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Anzahl der Publikationen: 24
Zeitschriftenartikel
Orth, Martin F.; Surdez, Didier; Faehling, Tobias; Ehlers, Anna C.; Marchetto, Aruna; Grossetete, Sandrine; Volckmann, Richard; Zwijnenburg, Danny A.; Gerke, Julia S.; Zaidi, Sakina; Alonso, Javier; Sastre, Ana; Baulande, Sylvain; Sill, Martin; Cidre-Aranaz, Florencia; Ohmura, Shunya; Kirchner, Thomas; Hauck, Stefanie M.; Reischl, Eva; Gymrek, Melissa; Pfister, Stefan M.; Strauch, Konstantin; Koster, Jan; Delattre, Olivier und Grunewald, Thomas G. . P.
(2022):
Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation.
In: Cell Reports, Bd. 41, Nr. 10, 111761
Vibert, Julien; Saulnier, Olivier; Collin, Celine; Petit, Floriane; Borgman, Kyra J. E.; Vigneau, Jeromine; Gautier, Maud; Zaidi, Sakina; Pierron, Gaelle; Watson, Sarah; Gruel, Nadege; Henon, Clemence; Postel-Vinay, Sophie; Deloger, Marc; Raynal, Virginie; Baulande, Sylvain; Laud-Duval, Karine; Hill, Veronique; Grossetete, Sandrine; Dingli, Florent; Loew, Damarys; Torrejon, Jacob; Ayrault, Olivier; Orth, Martin F.; Grunewald, Thomas G. P.; Surdez, Didier; Coulon, Antoine; Waterfall, Joshua J. und Delattre, Olivier
(2022):
Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions.
In: Molecular Cell, Bd. 82, Nr. 13: S. 2458-2471
Cidre-Aranaz, Florencia; Li, Jing; Hoelting, Tilman L. B.; Orth, Martin F.; Imle, Roland; Kutschmann, Stefanie; Ammirati, Giuli; Ceranski, Katharina; Carreno-Gonzalez, Martha Julia; Kasan, Merve; Marchetto, Aruna; Funk, Cornelius M.; Bestvater, Felix; Bersini, Simone; Arrigoni, Chiara; Moretti, Matteo; Thiel, Uwe; Baumhoer, Daniel; Sahm, Felix; Pfister, Stefan M.; Hartmann, Wolfgang; Dirksen, Uta; Romero-Perez, Laura; Banito, Ana; Ohmura, Shunya; Musa, Julian; Kirchner, Thomas; Knott, Maximilian M. L. und Grunewald, Thomas G. P.
(2022):
Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma.
In: Molecular Cancer, Bd. 21, Nr. 1, 1
Rossi, Matteo; Altea-Manzano, Patricia; Demicco, Margherita; Doglioni, Ginevra; Bornes, Laura; Fukano, Marina; Vandekeere, Anke; Cuadros, Alejandro M.; Fernandez-Garcia, Juan; Riera-Domingo, Carla; Jauset, Cristina; Planque, Melanie; Alkan, H. Furkan; Nittner, David; Zuo, Dongmei; Broadfield, Lindsay A.; Parik, Sweta; Pane, Antonino Alejandro; Rizzollo, Francesca; Rinaldi, Gianmarco; Zhang, Tao; Teoh, Shao Thing; Aurora, Arin B.; Karras, Panagiotis; Vermeire, Ines; Broekaert, Dorien; Elsen, Joke van; Knott, Maximilian M. L.; Orth, Martin F.; Demeyer, Sofie; Eelen, Guy; Dobrolecki, Lacey E.; Bassez, Ayse; Brussel, Thomas van; Sotlar, Karl; Lewis, Michael T.; Bartsch, Harald; Wuhrer, Manfred; Veelen, Peter van; Carmeliet, Peter; Cools, Jan; Morrison, Sean J.; Marine, Jean-Christophe; Lambrechts, Diether; Mazzone, Massimiliano; Hannon, Gregory J.; Lunt, Sophia Y.; Grünewald, Thomas G. P.; Park, Morag; Rheenen, Jacco van und Fendt, Sarah-Maria
(2022):
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis.
In: Nature, Bd. 605, Nr. 7911: S. 747-753
Voeltzke, Kai; Scharov, Katerina; Funk, Cornelius Maximilian; Kahler, Alisa; Picard, Daniel; Hauffe, Laura; Orth, Martin F.; Remke, Marc; Esposito, Irene; Kirchner, Thomas; Schramm, Alexander; Rotblat, Barak; Grunewald, Thomas G. P.; Reifenberger, Guido und Leprivier, Gabriel
(2022):
EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma.
