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Anzahl der Publikationen: 15
Zeitschriftenartikel
Yu, Chen; Lad, Eleonora M.; Mathew, Rose; Shiraki, Nobuhiko; Littleton, Sejiro; Chen, Yun; Hou, Jinchao; Schlepckow, Kai; Degan, Simone; Chew, Lindsey; Amason, Joshua; Kalnitsky, Joan; Bowes Rickman, Catherine; Proia, Alan D.; Colonna, Marco; Haass, Christian und Saban, Daniel R.
(2024):
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2.
In: Journal of Experimental Medicine, Bd. 221, Nr. 3, e20231011
Piollet, Marie 
ORCID: https://orcid.org/0000-0002-2025-6594; Porsch, Florentina ORCID: https://orcid.org/0000-0002-2633-6632; Rizzo, Giuseppe; Kapser, Frederieke; Schulz, Dirk J. J.; Kiss, Máté G.; Schlepckow, Kai; Morenas-Rodriguez, Estrella; Sen, Mustafa Orkun; Gropper, Julius; Bandi, Sourish Reddy; Schäfer, Sarah; Krammer, Tobias ORCID: https://orcid.org/0000-0002-7638-9476; Leipold, Alexander M.; Hoke, Matthias; Ozsvár-Kozma, Mária; Beneš, Hannah; Schillinger, Martin; Minar, Erich; Roesch, Melanie; Göderle, Laura ORCID: https://orcid.org/0000-0003-1037-3137; Hladik, Anastasiya; Knapp, Sylvia ORCID: https://orcid.org/0000-0001-9016-5244; Colonna, Marco ORCID: https://orcid.org/0000-0001-5222-4987; Martini, Rudolf; Saliba, Antoine-Emmanuel ORCID: https://orcid.org/0000-0001-8539-2784; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Zernecke, Alma ORCID: https://orcid.org/0000-0001-8551-4729; Binder, Christoph J. ORCID: https://orcid.org/0000-0001-8313-7050 und Cochain, Clément ORCID: https://orcid.org/0000-0002-0340-1745
(2024):
TREM2 protects from atherosclerosis by limiting necrotic core formation.
In: Nature Cardiovascular Research, Bd. 3, Nr. 3: S. 269-282
[PDF, 11MB]
ORCID: https://orcid.org/0000-0002-2025-6594; Porsch, Florentina ORCID: https://orcid.org/0000-0002-2633-6632; Rizzo, Giuseppe; Kapser, Frederieke; Schulz, Dirk J. J.; Kiss, Máté G.; Schlepckow, Kai; Morenas-Rodriguez, Estrella; Sen, Mustafa Orkun; Gropper, Julius; Bandi, Sourish Reddy; Schäfer, Sarah; Krammer, Tobias ORCID: https://orcid.org/0000-0002-7638-9476; Leipold, Alexander M.; Hoke, Matthias; Ozsvár-Kozma, Mária; Beneš, Hannah; Schillinger, Martin; Minar, Erich; Roesch, Melanie; Göderle, Laura ORCID: https://orcid.org/0000-0003-1037-3137; Hladik, Anastasiya; Knapp, Sylvia ORCID: https://orcid.org/0000-0001-9016-5244; Colonna, Marco ORCID: https://orcid.org/0000-0001-5222-4987; Martini, Rudolf; Saliba, Antoine-Emmanuel ORCID: https://orcid.org/0000-0001-8539-2784; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Zernecke, Alma ORCID: https://orcid.org/0000-0001-8551-4729; Binder, Christoph J. ORCID: https://orcid.org/0000-0001-8313-7050 und Cochain, Clément ORCID: https://orcid.org/0000-0002-0340-1745
(2024):
TREM2 protects from atherosclerosis by limiting necrotic core formation.
In: Nature Cardiovascular Research, Bd. 3, Nr. 3: S. 269-282
[PDF, 11MB]
Krammer, Christine; Yang, Bishan; Reichl, Sabrina; Besson‐Girard, Simon ORCID: https://orcid.org/0000-0003-1194-5256; Ji, Hao; Bolini, Verena; Schulte, Corinna; Noels, Heidi; Schlepckow, Kai; Jocher, Georg; Werner, Georg; Willem, Michael; El Bounkari, Omar ORCID: https://orcid.org/0000-0002-3051-2096; Kapurniotu, Aphrodite ORCID: https://orcid.org/0000-0001-6124-7232; Gokce, Ozgun; Weber, Christian; Mohanta, Sarajo ORCID: https://orcid.org/0000-0001-6144-4092 und Bernhagen, Jürgen ORCID: https://orcid.org/0000-0003-2996-2652
(2023):
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice.
