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Anzahl der Publikationen: 29
Zeitschriftenartikel
Assfalg, Marlene; Guener, Goekhan; Mueller, Stephan A.; Breimann, Stephan; Langosch, Dieter; Muhle-Goll, Claudia; Frishman, Dmitrij; Steiner, Harald und Lichtenthaler, Stefan F.
(2024):
Cleavage efficiency of the intramembrane protease γ-secretase is reduced by the palmitoylation of a substrate's transmembrane domain.
In: Faseb Journal, Bd. 38, Nr. 2, e23442
[PDF, 12MB]
Dawkins, Edgar; Derks, Rico J. E.; Schifferer, Martina; Trambauer, Johannes; Winkler, Edith; Simons, Mikael; Paquet, Dominik; Giera, Martin; Kamp, Frits und Steiner, Harald
(2023):
Membrane lipid remodeling modulates γ-secretase processivity.
In: Journal of Biological Chemistry, Bd. 299, Nr. 4, 103027
[PDF, 2MB]
Werner, Nadine T. T.; Hoegel, Philipp; Guener, Gokhan; Stelzer, Walter; Wozny, Manfred; Assfalg, Marlene; Lichtenthaler, Stefan F.; Steiner, Harald und Langosch, Dieter
(2023):
Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase.
In: Communications Biology, Bd. 6, Nr. 1, 177
[PDF, 3MB]
Guener, Goekhan; Assfalg, Marlene; Zhao, Kai; Dreyer, Tobias; Lahiri, Shibojyoti; Lo, Yun; Slivinschi, Bianca Ionela; Imhof, Axel; Jocher, Georg; Strohm, Laura; Behrends, Christian; Langosch, Dieter; Bronger, Holger; Nimsky, Christopher; Bartsch, Joerg W.; Riddell, Stanley R.; Steiner, Harald und Lichtenthaler, Stefan F.
(2022):
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for gamma-secretase activity.
In: EMBO Molecular Medicine, Bd. 14, Nr. 10, e16084
[PDF, 1MB]
Lichtenthaler, Stefan F.; Tschirner, Sarah K. und Steiner, Harald
(2022):
Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
In: Current Opinion in Neurobiology, Bd. 72: S. 101-110
[PDF, 7MB]
Saretz, Stefan; Basset, Gabriele; Useini, Liridona; Laube, Markus; Pietzsch, Jens; Draca, Dijana; Maksimovic-Ivanic, Danijela; Trambauer, Johannes; Steiner, Harald und Hey-Hawkins, Evamarie
(2021):
Modulation of gamma-Secretase Activity by a Carborane-Based Flurbiprofen Analogue.
In: Molecules, Bd. 26, Nr. 10, 2843
Junker, Julia; Kamp, Frits; Winkler, Edith; Steiner, Harald; Bracher, Franz und Müller, Christoph
(2021):
Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS.
In: Journal of Steroid Biochemistry and Molecular Biology, Bd. 211, 105880
Colombo, Alessio Vittorio; Sadler, Rebecca Katie; Llovera, Gemma; Singh, Vikramjeet; Roth, Stefan; Heindl, Steffanie; Monasor, Laura Sebastian; Verhoeven, Aswin; Peters, Finn; Parhizkar, Samira; Kamp, Frits; de Aguero, Mercedes Gomez; MacPherson, Andrew J.; Winkler, Edith; Herms, Jochen; Benakis, Corinne; Dichgans, Martin 
ORCID: https://orcid.org/0000-0002-0654-387X; Steiner, Harald; Giera, Martin; Haass, Christian; Tahirovic, Sabina und Liesz, Arthur
(2021):
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition.
In: eLife, Bd. 10, e59826
[PDF, 2MB]
ORCID: https://orcid.org/0000-0002-0654-387X; Steiner, Harald; Giera, Martin; Haass, Christian; Tahirovic, Sabina und Liesz, Arthur
(2021):
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition.