In: Cell Death Discovery, Bd. 8, Nr. 1, 157
Li, Jing; Ohmura, Shunya; Marchetto, Aruna; Orth, Martin F.; Imle, Roland; Dallmayer, Marlene; Musa, Julian; Knott, Maximilian M. L.; Holting, Tilman L. B.; Stein, Stefanie; Funk, Cornelius M.; Sastre, Ana; Alonso, Javier; Bestvater, Felix; Kasan, Merve; Romero-Perez, Laura; Hartmann, Wolfgang; Ranft, Andreas; Banito, Ana; Dirksen, Uta; Kirchner, Thomas; Cidre-Aranaz, Florencia und Gruenewald, Thomas G. P.
(2021):
Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer.
In: Nature Communications, Bd. 12, Nr. 1, 5356
Orth, Martin F.; Buecklein, Veit Leonhard; Kampmann, Eric; Subklewe, Marion; Noessner, Elfriede; Cidre-Aranaz, Florencia; Romero-Perez, Laura; Wehweck, Fabienne Sophie; Lindner, Lars; Issels, Rolf; Kirchner, Thomas; Altendorf-Hofmann, Annelore; Grunewald, Thomas G. P. und Knösel, Thomas
(2020):
A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas.
In: Cancer Immunology Immunotherapy, Bd. 69, Nr. 7: S. 1353-1362
Galai, Geut; Ben-David, Hila; Levin, Liron; Orth, Martin F.; Grünewald, Thomas G. P.; Pilosof, Shai; Bershtein, Shimon und Rotblat, Barak
(2020):
Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning.
In: Cancers, Bd. 12, Nr. 4, 825
Orth, Martin F.; Hoelting, Tilman L. B.; Dallmayer, Marlene; Wehweck, Fabienne S.; Paul, Tanja; Musa, Julian; Baldauf, Michaela C.; Surdez, Didier; Delattre, Olivier; Knott, Maximilian M. L.; Romero-Perez, Laura; Kasan, Merve; Cidre-Aranaz, Florencia; Gerke, Julia S.; Ohmura, Shunya; Li, Jing; Marchetto, Aruna; Henssen, Anton G.; Oezen, Oezlem; Sugita, Shintaro; Hasegawa, Tadashi; Kanaseki, Takayuki; Bertram, Stefanie; Dirksen, Uta; Hartmann, Wolfgang; Kirchner, Thomas und Grünewald, Thomas G. P.
(2020):
High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma.
In: Cancers, Bd. 12, Nr. 3, 644
Herrmann, Andreas B.; Müller, Martha-Lena; Orth, Martin F.; Müller, Jörg P.; Zernecke, Alma; Hochhaus, Andreas; Ernst, Thomas; Butt, Elke und Frietsch, Jochen J.
(2020):
Knockout of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance.
In: Journal of Cellular and Molecular Medicine, Bd. 24, Nr. 5: S. 2942-2955
Marchetto, Aruna; Ohmura, Shunya; Orth, Martin F.; Knott, Maximilian M. L.; Colombo, Maria V.; Arrigoni, Chiara; Bardinet, Victor; Saucier, David; Wehweck, Fabienne S.; Li, Jing; Stein, Stefanie; Gerke, Julia S.; Baldauf, Michaela C.; Musa, Julian; Dallmayer, Marlene; Romero-Perez, Laura; Hoelting, Tilman L. B.; Amatruda, James F.; Cossarizza, Andrea; Henssen, Anton G.; Kirchner, Thomas; Moretti, Matteo; Cidre-Aranaz, Florencia; Sannino, Giuseppina und Grünewald, Thomas G. P.
(2020):
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.
In: Nature Communications, Bd. 11, Nr. 1, 2423
[PDF, 2MB]
Triki, Mouna; Rinaldi, Gianmarco; Planque, Melanie; Broekaert, Dorien; Winkelkotte, Alina M.; Maier, Carina R.; Raman, Sudha Janaki; Vandekeere, Anke; Elsen, Joke van; Orth, Martin F.; Grünewald, Thomas G. P.; Schulze, Almut und Fendt, Sarah-Maria
(2020):
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
In: Cell Reports, Bd. 31, Nr. 12, 107806
Gerke, Julia S.; Orth, Martin F.; Tolkach, Yuri; Romero‐Pérez, Laura; Wehweck, Fabienne S.; Stein, Stefanie; Musa, Julian; Knott, Maximilian M.L.; Hölting, Tilman L.B.; Li, Jing; Sannino, Giuseppina; Marchetto, Aruna; Ohmura, Shunya; Cidre‐Aranaz, Florencia; Müller‐Nurasyid, Martina; Strauch, Konstantin; Stief, Christian; Kristiansen, Glen; Kirchner, Thomas; Buchner, Alexander und Grünewald, Thomas G. P.
