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Zeitschriftenartikel
Tschirner, Sarah K. 
ORCID: https://orcid.org/0009-0007-4972-9811; Schmidt, Andree ORCID: https://orcid.org/0000-0002-8254-0777; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Horiguchi, Naotaka und Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575
(2026):
Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non‐Human Primates.
In: Proteomics, Bd. 26, Nr. 1: S. 100-107
[PDF, 1MB]
ORCID: https://orcid.org/0009-0007-4972-9811; Schmidt, Andree ORCID: https://orcid.org/0000-0002-8254-0777; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Horiguchi, Naotaka und Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575
(2026):
Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non‐Human Primates.
In: Proteomics, Bd. 26, Nr. 1: S. 100-107
[PDF, 1MB]
Tschirner, Sarah K.; Zuchero, Y. Joy Yu ORCID: https://orcid.org/0000-0001-5183-7968; Getz, Jennifer A. ORCID: https://orcid.org/0000-0003-1777-8401; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Nalbach, Karsten ORCID: https://orcid.org/0000-0002-3928-4026; Kennedy, Matthew E.; Lewcock, Joseph W. ORCID: https://orcid.org/0000-0003-3012-7881 und Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575
(2025):
Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.
In: Molecular & Cellular Proteomics, Bd. 24, Nr. 7, 101012
[PDF, 1MB]
ORCID: https://orcid.org/0000-0001-5183-7968; Getz, Jennifer A. ORCID: https://orcid.org/0000-0003-1777-8401; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Nalbach, Karsten ORCID: https://orcid.org/0000-0002-3928-4026; Kennedy, Matthew E.; Lewcock, Joseph W. ORCID: https://orcid.org/0000-0003-3012-7881 und Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575
(2025):
Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.
In: Molecular & Cellular Proteomics, Bd. 24, Nr. 7, 101012
[PDF, 1MB]
Heger, Leonie M.; Kertess, Leonie; Kaufhold, Clara; Gubinelli, Francesco; Cardona‐Alberich, Aida; Özata, Gamze; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Tschirner, Sarah K.; Stehling, Oliver; Schifferer, Martina; Peron, Camille; Tiranti, Valeria; Lill, Roland; Iuso, Arcangela; Zecca, Luigi; Strupp, Michael ORCID: https://orcid.org/0000-0002-9544-2279; Oertel, Wolfgang H. ORCID: https://orcid.org/0000-0002-7582-8166; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575 und Burbulla, Lena F. ORCID: https://orcid.org/0009-0008-5440-1148
(2025):
Patient‐Derived Neurons Exhibit α‐Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein–Associated Neurodegeneration.
In: Movement Disorders [Forthcoming]
ORCID: https://orcid.org/0000-0003-3414-307X; Tschirner, Sarah K.; Stehling, Oliver; Schifferer, Martina; Peron, Camille; Tiranti, Valeria; Lill, Roland; Iuso, Arcangela; Zecca, Luigi; Strupp, Michael ORCID: https://orcid.org/0000-0002-9544-2279; Oertel, Wolfgang H. ORCID: https://orcid.org/0000-0002-7582-8166; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575 und Burbulla, Lena F. ORCID: https://orcid.org/0009-0008-5440-1148
(2025):
Patient‐Derived Neurons Exhibit α‐Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein–Associated Neurodegeneration.
In: Movement Disorders [Forthcoming]
Heininger, Hannah; Feng, Xiao ORCID: https://orcid.org/0009-0004-0968-6405; Altunkaya, Alp; Zheng, Fang ORCID: https://orcid.org/0000-0002-5699-8063; Stockinger, Florian ORCID: https://orcid.org/0009-0002-9101-7491; Wefers, Benedikt; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Giesbertz, Pieter ORCID: https://orcid.org/0000-0001-7461-8602; Tschirner, Sarah K. ORCID: https://orcid.org/0009-0007-4972-9811; Shqau, Dorina ORCID: https://orcid.org/0009-0001-5047-4410; Adelsberger, Helmuth; Ponomarenko, Alexey; Fenzl, Thomas ORCID: https://orcid.org/0000-0002-0132-9591; Alzheimer, Christian; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575 und Huth, Tobias ORCID: https://orcid.org/0000-0002-6414-8923
(2025):
BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions.
In: EMBO Reports [Forthcoming]
ORCID: https://orcid.org/0009-0004-0968-6405; Altunkaya, Alp; Zheng, Fang ORCID: https://orcid.org/0000-0002-5699-8063; Stockinger, Florian ORCID: https://orcid.org/0009-0002-9101-7491; Wefers, Benedikt; Müller, Stephan A. ORCID: https://orcid.org/0000-0003-3414-307X; Giesbertz, Pieter ORCID: https://orcid.org/0000-0001-7461-8602; Tschirner, Sarah K. ORCID: https://orcid.org/0009-0007-4972-9811; Shqau, Dorina ORCID: https://orcid.org/0009-0001-5047-4410; Adelsberger, Helmuth; Ponomarenko, Alexey; Fenzl, Thomas ORCID: https://orcid.org/0000-0002-0132-9591; Alzheimer, Christian; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575 und Huth, Tobias ORCID: https://orcid.org/0000-0002-6414-8923
(2025):
BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions.
