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Zeitschriftenartikel
Reich, Marvin 
ORCID: https://orcid.org/0000-0002-4567-0994; Simon, Matthew J. ORCID: https://orcid.org/0000-0002-0065-6486; Polke, Beate; Paris, Iñaki ORCID: https://orcid.org/0000-0002-3887-0277; Werner, Georg ORCID: https://orcid.org/0000-0001-5328-3049; Schrader, Christian; Spieth, Lena; Davis, Sonnet S. ORCID: https://orcid.org/0000-0001-7189-1427; Robinson, Sophie ORCID: https://orcid.org/0000-0003-1261-1370; de Melo, Gabrielly Lunkes ORCID: https://orcid.org/0009-0002-1342-3080; Schlaphoff, Lennart ORCID: https://orcid.org/0000-0001-8043-4025; Buschmann, Katrin; Berghoff, Stefan ORCID: https://orcid.org/0000-0002-3794-7295; Logan, Todd ORCID: https://orcid.org/0000-0003-2081-782X; Nuscher, Brigitte ORCID: https://orcid.org/0009-0000-4661-0742; de Weerd, Lis ORCID: https://orcid.org/0000-0002-3641-1851; Edbauer, Dieter ORCID: https://orcid.org/0000-0002-7186-4653; Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X; Suh, Jung H. ORCID: https://orcid.org/0000-0001-8119-326X; Sandmann, Thomas ORCID: https://orcid.org/0000-0002-6601-8890; Kariolis, Mihalis S. ORCID: https://orcid.org/0000-0003-2067-4013; DeVos, Sarah L. ORCID: https://orcid.org/0000-0003-0921-1763; Lewcock, Joseph W. ORCID: https://orcid.org/0000-0003-3012-7881; Paquet, Dominik ORCID: https://orcid.org/0000-0003-2065-1639; Capell, Anja ORCID: https://orcid.org/0000-0003-3118-911X; Di Paolo, Gilbert ORCID: https://orcid.org/0000-0003-1032-1265 und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2024):
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
In: Science Translational Medicine, Bd. 16, Nr. 750
ORCID: https://orcid.org/0000-0002-4567-0994; Simon, Matthew J. ORCID: https://orcid.org/0000-0002-0065-6486; Polke, Beate; Paris, Iñaki ORCID: https://orcid.org/0000-0002-3887-0277; Werner, Georg ORCID: https://orcid.org/0000-0001-5328-3049; Schrader, Christian; Spieth, Lena; Davis, Sonnet S. ORCID: https://orcid.org/0000-0001-7189-1427; Robinson, Sophie ORCID: https://orcid.org/0000-0003-1261-1370; de Melo, Gabrielly Lunkes ORCID: https://orcid.org/0009-0002-1342-3080; Schlaphoff, Lennart ORCID: https://orcid.org/0000-0001-8043-4025; Buschmann, Katrin; Berghoff, Stefan ORCID: https://orcid.org/0000-0002-3794-7295; Logan, Todd ORCID: https://orcid.org/0000-0003-2081-782X; Nuscher, Brigitte ORCID: https://orcid.org/0009-0000-4661-0742; de Weerd, Lis ORCID: https://orcid.org/0000-0002-3641-1851; Edbauer, Dieter ORCID: https://orcid.org/0000-0002-7186-4653; Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X; Suh, Jung H. ORCID: https://orcid.org/0000-0001-8119-326X; Sandmann, Thomas ORCID: https://orcid.org/0000-0002-6601-8890; Kariolis, Mihalis S. ORCID: https://orcid.org/0000-0003-2067-4013; DeVos, Sarah L. ORCID: https://orcid.org/0000-0003-0921-1763; Lewcock, Joseph W. ORCID: https://orcid.org/0000-0003-3012-7881; Paquet, Dominik ORCID: https://orcid.org/0000-0003-2065-1639; Capell, Anja ORCID: https://orcid.org/0000-0003-3118-911X; Di Paolo, Gilbert ORCID: https://orcid.org/0000-0003-1032-1265 und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2024):
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
In: Science Translational Medicine, Bd. 16, Nr. 750
