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Anzahl der Publikationen auf dieser Ebene: 759

2024

Corvaglia, Valentina ORCID logoORCID: https://orcid.org/0000-0002-6180-5975; Wu, Jiaojiao; Deepak, Deepak ORCID logoORCID: https://orcid.org/0000-0002-0412-2502; Loos, Manuel und Huc, Ivan ORCID logoORCID: https://orcid.org/0000-0001-7036-9696 (2024): Enhancing the Features of DNA Mimic Foldamers for Structural Investigations. In: Chemistry – A European Journal [PDF, 4MB]

Germer, Janin; Lessl, Anna-Lina; Pöhmerer, Jana; Grau, Melina; Weidinger, Eric; Höhn, Miriam; Yazdi, Mina; Cappelluti, Martino Alfredo; Lombardo, Angelo; Lächelt, Ulrich und Wagner, Ernst ORCID logoORCID: https://orcid.org/0000-0001-8413-0934 (2024): Lipo-Xenopeptide Polyplexes for CRISPR/Cas9 based Gene editing at ultra-low dose. In: Journal of Controlled Release, Bd. 370: S. 239-255 [PDF, 10MB]

Hartl, Natascha; Gabold, Bettina; Uhl, Philipp; Kromer, Adrian; Xiao, Ximian; Fricker, Gert; Mier, Walter; Liu, Runhui und Merkel, Olivia M. ORCID logoORCID: https://orcid.org/0000-0002-4151-3916 (2024): ApoE—functionalization of nanoparticles for targeted brain delivery—a feasible method for polyplexes? In: Drug Delivery and Translational Research, Bd. 14, Nr. 6: S. 1660-1677 [PDF, 1MB]

Jürgens, David Christian; Müller, Joschka T.; Nguyen, An Ny und Merkel, Olivia M. ORCID logoORCID: https://orcid.org/0000-0002-4151-3916 (2024): Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 198, 114242 [PDF, 2MB]

Klimt, Monika; Stadler, Martina; Binder, Ulrike ORCID logoORCID: https://orcid.org/0000-0002-2160-2903 und Krauss, Jürgen ORCID logoORCID: https://orcid.org/0000-0002-2464-2011 (2024): Synthesis of novel benzylamine antimycotics and evaluation of their antimycotic potency. In: Archiv der Pharmazie, Bd. 357, Nr. 5 [PDF, 2MB]

Nitsche, Valentin; Höfner, Georg; Kaiser, Jesko; Gertzen, Christoph G.W.; Seeger, Thomas; Niessen, Karin V.; Steinritz, Dirk; Worek, Franz; Gohlke, Holger; Paintner, Franz F. und Wanner, Klaus T. ORCID logoORCID: https://orcid.org/0000-0003-4399-1425 (2024): MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor. In: Toxicology Letters, Bd. 392: S. 94-106 [PDF, 4MB]

Reynders, Martin; Garścia, Małgorzata; Müller-Deku, Adrian; Wranik, Maximilian; Krauskopf, Kristina; Osa de la Rosa, Luis de la; Schaffer, Konstantin; Jötten, Anna; Rode, Alexander; Stierle, Valentin; Kraus, Yvonne; Baumgartner, Benedikt; Ali, Ahmed; Bubeneck, Andrei; Seal, Trina; Steinmetz, Michel O.; Paulitschke, Philipp und Thorn-Seshold, Oliver ORCID logoORCID: https://orcid.org/0000-0003-3981-651X (2024): A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol. In: Chemical Science [Forthcoming]

Schmitt, Carina ORCID logoORCID: https://orcid.org/0009-0006-5118-3785; Mauker, Philipp ORCID logoORCID: https://orcid.org/0009-0007-8740-7864; Vepřek, Nynke A. ORCID logoORCID: https://orcid.org/0000-0001-7301-265X; Gierse, Carolin ORCID logoORCID: https://orcid.org/0009-0002-7918-7877; Meiring, Joyce C. M. ORCID logoORCID: https://orcid.org/0000-0001-9166-5363; Kuch, Jürgen; Akhmanova, Anna; Dehmelt, Leif ORCID logoORCID: https://orcid.org/0000-0002-6559-6496 und Thorn‐Seshold, Oliver ORCID logoORCID: https://orcid.org/0000-0003-3981-651X (2024): A Photocaged Microtubule‐Stabilising Epothilone Allows Spatiotemporal Control of Cytoskeletal Dynamics. In: Angewandte Chemie International Edition [PDF, 5MB]

Sichler, Sonja; Höfner, Georg ORCID logoORCID: https://orcid.org/0000-0002-7957-4503; Nitsche, Valentin; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Paintner, Franz F. und Wanner, Klaus T. ORCID logoORCID: https://orcid.org/0000-0003-4399-1425 (2024): Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor. In: Toxicology Letters, Bd. 394: S. 23-31 [PDF, 2MB]

Steffens, Ricarda C.; Thalmayr, Sophie ORCID logoORCID: https://orcid.org/0009-0000-6457-3965; Weidinger, Eric; Seidl, Johanna; Folda, Paul; Höhn, Miriam und Wagner, Ernst ORCID logoORCID: https://orcid.org/0000-0001-8413-0934 (2024): Modulating efficacy and cytotoxicity of lipoamino fatty acid nucleic acid carriers using disulfide or hydrophobic spacers. In: Nanoscale, Bd. 16, Nr. 29: S. 13988-14005

