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Veröffentlichungsdatum
Anzahl der Publikationen: 24
2024
Reynders, Martin; Garścia, Małgorzata; Müller-Deku, Adrian; Wranik, Maximilian; Krauskopf, Kristina; Osa de la Rosa, Luis de la; Schaffer, Konstantin; Jötten, Anna; Rode, Alexander; Stierle, Valentin; Kraus, Yvonne; Baumgartner, Benedikt; Ali, Ahmed; Bubeneck, Andrei; Seal, Trina; Steinmetz, Michel O.; Paulitschke, Philipp und Thorn-Seshold, Oliver 
ORCID: https://orcid.org/0000-0003-3981-651X
(2024):
A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol.
In: Chemical Science [Forthcoming]
ORCID: https://orcid.org/0000-0003-3981-651X
(2024):
A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol.
In: Chemical Science [Forthcoming]
Mauker, Philipp; Beckmann, Daniela; Kitowski, Annabel; Heise, Constanze; Wientjens, Chantal; Davidson, Andrew J.; Wanderoy, Simone; Fabre, Gabin; Harbauer, Angelika B.; Wood, Will; Wilhelm, Christoph; Thorn-Seshold, Julia; Misgeld, Thomas; Kerschensteiner, Martin und Thorn-Seshold, Oliver
(2024):
Fluorogenic Chemical Probes for Wash-free Imaging of Cell Membrane Damage in Ferroptosis, Necrosis, and Axon Injury.
In: Journal of the American Chemical Society
2022
Felber, Jan G.; Poczka, Lena; Scholzen, Karoline C.; Zeisel, Lukas; Maier, Martin S.; Busker, Sander; Theisen, Ulrike; Brandstädter, Christina; Becker, Katja; Arnér, Elias S. J.; Thorn-Seshold, Julia und Thorn-Seshold, Oliver
(1. April 2022):
Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically.
In: Nature Communications, Bd. 13
[PDF, 2MB]
Scheck, Magdalena K.; Lehmann, Lisa; Zaucha, Magdalena; Schwarzlmüller, Paul; Huber, Kristina; Pritsch, Michael; Barba-Spaeth, Giovanna; Thorn-Seshold, Oliver; Krug, Anne B.; Endres, Stefan; Rothenfusser, Simon und Thorn-Seshold, Julia
(2022):
FluoRNT: A robust, efficient assay for the detection of neutralising antibodies against yellow fever virus 17D.
In: PLOS One 17(2) [PDF, 1MB]
In: PLOS One 17(2) [PDF, 1MB]
Müller-Deku, Adrian und Thorn-Seshold, Oliver
(2022):
Exhaustive Catalytic ortho-Alkoxylation of Azobenzenes: Flexible Access to Functionally Diverse Yellow-Light-Responsive Photoswitches.
In: Journal of Organic Chemistry, Bd. 87, Nr. 24: S. 16526-16531
Zeisel, Lukas; Felber, Jan G.; Scholzen, Karoline C.; Poczka, Lena; Cheff, Dorian; Maier, Martin S.; Cheng, Qing; Shen, Min; Hall, Matthew D.; Arner, Elias S. J.; Thorn-Seshold, Julia und Thorn-Seshold, Oliver
(2022):
Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe.
In: Chem, Bd. 8, Nr. 5: S. 1493-1517
Gao, Li; Kraus, Yvonne; Stegner, Andrea; Wein, Thomas; Heise, Constanze; Brunn, Leonie von; Fajardo-Ruiz, Elena; Thorn-Seshold, Julia und Thorn-Seshold, Oliver
(2022):
Self-reporting styrylthiazolium photopharmaceuticals: mitochondrial localisation as well as SAR drive biological activity.
In: Organic & Biomolecular Chemistry, Bd. 20, Nr. 39: S. 7787-7794
Gao, Li; Meiring, Joyce C. M.; Varady, Adam; Ruider, Iris E.; Heise, Constanze; Wranik, Maximilian; Velasco, Cecilia D.; Taylor, Jennifer A.; Terni, Beatrice; Weinert, Tobias; Standfuss, Jörg; Cabernard, Clemens C.; Llobet, Artur; Steinmetz, Michel O.; Bausch, Andreas R.; Distel, Martin; Thorn-Seshold, Julia; Akhmanova, Anna und Thorn-Seshold, Oliver
(2022):
In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M.
In: Journal of the American Chemical Society, Bd. 144, Nr. 12: S. 5614-5628
Felber, Jan G. und Thorn-Seshold, Oliver
(2022):
40 Years of Duocarmycins: A Graphical Structure/Function Review o Their Chemical Evolution, from SAR to Prodrugs and ADCs.
In: JACS Au, Bd. 2, Nr. 12: S. 2636-2644
Rushworth, James L.; Thawani, Aditya R.; Fajardo-Ruiz, Elena; Meiring, Joyce C. M.; Heise, Constanze; White, Andrew J. P.; Akhmanova, Anna; Brandt, Jochen R.; Thorn-Seshold, Oliver und Fuchter, Matthew J.
(2022):
[5]-Helistatins: Tubulin-Binding Helicenes with Antimitotic Activity.
In: JACS Au, Bd. 2, Nr. 11: S. 2561-2570
Küllmer, Florian; Vepřek, Nynke A.; Borowiak, Malgorzata; Nasufović, Veselin; Barutzki, Sebastian; Thorn-Seshold, Oliver; Arndt, Hans-Dieter und Trauner, Dirk
(2022):
Next Generation Opto-Jasplakinolides Enable Local Remodeling of Actin Networks.
