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Anzahl der Publikationen: 24
Zeitschriftenartikel
Wiese, Mats L.; Urban, Steffi; Rheinbaben, Sabrina von; Frost, Fabian; Sendler, Matthias; Weiss, Frank Ulrich; Buelow, Robin; Kromrey, Marie-Luise; Tran, Quang Trung; Lerch, Markus M.; Schauer, Birgit und Aghdassi, Ali A.
(2022):
Identification of early predictors for infected necrosis in acute pancreatitis.
In: BMC Gastroenterology, Bd. 22, Nr. 1, 405
Quang Trung, Tran; Sendler, Matthias; Wiese, Mats L.; Doller, Julia; Zierke, Lukas; Gischke, Marcel; Glaubitz, Juliane; Van, Huy Tran; Lalk, Michael; Bornscheuer, Uwe T.; Weiss, Frank Ulrich; Lerch, Markus M. und Aghdassi, Ali A.
(2022):
Systemic Bile Acids Affect the Severity of Acute Pancreatitis in Mice Depending on Their Hydrophobicity and the Disease Pathogenesis.
In: International Journal of Molecular Sciences, Bd. 23, Nr. 21, 13592
Smolinska, Agnieszka; Singer, Kerstin; Golchert, Janine; Smyczynska, Urszula; Fendler, Wojciech; Sendler, Matthias; Brandt, Jens van den; Singer, Stephan; Homuth, Georg; Lerch, Markus M. und Moskwa, Patryk
(2022):
DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis.
In: Cancers, Bd. 14, Nr. 17, 4077
Glaubitz, Juliane; Wilden, Anika; Golchert, Janine; Homuth, Georg; Voelker, Uwe; Broeker, Barbara M.; Thiele, Thomas; Lerch, Markus M.; Mayerle, Julia; Aghdassi, Ali A.; Weiss, Frank U. und Sendler, Matthias
(2022):
In mouse chronic pancreatitis CD25(+)FOXP3(+) regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response.
In: Nature Communications, Bd. 13, Nr. 1, 4502
Trapp, Simon; Aghdassi, Ali A.; Glaubitz, Juliane; Sendler, Matthias; Weiss, Frank Ulrich; Kuhn, Jens Peter; Kromrey, Marie-Luise; Mahajan, Ujjwal M.; Pallagi, Petra; Rakonczay, Zoltan; Venglovecz, Viktoria; Lerch, Markus M.; Hegyi, Peter und Mayerle, Julia
(2021):
Pancreatitis severity in mice with impaired CFTR function but pancreatic sufficiency is mediated via ductal and inflammatory cells-Not acinar cells.
In: Journal of Cellular and Molecular Medicine, Bd. 25, Nr. 10: S. 4658-4670
Mahajan, Ujjwal Mukund; Alnatsha, Ahmed; Li, Qi; Oehrle, Bettina; Weiss, Frank-Ulrich; Sendler, Matthias; Distler, Marius; Uhl, Waldemar; Fahlbusch, Tim; Goni, Elisabetta; Beyer, Georg; Chromik, Ansgar; Bahra, Markus; Klein, Fritz; Pilarsky, Christian; Gruetzmann, Robert; Lerch, Markus M.; Lauber, Kirsten; Christiansen, Nicole; Kamlage, Beate; Regel, Ivonne und Mayerle, Julia
(2021):
Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma.
In: Cells, Bd. 10, Nr. 7, 1821
Mahajan, Ujjwal M.; Li, Qi; Alnatsha, Ahmed; Maas, Jessica; Orth, Michael; Maier, Sebastian Hubertus; Peterhansl, Julian; Regel, Ivonne; Sendler, Matthias; Wagh, Preshit R.; Mishra, Neha; Xue, Yonggan; Allawadhi, Prince; Beyer, Georg; Kuehn, Jens-Peter; Marshall, Thomas; Appel, Bettina; Laemmerhirt, Felix; Belka, Claus; Mueller, Sabine; Weiss, Frank-Ulrich; Lauber, Kirsten; Lerch, Markus M. und Mayerle, Julia
(2021):
Tumor-Specific Delivery of 5-Fluorouracil-Incorporated Epidermal Growth Factor Receptor-Targeted Aptamers as an Efficient Treatment in Pancreatic Ductal Adenocarcinoma Models.
In: Gastroenterology, Bd. 161, Nr. 3: S. 996-1010
Frost, Fabian; Kacprowski, Tim; Ruehlemann, Malte; Weiss, Stefan; Bang, Corinna; Franke, Andre; Pietzner, Maik; Aghdassi, Ali A.; Sendler, Matthias; Voelker, Uwe; Voelzke, Henry; Mayerle, Julia; Weiss, Frank U.; Homuth, Georg und Lerch, Markus M.
