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Anzahl der Publikationen: 22
Zeitschriftenartikel
Vos, Winnie G.; van Os, Bram W.; den Toom, Myrthe; Beckers, Linda; van Roomen, Cindy P. A. A.; van Tiel, Claudia M.; Mohapatra, Bhopal C.; Band, Hamid; Nitz, Katrin; Weber, Christian; Atzler, Dorothee; de Winther, Menno P. J.; Bosmans, Laura A.; Lutgens, Esther und Seijkens, Tom T. P.
(2024):
T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation.
In: Frontiers in Immunology, Bd. 15, 1297893
[PDF, 3MB]
Poels, Kikkie; Schreurs, Maxime; Jansen, Matthijs; Vugts, Danielle J.; Seijkens, Tom T. P.; Dongen, Guus A. M. S. van; Lutgens, Esther und Beaino, Wissam
(2022):
Immuno-PET Imaging of Atherosclerotic Plaques with [Zr-89]Zr-Anti-CD40 mAb-Proof of Concept.
In: Biology, Bd. 11, Nr. 3, 408
Vos, Winnie G. 
ORCID: https://orcid.org/0000-0001-7805-7275; Lutgens, Esther und Seijkens, Tom T. P.
(2022):
Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer?
In: Journal for ImmunoTherapy of Cancer, Bd. 10, Nr. 9, e005611
ORCID: https://orcid.org/0000-0001-7805-7275; Lutgens, Esther und Seijkens, Tom T. P.
(2022):
Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer?
In: Journal for ImmunoTherapy of Cancer, Bd. 10, Nr. 9, e005611
Poels, Kikkie; Neppelenbroek, Suzanne I. M.; Kersten, Marie Jose; Antoni, M. Louisa; Lutgens, Esther und Seijkens, Tom T. P.
(2021):
Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem.
In: Journal for Immunotherapy of Cancer, Bd. 9, Nr. 6, e002916
Lacy, Michael; Buerger, Christina; Shami, Annelie; Ahmadsei, Maiwand; Winkels, Holger; Nitz, Katrin; Tiel, Claudia M. van; Seijkens, Tom T. P.; Kusters, Pascal J. H.; Karshovka, Ela; Prange, Koen H. M.; Wu, Yuting; Brouns, Sanne L. N.; Unterlugauer, Sigrid; Kuijpers, Marijke J. E.; Reiche, Myrthe E.; Steffens, Sabine; Edsfeldt, Andreas; Megens, Remco T. A.; Heemskerk, Johan W. M.; Goncalves, Isabel; Weber, Christian; Gerdes, Norbert; Atzler, Dorothee und Lutgens, Esther
(2021):
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.
In: Nature Communications, Bd. 12, Nr. 1, 3754
[PDF, 3MB]
Poels, Kikkie; Schnitzler, Johan G.; Waissi, Farahnaz; Levels, Johannes H. M.; Stroes, Erik S. G.; Daemen, Mat J. A. P.; Lutgens, Esther; Pennekamp, Anne-Marije; De Kleijn, Dominique P. V.; Seijkens, Tom T. P. und Kroon, Jeffrey
(12. November 2020):
Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability.
In: Frontiers in Cell and Developmental Biology, Bd. 8, 581641: S. 1-11
[PDF, 5MB]
Poels, Kikkie; Vos, Winnie G.; Lutgens, Esther und Seijkens, Tom T. P.
(5. Juni 2020):
E3 Ubiquitin Ligases as Immunotherapeutic Target in Atherosclerotic Cardiovascular Disease.
In: Frontiers in Cardiovascular Medicine, Bd. 7, 106: S. 1-8
[PDF, 724kB]
Poels, Kikkie; Leent, Mandy M. T. van; Boutros, Celine; Tissot, Hubert; Roy, Severine; Meerwaldt, Anu E.; Toner, Yohana C. A.; Reiche, Myrthe E.; Kusters, Pascal J. H.; Malinova, Tsveta; Huveneers, Stephan; Kaufman, Audrey E.; Mani, Venkatesh; Fayad, Zahi A.; Winther, Menno P. J. de; Marabelle, Aurelien; Mulder, Willem J. M.; Robert, Caroline; Seijkens, Tom T. P. und Lutgens, Esther
(2020):
Immune Checkpoint Inhibitor Therapy Aggravates T Cell-Driven Plaque Inflammation in Atherosclerosis.