In: eLife, Bd. 10, e59826
[PDF, 2MB]
Fukumori, Akio; Feilen, Lukas P. und Steiner, Harald
(2020):
Substrate recruitment by gamma-secretase.
In: Seminars in Cell & Developmental Biology, Bd. 105: S. 54-63
Trambauer, Johannes; Fukumori, Akio und Steiner, Harald
(2020):
Pathogenic A beta generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications.
In: Current Opinion in Neurobiology, Bd. 61: S. 73-81
Steiner, Andrea; Schlepckow, Kai; Brunner, Bettina; Steiner, Harald; Haass, Christian und Hagn, Franz
(2020):
gamma-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.
In: EMBO Journal, Bd. 39, Nr. 20, e104247
[PDF, 2MB]
Trambauer, Johannes; Rodríguez Sarmiento, Rosa María; Fukumori, Akio; Feederle, Regina; Baumann, Karlheinz und Steiner, Harald
(2020):
Aβ43‐producing PS1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation.
In: Embo Reports, Bd. 21, Nr. 1, e47996
[PDF, 1MB]
Kong, Li; Dawkins, Edgar; Campbell, Frederick; Winkler, Edith; Derks, Rico J. E.; Giera, Martin; Kamp, Frits; Steiner, Harald und Kros, Alexander
(2020):
Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function.
In: Biochimica et Biophysica Acta-Biomembranes, Bd. 1862, Nr. 5, 183200
Voeglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M.; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R.; Masters, Colin L.; Goate, Alison; Buckles, Virginia; Fox, Nick; Rossor, Martin; Chrem, Patricio; Allegri, Ricardo; Ringman, John M.; Höglinger, Guenter; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C.; Bateman, Randall J.; Danek, Adrian und Levin, Johannes
(2019):
Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.
In: Brain, Bd. 142: S. 1429-1440
[PDF, 476kB]
Junker, Julia; Chong, Isabelle; Kamp, Frits; Steiner, Harald; Giera, Martin; Müller, Christoph und Bracher, Franz
(2019):
Comparison of Strategies for the Determination of Sterol Sulfates via GC-MS Leading to a Novel Deconjugation-Derivatization Protocol.
In: Molecules, Bd. 24, Nr. 13, 2353
Mentrup, Torben; Theodorou, Kosta; Cabrera-Cabrera, Florencia; Hethig, Andreas O.; Happ, Kathrin; Gijbels, Marion; Gradtke, Ann-Christine; Rabe, Björn; Fukumori, Akio; Steiner, Harald; Tholey, Andreas; Fluhrer, Regina; Donners, Marjo und Schröder, Bernd
(2019):
Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
In: Journal of Experimental Medicine, Bd. 216, Nr. 4: S. 807-830
Götz, Alexander; Mylonas, Nadine; Hoegel, Philipp; Silber, Mara; Heinel, Hannes; Menig, Simon; Vogel, Alexander; Feyrer, Hannes; Huster, Daniel; Luy, Burkhard; Langosch, Dieter; Scharnagl, Christina; Muhle-Goll, Claudia; Kamp, Frits und Steiner, Harald
(2019):
Modulating Hinge Flexibility in the APP Transmembrane Domain Alters gamma-Secretase Cleavage.
In: Biophysical Journal, Bd. 116, Nr. 11: S. 2103-2120
Kamp, Frits; Scheidt, Holger A.; Winkler, Edith; Basset, Gabriele; Heinel, Hannes; Hutchison, James M.; LaPointe, Loren M.; Sanders, Charles R.; Steiner, Harald und Huster, Daniel
(2018):
Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its alpha-Helical Conformation, and Inhibits gamma-Secretase Nonselectively in Liposomes.
In: ACS Chemical Neuroscience, Bd. 9, Nr. 7: S. 1702-1713
Tretter, Jana Ylva; Schorpp, Kenji; Luxenburger, Elke; Trambauer, Johannes; Steiner, Harald; Hadian, Kamyar; Gires, Olivier und Niessing, Dierk
(2018):
A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.