(2021):
Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis.
In: Scientific Reports, Bd. 11, Nr. 1, 6677
Frost, Fabian; Kacprowski, Tim; Ruehlemann, Malte; Pietzner, Maik; Bang, Corinna; Franke, Andre; Nauck, Matthias; Voelker, Uwe; Voelzke, Henry; Doerr, Marcus; Baumbach, Jan; Sendler, Matthias; Schulz, Christian; Mayerle, Julia; Weiss, Frank U.; Homuth, Georg und Lerch, Markus M.
(2021):
Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function.
In: Gut, Bd. 70, Nr. 3: S. 522-530
Glaubitz, Juliane; Wilden, Anika; Brandt, Cindy van den; Weiss, Frank U.; Broeker, Barbara M.; Mayerle, Julia; Lerch, Markus M. und Sendler, Matthias
(2020):
Experimental pancreatitis is characterized by rapid T cell activation, Th2 differentiation that parallels disease severity, and improvement after CD4(+) T cell depletion.
In: Pancreatology, Bd. 20, Nr. 8
Frost, Fabian; Weiss, Frank U.; Sendler, Matthias; Kacprowski, Tim; Ruehlemann, Malte; Bang, Corinna; Franke, Andre; Voelker, Uwe; Voelzke, Henry; Lamprecht, Georg; Mayerle, Julia; Aghdassi, Ali A.; Homuth, Georg und Lerch, Markus M.
(2020):
The Gut Microbiome in Patients With Chronic Pancreatitis Is Characterized by Significant Dysbiosis and Overgrowth by Opportunistic Pathogens.
In: Clinical and Translational Gastroenterology, Bd. 11, Nr. 9, e00232
Mahajan, Ujjwal M.; Goni, Elisabetta; Langhoff, Enno; Li, Qi; Costello, Eithne; Greenhalf, William; Kruger, Stephan; Ormanns, Steffen; Halloran, Christopher; Ganeh, Paula; Marron, Manuela; Laemmerhirt, Felix; Zhao, Yue; Beyer, Georg; Weiss, Frank-Ulrich; Sendler, Matthias; Bruns, Christiane J.; Kohlmann, Thomas; Kirchner, Thomas; Werner, Jens; D'Haese, Jan G.; Bergwelt, Michael von; Heinemann, Volker; Neoptolemos, John P.; Buechler, Markus W.; Belka, Claus; Boeck, Stefan; Lerch, Markus M. und Mayerle, Julia
(2020):
Cathepsin D Expression and Gemcitabine Resistance in Pancreatic Cancer.
In: Jnci Cancer Spectrum, Bd. 4, Nr. 1, pkz060
Malla, Sudarshan R.; Krueger, Burkhard; Wartmann, Thomas; Sendler, Matthias; Mahajan, Ujjwal M.; Weiss, F. Ulrich; Thiel, Franziska G.; De Boni, Carina; Gorelick, Fred S.; Halangk, Walter; Aghdassi, Ali A.; Reinheckel, Thomas; Gukovskaya, Anna S.; Lerch, Markus M. und Mayerle, Julia
(2020):
Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice.
In: Cellular and Molecular Life Sciences, Bd. 77, Nr. 9: S. 1811-1825
John, Daniel S.; Aschenbach, Julia; Krüger, Burkhard; Sendler, Matthias; Weiss, F. Ulrich; Mayerle, Julia; Lerch, Markus M. und Aghdassi, Ali A.
(2019):
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
In: Journal of Biological Chemistry, Bd. 294, Nr. 2: S. 697-707
Lukas, Jan; Pospech, Jola; Oppermann, Christina; Hund, Christina; Iwanov, Katharina; Pantoom, Supansa; Petters, Janine; Frech, Moritz; Seemann, Susanne; Thiel, Franziska-Gisela; Modenbach, Jana-Marielle; Bolsmann, Robert; Chama, Laura de Freitas; Kraatz, Franziska; El-Hage, Firas; Gronbach, Manuel; Klein, Annelie; Müller, Regina; Salloch, Sabine; Weiss, Frank-Ulrich; Simon, Peter; Wagh, Preshit; Klemenz, Almuth; Krüger, Elke; Mayerle, Julia; Delcea, Mihaela; Kragl, Udo; Beller, Matthias; Rolfs, Arndt; Lerch, Markus M. und Sendler, Matthias
(2019):
Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.