In: Jacc: Cardiooncology, Bd. 2, Nr. 4: S. 599-610
Bosmans, Laura A.; Bosch, Lena; Kusters, Pascal J. H.; Lutgens, Esther und Seijkens, Tom T. P.
(2020):
The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease.
In: Journal of Cardiovascular Translational Research, Bd. 14, Nr. 1: S. 13-22
Poels, Kikkie; Leent, Mandy M. T. van; Reiche, Myrthe E.; Kusters, Pascal J. H.; Huveneers, Stephan; Winther, Menno P. J. de; Mulder, Willem J. M.; Lutgens, Esther und Seijkens, Tom T. P.
(2020):
Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice.
In: Cells, Bd. 9, Nr. 9, 1987
Lutgens, Esther und Seijkens, Tom T. P.
(2020):
Cancer patients receiving immune checkpoint inhibitor therapy are at an increased risk for atherosclerotic cardiovascular disease.
In: Journal for Immunotherapy of Cancer, Bd. 8, Nr. 1, e000300
Schnitzler, Johan G.; Poels, Kikkie; Stiekema, Lotte C. A.; Yeang, Calvin; Tsimikas, Sotirios; Kroon, Jeffrey; Stroes, Erik S. G.; Lutgens, Esther und Seijkens, Tom T. P.
(2020):
Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes.
In: International Journal of Cardiology, Bd. 315: S. 81-85
Aarts, Suzanne A. B. M.; Seijkens, Tom T. P.; Kusters, Pascal J. H.; van Tiel, Claudia M.; Reiche, Myrthe E.; den Toom, Myrthe; Beckers, Linda; van Roomen, Cindy P. A. A.; de Winther, Menno P. J.; Kooij, Gijs und Lutgens, Esther
(2019):
Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis.
In: Journal of Pathology, Bd. 247, Nr. 4: S. 471-480
Seijkens, Tom T. P.; Poels, Kikkie; Meiler, Svenja; van Tiel, Claudia M.; Kusters, Pascal J. H.; Reiche, Myrthe; Atzler, Dorothee; Winkels, Holger; Tjwa, Marc; Poelman, Hessel; Slutter, Bram; Kuiper, Johan; Gijbels, Marion; Kuivenhoven, Jan Albert; Matic, Ljubica Perisic; Paulsson-Berne, Gabrielle; Hedin, Ulf; Hansson, Goran K.; Nicolaes, Gerry A. F.; Daemen, Mat J. A. P.; Weber, Christian; Gerdes, Norbert; de Winther, Menno P. J. und Lutgens, Esther
(2019):
Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8(+) T cell-mediated macrophage death.
In: European Heart Journal, Bd. 40, Nr. 4
Seijkens, Tom T. P.; Tiel, Claudia M. van; Kusters, Pascal J. H.; Atzler, Dorothee; Soehnlein, Oliver; Zarzycka, Barbara; Aarts, Suzanne A. B. M.; Lameijer, Marnix; Gijbels, Marion J.; Beckers, Linda; Toom, Myrthe den; Slutter, Bram; Kuiper, Johan; Duchene, Johan; Aslani, Maria; Megens, Remco T. A.; Veer, Cornelis van 't; Kooij, Gijs; Schrijver, Roy; Hoeksema, Marten A.; Boon, Louis; Fay, Francois; Tang, Jun; Baxter, Samantha; Jongejan, Aldo; Moerland, Perry D.; Vriend, Gert; Bleijlevens, Boris; Fisher, Edward A.; Duivenvoorden, Raphael; Gerdes, Norbert; Winther, Menno P. J. de; Nicolaes, Gerry A.; Mulder, Willem J. M.; Weber, Christian und Lutgens, Esther
(2018):
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.