In: Journal of Biological Chemistry, Bd. 293, Nr. 23: S. 8994-9005
Schlepckow, Kai; Kleinberger, Gernot; Fukumori, Akio; Feederle, Regina; Lichtenthaler, Stefan F.; Steiner, Harald und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2017):
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
In: Embo Molecular Medicine, Bd. 9, Nr. 10: S. 1356-1365
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4869-1627
(2017):
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
In: Embo Molecular Medicine, Bd. 9, Nr. 10: S. 1356-1365
[PDF, 1MB]
Langosch, Dieter und Steiner, Harald
(2017):
Substrate processing in intramembrane proteolysis by gamma-secretase-the role of protein dynamics.
In: Biological Chemistry, Bd. 398, Nr. 4: S. 441-453
Hüttl, Susann; Helfrich, Felix; Mentrup, Torben; Held, Sebastian; Fukumori, Akio; Steiner, Harald; Saftig, Paul; Fluhrer, Regina und Schröder, Bernd
(2016):
Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74.
In: Biochemical Journal, Bd. 473: S. 1405-1422
Fleck, Daniel; Voss, Matthias; Brankatschk, Ben; Giudici, Camilla; Hampel, Heike; Schwenk, Benjamin; Edbauer, Dieter; Fukumori, Akio; Steiner, Harald; Kremmer, Elisabeth; Haug-Kröper, Martina; Rossner, Moritz J.; Fluhrer, Regina; Willem, Michael und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2016):
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
In: Journal of Biological Chemistry, Bd. 291, Nr. 1: S. 318-333
ORCID: https://orcid.org/0000-0002-4869-1627
(2016):
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
In: Journal of Biological Chemistry, Bd. 291, Nr. 1: S. 318-333
Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer-Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F.; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
Fukumori, Akio und Steiner, Harald
(2016):
Substrate recruitment of gamma-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.
In: Embo Journal, Bd. 35, Nr. 15: S. 1628-1643
Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer-Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F.; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
[PDF, 1MB]
Brendel, Matthias; Jaworska, Anna; Grieinger, Eric; Rötzer, Christina; Burgold, Steffen; Gildehaus, Franz-Josef; Carlsen, Janette; Cumming, Paul; Baumann, Karlheinz; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Steiner, Harald; Bartenstein, Peter; Herms, Jochen und Rominger, Axel
(2015):
Cross-Sectional Comparison of Small Animal [F-18]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models.
In: PLOS ONE 10(2), e0116678 [PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4869-1627; Steiner, Harald; Bartenstein, Peter; Herms, Jochen und Rominger, Axel
(2015):
Cross-Sectional Comparison of Small Animal [F-18]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models.
In: PLOS ONE 10(2), e0116678 [PDF, 1MB]
Fluhrer, Regina; Kamp, Frits; Grammer, Gudula; Nuscher, Brigitte; Steiner, Harald; Beyer, Klaus und Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627
(2011):
The Nicastrin ectodomain adopts a highly thermostable structure.
In: Biological Chemistry, Bd. 392, Nr. 11: S. 995-1001
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4869-1627
(2011):
The Nicastrin ectodomain adopts a highly thermostable structure.
In: Biological Chemistry, Bd. 392, Nr. 11: S. 995-1001
[PDF, 1MB]
Kaether, Christoph; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627 und Steiner, Harald
(2006):
Assembly, trafficking and function of gamma-secretase.
In: Neurodegenerative Diseases, Nr. 4-5: S. 275-283
[PDF, 402kB]
ORCID: https://orcid.org/0000-0002-4869-1627 und Steiner, Harald
(2006):
Assembly, trafficking and function of gamma-secretase.
In: Neurodegenerative Diseases, Nr. 4-5: S. 275-283
[PDF, 402kB]