Thees, Katharina; Untergehrer, Martin; Jourjine, Ilya A. P. ORCID logoORCID: https://orcid.org/0000-0001-5813-056X und Bracher, Franz ORCID logoORCID: https://orcid.org/0000-0003-0009-8629 (2024): Synthesis of 1,4‐Disubstituted and 1‐Substituted β‐Carbolines via 3‐Substituted 2‐Acylindoles. In: European Journal of Organic Chemistry, Bd. 27, Nr. 19 [PDF, 3MB]

2023

Adams, Friederike ORCID logoORCID: https://orcid.org/0000-0002-4362-0387; Zimmermann, Christoph M.; Baldassi, Domizia; Pehl, Thomas M. ORCID logoORCID: https://orcid.org/0000-0001-5930-8091; Weingarten, Philipp; Kachel, Iris; Kränzlein, Moritz ORCID logoORCID: https://orcid.org/0000-0001-9851-0735; Jürgens, David C.; Braubach, Peter ORCID logoORCID: https://orcid.org/0000-0003-3673-7779; Alexopoulos, Ioannis ORCID logoORCID: https://orcid.org/0000-0002-5601-2831; Wygrecka, Malgorzata ORCID logoORCID: https://orcid.org/0000-0002-3656-2932 und Merkel, Olivia M. ORCID logoORCID: https://orcid.org/0000-0002-4151-3916 (2023): Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis. In: Small [PDF, 3MB]

Corvaglia, Valentina ORCID logoORCID: https://orcid.org/0000-0002-6180-5975; Sanchez, Florian; Menke, Friedericke S.; Douat, Céline ORCID logoORCID: https://orcid.org/0000-0003-2678-1047 und Huc, Ivan ORCID logoORCID: https://orcid.org/0000-0001-7036-9696 (2023): Optimization and Automation of Helical Aromatic Oligoamide Foldamer Solid‐Phase Synthesis. In: Chemistry – A European Journal, Bd. 29, Nr. 36 [PDF, 2MB]

Dengler, Sebastian ORCID logoORCID: https://orcid.org/0000-0002-0770-0267; Howard, Ryan T.; Morozov, Vasily; Tsiamantas, Christos ORCID logoORCID: https://orcid.org/0000-0002-9326-7892; Huang, Wei‐En; Liu, Zhiwei; Dobrzanski, Christopher; Pophristic, Vojislava; Brameyer, Sophie; Douat, Céline ORCID logoORCID: https://orcid.org/0000-0003-2678-1047; Suga, Hiroaki ORCID logoORCID: https://orcid.org/0000-0002-5298-9186 und Huc, Ivan ORCID logoORCID: https://orcid.org/0000-0001-7036-9696 (2023): Display Selection of a Hybrid Foldamer–Peptide Macrocycle. In: Angewandte Chemie International Edition, Bd. 62, Nr. 46 [PDF, 1MB]

Jourjine, Ilya A. P. ORCID logoORCID: https://orcid.org/0000-0001-5813-056X und Bracher, Franz ORCID logoORCID: https://orcid.org/0000-0003-0009-8629 (2023): Collective Total Synthesis of 4‐Azafluorenone Alkaloids. In: European Journal of Organic Chemistry, Bd. 26, Nr. 28 [PDF, 3MB]

Menke, Friedericke S.; Wicher, Barbara ORCID logoORCID: https://orcid.org/0000-0003-2254-2508; Maurizot, Victor ORCID logoORCID: https://orcid.org/0000-0001-6104-796X und Huc, Ivan ORCID logoORCID: https://orcid.org/0000-0001-7036-9696 (2023): Homochiral versus Heterochiral Dimeric Helical Foldamer Bundles: Chlorinated‐Solvent‐Dependent Self‐Sorting. In: Angewandte Chemie International Edition, Bd. 62, Nr. 12 [PDF, 969kB]

Mukhopadhyay, Tufan K. ORCID logoORCID: https://orcid.org/0000-0001-8888-5373; Willems, Sabine ORCID logoORCID: https://orcid.org/0000-0002-9755-3394; Arp, Christopher J. ORCID logoORCID: https://orcid.org/0000-0002-5059-6178; Morstein, Johannes; Haake, Caleb T.; Merk, Daniel ORCID logoORCID: https://orcid.org/0000-0002-5359-8128 und Trauner, Dirk ORCID logoORCID: https://orcid.org/0000-0002-6782-6056 (2023): Development of Light‐Activated LXR Agonists. In: ChemMedChem, Bd. 18, Nr. 11 [PDF, 5MB]

Währa, Mark; Allmendinger, Lars; Höfner, Georg ORCID logoORCID: https://orcid.org/0000-0002-7957-4503 und Wanner, Klaus T. ORCID logoORCID: https://orcid.org/0000-0003-4399-1425 (2023): Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR). In: ChemMedChem, Bd. 18, Nr. 10 [PDF, 1MB]

Zaienne, Daniel; Isigkeit, Laura; Marschner, Julian A.; Duensing‐Kropp, Silke; Höfner, Georg und Merk, Daniel ORCID logoORCID: https://orcid.org/0000-0002-5359-8128 (2023): Structural Modification of the Natural Product Valerenic Acid Tunes RXR Homodimer Agonism. In: ChemMedChem, Bd. 18, Nr. 21 [PDF, 895kB]

