joanna und Lech, Maciej
(2022):
Macrophage-Specific MCPIP1/Regnase-1 Attenuates Kidney Ischemia-Reperfusion Injury by Shaping the Local Inflammatory Response and Tissue Regeneration.
In: Cells, Bd. 11, Nr. 3, 397
Lichtnekert, Julia; Anders, Hans-Joachim und Lech, Maciej
(2022):
Lupus Nephritis: Current Perspectives and Moving Forward.
In: Journal of Inflammation Research, Bd. 15: S. 6533-6552
Sen, Tathambika Tejeswini; Kale, Ajinath; Lech, Maciej; Anders, Hans-Joachim und Gaikwad, Anil Bhanudas
(2022):
Promising novel therapeutic targets for kidney disease: Emphasis on kidney-specific proteins.
In: Drug Discovery Today, Bd. 28, Nr. 2: S. 1-10
Lorenz, Georg; Ribeiro, Andrea; Rauchhaupt, Ekatharina von; Wuerf, Vivian; Schmaderer, Christoph; Cohen, Clemens D.; Vohra, Twinkle; Anders, Hans-Joachim; Lindenmeyer, Maja und Lech, Maciej
(2022):
GDF15 Suppresses Lymphoproliferation and Humoral Autoimmunity in a Murine Model of Systemic Lupus Erythematosus.
In: Journal of Innate Immunity, Bd. 14, Nr. 6: S. 673-689
[PDF, 2MB]
2021
Dobosz, Ewelina; Wadowska, Marta; Kaminska, Marta; Wilamowski, Mateusz; Honarpisheh, Mohsen; Bryzek, Danuta; Potempa, Jan; Jura, Jolanta; Lech, Maciej und Koziel, Joanna
(26. Februar 2021):
MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils.
In: Frontiers in Immunology, Bd. 12, 627922
[PDF, 2MB]
Dobosz, Ewelina; Lorenz, Georg; Ribeiro, Andrea; Wuerf, Vivian; Wadowska, Marta; Kotlinowski, Jerzy; Schmaderer, Christoph; Potempa, Jan; Fu, Mingui; Koziel, Joanna und Lech, Maciej
(2021):
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.
In: Disease Models & Mechanisms, Bd. 14, Nr. 3, dmm047589
Dobosz, Ewelina 
ORCID: https://orcid.org/0000-0002-0151-9723; Lorenz, Georg; Ribeiro, Andrea; Würf, Vivian; Wadowska, Marta ORCID: https://orcid.org/0000-0003-1293-1091; Kotlinowski, Jerzy ORCID: https://orcid.org/0000-0002-3133-3364; Schmaderer, Christoph; Potempa, Jan ORCID: https://orcid.org/0000-0002-3600-7461; Fu, Mingui; Koziel, Joanna ORCID: https://orcid.org/0000-0003-3436-6425 und Lech, Maciej ORCID: https://orcid.org/0000-0002-4293-2733
(2021):
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.
In: Disease Models & Mechanisms, Bd. 14, Nr. 3, dmm047589
[PDF, 8MB]
ORCID: https://orcid.org/0000-0002-0151-9723; Lorenz, Georg; Ribeiro, Andrea; Würf, Vivian; Wadowska, Marta ORCID: https://orcid.org/0000-0003-1293-1091; Kotlinowski, Jerzy ORCID: https://orcid.org/0000-0002-3133-3364; Schmaderer, Christoph; Potempa, Jan ORCID: https://orcid.org/0000-0002-3600-7461; Fu, Mingui; Koziel, Joanna ORCID: https://orcid.org/0000-0003-3436-6425 und Lech, Maciej ORCID: https://orcid.org/0000-0002-4293-2733
(2021):
Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.
In: Disease Models & Mechanisms, Bd. 14, Nr. 3, dmm047589
[PDF, 8MB]
Kotlinowski, Jerzy; Hutsch, Tomasz; Czyzynska-Cichon, Izabela; Wadowska, Marta; Pydyn, Natalia; Jasztal, Agnieszka; Kij, Agnieszka; Dobosz, Ewelina; Lech, Maciej; Miekus, Katarzyna; Pospiech, Ewelina; Fu, Mingui; Jura, Jolanta; Koziel, Joanna und Chlopicki, Stefan
(2021):
Deletion of Mcpip1 in Mcpip1(fl/fl)Alb(Cre) mice recapitulates the phenotype of human primary biliary cholangitis.
