Horizon 2020 > ERC Grants > ERC Advanced Grant > ERC Grant 833440: IMMUNOTHROMBOSIS - Cross-talk between platelets and immunity - implications for host homeostasis and defense

2022

Kaiser, Rainer ORCID: 0000-0003-1750-3395; Escaig, Raphael; Kranich, Jan ORCID: 0000-0002-9928-4132; Hoffknecht, Marie-Louise ORCID: 0000-0002-5894-0308; Anjum, Afra ORCID: 0000-0002-1976-4102; Polewka, Vivien; Mader, Magdalena; Hu, Wenbo; Belz, Larissa; Gold, Christoph; Titova, Anna; Lorenz, Michael; Pekayvaz, Kami ORCID: 0000-0003-4040-650X; Kääb, Stefan ORCID: 0000-0001-8824-3581; Gaertner, Florian ORCID: 0000-0001-6120-3723; Stark, Konstantin; Brocker, Thomas ORCID: 0000-0001-7060-5433; Massberg, Steffen ORCID: 0000-0001-7387-3986; Nicolai, Leo ORCID: 0000-0003-0776-5885 (2022): Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI. In: Blood, Vol. 140, No. 2: pp. 121-139 [PDF, 5MB]

Nicolai, Leo; Kaiser, Rainer; Escaig, Raphael; Hoffknecht, Marie-Louise; Anjum, Afra; Leunig, Alexander; Pircher, Joachim; Ehrlich, Andreas; Lorenz, Michael; Ishikawa-Ankerhold, Hellen; Aird, William C.; Massberg, Steffen ORCID: 0000-0001-7387-3986; Gaertner, Florian (2022): Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivo. In: Haematologica, Vol. 107, No. 7 [PDF, 1MB]

Nicolai, Leo ORCID: 0000-0003-0776-5885; Leunig, Alexander ORCID: 0000-0002-9179-9203; Pekayvaz, Kami ORCID: 0000-0003-4040-650X; Esefeld, Max ORCID: 0000-0002-8425-618X; Anjum, Afra ORCID: 0000-0002-1976-4102; Rath, Justina; Riedlinger, Eva; Ehreiser, Vincent ORCID: 0000-0002-8820-8839; Mader, Magdalena; Eivers, Luke ORCID: 0000-0002-6049-0377; Hoffknecht, Marie-Louise ORCID: 0000-0002-5894-0308; Zhang, Zhe; Kugelmann, Daniela ORCID: 0000-0002-2512-4240; Rossaro, Dario ORCID: 0000-0003-1301-8739; Escaig, Raphael; Kaiser, Rainer ORCID: 0000-0003-1750-3395; Polewka, Vivien; Titova, Anna; Petzold, Tobias ORCID: 0000-0001-7805-5632; Spiekermann, Karsten ORCID: 0000-0002-5139-4957; Iannacone, Matteo ORCID: 0000-0002-9370-2671; Thiele, Thomas; Greinacher, Andreas ORCID: 0000-0001-8343-7336; Stark, Konstantin ORCID: 0000-0002-5369-8399; Massberg, Steffen ORCID: 0000-0001-7387-3986 (2022): Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration. In: Blood, Vol. 140, No. 5: pp. 478-490 [PDF, 2MB]

Pekayvaz, Kami ORCID: 0000-0003-4040-650X; Leunig, Alexander ORCID: 0000-0002-9179-9203; Kaiser, Rainer ORCID: 0000-0003-1750-3395; Joppich, Markus ORCID: 0000-0002-6665-8951; Brambs, Sophia; Janjic, Aleksandar ORCID: 0000-0001-7180-5381; Popp, Oliver; Nixdorf, Daniel ORCID: 0000-0003-1612-9952; Fumagalli, Valeria; Schmidt, Nora ORCID: 0000-0002-3232-3491; Polewka, Vivien; Anjum, Afra ORCID: 0000-0002-1976-4102; Knottenberg, Viktoria; Eivers, Luke; Wange, Lucas E. ORCID: 0000-0002-3275-9156; Gold, Christoph; Kirchner, Marieluise ORCID: 0000-0002-7049-534X; Muenchhoff, Maximilian ORCID: 0000-0001-7016-0470; Hellmuth, Johannes C. ORCID: 0000-0001-8409-3037; Scherer, Clemens ORCID: 0000-0003-2816-6793; Rubio-Acero, Raquel; Eser, Tabea; Deák, Flora; Puchinger, Kerstin; Kuhl, Niklas; Linder, Andreas; Saar, Kathrin ORCID: 0000-0002-4483-1557; Tomas, Lukas ORCID: 0000-0001-9371-8721; Schulz, Christian ORCID: 0000-0002-8149-0747; Wieser, Andreas; Enard, Wolfgang ORCID: 0000-0002-4056-0550; Kroidl, Inge; Geldmacher, Christof; Bergwelt-Baildon, Michael von ORCID: 0000-0002-1952-052X; Keppler, Oliver T.; Munschauer, Mathias ORCID: 0000-0001-6143-4548; Iannacone, Matteo ORCID: 0000-0002-9370-2671; Zimmer, Ralf; Mertins, Philipp ORCID: 0000-0002-2245-528X; Hubner, Norbert; Hoelscher, Michael; Massberg, Steffen ORCID: 0000-0001-7387-3986; Stark, Konstantin ORCID: 0000-0002-5369-8399; Nicolai, Leo ORCID: 0000-0003-0776-5885 (2022): Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection. In: Nature Communications, Vol. 13, 1018 [PDF, 7MB]