Kedia, Shreeya; Ji, Hao; Feng, Ruoqing; Androvic, Peter; Spieth, Lena; Liu, Lu ORCID: https://orcid.org/0000-0002-6233-0705; Franz, Jonas ORCID: https://orcid.org/0000-0001-7523-6622; Zdiarstek, Hanna ORCID: https://orcid.org/0009-0009-1341-3107; Anderson, Katrin Perez; Kaboglu, Cem ORCID: https://orcid.org/0000-0002-7887-1602; Liu, Qian; Mattugini, Nicola; Cherif, Fatma; Prtvar, Danilo ORCID: https://orcid.org/0009-0004-8251-1441; Cantuti-Castelvetri, Ludovico ORCID: https://orcid.org/0000-0002-0642-1610; Liesz, Arthur ORCID: https://orcid.org/0000-0002-9069-2594; Schifferer, Martina ORCID: https://orcid.org/0000-0002-0500-8218; Stadelmann, Christine ORCID: https://orcid.org/0000-0003-1766-5458; Tahirovic, Sabina ORCID: https://orcid.org/0000-0003-4403-9559; Gokce, Ozgun ORCID: https://orcid.org/0000-0001-6319-404X und Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X
(2024):
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
In: Nature Neuroscience, Bd. 27, Nr. 8: S. 1468-1474
[PDF, 21MB]
ORCID: https://orcid.org/0000-0002-6233-0705; Franz, Jonas ORCID: https://orcid.org/0000-0001-7523-6622; Zdiarstek, Hanna ORCID: https://orcid.org/0009-0009-1341-3107; Anderson, Katrin Perez; Kaboglu, Cem ORCID: https://orcid.org/0000-0002-7887-1602; Liu, Qian; Mattugini, Nicola; Cherif, Fatma; Prtvar, Danilo ORCID: https://orcid.org/0009-0004-8251-1441; Cantuti-Castelvetri, Ludovico ORCID: https://orcid.org/0000-0002-0642-1610; Liesz, Arthur ORCID: https://orcid.org/0000-0002-9069-2594; Schifferer, Martina ORCID: https://orcid.org/0000-0002-0500-8218; Stadelmann, Christine ORCID: https://orcid.org/0000-0003-1766-5458; Tahirovic, Sabina ORCID: https://orcid.org/0000-0003-4403-9559; Gokce, Ozgun ORCID: https://orcid.org/0000-0001-6319-404X und Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X
(2024):
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
In: Nature Neuroscience, Bd. 27, Nr. 8: S. 1468-1474
[PDF, 21MB]
Sasmita, Andrew Octavian ORCID: https://orcid.org/0000-0001-7379-6749; Depp, Constanze ORCID: https://orcid.org/0000-0003-2868-6932; Nazarenko, Taisiia; Sun, Ting ORCID: https://orcid.org/0000-0002-7104-7215; Siems, Sophie B.; Ong, Erinne Cherisse ORCID: https://orcid.org/0009-0002-4047-7340; Nkeh, Yakum B. ORCID: https://orcid.org/0009-0006-9601-4408; Böhler, Carolin; Yu, Xuan; Bues, Bastian ORCID: https://orcid.org/0000-0002-8302-6235; Evangelista, Lisa ORCID: https://orcid.org/0009-0006-2396-4656; Mao, Shuying; Morgado, Barbara ORCID: https://orcid.org/0000-0001-8174-9301; Wu, Zoe; Ruhwedel, Torben ORCID: https://orcid.org/0000-0002-9535-9395; Subramanian, Swati; Börensen, Friederike; Overhoff, Katharina; Spieth, Lena; Berghoff, Stefan A.; Sadleir, Katherine Rose; Vassar, Robert; Eggert, Simone; Goebbels, Sandra; Saito, Takashi ORCID: https://orcid.org/0000-0002-9659-9251; Saido, Takaomi ORCID: https://orcid.org/0000-0003-1970-6903; Saher, Gesine ORCID: https://orcid.org/0000-0003-3507-9604; Möbius, Wiebke ORCID: https://orcid.org/0000-0002-2902-7165; Castelo-Branco, Gonçalo ORCID: https://orcid.org/0000-0003-2247-9393; Klafki, Hans-Wolfgang; Wirths, Oliver ORCID: https://orcid.org/0000-0002-4115-0334; Wiltfang, Jens ORCID: https://orcid.org/0000-0003-1492-5330; Jäkel, Sarah; Yan, Riqiang und Nave, Klaus-Armin ORCID: https://orcid.org/0000-0001-8724-9666
(2024):
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice.