2022

Adouvi, Gustave; Isigkeit, Laura; Lopez-Garcia, Ursula; Chaikuad, Apirat; Marschner, Julian A.; Schubert-Zsilavecz, Manfred und Merk, Daniel (2022): Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXR alpha, RXR beta, and RXR gamma. In: Journal of Medicinal Chemistry, Bd. 66, Nr. 1: S. 333-344

Arifi, Silvia; Zaienne, Daniel; Heering, Jan; Wein, Thomas; Zhubi, Rezart; Chaikuad, Apirat; Knapp, Stefan; Marschner, Julian A. und Merk, Daniel (2022): Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands. In: Bioorganic Chemistry, Bd. 129, 106164

Arroyo-Araujo, Maria; Voelkl, Bernhard; Laloux, Clement; Novak, Janja; Koopmans, Bastijn; Waldron, Ann-Marie; Seiffert, Isabel; Stirling, Helen; Aulehner, Katharina; Janhunen, Sanna K.; Ramboz, Sylvie; Potschka, Heidrun; Holappa, Johanna; Fine, Tania; Loos, Maarten; Boulanger, Bruno; Wurbel, Hanno und Kas, Martien J. (2022): Systematic assessment of the replicability and generalizability of preclinical findings: Impact of protocol harmonization across laboratory sites.
In: PLOS Biology 20(11), e3001886

Baldassi, Domizia; Ambike, Shubhankar; Feuerherd, Martin; Cheng, Cho-Chin; Peeler, David J.; Feldmann, Daniel P.; Porras-Gonzalez, Diana Leidy; Wei, Xin; Keller, Lea-Adriana; Kneidinger, Nikolaus; Stoleriu, Mircea Gabriel; Popp, Andreas; Burgstaller, Gerald; Pun, Suzie H.; Michler, Thomas und Merkel, Olivia M. (2022): Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes. In: Journal of Controlled Release, Bd. 345: S. 661-674

Baldassi, Domizia; Ngo, Thi My Hanh und Merkel, Olivia M. (2022): Optimization of Lung Surfactant Coating of siRNA Polyplexes for Pulmonary Delivery. In: Pharmaceutical Research [PDF, 6MB]

Becirovic, Elvir ORCID logoORCID: https://orcid.org/0000-0001-8801-0649 (2022): Maybe you can turn me on: CRISPRa-based strategies for therapeutic applications. In: Cellular and Molecular Life Sciences, Bd. 79, Nr. 2, 130: S. 1-9 [PDF, 2MB]

Berger, Simone ORCID logoORCID: https://orcid.org/0000-0002-3572-7205; Berger, Martin ORCID logoORCID: https://orcid.org/0000-0002-0926-653X; Bantz, Christoph; Maskos, Michael und Wagner, Ernst ORCID logoORCID: https://orcid.org/0000-0001-8413-0934 (2022): Performance of nanoparticles for biomedical applications: The in vitro/in vivo discrepancy. In: Biophysics Reviews, Bd. 3, Nr. 1, 011303

Bindl, Daniel ORCID logoORCID: https://orcid.org/0000-0002-2878-7592; Mandal, Pradeep K. ORCID logoORCID: https://orcid.org/0000-0001-5996-956X; Allmendinger, Lars und Huc, Ivan ORCID logoORCID: https://orcid.org/0000-0001-7036-9696 (2022): Discrete Stacked Dimers of Aromatic Oligoamide Helices. In: Angewandte Chemie International Edition, Bd. 61, Nr. 11 [PDF, 2MB]

Bindl, Daniel; Mandal, Pradeep K. und Huc, Ivan (2022): Generalizing the Aromatic delta-Amino Acid Foldamer Helix. In: Chemistry - A European Journal, Bd. 28, Nr. 31 [PDF, 1MB]

Bluemel, Oliver; Anuschek, Moritz; Buecheler, Jakob W.; Hoelzl, Georg; Bechtold-Peters, Karoline und Friess, Wolfgang (2022): The effect of mAb and excipient cryoconcentration on long-term frozen storage stability - Part 1: Higher molecular weight species and subvisible particle formation. In: International Journal of Pharmaceutics: X, Bd. 4, 100108

Bluemel, Oliver; Buecheler, Jakob W.; Hauptmann, Astrid; Hoelzl, Georg; Bechtold-Peters, Karoline und Friess, Wolfgang (2022): The effect of mAb and excipient cryoconcentration on long-term frozen storage stability - part 2: Aggregate formation and oxidation. In: International Journal of Pharmaceutics: X, Bd. 4, 100109

Bluemel, Oliver; Pavlistic, Andraz; Likozar, Blaz; Rodrigues, Miguel A.; Geraldes, Vitor; Bechtold-Peters, Karoline und Friess, Wolfgang (2022): Computational fluid dynamic simulations of temperature, cryoconcentration, and stress time during large-scale freezing and thawing of monoclonal antibody solutions. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 177: S. 107-112

Bluemel, Oliver; Rodrigues, A. Miguel; Buecheler, W. Jakob; Geraldes, Vitor; Hoelzl, Georg; Hauptmann, Astrid; Bechtold-Peters, Karoline und Friess, Wolfgang (2022): Evaluation of Two Novel Scale-Down Devices for Testing Monoclonal Antibody Aggregation During Large-Scale Freezing. In: Journal of Pharmaceutical Sciences, Bd. 111, Nr. 7: S. 1973-1983