Petzold, Tobias ORCID: 0000-0001-7805-5632; Zhang, Zhe; Ballesteros, Iván; Saleh, Inas; Polzin, Amin; Thienel, Manuela; Liu, Lulu; Ul Ain, Qurrat; Ehreiser, Vincent; Weber, Christian; Kilani, Badr; Mertsch, Pontus; Götschke, Jeremias; Cremer, Sophie; Fu, Wenwen; Lorenz, Michael; Ishikawa-Ankerhold, Hellen; Raatz, Elisabeth; El-Nemr, Shaza; Görlach, Agnes; Marhuenda, Esther; Stark, Konstantin; Pircher, Joachim; Stegner, David; Gieger, Christian; Schmidt-Supprian, Marc; Gaertner, Florian; Almendros, Isaac; Kelm, Malte; Schulz, Christian; Hidalgo, Andrés; Massberg, Steffen ORCID: 0000-0001-7387-3986 (2022): Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease. In: Immunity, Vol. 55: pp. 1-15 [PDF, 4MB]

2021

Kaiser, Rainer ORCID: 0000-0003-1750-3395; Leunig, Alexander ORCID: 0000-0002-9179-9203; Pekayvaz, Kami ORCID: 0000-0003-4040-650X; Popp, Oliver ORCID: 0000-0001-6240-4666; Joppich, Markus ORCID: 0000-0002-6665-8951; Polewka, Vivien; Escaig, Raphael; Anjum, Afra ORCID: 0000-0002-1976-4102; Hoffknecht, Marie-Louise ORCID: 0000-0002-5894-0308; Gold, Christoph; Brambs, Sophia; Engel, Anouk; Stockhausen, Sven; Knottenberg, Viktoria; Titova, Anna; Haji, Mohamed; Scherer, Clemens ORCID: 0000-0003-2816-6793; Muenchhoff, Maximilian; Hellmuth, Johannes C.; Saar, Kathrin; Schubert, Benjamin ORCID: 0000-0003-3412-1102; Hilgendorff, Anne ORCID: 0000-0002-3725-996X; Schulz, Christian; Kääb, Stefan ORCID: 0000-0001-8824-3581; Zimmer, Ralf ORCID: 0000-0003-1439-2327; Hübner, Norbert; Massberg, Steffen ORCID: 0000-0001-7387-3986; Mertins, Philipp; Nicolai, Leo ORCID: 0000-0003-0776-5885; Stark, Konstantin (2021): Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19. In: JCI Insight, Vol. 6, No. 18, e150862 [PDF, 1MB]

Stark, Konstantin ORCID: 0000-0002-5369-8399; Massberg, Steffen ORCID: 0000-0001-7387-3986 (2021): Interplay between inflammation and thrombosis in cardiovascular pathology. In: Nature Reviews Cardiology, Vol. 18, No. 9: pp. 666-682

2020

Nicolai, Leo; Leunig, Alexander; Brambs, Sophia; Kaiser, Rainer; Weinberger, Tobias; Weigand, Michael; Muenchhoff, Maximilian; Hellmuth, Johannes C.; Ledderose, Stephan; Schulz, Heiko; Scherer, Clemens; Rudelius, Martina; Zoller, Michael; Höchter, Dominik J.; Keppler, Oliver T.; Teupser, Daniel; Zwißler, Bernhard; Bergwelt-Baildon, Michael; Kääb, Stefan; Massberg, Steffen; Pekayvaz, Kami; Stark, Konstantin (28. July 2020): Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy. In: Circulation, Vol. 142, No. 12: pp. 1176-1189 [PDF, 16MB]

Nicolai, Leo; Schiefelbein, Karin; Lipsky, Silvia; Leunig, Alexander; Hoffknecht, Marie; Pekayvaz, Kami; Raude, Ben; Marx, Charlotte; Ehrlich, Andreas; Pircher, Joachim; Zhang, Zhe; Saleh, Inas; Marel, Anna-Kristina; Lof, Achim; Petzold, Tobias; Lorenz, Michael; Stark, Konstantin; Pick, Robert; Rosenberger, Gerhild; Weckbach, Ludwig; Uhl, Bernd; Xia, Sheng; Reichel, Christoph Andreas; Walzog, Barbara; Schulz, Christian; Zheden, Vanessa; Bender, Markus; Li, Rong; Massberg, Steffen ORCID: 0000-0001-7387-3986; Gaertner, Florian (2020): Vascular surveillance by haptotactic blood platelets in inflammation and infection. In: Nature Communications, Vol. 11, No. 1, 5778 [PDF, 7MB]