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Anzahl der Publikationen: 16
Zeitschriftenartikel
Levin, Johannes; Sing, Nand; Melbourne, Sue; Morgan, Amber; Mariner, Carla; Spillantini, Maria Grazia; Wegrzynowicz, Michal; Dalley, Jeffrey W.; Langer, Simon; Ryazanov, Sergey; Leonov, Andrei; Griesinger, Christian; Schmidt, Felix; Weckbecker, Daniel; Prager, Kai; Matthias, Torsten und Giese, Armin
(2022):
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind placebo-controlled phase 1a trial.
In: Ebiomedicine, Bd. 80, 104021
Antonschmidt, Leif; Matthes, Dirk; Dervisoglu, Riza; Frieg, Benedikt; Dienemann, Christian; Leonov, Andrei; Nimerovsky, Evgeny; Sant, Vrinda; Ryazanov, Sergey; Giese, Armin; Schroeder, Gunnar F.; Becker, Stefan; de Groot, Bert L.; Griesinger, Christian und Andreas, Loren B.
(2022):
The clinical drug candidate anle138b binds in a cavity of lipidic alpha-synuclein fibrils.
In: Nature Communications, Bd. 13, Nr. 1, 5385
Maurer, Andreas; Leonov, Andrei; Ryazanov, Sergey; Herfert, Kristina; Kuebler, Laura; Buss, Sabrina; Schmidt, Felix; Weckbecker, Daniel; Linder, Ruth; Bender, Dirk; Giese, Armin; Pichler, Bernd J. und Griesinger, Christian
(2020):
C-11 Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to alpha-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier.
In: Chemmedchem, Bd. 15, Nr. 5: S. 411-415
Camilleri, Angelique; Ghio, Stephanie; Caruana, Mario; Weckbecker, Daniel; Schmidt, Felix; Kamp, Frits; Leonov, Andrei; Ryazanov, Sergey; Griesinger, Christian; Giese, Armin; Cauchi, Ruben J. und Vassallo, Neville
(2020):
Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin.
In: Biochimica et Biophysica Acta-Biomembranes, Bd. 1862, Nr. 2, 183064
Lemos, Miguel; Venezia, Serena; Refolo, Violetta; Heras-Garvin, Antonio; Schmidhuber, Sabine; Giese, Armin; Leonov, Andrei; Ryazanov, Sergey; Griesinger, Christian; Galabova, Gergana; Staffler, Guenther; Wenning, Gregor Karl und Stefanova, Nadia
(2020):
Targeting alpha-synuclein by PD03 AFFITOPE (R) and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance.
In: Translational Neurodegeneration, Bd. 9, Nr. 1, 38
Saravanan, Manikam S.; Ryazanov, Sergey; Leonov, Andrei; Nicolai, Janine; Praest, Patrique; Giese, Armin; Winter, Roland; Khemtemourian, Lucie; Griesinger, Christian und Killian, J. Antoinette
(2019):
The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers.
In: Scientific Reports, Bd. 9, 19023
[PDF, 1MB]
Wegrzynowici, Michal; Bar-On, Dana; Calo, Laura; Anichtchik, Oleg; Iovino, Mariangela; Xia, Jing; Ryazanov, Sergey; Leonov, Andrei; Giese, Armin; Dalley, Jeffrey W.; Griesinger, Christian; Ashery, Uri und Spillantini, Maria Grazia
(2019):
Depopulation of dense alpha-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
In: Acta Neuropathologica, Bd. 138, Nr. 4: S. 575-595
Ghio, Stephanie; Camilleri, Angelique; Caruana, Mario; Ruf, Viktoria C.; Schmidt, Felix; Leonov, Andrei; Ryazanov, Sergey; Griesinger, Christian; Cauchi, Ruben J.; Kamp, Frits; Giese, Armin und Vassallo, Neville
(2019):
Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes.