In: Biochimica et Biophysica Acta-Molecular Basis of Disease, Bd. 1867, Nr. 5, 166086
2020
Kober-Hasslacher, Maike; Oh-Strauss, Hyunju; Kumar, Dilip; Soberon, Valeria; Diehl, Carina; Lech, Maciej; Engleitner, Thomas; Katab, Eslam; Fernandez-Saiz, Jvanesa; Piontek, Guido; Li, Hongwei; Menze, Bjorn; Ziegenhain, Christoph; Enard, Wolfgang; Rad, Roland; Boettcher, Jan P.; Anders, Hans-Joachim; Rudelius, Martina und Schmidt-Supprian, Marc
(2020):
c-Rel gain in B cells drives germinal center reactions and autoantibody production.
In: Journal of Clinical Investigation, Bd. 130, Nr. 6: S. 3270-3286
Moschovaki-Filippidou, Foteini; Steiger, Stefanie; Lorenz, Georg; Schmaderer, Christoph; Ribeiro, Andrea; Rauchhaupt, Ekaterina von; Cohen, Clemens D.; Anders, Hans-Joachim; Lindenmeyer, Maja und Lech, Maciej
(2020):
Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice.
In: International Journal of Molecular Sciences, Bd. 21, Nr. 19, 6978
Sellmayr, Markus; Petzsche, Moritz Roman Hernandez; Ma, Qiuyue; Krueger, Nils; Liapis, Helen; Brink, Andreas; Lenz, Barbara; Angelotti, Maria Lucia; Gnemmi, Viviane; Kuppe, Christoph; Kim, Hyojin; Bindels, Eric Monique Johannes; Tajti, Ferenc; Saez-Rodriguez, Julio; Lech, Maciej; Kramann, Rafael; Romagnani, Paola; Anders, Hans-Joachim und Steiger, Stefanie
(2020):
Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease.
In: Journal of the American Society of Nephrology, Bd. 31, Nr. 12: S. 2773-2792
Metzger, Philipp; Kirchleitner, Sabrina V.; Boehmer, Daniel F. R.; Hörth, Christine; Eisele, Angelika; Ormanns, Steffen; Gunzer, Matthias; Lech, Maciej; Lauber, Kirsten; Endres, Stefan; Duewell, Peter; Schnurr, Max und König, Lars M.
(2020):
Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model.
In: Cancer immunology, immunotherapy : CII, Bd. 69: S. 2101-2112
[PDF, 1MB]
2019
Lorenz, Georg; Moschovaki-Filippidou, Foteini; Wuerf, Vivian; Metzger, Philipp; Steiger, Stefanie; Batz, Falk; Carbajo-Lozoya, Javier; Koziel, Joanna; Schnurr, Max; Cohen, Clemens D.; Schmaderer, Christoph; Anders, Hans-Joachim; Lindenmeyer, Maja und Lech, Maciej
(1. Oktober 2019):
IFN Regulatory Factor 4 Controls Post-ischemic Inflammation and Prevents Chronic Kidney Disease.
In: Frontiers in Immunology, Bd. 10, 2162
[PDF, 2MB]
Kemmner, Stephan; Bachmann, Quirin; Steiger, Stefanie; Lorenz, Georg; Honarpisheh, Mohsen; Foresto-Neto, Orestes; Wang, Shijun; Carbajo-Lozoya, Javier; Alt, Verena; Schulte, Christian; Chmielewski, Stefan; Bluyssen, Hans A. R.; Heemann, Uwe; Baumann, Marcus; Lech, Maciej und Schmaderer, Christoph
(2019):
STAT1 regulates macrophage number and phenotype and prevents renal fibrosis after ischemia-reperfusion injury.
In: American Journal of Physiology-Renal Physiology, Bd. 316, Nr. 2:
F277-F291
Bryzek, Danuta; Ciaston, Izabela; Dobosz, Ewelina; Gasiorek, Anna; Makarska, Anna; Sarna, Michal; Eick, Sigrun; Puklo, Magdalena; Lech, Maciej; Potempa, Barbara; Potempa, Jan und Koziel, Joanna
(2019):
Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits.
In: PLOS Pathogens 15(5), e1007773 [PDF, 2MB]
In: PLOS Pathogens 15(5), e1007773 [PDF, 2MB]
2018
Honarpisheh, Mohsen; Foresto-Neto, Orestes; Steiger, Stefanie; Kraft, Franziska; Koehler, Paulina; Rauchhaupt, Ekaterina von; Potempa, Jan; Adamowicz, Karina; Koziel, Joanna und Lech, Maciej
(2018):
Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease.