In: Nature Neuroscience, Bd. 27, Nr. 9: S. 1668-1674
[PDF, 14MB]
ORCID: https://orcid.org/0000-0001-7379-6749; Depp, Constanze ORCID: https://orcid.org/0000-0003-2868-6932; Nazarenko, Taisiia; Sun, Ting ORCID: https://orcid.org/0000-0002-7104-7215; Siems, Sophie B.; Ong, Erinne Cherisse ORCID: https://orcid.org/0009-0002-4047-7340; Nkeh, Yakum B. ORCID: https://orcid.org/0009-0006-9601-4408; Böhler, Carolin; Yu, Xuan; Bues, Bastian ORCID: https://orcid.org/0000-0002-8302-6235; Evangelista, Lisa ORCID: https://orcid.org/0009-0006-2396-4656; Mao, Shuying; Morgado, Barbara ORCID: https://orcid.org/0000-0001-8174-9301; Wu, Zoe; Ruhwedel, Torben ORCID: https://orcid.org/0000-0002-9535-9395; Subramanian, Swati; Börensen, Friederike; Overhoff, Katharina; Spieth, Lena; Berghoff, Stefan A.; Sadleir, Katherine Rose; Vassar, Robert; Eggert, Simone; Goebbels, Sandra; Saito, Takashi ORCID: https://orcid.org/0000-0002-9659-9251; Saido, Takaomi ORCID: https://orcid.org/0000-0003-1970-6903; Saher, Gesine ORCID: https://orcid.org/0000-0003-3507-9604; Möbius, Wiebke ORCID: https://orcid.org/0000-0002-2902-7165; Castelo-Branco, Gonçalo ORCID: https://orcid.org/0000-0003-2247-9393; Klafki, Hans-Wolfgang; Wirths, Oliver ORCID: https://orcid.org/0000-0002-4115-0334; Wiltfang, Jens ORCID: https://orcid.org/0000-0003-1492-5330; Jäkel, Sarah; Yan, Riqiang und Nave, Klaus-Armin ORCID: https://orcid.org/0000-0001-8724-9666
(2024):
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice.
In: Nature Neuroscience, Bd. 27, Nr. 9: S. 1668-1674
[PDF, 14MB]
Spieth, Lena und Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X
(2024):
Remember oligodendrocytes. Uncovering their overlooked role in Alzheimer’s disease.
In: PLoS Biology 22(9), e3002798 [PDF, 666kB]
ORCID: https://orcid.org/0000-0001-5329-192X
(2024):
Remember oligodendrocytes. Uncovering their overlooked role in Alzheimer’s disease.
In: PLoS Biology 22(9), e3002798 [PDF, 666kB]
Kaji, Seiji; Berghoff, Stefan A.; Spieth, Lena; Schlaphoff, Lennart; Sasmita, Andrew O.; Vitale, Simona; Büschgens, Luca; Kedia, Shreeya; Zirngibl, Martin; Nazarenko, Taisiia; Damkou, Alkmini; Hosang, Leon; Depp, Constanze; Kamp, Frits; Scholz, Patricia; Ewers, David; Giera, Martin; Ischebeck, Till; Wurst, Wolfgang ORCID: https://orcid.org/0000-0003-4422-7410; Wefers, Benedikt ORCID: https://orcid.org/0000-0002-2492-9389; Schifferer, Martina ORCID: https://orcid.org/0000-0002-0500-8218; Willem, Michael; Nave, Klaus-Armin; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas; Jäkel, Sarah; Wirths, Oliver ORCID: https://orcid.org/0000-0002-4115-0334; Saher, Gesine ORCID: https://orcid.org/0000-0003-3507-9604 und Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X
(2024):
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis.