(2020):
Integrative clinical transcriptome analysis reveals TMPRSS2‐ERG dependency of prognostic biomarkers in prostate adenocarcinoma.
In: International Journal of Cancer, Bd. 146, Nr. 7: S. 2036-2046
[PDF, 10MB]
Dallmayer, Marlene; Li, Jing; Ohmura, Shunya; Rubio, Rebeca Alba; Baldauf, Michaela C.; Hoelting, Tilman L. B.; Musa, Julian; Knott, Max M. L.; Stein, Stefanie; Cidre-Aranaz, Florencia; Wehweck, Fabienne S.; Romero-Perez, Laura; Gerke, Julia S.; Orth, Martin F.; Marchetto, Aruna; Kirchner, Thomas; Bach, Horacio; Sannino, Giuseppina und Grünewald, Thomas G. P.
(2019):
Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma.
In: Cell Death & Disease, Bd. 10, 116
Orth, Martin F.; Gerke, Julia S.; Knoesel, Thomas; Altendorf-Hofmann, Annelore; Musa, Julian; Alba-Rubio, Rebeca; Stein, Stefanie; Hoelting, Tilman L. B.; Cidre-Aranaz, Florencia; Romero-Perez, Laura; Dallmayer, Marlene; Baldauf, Michaela C.; Marchetto, Aruna; Sannino, Giuseppina; Knott, Maximilian M. L.; Wehweck, Fabienne; Ohmura, Shunya; Li, Jing; Hakozaki, Michiyuki; Kirchner, Thomas; Dandekar, Thomas; Butt, Elke und Grünewald, Thomas G. P.
(2019):
Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma.
In: International Journal of Cancer, Bd. 144, Nr. 4: S. 859-867
Vriens, Kim; Christen, Stefan; Parik, Sweta; Broekaert, Dorien; Yoshinaga, Kazuaki; Talebi, Ali; Dehairs, Jonas; Escalona-Noguero, Carmen; Schmieder, Roberta; Cornfield, Thomas; Charlton, Catriona; Romero-Perez, Laura; Rossi, Matteo; Rinaldi, Gianmarco; Orth, Martin F.; Boon, Ruben; Kerstens, Axelle; Kwan, Suet Ying; Faubert, Brandon; Mendez-Lucas, Andres; Kopitz, Charlotte C.; Chen, Ting; Fernandez-Garcia, Juan; Duarte, Joao A. G.; Schmitz, Arndt A.; Steigemann, Patrick; Najimi, Mustapha; Haegebarth, Andrea; Van Ginderachter, Jo A.; Sokal, Etienne; Gotoh, Naohiro; Wong, Kwok-Kin; Verfaillie, Catherine; Derua, Rita; Munck, Sebastian; Yuneva, Mariia; Beretta, Laura; DeBerardinis, Ralph J.; Swinnen, Johannes V.; Hodson, Leanne; Cassiman, David; Verslype, Chris; Christian, Sven; Grünewald, Sylvia; Grünewald, Thomas G. P. und Fendt, Sarah-Maria
(2019):
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
In: Nature, Bd. 566, Nr. 7744
Sannino, Giuseppina; Marchetto, Aruna; Ranft, Andreas; Jabar, Susanne; Zacherl, Constanze; Alba-Rubio, Rebeca; Stein, Stefanie; Wehweck, Fabienne S.; Kiran, Merve M.; Hoelting, Tilman L. B.; Musa, Julian; Romero-Perez, Laura; Cidre-Aranaz, Florencia; Knott, Maximilian M. L.; Li, Jing; Jürgens, Heribert; Sastre, Ana; Alonso, Javier; Da Silveira, Willian; Hardiman, Gary; Gerke, Julia S.; Orth, Martin F.; Hartmann, Wolfgang; Kirchner, Thomas; Ohmura, Shunya; Dirksen, Uta und Grünewald, Thomas G. P.
(2019):
Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients.