Bohn, Torsten; de Lera, Angel R.; Landrier, Jean-Francois; Carlsen, Harald; Merk, Daniel; Todt, Tilman; Renaut, Jenny und Ruehl, Ralph (2022): State-of-the-art methodological investigation of carotenoid activity and metabolism - from organic synthesis via metabolism to biological activity - exemplified by a novel retinoid signalling pathway. In: Food & Function, Bd. 14, Nr. 2: S. 621-638

Capeloa, Leon; Yazdi, Mina; Zhang, Heyang; Chen, Xiaobing; Nie, Yu; Wagner, Ernst; Lachelt, Ulrich und Barz, Matthias (2022): Cross-Linkable Polyion Complex Micelles from Polypept(o)ide-Based ABC-Triblock Copolymers for siRNA Delivery. In: Macromolecular Rapid Communications, Bd. 43, Nr. 12, 2100698

Carfagna, Marco; Rosa, Monica; Hawe, Andrea und Friess, Wolfgang (2022): Design of freeze-drying cycles: The determination of heat transfer coefficient by using heat flux sensor and MicroFD. In: International Journal of Pharmaceutics, Bd. 621, 121763

Chen, Cheng-Chang; Krogsaeter, Einar; Kuo, Ching-Ying; Huang, Min-Chuan; Chang, Sui-Yuan und Biel, Martin (2022): Endolysosomal cation channels point the way towards precision medicine of cancer and infectious diseases. In: Biomedicine & Pharmacotherapy, Bd. 148, 112751

Conte, Gemma; Costabile, Gabriella; Baldassi, Domizia; Rondelli, Valeria; Bassi, Rosaria; Colombo, Diego; Linardos, Giulia; Fiscarelli, Ersilia V.; Sorrentino, Raffaella; Miro, Agnese; Quaglia, Fabiana; Brocca, Paola; D'Angelo, Ivana; Merkel, Olivia M. und Ungaro, Francesca (2022): Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference? In: ACS Applied Materials & Interfaces, Bd. 14, Nr. 6: S. 7565-7578

Deiringer, Natalie; Aleshkevich, Sofya; Mueller, Christoph und Friess, Wolfgang (2022): Modification of Tubings for Peristaltic Pumping of Biopharmaceutics. In: Journal of Pharmaceutical Sciences, Bd. 111, Nr. 12: S. 3251-3260

Deiringer, Natalie und Friess, Wolfgang (2022): Proteins on the Rack: Mechanistic Studies on Protein Particle Formation During Peristaltic Pumping. In: Journal of Pharmaceutical Sciences, Bd. 111, Nr. 5: S. 1370-1378

Deiringer, Natalie und Friess, Wolfgang (2022): Reaching the breaking point: Effect of tubing characteristics on protein particle formation during peristaltic pumping. In: International Journal of Pharmaceutics, Bd. 627, 122216

Deiringer, Natalie; Ruediger, Daniel; Luxbacher, Thomas; Zahler, Stefan und Friess, Wolfgang (2022): Catching Speedy Gonzales: Driving forces for Protein Film Formation on Silicone Rubber Tubing During Pumping. In: Journal of Pharmaceutical Sciences, Bd. 111, Nr. 6: S. 1577-1586

Dengler, Sebastian; Douat, Celine und Huc, Ivan (2022): Differential Peptide Multi-Macrocyclizations at the Surface of a Helical Foldamer Template. In: Angewandte Chemie International Edition, Bd. 61, Nr. 44 [PDF, 5MB]

Dizaji, Negar Mirzazadeh; Lin, Yi; Bein, Thomas; Wagner, Ernst; Wuttke, Stefan; Laechelt, Ulrich und Engelke, Hanna (2022): Biomimetic Mineralization of Iron-Fumarate Nanoparticles for Protective Encapsulation and Intracellular Delivery of Proteins. In: Chemistry of Materials, Bd. 34, Nr. 19: S. 8684-8693

Ehrler, Johanna H. M.; Brunst, Steffen; Tjaden, Amelie; Kilu, Whitney; Heering, Jan; Hernandez-Olmos, Victor; Krommes, Andre; Kramer, Jan S.; Steinhilber, Dieter; Schubert-Zsilavecz, Manfred; Müller, Susanne; Merk, Daniel und Proschak, Ewgenij (2022): Compilation and evaluation of a fatty acid mimetics screening library. In: Biochemical Pharmacology, Bd. 204, 115191

Esfandyari, Dena; Idrissou, Bio Maria Gheo; Hennis, Konstantin; Avramopoulos, Petros; Dueck, Anne; El-Battrawy, Ibrahim; Grueter, Laurenz; Meier, Melanie Annemarie; Naeger, Anna Christina; Ramanujam, Deepak; Dorn, Tatjana; Meitinger, Thomas; Hagl, Christian; Milting, Hendrik; Borggrefe, Martin; Fenske, Stefanie; Biel, Martin; Dendorfer, Andreas; Sassi, Yassine; Moretti, Alessandra und Engelhardt, Stefan (2022): MicroRNA-365 regulates human cardiac action potential duration. In: Nature Communications, Bd. 13, Nr. 1, 220

Faudone, Giuseppe; Zhubi, Rezart; Celik, Fatih; Knapp, Stefan; Chaikuad, Apirat; Heering, Jan und Merk, Daniel (2022): Design of a Potent TLX Agonist by Rational Fragment Fusion. In: Journal of Medicinal Chemistry, Bd. 65, Nr. 3: S. 2288-2296