In: Advances in Medical Sciences, Bd. 64, Nr. 2: S. 315-323
Aghdassi, Ali A.; John, Daniel S.; Sendler, Matthias; Storck, Christian; Brandt, Cindy van den; Krüger, Burkhard; Weiss, Frank Ulrich; Mayerle, Julia und Lerch, Markus M.
(2019):
Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.
In: Scientific Reports, Bd. 9, 16774
[PDF, 2MB]
Mayerle, Julia; Sendler, Matthias; Hegyi, Eszter; Beyer, Georg; Lerch, Markus M. und Sahin-Toth, Miklos
(2019):
Genetics, Cell Biology, and Pathophysiology of Pancreatitis.
In: Gastroenterology, Bd. 156, Nr. 7
Frost, Fabian; Kacprowski, Tim; Ruehlemann, Malte; Bulow, Robin; Kühn, Jens-Peter; Franke, Andre; Heinsen, Femke-Anouska; Pietzner, Maik; Nauck, Matthias; Voelker, Uwe; Voelzke, Henry; Aghdassi, Ali A.; Sendler, Matthias; Mayerle, Julia; Weiss, Frank U.; Homuth, Georg und Lerch, Markus M.
(2019):
Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity.
In: Gastroenterology, Bd. 156, Nr. 4: S. 1010-1015
Aghdassi, Ali A.; John, Daniel S.; Sendler, Matthias; Weiss, F. Ulrich; Reinheckel, Thomas; Mayerle, Julia und Lerch, Markus M.
(2018):
Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
In: Journal of Biological Chemistry, Bd. 293, Nr. 3: S. 1018-1029
Mahajan, Ujjwal Mukund; Langhoff, Eno; Goni, Elisabetta; Costello, Eithne; Greenhalf, William; Halloran, Christopher; Ormanns, Steffen; Kruger, Stephan; Böck, Stefan; Ribback, Silvia; Beyer, Georg; Dombroswki, Frank; Weiss, Frank-Ulrich; Neoptolemos, John P.; Werner, Jens; D'Haese, Jan G.; Bazhin, Alexandr; Peterhansl, Julian; Pichlmeier, Svenja; Büchler, Markus W.; Kleeff, Jörg; Ganeh, Paula; Sendler, Matthias; Palmer, Daniel H.; Kohlmann, Thomas; Rad, Roland; Regel, Ivonne; Lerch, Markus M. und Mayerle, Julia
(2018):
Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma.
In: Gastroenterology, Bd. 155, Nr. 5: S. 1625-1639
Sendler, Matthias; Weiss, Frank-Ulrich; Golchert, Janine; Homuth, Georg; Brandt, Cindy van den; Mahajan, Ujjwal M.; Partecke, Lars-Ivo; Doering, Paula; Gukovsky, Ilya; Gukovskaya, Anna S.; Wagh, Preshit R.; Lerch, Markus M. und Mayerle, Julia
(2018):
Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.
In: Gastroenterology, Bd. 154, Nr. 3: S. 704-718
Venglovecz, Viktoria; Pallagi, Petra; Kemeny, Lajos; Balazs, Anita; Balla, Zsolt; Becskehazi, Eszter; Gal, Eleonora; Toth, Emese; Zvara, Agnes; Puskas, Laszlo G.; Borka, Katalin; Sendler, Matthias; Lerch, Markus M.; Mayerle, Julia; Kühn, Jens-Peter; Rakonczay, Zoltan und Hegyi, Peter
(2018):
The Importance of Aquaporin 1 in Pancreatitis and Its Relation to the CFTR Cl- Channel.
In: Frontiers in Physiology, Bd. 9, 854
[PDF, 2MB]
Märtin, Sandrina; Elperin, Jason M.; Lotshaw, Ethan; Sendler, Matthias; Späkman, Steven D.; Takakura, Kazuki; Reicher, Benjamin M.; Mareninova, Olga A.; Grippo, Paul J.; Mayerle, Julia; Lerch, Markus M. und Gukovskaya, Anna S.
(2017):
Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges.
In: American Journal of Physiology-Gastrointestinal and Liver Physiology, Bd. 313, Nr. 5:
G524-G536
Malla, Sudarshan R.; Kärrman Mardh, Carina; Günther, Annett; Mahajan, Ujjwal M.; Sendler, Matthias; D'Haese, Jan; Weiss, Frank Ulrich; Lerch, Markus M.; Hansen, Mark Berner und Mayerle, Julia
(2016):
Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis.
In: Pancreatology, Bd. 16, Nr. 5: S. 761-769