In: Scientific Reports, Bd. 8, 12169
[PDF, 3MB]
Honarpisheh, Mohsen; Köhler, Paulina; Rauchhaupt, Ekaterina von und Lech, Maciej
(2018):
The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis.
In: Journal of Immunology Research, Bd. 2018, 4126106
[PDF, 1MB]
Steiger, Stefanie; Grill, Julia Felicitas; Ma, Qiuyue; Bäuerle, Tobias; Jordan, Jutta; Smolle, Michaela; Böhland, Claudia; Lech, Maciej und Anders, Hans-Joachim
(2018):
Anti-Transforming Growth Factor β IgG Elicits a Dual Effect on Calcium Oxalate Crystallization and Progressive Nephrocalcinosis-Related Chronic Kidney Disease.
In: Frontiers in Immunology, Bd. 9, 619
[PDF, 8MB]
2017
Lorenz, Georg; Steubl, Dominik; Kemmner, Stephan; Pasch, Andreas; Koch-Sembdner, Wilhelm; Pham, Dang; Haller, Bernhard; Bachmann, Quirin; Mayer, Christopher C.; Wassertheurer, Siegfried; Angermann, Susanne; Lech, Maciej; Moog, Philipp; Bauer, Axel; Heemann, Uwe und Schmaderer, Christoph
(2017):
Worsening calcification propensity precedes all-cause and cardiovascular mortality in haemodialyzed patients.
In: Scientific Reports, Bd. 7, 13368
[PDF, 1MB]
Glowczyk, Izabela; Wong, Alicia; Potempa, Barbara; Babyak, Olena; Lech, Maciej; Lamont, Richard J.; Potempa, Jan und Koziel, Joanna
(2017):
Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.
In: Frontiers in Cellular and infection Microbiology, Bd. 7, 140
[PDF, 3MB]
Kemmner, Stephan; Bachmann, Quirin; Lorenz, Georg; Foresto-Neto, Orestes; Baumann, Marcus; Heemann, Uwe; Lech, Maciej und Schmaderer, Christoph
(2017):
STAT1 prevents renal fibrosis via regulation of macrophage number upon renal ischemic injury.
In: Transplant international, Bd. 30: S. 333-334
Steiger, Stefanie; Kumar, Santhosh V.; Honarpisheh, Mohsen; Lorenz, Georg; Günthner, Roman; Romoli, Simone; Gröbmayr, Regina; Susanti, Heni-Eka; Potempa, Jan; Koziel, Joanna und Lech, Maciej
(2017):
Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis.
In: Journal of Immunology, Bd. 199, Nr. 4: S. 1440-1452
Lorenz, Georg; Lech, Maciej und Anders, Hans-Joachim
(2017):
Toll-like receptor activation in the pathogenesis of lupus nephritis.
In: Clinical Immunology, Bd. 185: S. 86-94
Mulay, Shrikant R.; Eberhard, Jonathan N.; Desai, Jyaysi; Marschner, Julian A.; Kumar, Santhosh V. R.; Weidenbusch, Marc; Grigorescu, Melissa; Lech, Maciej; Eltrich, Nuru; Müller, Lisa; Hans, Wolfgang; Hrabe de Angelis, Martin; Vielhauer, Volker; Hoppe, Bernd; Asplin, John; Burzlaff, Nicolai; Herrmann, Martin; Evan, Andrew und Anders, Hans-Joachim
(2017):
Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease.
In: Journal of the American Society of Nephrology, Bd. 28, Nr. 3: S. 761-768
2016
Seleznik, Gitta; Seeger, Harald; Bauer, Judith; Fu, Kai; Czerkowicz, Julie; Papandile, Adrian; Poreci, Uriana; Rabah, Dania; Ranger, Ann; Cohen, Clemens D.; Lindenmeyer, Maja; Chen, Jin; Edenhofer, Ilka; Anders, Hans J.; Lech, Maciej; Wüthrich, Rudolf P.; Ruddle, Nancy H.; Moeller, Marcus J.; Kozakowski, Nicolas; Regele, Heinz; Browning, Jeffrey L.; Heikenwalder, Mathias und Segerer, Stephan
(2016):
The lymphotoxin beta receptor is a potential therapeutic target in renal inflammation.
In: Kidney international, Bd. 89, Nr. 1: S. 113-126
Honarpisheh, Mohsen; Desai, Jyaysi; Maschner, Julian A.; Weidenbusch, Marc; Lech, Maciej; Vielhauer, Volker; Anders, Hans-Joachim und Mulay, Shrikant R.
(2016):
Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.