In: The FASEB Journal, Bd. 37, Nr. 3
[PDF, 12MB]
ORCID: https://orcid.org/0000-0003-1194-5256; Ji, Hao; Bolini, Verena; Schulte, Corinna; Noels, Heidi; Schlepckow, Kai; Jocher, Georg; Werner, Georg; Willem, Michael; El Bounkari, Omar ORCID: https://orcid.org/0000-0002-3051-2096; Kapurniotu, Aphrodite ORCID: https://orcid.org/0000-0001-6124-7232; Gokce, Ozgun; Weber, Christian; Mohanta, Sarajo ORCID: https://orcid.org/0000-0001-6144-4092 und Bernhagen, Jürgen ORCID: https://orcid.org/0000-0003-2996-2652
(2023):
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice.
In: The FASEB Journal, Bd. 37, Nr. 3
[PDF, 12MB]
van Lengerich, Bettina; Zhan, Lihong; Xia, Dan; Chan, Darren; Joy, David; Park, Joshua I.; Tatarakis, David; Calvert, Meredith; Hummel, Selina; Lianoglou, Steve; Pizzo, Michelle E.; Prorok, Rachel; Thomsen, Elliot; Bartos, Laura M.; Beumers, Philipp; Capell, Anja; Davis, Sonnet S.; de Weerd, Lis; Dugas, Jason C.; Duque, Joseph; Earr, Timothy; Gadkar, Kapil; Giese, Tina; Gill, Audrey; Gnoerich, Johannes; Ha, Connie; Kannuswamy, Malavika; Kim, Do Jin; Kunte, Sebastian T.; Kunze, Lea H.; Lac, Diana; Lechtenberg, Kendra; Leung, Amy Wing-Sze; Liang, Chun-Chi; Lopez, Isabel; McQuade, Paul; Modi, Anuja; Torres, Vanessa O.; Nguyen, Hoang N.; Pesaemaa, Ida; Propson, Nicholas; Reich, Marvin; Robles-Colmenares, Yaneth; Schlepckow, Kai; Slemann, Luna; Solanoy, Hilda; Suh, Jung H.; Thorne, Robert G.; Vieira, Chandler; Wind-Mark, Karin; Xiong, Ken; Zuchero, Y. Joy Yu; Diaz, Dolo; Dennis, Mark S.; Huang, Fen; Scearce-Levie, Kimberly; Watts, Ryan J.; Haass, Christian; Lewcock, Joseph W.; Di Paolo, Gilbert; Brendel, Matthias; Sanchez, Pascal E. und Monroe, Kathryn M.
(2023):
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
In: Nature Neuroscience, Bd. 26, Nr. 3:
416-+
[PDF, 13MB]
Schlepckow, Kai; Morenas-Rodríguez, Estrella; Hong, Soyon und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2023):
Stimulation of TREM2 with agonistic antibodies—an emerging therapeutic option for Alzheimer's disease.
In: Lancet Neurology, Bd. 22, Nr. 11: S. 1048-1060
ORCID: https://orcid.org/0000-0002-4869-1627
(2023):
Stimulation of TREM2 with agonistic antibodies—an emerging therapeutic option for Alzheimer's disease.
In: Lancet Neurology, Bd. 22, Nr. 11: S. 1048-1060
Krammer, Christine; Yang, Bishan; Reichl, Sabrina; Besson‐Girard, Simon ORCID: https://orcid.org/0000-0003-1194-5256; Ji, Hao; Bolini, Verena; Schulte, Corinna; Noels, Heidi; Schlepckow, Kai; Jocher, Georg; Werner, Georg; Willem, Michael; El Bounkari, Omar ORCID: https://orcid.org/0000-0002-3051-2096; Kapurniotu, Aphrodite ORCID: https://orcid.org/0000-0001-6124-7232; Gokce, Ozgun; Weber, Christian; Mohanta, Sarajo ORCID: https://orcid.org/0000-0001-6144-4092 und Bernhagen, Jürgen ORCID: https://orcid.org/0000-0003-2996-2652
(2023):
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice.
In: The FASEB Journal, Bd. 37, Nr. 3
[PDF, 12MB]
ORCID: https://orcid.org/0000-0003-1194-5256; Ji, Hao; Bolini, Verena; Schulte, Corinna; Noels, Heidi; Schlepckow, Kai; Jocher, Georg; Werner, Georg; Willem, Michael; El Bounkari, Omar ORCID: https://orcid.org/0000-0002-3051-2096; Kapurniotu, Aphrodite ORCID: https://orcid.org/0000-0001-6124-7232; Gokce, Ozgun; Weber, Christian; Mohanta, Sarajo ORCID: https://orcid.org/0000-0001-6144-4092 und Bernhagen, Jürgen ORCID: https://orcid.org/0000-0003-2996-2652
(2023):
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice.
In: The FASEB Journal, Bd. 37, Nr. 3
[PDF, 12MB]
Rizzo, Giuseppe; Gropper, Julius; Piollet, Marie; Vafadarnejad, Ehsan; Rizakou, Anna; Bandi, Sourish Reddy; Arampatzi, Panagiota; Krammer, Tobias; DiFabion, Nina; Dietrich, Oliver; Arias-Loza, Anahi Paula; Prinz, Marco; Mack, Matthias; Schlepckow, Kai; Haass, Christian; Silvestre, Jean Sebastien; Zernecke, Alma; Saliba, Antoine Emmanuel und Cochain, Clement
(2022):
Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction.