In: Immunity, Bd. 57, Nr. 11: S. 2651-2668
[PDF, 11MB]
ORCID: https://orcid.org/0000-0003-4422-7410; Wefers, Benedikt ORCID: https://orcid.org/0000-0002-2492-9389; Schifferer, Martina ORCID: https://orcid.org/0000-0002-0500-8218; Willem, Michael; Nave, Klaus-Armin; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas; Jäkel, Sarah; Wirths, Oliver ORCID: https://orcid.org/0000-0002-4115-0334; Saher, Gesine ORCID: https://orcid.org/0000-0003-3507-9604 und Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X
(2024):
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis.
In: Immunity, Bd. 57, Nr. 11: S. 2651-2668
[PDF, 11MB]
Depp, Constanze; Sun, Ting; Sasmita, Andrew Octavian; Spieth, Lena; Berghoff, Stefan A.; Nazarenko, Taisiia; Overhoff, Katharina; Steixner-Kumar, Agnes A.; Subramanian, Swati; Arinrad, Sahab; Ruhwedel, Torben; Moebius, Wiebke; Goebbels, Sandra; Saher, Gesine; Werner, Hauke B.; Damkou, Alkmini; Zampar, Silvia; Wirths, Oliver; Thalmann, Maik; Simons, Mikael; Saito, Takashi; Saido, Takaomi; Krueger-Burg, Dilja; Kawaguchi, Riki; Willem, Michael; Haass, Christian; Geschwind, Daniel; Ehrenreich, Hannelore; Stassart, Ruth und Nave, Klaus-Armin
(2023):
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.
In: Nature, Bd. 618, Nr. 7964: S. 349-357
[PDF, 20MB]
Duking, Tim; Spieth, Lena; Berghoff, Stefan A.; Piepkorn, Lars; Schmidke, Annika M.; Mitkovski, Miso; Kannaiyan, Nirmal; Hosang, Leon; Scholz, Patricia; Shaib, Ali H.; Schneider, Lennart V.; Hesse, Dorte; Ruhwedel, Torben; Sun, Ting; Linhoff, Lisa; Trevisiol, Andrea; Koehler, Susanne; Pastor, Adrian Marti; Misgeld, Thomas; Sereda, Michael; Hassouna, Imam; Rossner, Moritz J.; Odoardi, Francesca; Ischebeck, Till; de Hoz, Livia; Hirrlinger, Johannes; Jahn, Olaf und Saher, Gesine
(2022):
Ketogenic diet uncovers differential metabolic plasticity of brain cells.
In: Science Advances, Bd. 8, Nr. 37
[PDF, 1MB]
Berghoff, Stefan A.; Spieth, Lena; Sun, Ting; Hosang, Leon; Depp, Constanze; Sasmita, Andrew O.; Vasileva, Martina H.; Scholz, Patricia; Zhao, Yu; Krueger-Burg, Dilja; Wichert, Sven; Brown, Euan R.; Michail, Kyriakos; Nave, Klaus-Armin; Bonn, Stefan; Odoardi, Francesca; Rossner, Moritz; Ischebeck, Till; Edgar, Julia M. und Saher, Gesine
(2021):
Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice.
In: Cell Reports, Bd. 37, Nr. 4, 109889
Berghoff, Stefan A.; Spieth, Lena; Sun, Ting; Hosang, Leon; Schlaphoff, Lennart; Depp, Constanze; Duking, Tim; Winchenbach, Jan; Neuber, Jonathan; Ewers, David; Scholz, Patricia; van der Meer, Franziska; Cantuti-Castelvetri, Ludovico; Sasmita, Andrew O.; Meschkat, Martin; Ruhwedel, Torben; Mobius, Wiebke; Sankowski, Roman; Prinz, Marco; Huitinga, Inge; Sereda, Michael W.; Odoardi, Francesca; Ischebeck, Till; Simons, Mikael; Stadelmann-Nessler, Christine; Edgar, Julia M.; Nave, Klaus-Armin und Saher, Gesine
(2021):
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
In: Nature Neuroscience, Bd. 24, Nr. 1: S. 47-60
[PDF, 8MB]