In: Bioscience Reports, Bd. 36, e00425
[PDF, 2MB]
Dobosz, Ewelina; Wilamowski, Mateusz; Lech, Maciej; Bugara, Beata; Jura, Jolanta; Potempa, Jan und Koziel, Joanna
(2016):
MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production.
In: Journal of innate Immunity, Bd. 8, Nr. 6: S. 564-578
[PDF, 402kB]
Mulay, Shrikant R.; Kumar, Santhosh V.; Lech, Maciej; Desai, Jyaysi und Anders, Hans-Joachim
(2016):
How Kidney Cell Death Induces Renal Necroinflammation.
In: Seminars in Nephrology, Bd. 36, Nr. 3: S. 162-173
2015
Lech, Maciej; Lorenz, Georg; Kulkarni, Onkar P.; Grosser, Marian O. O.; Stigrot, Nora; Darisipudi, Murthy N.; Günthner, Roman; Wintergerst, Maximilian W. M.; Anz, David; Susanti, Heni Eka und Anders, Hans-Joachim
(2015):
NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-beta receptor signalling.
In: Annals of the rheumatic diseases, Bd. 74, Nr. 12: S. 2224-2235
[PDF, 3MB]
2013
Günthner, Roman; Kumar, Vankayala Ramaiah Santhosh; Lorenz, Georg; Anders, Hans-Joachim und Lech, Maciej
(September 2013):
Pattern-Recognition Receptor Signaling Regulator mRNA Expression in Humans and Mice, and in Transient Inflammation or Progressive Fibrosis.
In: International Journal of Molecular Sciences, Bd. 14, Nr. 9: S. 18124-18147
[PDF, 0B]
Ramaiah, Santhosh Kumar Vankayala; Günthner, Roman; Lech, Maciej und Anders, Hans-Joachim
(Juli 2013):
Toll-Like Receptor and Accessory Molecule mRNA Expression in Humans and Mice as Well as in Murine Autoimmunity, Transient Inflammation, and Progressive Fibrosis.
In: International Journal of Molecular Sciences, Bd. 14, Nr. 7: S. 13213-13230
[PDF, 939kB]
2012
Lech, Maciej; Susanti, Heni Eka; Römmele, Christoph; Gröbmayr, Regina; Günthner, Roman und Anders, Hans-Joachim
(18. Dezember 2012):
Quantitative Expression of C-Type Lectin Receptors in Humans and Mice.
In: International Journal of Molecular Sciences, Bd. 13, Nr. 12: S. 10113-10131
[PDF, 2MB]
Lech, Maciej; Susanti, Heni Eka; Römmele, Christoph; Gröbmayr, Regina; Günthner, Roman und Anders, Hans-Joachim
(August 2012):
Quantitative Expression of C-Type Lectin Receptors in Humans and Mice.
In: International Journal of Molecular Sciences, Bd. 13, Nr. 8: S. 10113-10131
[PDF, 774kB]
Lech, Maciej; Gröbmayr, Regina; Weidenbusch, Marc und Anders, Hans-Joachim
(2012):
Tissues Use Resident Dendritic Cells and Macrophages to Maintain Homeostasis and to Regain Homeostasis upon Tissue Injury: The Immunoregulatory Role of Changing Tissue Environments.
In: Mediators of Inflammation, Bd. 2012, 951390
[PDF, 1MB]
2011
Lech, Maciej; Kantner, Claudia; Kulkarni, Onkar P.; Ryu, Mi; Vlasova, Ekaterina; Heesemann, Jürgen; Anz, David; Endres, Stefan; Kobayashi, Koichi S.; Flavell, Richard A.; Martin, Javier und Anders, Hans-Joachim
(Dezember 2011):
Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus.
In: Annals of the rheumatic diseases, Bd. 70, Nr. 12: S. 2207-17
[PDF, 778kB]
Skuginna, Veronika; Lech, Maciej; Allam, Ramanjaneyulu; Ryu, Mi; Clauss, Sebastian; Susanti, Heni Eka; Römmele, Christoph; Garlanda, Cecilia; Mantovani, Alberto und Anders, Hans-Joachim
(2011):
Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction.
In: PLOS ONE 6(4), e19204 [PDF, 1MB]
In: PLOS ONE 6(4), e19204 [PDF, 1MB]
Lech, Maciej; Römmele, Christoph; Kulkarni, Onkar P.; Susanti, Heni Eka; Migliorini, Adriana; Garlanda, Cecilia; Mantovani, Alberto und Anders, Hans-Joachim
(2011):
Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus.
In: PLOS ONE 6(5), e20118 [PDF, 1MB]
In: PLOS ONE 6(5), e20118 [PDF, 1MB]