In: ACS Chemical Neuroscience, Bd. 10, Nr. 8: S. 3815-3829
Brendel, Matthias; Deussing, Maximilian; Blume, Tanja; Kaiser, Lena; Probst, Federico; Overhoff, Felix; Peters, Finn; Ungern-Sternberg, Barbara von; Ryazanov, Sergey; Leonov, Andrei; Griesinger, Christian; Zwergal, Andreas; Levin, Johannes; Bartenstein, Peter; Yakushev, Igor; Cumming, Paul; Boening, Guido; Ziegler, Sibylle; Herms, Jochen; Giese, Armin und Rominger, Axel
(2019):
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau.
In: Alzheimers Research & Therapy, Bd. 11, 67
Bartels, Martin; Weckbecker, Daniel; Kuhn, Peer-Hendrik; Ryazanov, Sergey; Leonov, Andrei; Griesinger, Christian; Lichtenthaler, Stefan F.; Boetzel, Kai und Giese, Armin
(2019):
Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression.
In: Scientific Reports, Bd. 9, 9100
[PDF, 7MB]
Heras-Garvin, Antonio; Weckbecker, Daniel; Ryazanov, Sergey; Leonov, Andrei; Griesinger, Christian; Giese, Armin; Wenning, Gregor K. und Stefanova, Nadia
(2018):
Anle138b modulates alpha-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy.
In: Movement Disorders
[PDF, 779kB]
Hernandez, Ana Martinez; Urbanke, Hendrik; Gillman, Alan L.; Lee, Joon; Ryazanov, Sergey; Agbemenyah, Hope Y.; Benito, Eva; Jain, Gaurav; Kaurani, Lalit; Grigorian, Gayane; Leonov, Andrei; Rezaei-Ghaleh, Nasrollah; Wilken, Petra; Arce, Fernando Teran; Wagner, Jens; Fuhrman, Martin; Caruana, Mario; Camilleri, Angelique; Vassallo, Neville; Zweckstetter, Markus; Benz, Roland; Giese, Armin; Schneider, Anja; Korte, Martin; Lal, Ratnesh; Griesinger, Christian; Eichele, Gregor und Fischer, Andre
(2018):
The diphenylpyrazole compound anle138b blocks A beta channels and rescues disease phenotypes in a mouse model for amyloid pathology.
In: EMBO Molecular Medicine, Bd. 10, Nr. 1: S. 32-47
[PDF, 1MB]
Reiner, Anne M.; Schmidt, Felix; Ryazanov, Sergey; Leonov, Andrei; Weckbecker, Daniel; Deeg, Andreas A.; Griesinger, Christian; Giese, Armin und Zinth, Wolfgang
(2018):
Photophysics of diphenyl-pyrazole compounds in solutions and alpha-synuclein aggregates.
In: Biochimica et Biophysica Acta-General Subjects, Bd. 1862, Nr. 4: S. 800-807
Turriani, Elisa; Lazaro, Diana F.; Ryazanov, Sergey; Leonov, Andrei; Giese, Armin; Schön, Margarete; Schön, Michael P.; Griesinger, Christian; Outeiro, Tiago F.; Arndt-Jovin, Donna J. und Becker, Dorothea
(2017):
Treatment with diphenyl-pyrazole compound anle138b/c reveals that alpha-synuclein protects melanoma cells from autophagic cell death.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 114, Nr. 25, E4971-E4977
Fellner, Lisa; Kuzdas-Wood, Daniela; Levin, Johannes; Ryazanov, Sergey; Leonov, Andrei; Griesinger, Christian; Giese, Armin; Wenning, Gregor K. und Stefanova, Nadia
(2016):
Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy.
In: Frontiers in Neuroscience, Bd. 10, 99
[PDF, 5MB]
Sadasivam, Saravanan Manikam; Ryazanov, Sergey; Leonov, Andrei; Roeters, Steven; Wouterson, Sander; Giese, Armin; Griesinger, Christian und Killian, J. Antoinette
(2016):
Effect of the Novel Amyloid Inhibitor "anle145c" on Aggregation of Islet Amyloid Polypeptide and how it is Modulated by Membranes.
In: Biophysical Journal, Bd. 110, Nr. 3:
420A-420A