Felber, Jan G.; Poczka, Lena; Scholzen, Karoline C.; Zeisel, Lukas; Maier, Martin S.; Busker, Sander; Theisen, Ulrike; Brandstädter, Christina; Becker, Katja; Arnér, Elias S. J.; Thorn-Seshold, Julia und Thorn-Seshold, Oliver (1. April 2022): Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically. In: Nature Communications, Bd. 13 [PDF, 2MB]

Felber, Jan G. und Thorn-Seshold, Oliver (2022): 40 Years of Duocarmycins: A Graphical Structure/Function Review o Their Chemical Evolution, from SAR to Prodrugs and ADCs. In: JACS Au, Bd. 2, Nr. 12: S. 2636-2644

Fernandez, Belen; Olmedo, Pablo; Gil, Fernando; Fdez, Elena; Naaldijk, Yahaira; Rivero-Rios, Pilar; Bracher, Franz; Grimm, Christian; Churchill, Grant C. und Hilfiker, Sabine (2022): Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB. In: Cell Death & Disease, Bd. 13, Nr. 12, 1047

Freitag, Marvin; Jaklin, Sigrun; Padovani, Francesco; Radzichevici, Ecaterina; Zernia, Sarah; Schmoller, Kurt M. und Stigler, Johannes (2022): Single-molecule experiments reveal the elbow as an essential folding guide in SMC coiled-coil arms. In: Biophysical Journal, Bd. 121, Nr. 23: S. 4702-4713

Gabold, Bettina; Adams, Friederike; Brameyer, Sophie; Jung, Kirsten; Ried, Christian L.; Merdan, Thomas und Merkel, Olivia M. (2022): Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. In: Drug Delivery and Translational Research, Bd. 13, Nr. 3: S. 822-838 [PDF, 2MB]

Gao, Li; Kraus, Yvonne; Stegner, Andrea; Wein, Thomas; Heise, Constanze; Brunn, Leonie von; Fajardo-Ruiz, Elena; Thorn-Seshold, Julia und Thorn-Seshold, Oliver (2022): Self-reporting styrylthiazolium photopharmaceuticals: mitochondrial localisation as well as SAR drive biological activity. In: Organic & Biomolecular Chemistry, Bd. 20, Nr. 39: S. 7787-7794

Gao, Li ORCID logoORCID: https://orcid.org/0000-0003-3963-4847; Meiring, Joyce C. M. ORCID logoORCID: https://orcid.org/0000-0001-9166-5363; Heise, Constanze; Rai, Ankit; Müller‐Deku, Adrian ORCID logoORCID: https://orcid.org/0000-0001-6050-2545; Akhmanova, Anna ORCID logoORCID: https://orcid.org/0000-0002-9048-8614; Thorn‐Seshold, Julia ORCID logoORCID: https://orcid.org/0000-0002-4879-4159 und Thorn‐Seshold, Oliver ORCID logoORCID: https://orcid.org/0000-0003-3981-651X (2022): Photoswitchable Epothilone‐Based Microtubule Stabilisers Allow GFP‐Imaging‐Compatible, Optical Control over the Microtubule Cytoskeleton**. In: Angewandte Chemie International Edition, Bd. 61, Nr. 10 [PDF, 7MB]

Gao, Li; Meiring, Joyce C. M.; Varady, Adam; Ruider, Iris E.; Heise, Constanze; Wranik, Maximilian; Velasco, Cecilia D.; Taylor, Jennifer A.; Terni, Beatrice; Weinert, Tobias; Standfuss, Jörg; Cabernard, Clemens C.; Llobet, Artur; Steinmetz, Michel O.; Bausch, Andreas R.; Distel, Martin; Thorn-Seshold, Julia; Akhmanova, Anna und Thorn-Seshold, Oliver (2022): In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M. In: Journal of the American Chemical Society, Bd. 144, Nr. 12: S. 5614-5628

Glas, Carina; Naydenova, Eli; Lechner, Severin; Woessner, Nathalie; Yang, Liu; Dietschreit, Johannes C. B.; Sun, Hongyan; Jung, Manfred; Kuster, Bernhard; Ochsenfeld, Christian und Bracher, Franz (2022): Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition. In: European Journal of Medicinal Chemistry, Bd. 240, 114594

Gole, Bappaditya; Kauffmann, Brice; Tron, Arnaud; Maurizot, Victor; McClenaghan, Nathan; Huc, Ivan und Ferrand, Yann (2022): Selective and Cooperative Photocycloadditions within Multistranded Aromatic Sheets. In: Journal of the American Chemical Society, Bd. 144, Nr. 15: S. 6894-6906

Gut, Fabian; Kaeshammer, Lisa; Lammens, Katja; Bartho, Joseph D.; Boggusch, Anna-Maria; Logt, Erik van de; Kessler, Brigitte und Hopfner, Karl-Peter (2022): Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50. In: Molecular Cell, Bd. 82, Nr. 18: S. 3513-3522

Heering, Jan; Jores, Nathalie; Kilu, Whitney; Schallmayer, Espen; Peelen, Evelyn; Muehler, Andreas; Kohlhof, Hella; Vitt, Daniel; Linhard, Verena; Gande, Santosh L.; Chaikuad, Apirat; Sreeramulu, Sridhar; Schwalbe, Harald und Merk, Daniel (2022): Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators. In: ACS Chemical Biology, Bd. 17, Nr. 11: S. 3159-3168

