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Anzahl der Publikationen: 21
Zeitschriftenartikel
Sai, Minh; Herwijnen, Niels van und Merk, Daniel 
ORCID: https://orcid.org/0000-0002-5359-8128
(2024):
Azologs of the Fatty Acid Mimetic Drug Cinalukast Enable Light‐Induced PPARα Activation.
In: ChemMedChem
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-5359-8128
(2024):
Azologs of the Fatty Acid Mimetic Drug Cinalukast Enable Light‐Induced PPARα Activation.
In: ChemMedChem
[PDF, 1MB]
Mukhopadhyay, Tufan K. ORCID: https://orcid.org/0000-0001-8888-5373; Willems, Sabine ORCID: https://orcid.org/0000-0002-9755-3394; Arp, Christopher J. ORCID: https://orcid.org/0000-0002-5059-6178; Morstein, Johannes; Haake, Caleb T.; Merk, Daniel ORCID: https://orcid.org/0000-0002-5359-8128 und Trauner, Dirk ORCID: https://orcid.org/0000-0002-6782-6056
(2023):
Development of Light‐Activated LXR Agonists.
In: ChemMedChem, Bd. 18, Nr. 11
[PDF, 5MB]
ORCID: https://orcid.org/0000-0001-8888-5373; Willems, Sabine ORCID: https://orcid.org/0000-0002-9755-3394; Arp, Christopher J. ORCID: https://orcid.org/0000-0002-5059-6178; Morstein, Johannes; Haake, Caleb T.; Merk, Daniel ORCID: https://orcid.org/0000-0002-5359-8128 und Trauner, Dirk ORCID: https://orcid.org/0000-0002-6782-6056
(2023):
Development of Light‐Activated LXR Agonists.
In: ChemMedChem, Bd. 18, Nr. 11
[PDF, 5MB]
Zaienne, Daniel; Isigkeit, Laura; Marschner, Julian A.; Duensing‐Kropp, Silke; Höfner, Georg und Merk, Daniel ORCID: https://orcid.org/0000-0002-5359-8128
(2023):
Structural Modification of the Natural Product Valerenic Acid Tunes RXR Homodimer Agonism.
In: ChemMedChem, Bd. 18, Nr. 21
[PDF, 895kB]
ORCID: https://orcid.org/0000-0002-5359-8128
(2023):
Structural Modification of the Natural Product Valerenic Acid Tunes RXR Homodimer Agonism.
In: ChemMedChem, Bd. 18, Nr. 21
[PDF, 895kB]
Willems, Sabine; Marschner, Julian A.; Kilu, Whitney; Faudone, Giuseppe; Busch, Romy; Duensing‐Kropp, Silke; Heering, Jan und Merk, Daniel
(30. Juni 2022):
Nurr1 Modulation Mediates Neuroprotective Effects of Statins.
In: Advanced Science, Bd. 9, Nr. 18
[PDF, 4MB]
Zaienne, Daniel; Arifi, Silvia; Marschner, Julian A.; Heering, Jan und Merk, Daniel
(2022):
Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR-1) Reveals Inverse NOR-1 Agonists.
In: Chemmedchem, Bd. 17, Nr. 16, e202200259
Adouvi, Gustave; Isigkeit, Laura; Lopez-Garcia, Ursula; Chaikuad, Apirat; Marschner, Julian A.; Schubert-Zsilavecz, Manfred und Merk, Daniel
(2022):
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXR alpha, RXR beta, and RXR gamma.
In: Journal of Medicinal Chemistry, Bd. 66, Nr. 1: S. 333-344
Heering, Jan; Jores, Nathalie; Kilu, Whitney; Schallmayer, Espen; Peelen, Evelyn; Muehler, Andreas; Kohlhof, Hella; Vitt, Daniel; Linhard, Verena; Gande, Santosh L.; Chaikuad, Apirat; Sreeramulu, Sridhar; Schwalbe, Harald und Merk, Daniel
(2022):
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.
In: ACS Chemical Biology, Bd. 17, Nr. 11: S. 3159-3168
Ehrler, Johanna H. M.; Brunst, Steffen; Tjaden, Amelie; Kilu, Whitney; Heering, Jan; Hernandez-Olmos, Victor; Krommes, Andre; Kramer, Jan S.; Steinhilber, Dieter; Schubert-Zsilavecz, Manfred; Müller, Susanne; Merk, Daniel und Proschak, Ewgenij
(2022):
Compilation and evaluation of a fatty acid mimetics screening library.
In: Biochemical Pharmacology, Bd. 204, 115191
Isigkeit, Laura; Chaikuad, Apirat und Merk, Daniel
(2022):
A Consensus Compound/Bioactivity Dataset for Data-Driven Drug Design and Chemogenomics.
In: Molecules, Bd. 27, Nr. 8, 2513
Helmstaedter, Moritz; Schierle, Simone; Isigkeit, Laura; Proschak, Ewgenij; Marschner, Julian Aurelio und Merk, Daniel
(2022):
Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor Agonists.
