![[höher]](/style/images/multi_up.png)
Eine Ebene höherGruppiert nach: Dokumententyp |
Veröffentlichungsdatum
Anzahl der Publikationen: 9
2025
Trambauer, Johannes; Rodriguez Sarmiento, Rosa Maria; Garringer, Holly J.; Salbaum, Katja; Pedro, Liliana D.; Crusius, Dennis; Vidal, Ruben; Ghetti, Bernardino; Paquet, Dominik 
ORCID: https://orcid.org/0000-0003-2065-1639; Baumann, Karlheinz; Lindemann, Lothar und Steiner, Harald
(2025):
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.
In: Alzheimer's Research & Therapy, Bd. 17, 49
[PDF, 4MB]
ORCID: https://orcid.org/0000-0003-2065-1639; Baumann, Karlheinz; Lindemann, Lothar und Steiner, Harald
(2025):
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.
In: Alzheimer's Research & Therapy, Bd. 17, 49
[PDF, 4MB]
2023
Dawkins, Edgar; Derks, Rico J. E.; Schifferer, Martina; Trambauer, Johannes; Winkler, Edith; Simons, Mikael; Paquet, Dominik; Giera, Martin; Kamp, Frits und Steiner, Harald
(2023):
Membrane lipid remodeling modulates γ-secretase processivity.
In: Journal of Biological Chemistry, Bd. 299, Nr. 4, 103027
[PDF, 2MB]
2021
Saretz, Stefan; Basset, Gabriele; Useini, Liridona; Laube, Markus; Pietzsch, Jens; Draca, Dijana; Maksimovic-Ivanic, Danijela; Trambauer, Johannes; Steiner, Harald und Hey-Hawkins, Evamarie
(2021):
Modulation of gamma-Secretase Activity by a Carborane-Based Flurbiprofen Analogue.
In: Molecules, Bd. 26, Nr. 10, 2843
2020
Trambauer, Johannes; Rodríguez Sarmiento, Rosa María; Fukumori, Akio; Feederle, Regina; Baumann, Karlheinz und Steiner, Harald
(2020):
Aβ43‐producing PS1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation.
In: Embo Reports, Bd. 21, Nr. 1, e47996
[PDF, 1MB]
Trambauer, Johannes; Fukumori, Akio und Steiner, Harald
(2020):
Pathogenic A beta generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications.
In: Current Opinion in Neurobiology, Bd. 61: S. 73-81
2019
Voeglein, Jonathan; Willem, Michael; Trambauer, Johannes; Schönecker, Sonja; Dieterich, Marianne und Biskup, Saskia
(2019):
Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-beta processing effects.
In: Neurobiology of Aging, Bd. 84, 241.e5-241.e11
[PDF, 597kB]
2018
Tretter, Jana Ylva; Schorpp, Kenji; Luxenburger, Elke; Trambauer, Johannes; Steiner, Harald; Hadian, Kamyar; Gires, Olivier und Niessing, Dierk
(2018):
A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.
In: Journal of Biological Chemistry, Bd. 293, Nr. 23: S. 8994-9005
2016
Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer-Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F.; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
[PDF, 1MB]
ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
[PDF, 1MB]
Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer-Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F.; Haass, Christian ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465
ORCID: https://orcid.org/0000-0002-4869-1627; Arzberger, Thomas und Steiner, Harald
(2016):
Generation and deposition of A43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
In: Embo Molecular Medicine, Bd. 8, Nr. 5: S. 458-465