Helmstaedter, Moritz; Schierle, Simone; Isigkeit, Laura; Proschak, Ewgenij; Marschner, Julian Aurelio und Merk, Daniel (2022): Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor Agonists. In: International Journal of Molecular Sciences, Bd. 23, Nr. 17, 10070

Hennis, Konstantin; Biel, Martin; Fenske, Stefanie und Wahl-Schott, Christian (2022): Paradigm shift: new concepts for HCN4 function in cardiac pacemaking. In: Pflugers Archiv-European Journal of Physiology, Bd. 474, Nr. 7: S. 649-663 [PDF, 4MB]

Hennis, Konstantin; Roetzer, Rene D.; Rilling, Julia; Wu, Yakun; Thalhammer, Stefan B.; Biel, Martin; Wahl-Schott, Christian und Fenske, Stefanie (2022): In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability. In: Nature Protocols, Bd. 17, Nr. 5: S. 1189-1222

Isigkeit, Laura; Chaikuad, Apirat und Merk, Daniel (2022): A Consensus Compound/Bioactivity Dataset for Data-Driven Drug Design and Chemogenomics. In: Molecules, Bd. 27, Nr. 8, 2513

Ismail, Sherif; Flemming, Dirk; Thoms, Matthias; Gomes-Filho, Jose Vicente; Randau, Lennart; Beckmann, Roland und Hurt, Ed (2022): Emergence of the primordial pre-60S from the 90S pre-ribosome. In: Cell Reports, Bd. 39, Nr. 1, 110640

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2021

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Domnowski, Martin; Lo Presti, Ken; Binder, Jonas; Reindl, Josef; Lehmann, Lucille; Kummer, Felix; Wolber, Meike; Satzger, Marion; Dehling, Marco; Jaehrling, Jan und Frieß, Wolfgang (2021): Generation of mAb Variants with Less Attractive Self-Interaction but Preserved Target Binding by Well-Directed Mutation. In: Molecular Pharmaceutics, Bd. 18, Nr. 1: S. 236-245

Domnowski, Martin; Maruno, Takahiro; Enomoto, Kanta; Kummer, Felix; Kulakova, Alina; Harris, Pernille; Uchiyama, Susumu; Jaehrling, Jan und Friess, Wolfgang (2021): A Multi-Method Approach to Assess the Self-Interaction Behavior of Infliximab. In: Journal of Pharmaceutical Sciences, Bd. 110, Nr. 5: S. 1979-1988

Donthamsetti, Prashant; Konrad, David B.; Hetzler, Belinda; Fu, Zhu; Trauner, Dirk und Isacoff, Ehud Y. (2021): Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor. In: Journal of the American Chemical Society, Bd. 143, Nr. 24: S. 8951-8956

Ehlers, Sarah; Frieß, Wolfgang und Schroeder, Rudolf (2021): Impact of chamber wall temperature on energy transfer during freeze-drying. In: International Journal of Pharmaceutics, Bd. 592, 120025

Ehlers, Sarah; Schroeder, Rudolf und Frieß, Wolfgang (2021): Trouble With the Neighbor During Freeze-Drying: Rivalry About Energy. In: Journal of Pharmaceutical Sciences, Bd. 110, Nr. 3: S. 1219-1226

Ehlers, Sarah; Schröder, Rudolf und Frieß, Wolfgang (2021): Process optimization and transfer of freeze-drying in nested vial systems. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 159: S. 143-150

Faudone, Giuseppe; Kilu, Whitney; Ni, Xiaomin; Chaikuad, Apirat; Sreeramulu, Sridhar; Heitel, Pascal; Schwalbe, Harald; Knapp, Stefan; Schubert-Zsilavecz, Manfred; Heering, Jan und Merk, Daniel (2021): The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines. In: ACS Pharmacology & Translational Science, Bd. 4, Nr. 6: S. 1794-1807

Freitag, Franziska und Wagner, Ernst (2021): Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach. In: Advanced Drug Delivery Reviews, Bd. 168: S. 30-54

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Ghanawi, Hanaa; Hennlein, Luisa; Zare, Abdolhossein; Bader, Jakob; Salehi, Saeede; Hornburg, Daniel; Ji, Changhe; Sivadasan, Rajeeve; Drepper, Carsten; Meissner, Felix; Mann, Matthias; Jablonka, Sibylle; Briese, Michael und Sendtner, Michael (2021): Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin. In: Nucleic Acids Research, Bd. 49, Nr. 21: S. 12284-12305

Glas, Carina; Wirawan, Ricky und Bracher, Franz (2021): A Short Approach to N-Aryl-1,2,3,4-tetrahydroisoquinolines from N-(2-Bromobenzyl)anilines via a Reductive Amination/Palladium-Catalyzed Ethoxyvinylation/Reductive N-Alkylation Sequence. In: Synthesis-Stuttgart, Bd. 53, Nr. 11: S. 1943-1954

Groel, Sebastian; Menzen, Tim und Winter, Gerhard (2021): Calorimetric Investigation of the Relaxation Phenomena in Amorphous Lyophilized Solids. In: Pharmaceutics, Bd. 13, Nr. 10, 1735