In: International Journal of Molecular Sciences, Bd. 23, Nr. 17, 10070
Bohn, Torsten; de Lera, Angel R.; Landrier, Jean-Francois; Carlsen, Harald; Merk, Daniel; Todt, Tilman; Renaut, Jenny und Ruehl, Ralph
(2022):
State-of-the-art methodological investigation of carotenoid activity and metabolism - from organic synthesis via metabolism to biological activity - exemplified by a novel retinoid signalling pathway.
In: Food & Function, Bd. 14, Nr. 2: S. 621-638
Willems, Sabine und Merk, Daniel
(2022):
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.
In: Journal of Medicinal Chemistry, Bd. 65, Nr. 14: S. 9548-9563
Faudone, Giuseppe; Zhubi, Rezart; Celik, Fatih; Knapp, Stefan; Chaikuad, Apirat; Heering, Jan und Merk, Daniel
(2022):
Design of a Potent TLX Agonist by Rational Fragment Fusion.
In: Journal of Medicinal Chemistry, Bd. 65, Nr. 3: S. 2288-2296
Arifi, Silvia; Zaienne, Daniel; Heering, Jan; Wein, Thomas; Zhubi, Rezart; Chaikuad, Apirat; Knapp, Stefan; Marschner, Julian A. und Merk, Daniel
(2022):
Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
In: Bioorganic Chemistry, Bd. 129, 106164
Willems, Sabine; Mueller, Marcel; Ohrndorf, Julia; Heering, Jan; Proschak, Ewgenij und Merk, Daniel
(2022):
Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries.
In: Chemmedchem, Bd. 17, Nr. 8, e202200026
Zaienne, Daniel; Willems, Sabine; Schierle, Simone; Heering, Jan und Merk, Daniel
(2021):
Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.
In: Journal of Medicinal Chemistry, Bd. 64, Nr. 20: S. 15126-15140
Mueller, Susanne; Ackloo, Suzanne; Al Chawaf, Arij; Al-Lazikani, Bissan; Antolin, Albert; Baell, Jonathan B.; Beck, Hartmut; Beedie, Shaunna; Betz, Ulrich A. K.; Bezerra, Gustavo Arruda; Brennan, Paul E.; Brown, David; Brown, Peter J.; Bullock, Alex N.; Carter, Adrian J.; Chaikuad, Apirat; Chaineau, Mathilde; Ciulli, Alessio; Collins, Ian; Dreher, Jan; Drewry, David; Edfeldt, Kristina; Edwards, Aled M.; Egner, Ursula; Frye, Stephen V.; Fuchs, Stephen M.; Hall, Matthew D.; Hartung, Ingo V.; Hillisch, Alexander; Hitchcock, Stephen H.; Homan, Evert; Kannan, Natarajan; Kiefer, James R.; Knapp, Stefan; Kostic, Milka; Kubicek, Stefan; Leach, Andrew R.; Lindemann, Sven; Marsden, Brian D.; Matsui, Hisanori; Meier, Jordan L.; Merk, Daniel; Michel, Maurice; Morgan, Maxwell R.; Mueller-Fahrnow, Anke; Owen, Dafydd R.; Perry, Benjamin G.; Rosenberg, Saul H.; Saikatendu, Kumar Singh; Schapira, Matthieu; Scholten, Cora; Sharma, Sujata; Simeonov, Anton; Sundstrom, Michael; Superti-Furga, Giulio; Todd, Matthew H.; Tredup, Claudia; Vedadi, Masoud; Delft, Frank von; Willson, Timothy M.; Winter, Georg E.; Workman, Paul und Arrowsmith, Cheryl H.
(2021):
Target 2035-update on the quest for a probe for every protein.
In: Rsc Medicinal Chemistry, Bd. 13, Nr. 1: S. 13-21
Lang, Alisa; Isigkeit, Laura; Schubert-Zsilavecz, Manfred und Merk, Daniel
(2021):
The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators.
In: Journal of Medicinal Chemistry, Bd. 64, Nr. 23: S. 16956-16973
Faudone, Giuseppe; Kilu, Whitney; Ni, Xiaomin; Chaikuad, Apirat; Sreeramulu, Sridhar; Heitel, Pascal; Schwalbe, Harald; Knapp, Stefan; Schubert-Zsilavecz, Manfred; Heering, Jan und Merk, Daniel
(2021):
The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines.
In: ACS Pharmacology & Translational Science, Bd. 4, Nr. 6: S. 1794-1807
Hinnah, Konstantin; Willems, Sabine; Morstein, Johannes; Heering, Jan; Hartrampf, Felix W. W.; Broichhagen, Johannes; Leippe, Philipp; Merk, Daniel und Trauner, Dirk
(2020):
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma).
In: Journal of Medicinal Chemistry, Bd. 63, Nr. 19: S. 10908-10920
Morstein, Johannes; Trads, Julie B.; Hinnah, Konstantin; Willems, Sabine; Barber, David M.; Trauner, Michael; Merk, Daniel und Trauner, Dirk
(2020):
Optical control of the nuclear bile acid receptor FXR with a photohormone.
In: Chemical Science, Bd. 11, Nr. 2: S. 429-434