In: Ebiomedicine, Bd. 47: S. 156-162
Musa, Julian; Cidre-Aranaz, Florencia; Aynaud, Marie-Ming; Orth, Martin F.; Knott, Maximilian M. L.; Mirabeau, Olivier; Mazor, Gal; Varon, Mor; Hoelting, Tilman L. B.; Grossetete, Sandrine; Gartlgruber, Moritz; Surdez, Didier; Gerke, Julia S.; Ohmura, Shunya; Marchetto, Aruna; Dallmayer, Marlene; Baldauf, Michaela C.; Stein, Stefanie; Sannino, Giuseppina; Li, Jing; Romero-Perez, Laura; Westermann, Frank; Hartmann, Wolfgang; Dirksen, Uta; Gymrek, Melissa; Anderson, Nathaniel D.; Shlien, Adam; Rotblat, Barak; Kirchner, Thomas; Delattre, Olivier und Grünewald, Thomas G. P.
(2019):
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.
In: Nature Communications, Bd. 10, 4128
[PDF, 2MB]
Steinestel, Konrad; Trautmann, Marcel; Jansen, Esther-Pia; Dirksen, Uta; Rehkaemper, Jan; Mikesch, Jan-Henrik; Gerke, Julia S.; Orth, Martin F.; Sannino, Giuseppina; Arteaga, Maria-Francisca; Rossig, Claudia; Wardelmann, Eva; Grünewald, Thomas G. P. und Hartmann, Wolfgang
(2019):
Focal adhesion kinase confers pro-migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma.
In: Molecular Oncology, Bd. 14, Nr. 2: S. 248-260
Baldauf, Michaela C.; Gerke, Julia S.; Kirschner, Andreas; Blaeschke, Franziska; Effenberger, Manuel; Schober, Kilian; Rubio, Rebeca Alba; Kanaseki, Takayuki; Kiran, Merve M.; Dallmayer, Marlene; Musa, Julian; Akpolat, Nurset; Akatli, Ayse N.; Rosman, Fernando C.; Ozen, Ozlem; Sugita, Shintaro; Hasegawa, Tadashi; Sugimura, Haruhiko; Baumhoer, Daniel; Knott, Maximilian M. L.; Sannino, Giuseppina; Marchetto, Aruna; Li, Jing; Busch, Dirk H.; Feuchtinger, Tobias; Ohmura, Shunya; Orth, Martin F.; Thiel, Uwe; Kirchner, Thomas und Gruenewald, Thomas G. P.
(2018):
Systematic identification of cancer-specific MHC-binding peptides with RAVEN.
In: Oncoimmunology, Bd. 7, Nr. 9, e1481558
Baldauf, Michaela C.; Orth, Martin F.; Dallmayer, Marlene; Marchetto, Aruna; Gerke, Julia S.; Rubio, Rebeca Alba; Kiran, Merve M.; Musa, Julian; Knott, Maximilian M. L.; Ohmura, Shunya; Li, Jing; Akpolat, Nusret; Akatli, Ayse N.; Ozen, Ozlem; Dirksen, Uta; Hartmann, Wolfgang; Alava, Enrique de; Baumhoer, Daniel; Sannino, Giuseppina; Kirchner, Thomas und Gruenewald, Thomas G. P.
(2018):
Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets.
In: Oncotarget, Bd. 9, Nr. 2: S. 1587-1601
Sannino, Giuseppina; Orth, Martin F. und Grünewald, Thomas G. P.
(2017):
Next steps in Ewing sarcoma (epi-) genomics.
In: Future Oncology, Bd. 13, Nr. 14: S. 1207-1211
Elia, Ilaria; Brökärt, Dorien; Christen, Stefan; Boon, Ruben; Radaelli, Enrico; Orth, Martin F.; Verfaillie, Catherine; Grünewald, Thomas G. P. und Fendt, Sarah-Maria
(2017):
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.
In: Nature Communications, Bd. 8, 15267
[PDF, 2MB]
Boeva, Valentina; Louis-Brennetot, Caroline; Peltier, Agathe; Durand, Simon; Pierre-Eugene, Cecile; Raynal, Virginie; Etchevers, Heather C.; Thomas, Sophie; Lermine, Alban; Daudigeos-Dubus, Estelle; Geoerger, Birgit; Orth, Martin F.; Grünewald, Thomas G. P.; Diaz, Elise; Ducos, Bertrand; Surdez, Didier; Carcaboso, Angel M.; Medvedeva, Irina; Deller, Thomas; Combaret, Valerie; Lapouble, Eve; Pierron, Gaelle; Grossetete-Lalami, Sandrine; Baulande, Sylvain; Schleiermacher, Gudrun; Barillot, Emmanuel; Rohrer, Hermann; Delattre, Olivier und Janoueix-Lerosey, Isabelle
(2017):
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.
In: Nature Genetics, Bd. 49, Nr. 9: S. 1408-1413