In: Angewandte Chemie International Edition, Bd. 61, Nr. 48, e202210220
Müller, Markus; Niemeyer, Konstantin; Urban, Nicole; Ojha, Navin K.; Zufall, Frank; Leinders-Zufall, Trese; Schäfer, Michael und Thorn-Seshold, Oliver
(2022):
BTDAzo: A Photoswitchable TRPC5 Channel Activator.
In: Angewandte Chemie International Edition, Bd. 61, Nr. 36
[PDF, 11MB]
Ober, Martina F.; Müller-Deku, Adrian; Baptist, Anna; Ajanovic, Benjamin; Amenitsch, Heinz; Thorn-Seshold, Oliver und Nickel, Bert
(2022):
SAXS measurements of azobenzene lipid vesicles reveal buffer-dependent photoswitching and quantitative Z -> E isomerisation by X-rays.
In: Nanophotonics, Bd. 11, Nr. 10: S. 2361-2368
[PDF, 1MB]
2021
Sailer, Alexander; Meiring, Joyce C. M.; Heise, Constanze; Pettersson, Linda N.; Akhmanova, Anna; Thorn-Seshold, Julia und Thorn-Seshold, Oliver
(2021):
Pyrrole Hemithioindigo Antimitotics with Near-Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single-Cell Precision**.
In: Angewandte Chemie-International Edition, Bd. 60, Nr. 44: S. 23695-23704
Gao, Li; Meiring, Joyce C. M.; Kraus, Yvonne; Wranik, Maximilian; Weinert, Tobias; Pritzl, Stefanie D.; Bingham, Rebekkah; Ntouliou, Evangelia; Jansen, Klara I.; Olieric, Natacha; Standfuss, Jörg; Kapitein, Lukas C.; Lohmüller, Theobald; Ahlfeld, Julia; Akhmanova, Anna; Steinmetz, Michel O. und Thorn-Seshold, Oliver
(2021):
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton.
In: Cell Chemical Biology, Bd. 28, Nr. 2: S. 228-241
2020
Sailer, Alexander; Ermer, Franziska; Kraus, Yvonne; Hammar, Rebekkah; Lutter, Ferdinand H.; Ahlfeld, Julia und Thorn-Seshold, Oliver
(2020):
Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo.
In: Beilstein Journal of Organic Chemistry, Bd. 16: S. 125-134
Theisen, Ulrike; Ernst, Alexander U.; Heyne, Ronja L. S.; Ring, Tobias P.; Thorn-Seshold, Oliver und Koster, Reinhard W.
(2020):
Microtubules and motor proteins support zebrafish neuronal migration by directing cargo.
In: Journal of Cell Biology, Bd. 219, Nr. 10, e201908040
Borowiak, Malgorzata; Kuellmer, Florian; Gegenfurtner, Florian; Peil, Sebastian; Nasufovic, Veselin; Zahler, Stefan; Thorn-Seshold, Oliver; Trauner, Dirk und Arndt, Hans-Dieter
(2020):
Optical Manipulation of F-Actin with Photoswitchable Small Molecules.
In: Journal of the American Chemical Society, Bd. 142, Nr. 20: S. 9240-9249
Kraus, Yvonne; Glas, Carina; Melzer, Benedikt; Gao, Li; Heise, Constanze; Preusse, Monique; Ahlfeld, Julia; Bracher, Franz und Thorn-Seshold, Oliver
(2020):
Isoquinoline-based biaryls as a robust scaffold for microtubule inhibitors.
In: European Journal of Medicinal Chemistry, Bd. 186, 111865
Kopf, Aglaja; Renkawitz, Jörg; Hauschild, Robert; Girkontaite, Irute; Tedford, Kerry; Merrin, Jack; Thorn-Seshold, Oliver; Trauner, Dirk; Haecker, Hans; Fischer, Klaus-Dieter; Kiermaier, Eva und Sixt, Michael
(2020):
Microtubules control cellular shape and coherence in amoeboid migrating cells.
In: Journal of Cell Biology, Bd. 219, Nr. 6, e201907154
Müller-Deku, Adrian; Meiring, Joyce C. M.; Loy, Kristina; Kraus, Yvonne; Heise, Constanze; Bingham, Rebekkah; Jansen, Klara I.; Qu, Xiaoyi; Bartolini, Francesca; Kapitein, Lukas C.; Akhmanova, Anna; Ahlfeld, Julia; Trauner, Dirk und Thorn-Seshold, Oliver
(2020):
Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton.
In: Nature communications, Bd. 11, Nr. 1, 4640
[PDF, 7MB]
2019
Sailer, Alexander; Ermer, Franziska; Kraus, Yvonne; Lutter, Ferdinand H.; Donau, Carsten; Bremerich, Maximilian; Ahlfeld, Julia und Thorn-Seshold, Oliver
(2019):
Hemithioindigos for Cellular Photopharmacology: Desymmetrised Molecular Switch Scaffolds Enabling Design Control over the Isomer-Dependency of Potent Antimitotic Bioactivity.
In: Chembiochem, Bd. 20, Nr. 10: S. 1305-1314
2018
Singh, Amrita; Saha, Tanumoy; Begemann, Isabell; Ricker, Andrea; Nuesse, Harald; Thorn-Seshold, Oliver; Klingauf, Jürgen; Galic, Milos und Matis, Maja
(2018):
Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis.
In: Nature Cell Biology, Bd. 20, Nr. 10: S. 1126-1133
2017
Eguchi, Kohgaku; Taoufiq, Zacharie; Thorn-Seshold, Oliver; Trauner, Dirk; Hasegawa, Masato und Takahashi, Tomoyuki
(2017):
Wild-Type Monomeric alpha-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held.
In: Journal of Neuroscience, Bd. 37, Nr. 25: S. 6043-6052