Gryzlo, Beata; Zareba, Paula; Malawska, Katarzyna; Mazur, Gabriela; Rapacz, Anna; Latka, Kamil; Höfner, Georg C.; Latacz, Gniewomir; Bajda, Marek; Salat, Kinga; Wanner, Klaus T.; Malawska, Barbara und Kulig, Katarzyna (2021): Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity. In: ACS Chemical Neuroscience, Bd. 12, Nr. 16: S. 3073-3100

Hennis, Konstantin; Roetzer, Rene D.; Piantoni, Chiara; Biel, Martin; Wahl-Schott, Christian und Fenske, Stefanie (27. Mai 2021): Speeding Up the Heart? Traditional and New Perspectives on HCN4 Function. In: Frontiers in Physiology, Bd. 12, 669029 [PDF, 4MB]

Hennis, Konstantin; Biel, Martin; Wahl-Schott, Christian und Fenske, Stefanie (2021): Beyond pacemaking: HCN channels in sinoatrial node function. In: Progress in Biophysics & Molecular Biology, Bd. 166: S. 51-60

Härdter, Nicole; Menzen, Tim und Winter, Gerhard (2021): Minimizing Oxidation of Freeze-Dried Monoclonal Antibodies in Polymeric Vials Using a Smart Packaging Approach. In: Pharmaceutics, Bd. 13, Nr. 10, 1695

Joos, Markus; Schneider, Christian; Münchinger, Andreas; Moudrakovski, Igor; Usiskin, Robert; Maier, Joachim und Lotsch, Bettina V. (2021): Impact of hydration on ion transport in Li2Sn2S5 center dot xH(2)O. In: Journal of Materials Chemistry A, Bd. 9, Nr. 30: S. 16532-16544

Jourjine, Ilya A. P.; Zeisel, Lukas; Krauß, Jürgen und Bracher, Franz (2021): Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone. In: Beilstein Journal of Organic Chemistry, Bd. 17: S. 2668-2679

Junker, Julia; Kamp, Frits; Winkler, Edith; Steiner, Harald; Bracher, Franz und Müller, Christoph (2021): Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS. In: Journal of Steroid Biochemistry and Molecular Biology, Bd. 211, 105880

Karg, Cornelia A.; Doppler, Christian; Schilling, Charlotte; Jakobs, Franziska; Dal Colle, Marlene C. S.; Frey, Nadine; Bernhard, David; Vollmar, Angelika M. und Moser, Simone (2021): A yellow chlorophyll catabolite in leaves of Urtica dioica L.: An overlooked phytochemical that contributes to health benefits of stinging nettle. In: Food Chemistry, Bd. 359, 129906

Karg, Cornelia A.; Neubig, Christina M.; Roosen, Jutta und Moser, Simone (2021): Rising levels of antioxidative phyllobilins in stored agricultural produce and their impact on consumer acceptance. In: Npj Science of Food, Bd. 5, Nr. 1, 19

Karg, Cornelia A.; Wang, Shuaijun; Al Danaf, Nader; Pemberton, Ryan P.; Bernard, Denzil; Kretschmer, Maibritt; Schneider, Sabine; Zisis, Themistoklis; Vollmar, Angelika M.; Lamb, Don C.; Zahler, Stefan und Moser, Simone (2021): Tetrapyrrolic Pigments from Heme- and Chlorophyll Breakdown are Actin-Targeting Compounds. In: Angewandte Chemie-International Edition, Bd. 60, Nr. 41: S. 22578-22584

Keil, Tobias W. M. und Merkel, Olivia M. (2021): Characterization of positively charged polyplexes by tunable resistive pulse sensing. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 158: S. 359-364

Keil, Tobias W. M.; Zimmermann, Christoph; Baldassi, Domizia; Adams, Friederike; Frieß, Wolfgang; Mehta, Aditi und Merkel, Olivia M. (2021): Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano-in-Microparticles. In: Advanced Therapeutics, Bd. 4, Nr. 6, 2100073

Keller, Lea-Adriana; Merkel, Olivia und Popp, Andreas (2021): Intranasal drug delivery: opportunities and toxicologic challenges during drug development. In: Drug Delivery and Translational Research, Bd. 12, Nr. 4: S. 735-757

Keller, Marco; Sauvageot-Witzku, Karl; Geisslinger, Franz; Urban, Nicole; Schaefer, Michael; Bartel, Karin und Bracher, Franz (2021): The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet-Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids. In: Beilstein Journal of Organic Chemistry, Bd. 17: S. 2716-2725

Koch, Mirja; Scheel, Constanze; Ma, Hongwei; Yang, Fan; Stadlmeier, Michael; Glück, Andrea F.; Murenu, Elisa; Traube, Franziska R.; Carell, Thomas; Biel, Martin; Ding, Xi-Qin und Michalakis, Stylianos (2021): The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia. In: International Journal of Molecular Sciences, Bd. 22, Nr. 1, 52

Krauß, Jürgen; Müller, Christoph; Klimt, Monika; Valero, Leandro Jorquera; Martinez, Jose Francisco; Müller, Martin; Bartel, Karin; Binder, Ulrike und Bracher, Franz (2021): Synthesis, Biological Evaluation, and Structure-Activity Relationships of 4-Aminopiperidines as Novel Antifungal Agents Targeting Ergosterol Biosynthesis. In: Molecules, Bd. 26, Nr. 23, 7208

Krishnathas, G. Melissa; Strödke, Benjamin; Mittmann, Laura; Zech, Thomas; Berger, Lena M.; Reichel, Christoph A.; Rösser, Silvia; Schmid, Tobias; Knapp, Stefan; Müller, Susanne; Bracher, Franz; Fürst, Robert und Bischoff-Kont, Iris (2021): C81-evoked inhibition of the TNFR1-NF kappa B pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes. In: Faseb Journal, Bd. 35, Nr. 6, e21656

Kölbel, J.; Anuschek, M. L.; Seifert, I.; Frieß, Wolfgang und Zeitler, J. A. (2021): Stability of Protein-Sugar Lyophilizates Investigated with Terahertz Spectroscopy. 45th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), Buffalo, NY, USA, 8-13 Nov. 2020. In: 2020 45th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), IEEE.