In: EMBO Reports [Forthcoming]
Schmidt, Andree; Hrupka, Brian; Bebber, Frauke van; Sunil Kumar, Sanjay; Feng, Xiaoqi; Tschirner, Sarah K.; Aßfalg, Marlene; Müller, Stephan A.; Hilger, Laura Sophie; Hofmann, Laura I.; Pigoni, Martina; Jocher, Georg ORCID: https://orcid.org/0000-0002-7089-3487; Voytyuk, Iryna ORCID: https://orcid.org/0000-0003-3484-3658; Self, Emily L.; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Horiguchi, Naotaka; Feederle, Regina; Strooper, Bart De; Schulte-Merker, Stefan; Lammert, Eckhard; Moechars, Dieder; Schmid, Bettina und Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575
(2024):
The Alzheimer’s disease–linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
In: Journal of Clinical Investigation, Bd. 134, Nr. 16, e170550
[PDF, 8MB]
ORCID: https://orcid.org/0000-0002-7089-3487; Voytyuk, Iryna ORCID: https://orcid.org/0000-0003-3484-3658; Self, Emily L.; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Horiguchi, Naotaka; Feederle, Regina; Strooper, Bart De; Schulte-Merker, Stefan; Lammert, Eckhard; Moechars, Dieder; Schmid, Bettina und Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575
(2024):
The Alzheimer’s disease–linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
In: Journal of Clinical Investigation, Bd. 134, Nr. 16, e170550
[PDF, 8MB]
Song, Feizhi; Kovac, Valerija; Mohammadi, Behnam; Littau, Jessica L.; Scharfenberg, Franka; Matamoros Angles, Andreu; Vanni, Ilaria; Shafiq, Mohsin; Orge, Leonor; Galliciotti, Giovanna; Djakkani, Salma; Linsenmeier, Luise; Černilec, Maja; Hartman, Katrina; Jung, Sebastian; Tatzelt, Jörg; Neumann, Julia E.; Damme, Markus; Tschirner, Sarah K.; Lichtenthaler, Stefan F. ORCID: https://orcid.org/0000-0003-2211-2575; Ricklefs, Franz L.; Sauvigny, Thomas; Schmitz, Matthias; Zerr, Inga; Puig, Berta; Tolosa, Eva; Ferrer, Isidro; Magnus, Tim; Rupnik, Marjan S.; Sepulveda-Falla, Diego; Matschke, Jakob; Šmid, Lojze M.; Bresjanac, Mara; Andreoletti, Olivier; Krasemann, Susanne; Foliaki, Simote T.; Nonno, Romolo; Becker-Pauly, Christoph; Monzo, Cecile; Crozet, Carole; Haigh, Cathryn L.; Glatzel, Markus; Curin Serbec, Vladka und Altmeppen, Hermann C. ORCID: https://orcid.org/0000-0001-9439-6533
(2024):
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.
In: Acta Neuropathologica, Bd. 148, Nr. 1, 2
[PDF, 5MB]
ORCID: https://orcid.org/0000-0003-2211-2575; Ricklefs, Franz L.; Sauvigny, Thomas; Schmitz, Matthias; Zerr, Inga; Puig, Berta; Tolosa, Eva; Ferrer, Isidro; Magnus, Tim; Rupnik, Marjan S.; Sepulveda-Falla, Diego; Matschke, Jakob; Šmid, Lojze M.; Bresjanac, Mara; Andreoletti, Olivier; Krasemann, Susanne; Foliaki, Simote T.; Nonno, Romolo; Becker-Pauly, Christoph; Monzo, Cecile; Crozet, Carole; Haigh, Cathryn L.; Glatzel, Markus; Curin Serbec, Vladka und Altmeppen, Hermann C. ORCID: https://orcid.org/0000-0001-9439-6533
(2024):
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.
In: Acta Neuropathologica, Bd. 148, Nr. 1, 2
[PDF, 5MB]
Lichtenthaler, Stefan F.; Tschirner, Sarah K. und Steiner, Harald
(2022):
Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
In: Current Opinion in Neurobiology, Bd. 72: S. 101-110
[PDF, 7MB]
Jocher, Georg; Grass, Vincent; Tschirner, Sarah K.; Riepler, Lydia; Breimann, Stephan; Kaya, Tugberk; Oelsner, Madlen; Hamad, M. Sabri; Hofmann, Laura I.; Blobel, Carl P.; Schmidt-Weber, Carsten B.; Gökce, Özgün; Jakwerth, Constanze A.; Trimpert, Jakob; Kimpel, Janine; Pichlmair, Andreas und Lichtenthaler, Stefan F.
(2022):
ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion.
In: EMBO Reports, Bd. 23, Nr. 6, e54305
[PDF, 2MB]