Abstract
The naturally occurring stilbenoid oxyresveratrol was shown to influence inflammatory and metabolic processes. During cellular immune activation, tryptophan breakdown and neopterin formation via the enzymes indoleamine 2,3-dioxygenase-1 (IDO-1) and GTP-cyclohydrolase, respectively, are induced. Neopterin and the kynurenine to tryptophan ratio are reliable and pertinent biomarkers of Th1-type immune response and are also used in vitro to monitor effects of active plant ingredients on peripheral blood mononuclear cells (PSPRINGER NATUREs). We investigated the effects of oxyresveratrol on the activity of the above-mentioned pathways in mitogen-stimulated human PSPRINGER NATURE and in the myelomonocytic cell line THP-1. Oxyresveratrol exerted suppressive effects on tryptophan breakdown in both stimulated cell models. Of note, in PSPRINGER NATURE, tryptophan breakdown was induced at lower concentrations (5-20 mu M) and suppressed at higher treatment concentrations only. Neopterin formation was decreased dose-dependently in stimulated PSPRINGER NATURE. In unstimulated PSPRINGER NATURE similar, albeit lesser effects were observed. Data indicate that oxyresveratrol exerts distinct and concentration-dependent effects on different immune cell types. IDO-1 is targeted by oxyresveratrol and its activity can be modulated in both directions. Detailed investigations of the interactions would be interesting to fully explore the activity of this phytocompound.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung |
| Themengebiete: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| ISSN: | 0933-4807 |
| Sprache: | Englisch |
| Dokumenten ID: | 101006 |
| Datum der Veröffentlichung auf Open Access LMU: | 05. Jun. 2023, 15:36 |
| Letzte Änderungen: | 17. Okt. 2023, 15:06 |
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