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Simonetti, Francesca 
ORCID: https://orcid.org/0000-0001-6437-8879; Zhong, Weijia ORCID: https://orcid.org/0000-0003-3429-250X; Hutten, Saskia; Uliana, Federico ORCID: https://orcid.org/0000-0002-8185-6438; Schifferer, Martina ORCID: https://orcid.org/0000-0002-0500-8218; Rezaei, Ali ORCID: https://orcid.org/0000-0001-8974-1304; Ramirez, Lisa Marie; Hochmair, Janine ORCID: https://orcid.org/0000-0001-9384-9764; Sankar, Rithika ORCID: https://orcid.org/0009-0007-0463-4042; Gopalan, Anusha; Kielisch, Fridolin ORCID: https://orcid.org/0000-0003-3573-8067; Riemenschneider, Henrick ORCID: https://orcid.org/0009-0003-9633-7360; Ruf, Viktoria; Schmidt, Carla ORCID: https://orcid.org/0000-0001-9410-1424; Simons, Mikael; Zweckstetter, Markus; Wegmann, Susanne ORCID: https://orcid.org/0000-0002-5388-2479; Lashley, Tammaryn ORCID: https://orcid.org/0000-0001-7389-0348; Polymenidou, Magdalini ORCID: https://orcid.org/0000-0003-1271-9445; Edbauer, Dieter ORCID: https://orcid.org/0000-0002-7186-4653 und Dormann, Dorothee ORCID: https://orcid.org/0000-0002-9260-2775
(2025):
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.
In: EMBO Journal [Forthcoming]
ORCID: https://orcid.org/0000-0001-6437-8879; Zhong, Weijia ORCID: https://orcid.org/0000-0003-3429-250X; Hutten, Saskia; Uliana, Federico ORCID: https://orcid.org/0000-0002-8185-6438; Schifferer, Martina ORCID: https://orcid.org/0000-0002-0500-8218; Rezaei, Ali ORCID: https://orcid.org/0000-0001-8974-1304; Ramirez, Lisa Marie; Hochmair, Janine ORCID: https://orcid.org/0000-0001-9384-9764; Sankar, Rithika ORCID: https://orcid.org/0009-0007-0463-4042; Gopalan, Anusha; Kielisch, Fridolin ORCID: https://orcid.org/0000-0003-3573-8067; Riemenschneider, Henrick ORCID: https://orcid.org/0009-0003-9633-7360; Ruf, Viktoria; Schmidt, Carla ORCID: https://orcid.org/0000-0001-9410-1424; Simons, Mikael; Zweckstetter, Markus; Wegmann, Susanne ORCID: https://orcid.org/0000-0002-5388-2479; Lashley, Tammaryn ORCID: https://orcid.org/0000-0001-7389-0348; Polymenidou, Magdalini ORCID: https://orcid.org/0000-0003-1271-9445; Edbauer, Dieter ORCID: https://orcid.org/0000-0002-7186-4653 und Dormann, Dorothee ORCID: https://orcid.org/0000-0002-9260-2775
(2025):
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.
In: EMBO Journal [Forthcoming]
Riemenschneider, Henrick; Simonetti, Francesca; Sheth, Udit; Katona, Eszter; Roth, Stefan; Hutten, Saskia; Farny, Daniel; Michaelsen, Meike; Nuscher, Brigitte; Schmidt, Michael K.; Flatley, Andrew; Schepers, Aloys; da Silva, Lara Gruijs A.; Zhou, Qihui; Klopstock, Thomas; Liesz, Arthur; Arzberger, Thomas; Herms, Jochen; Feederle, Regina; Gendron, Tania F.; Dormann, Dorothee und Edbauer, Dieter
(2023):
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
In: Acta Neuropathologica Communications, Bd. 11, Nr. 1, 112
[PDF, 6MB]
Zibold, Julia; Lessard, Lola E. R.; Picard, Flavien; da Silva, Lara Gruijs; Zadorozhna, Yelyzaveta; Streichenberger, Nathalie; Belotti, Edwige; Osseni, Alexis; Emerit, Andrea; Errazuriz-Cerda, Elisabeth; Michel-Calemard, Laurence; Menassa, Rita; Coudert, Laurent; Wiessner, Manuela; Stucka, Rolf; Klopstock, Thomas; Simonetti, Francesca; Hutten, Saskia; Nonaka, Takashi; Hasegawa, Masato; Strom, Tim M.; Bernard, Emilien; Ollagnon, Elisabeth; Urtizberea, Andoni; Dormann, Dorothee; Petiot, Philippe; Schaeffer, Laurent; Senderek, Jan und Leblanc, Pascal
(2023):
The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis.
In: Brain
[PDF, 1MB]
da Silva, Lara A. Gruijs; Simonetti, Francesca; Hutten, Saskia; Riemenschneider, Henrick; Sternburg, Erin L.; Pietrek, Lisa M.; Gebel, Jakob; Doetsch, Volker; Edbauer, Dieter; Hummer, Gerhard; Stelzl, Lukas S. und Dormann, Dorothee
(2022):
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
In: EMBO Journal, Bd. 41, Nr. 8, e108443
[PDF, 6MB]
Hutten, Saskia; Usluer, Sinem; Bourgeois, Benjamin; Simonetti, Francesca; Odeh, Hana M.; Fare, Charlotte M.; Czuppa, Mareike; Hruska-Plochan, Marian; Hofweber, Mario; Polymenidou, Magdalini; Shorter, James; Edbauer, Dieter; Madl, Tobias und Dormann, Dorothee
(2020):
Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.
In: Cell Reports, Bd. 33, Nr. 12, 108538
[PDF, 3MB]