In: Journal of the American College of Cardiology, Bd. 71, Nr. 5: S. 527-542
Kusters, Pascal J. H.; Lutgens, Esther und Seijkens, Tom T. P.
(2018):
Exploring immune checkpoints as potential therapeutic targets in atherosclerosis.
In: Cardiovascular Research, Bd. 114, Nr. 3: S. 368-377
Kusters, Pascal J. H.; Seijkens, Tom T. P.; Beckers, Linda; Lievens, Dirk; Winkels, Holger; Waard, Vivian de; Duijvestijn, Adriaan; Liljeqvist, Moritz Lindquist; Roy, Joy; Daugherty, Alan; Newby, Andrew; Gerdes, Norbert und Lutgens, Esther
(2018):
CD40L Deficiency Protects Against Aneurysm Formation.
In: Arteriosclerosis Thrombosis and Vascular Biology, Bd. 38, Nr. 5: S. 1076-1085
[PDF, 1MB]
Lameijer, Marnix; Binderup, Tina; Leent, Mandy M. T. van; Senders, Max L.; Fay, Francois; Malkus, Joost; Sanchez-Gaytan, Brenda L.; Teunissen, Abraham J. P.; Karakatsanis, Nicolas; Robson, Philip; Zhou, Xianxiao; Ye, Yuxiang; Wojtkiewicz, Gregory; Tang, Jun; Seijkens, Tom T. P.; Kroon, Jeffrey; Stroes, Erik S. G.; Kjaer, Andreas; Ochando, Jordi; Reiner, Thomas; Perez-Medina, Carlos; Calcagno, Claudia; Fischer, Edward A.; Zhang, Bin; Temel, Ryan E.; Swirski, Filip K.; Nahrendorf, Matthias; Fayad, Zahi A.; Lutgens, Esther; Mulder, Willem J. M. und Duivenvoorden, Raphael
(2018):
Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates.
In: Nature Biomedical Engineering, Bd. 2, Nr. 5: S. 279-292
Aarts, Suzanne A. B. M.; Seijkens, Tom T. P.; Dorst, Koos J. F. van; Dijkstra, Christine D.; Kooij, Gijs und Lutgens, Esther
(2017):
The CD40-CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.
In: Frontiers in Immunology, Bd. 8, 1791
[PDF, 737kB]
Aarts, Suzanne A. B. M.; Seijkens, Tom T. P.; Kusters, Pascal J. H.; Pol, Susanne M. A. van der; Zarzycka, Barbara; Heijnen, Priscilla D. A. M.; Beckers, Linda; Toom, Myrthe den; Gijbels, Marion J. J.; Boon, Louis; Weber, Christian; Vries, Helga E. de; Nicolaes, Gerry A. F.; Dijkstra, Christine D.; Kooij, Gijs und Lutgens, Esther
(2017):
Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.
In: Journal of Neuroinflammation
14:105
[PDF, 3MB]
Berg, Susan M. van den; Seijkens, Tom T. P.; Kusters, Pascal J. H.; Beckers, Linda; Toom, Myrthe; den Smeets, Esther; Levels, Johannes; Winther, Menno P. J. de und Lutgens, Esther
(2016):
Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow.
In: FASEB Journal, Bd. 30, Nr. 5: S. 1779-1788
Legein, Bart; Janssen, Edith M.; Theelen, Thomas L.; Gijbels, Marion J.; Walraven, Joep; Klarquist, Jared S.; Hennies, Cassandra M.; Wouters, Kristiaan; Seijkens, Tom T. P.; Wijnands, Erwin; Sluimer, Judith C.; Lutgens, Esther; Zenke, Martin; Hildner, Kai; Biessen, Erik A. L. und Temmerman, Lieve
(2015):
Ablation of CD8 alpha(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice.
In: Scientific Reports, Bd. 5, 15414
[PDF, 2MB]