In: Cardiovascular Research, Bd. 119, Nr. 3: S. 772-785
[PDF, 1MB]
Morenas-Rodriguez, Estrella; Li, Yan; Nuscher, Brigitte; Franzmeier, Nicolai; Xiong, Chengjie; Suarez-Calvet, Marc; Fagan, Anne M.; Schultz, Stephanie; Gordon, Brian A.; Benzinger, Tammie L. S.; Hassenstab, Jason; McDade, Eric; Feederle, Regina; Karch, Celeste M.; Schlepckow, Kai; Morris, John C.; Kleinberger, Gernot; Nellgard, Bengt; Voglein, Jonathan; Blennow, Kaj; Zetterberg, Henrik; Ewers, Michael; Jucker, Mathias; Levin, Johannes; Bateman, Randall J. und Haass, Christian
(2022):
Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study.
In: Lancet Neurology, Bd. 21, Nr. 4: S. 329-341
[PDF, 761kB]
Bosch-Queralt, Mar; Cantuti-Castelvetri, Ludovico; Damkou, Alkmini; Schifferer, Martina; Schlepckow, Kai; Alexopoulos, Ioannis; Luetjohann, Dieter; Klose, Christian; Vaculciakova, Lenka; Masuda, Takahiro; Prinz, Marco; Monroe, Kathryn M.; Di Paolo, Gilbert; Lewcock, Joseph W.; Haass, Christian und Simons, Mikael
(2021):
Diet-dependent regulation of TGF beta impairs reparative innate immune responses after demyelination.
In: Nature Metabolism, Bd. 3, Nr. 2: S. 211-227
[PDF, 9MB]
Schlepckow, Kai; Monroe, Kathryn M.; Kleinberger, Gernot; Cantuti‐Castelvetri, Ludovico; Parhizkar, Samira; Xia, Dan; Willem, Michael; Werner, Georg; Pettkus, Nadine; Brunner, Bettina; Sülzen, Alice; Nuscher, Brigitte; Hampel, Heike; Xiang, Xianyuan; Feederle, Regina; Tahirovic, Sabina; Park, Joshua I.; Prorok, Rachel; Mahon, Cathal; Liang, Chun‐Chi; Shi, Ju; Kim, Do Jin; Sabelström, Hanna; Huang, Fen; Paolo, Gilbert di; Simons, Mikael; Lewcock, Joseph W. und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(7. April 2020):
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
, Bd. 12, Nr. 4, e11227
[PDF, 4MB]
ORCID: https://orcid.org/0000-0002-4869-1627
(7. April 2020):
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
, Bd. 12, Nr. 4, e11227
[PDF, 4MB]
Berner, Dennis Kristopher; Wessolowski, Luisa; Armbrust, Fred; Schneppenheim, Janna; Schlepckow, Kai; Koudelka, Tomas; Scharfenberg, Franka; Lucius, Ralph; Tholey, Andreas; Kleinberger, Gernot; Haass, Christian; Arnold, Philipp und Becker-Pauly, Christoph
(2020):
Meprin beta cleaves TREM2 and controls its phagocytic activity on macrophages.
In: FASEB Journal, Bd. 34, Nr. 5: S. 6675-6687
[PDF, 1MB]
Steiner, Andrea; Schlepckow, Kai; Brunner, Bettina; Steiner, Harald; Haass, Christian und Hagn, Franz
(2020):
gamma-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.
In: EMBO Journal, Bd. 39, Nr. 20, e104247
[PDF, 2MB]
Lewcock, Joseph W.; Schlepckow, Kai; Di Paolo, Gilbert; Tahirovic, Sabina; Monroe, Kathryn M. und Haass, Christian
(2020):
Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease.
In: Neuron, Bd. 108, Nr. 5: S. 801-821
Suarez-Calvet, Marc; Morenas-Rodriguez, Estrella; Kleinberger, Gernot; Schlepckow, Kai; Caballero, Miguel Angel Araque; Franzmeier, Nicolai; Capell, Anja; Fellerer, Katrin; Nuscher, Brigitte; Eren, Erden; Levin, Johannes; Deming, Yuetiva; Piccio, Laura; Karch, Celeste M.; Cruchaga, Carlos; Shaw, Leslie M.; Trojanowski, John Q.; Weiner, Michael; Ewers, Michael und Haass, Christian
(2019):
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid- pathology.
In: Molecular Neurodegeneration, Bd. 14, 1
[PDF, 1MB]
Schlepckow, Kai; Kleinberger, Gernot; Fukumori, Akio; Feederle, Regina; Lichtenthaler, Stefan F.; Steiner, Harald und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2017):
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
In: Embo Molecular Medicine, Bd. 9, Nr. 10: S. 1356-1365
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4869-1627
(2017):
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
In: Embo Molecular Medicine, Bd. 9, Nr. 10: S. 1356-1365
[PDF, 1MB]