Lang, Alisa; Isigkeit, Laura; Schubert-Zsilavecz, Manfred und Merk, Daniel (2021): The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators. In: Journal of Medicinal Chemistry, Bd. 64, Nr. 23: S. 16956-16973

Leser, Charlotte; Keller, Marco; Gerndt, Susanne; Urban, Nicole; Chen, Cheng-Chang; Schaefer, Michael; Grimm, Christian und Bracher, Franz (2021): Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. In: European Journal of Medicinal Chemistry, Bd. 210, 112966

Li, Yanfen; Schoen, Christian; Chen, Cheng-Chang; Yang, Zhuo; Liegl, Raffael; Murenu, Elisa; Schworm, Benedikt; Klugbauer, Norbert; Grimm, Christian; Wahl-Schott, Christian; Michalakis, Stylianos und Biel, Martin (2021): TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration. In: Life Science Alliance, Bd. 4, Nr. 8, e202101047

Lo Presti, Ken und Frieß, Wolfgang (2021): Adjustment of specific residual moisture levels in completely freeze-dried protein formulations by controlled spiking of small water volumes. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 169: S. 292-296

Loy, Dominik M.; Krzyszton, Rafal; Lächelt, Ulrich; Rädler, Joachim O. und Wagner, Ernst (2021): Controlling Nanoparticle Formulation: A Low-Budget Prototype for the Automation of a Microfluidic Platform. In: Processes, Bd. 9, Nr. 1, 129

Löbbert, Arnelle; Schanzer, Sonja; Krehenwinkel, Henrik; Bracher, Franz und Müller, Christoph (2021): Determination of multi pesticide residues in leaf and needle samples using a modified QuEChERS approach and gas chromatography-tandem mass spectrometry. In: Analytical Methods, Bd. 13, Nr. 9: S. 1138-1146

Mahapatra, Sujata; Polimeni, Marco; Gentiluomo, Lorenzo; Roessner, Dierk; Friess, Wolfgang; Peters, Guenther H. J.; Streicher, Werner W.; Lund, Mikael und Harris, Pernille (2021): Self-Interactions of Two Monoclonal Antibodies: Small-Angle X-ray Scattering, Light Scattering, and Coarse-Grained Modeling. In: Molecular Pharmaceutics, Bd. 19, Nr. 2: S. 508-519

Marschall, Christoph; Graf, Gesche; Witt, Madlen; Hauptmeier, Bernhard und Friess, Wolfgang (2021): Preparation of high concentration protein powder suspensions by milling of lyophilizates. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 166: S. 75-86

Mateus, Pedro; Jacquet, Antoine; Mendez-Ardoy, Alejandro; Boulloy, Alice; Kauffmann, Brice; Pecastaings, Gilles; Buffeteau, Thierry; Ferrand, Yann; Bassani, Dario M. und Huc, Ivan (2021): Sensing a binding event through charge transport variations using an aromatic oligoamide capsule. In: Chemical Science, Bd. 12, Nr. 10: S. 3743-3750

Mbianda, Johanne; Bakail, May; Andre, Christophe; Moal, Gwenaelle; Perrin, Marie E.; Pinna, Guillaume; Guerois, Raphael; Becher, Francois; Legrand, Pierre; Traore, Seydou; Douat, Celine; Guichard, Gilles und Ochsenbein, Francoise (2021): Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity. In: Science Advances, Bd. 7, Nr. 12, eabd9153

Mehta, Aditi; Michler, Thomas und Merkel, Olivia M. (2021): siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies? In: Advanced Healthcare Materials, Bd. 10, Nr. 7, 2001650

Messner, Martina; Mandl, Melanie M.; Hackl, Mathias W.; Reinhardt, Till; Ardelt, Maximilian A.; Szczepanowska, Karolina; Fraedrich, Julian E.; Waschke, Jens; Jeremias, Irmela; Fux, Anja; Stahl, Matthias; Vollmar, Angelika M.; Sieber, Stephan A. und Pachmayr, Johanna (2021): Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers. In: Scientific Reports, Bd. 11, Nr. 1, 11185

Meyer, Robina M.; Berger, Lukas; Nerkamp, Jörg; Scheler, Stefan; Nehring, Sebastian und Frieß, Wolfgang (2021): Identification of monoclonal antibody variants involved in aggregate formation -Part 1: Charge variants. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 158: S. 123-131

Meyer, Robina M.; Berger, Lukas; Nerkamp, Jörg; Scheler, Stefan; Nehring, Sebastian und Frieß, Wolfgang (2021): Identification of monoclonal antibody variants involved in aggregate formation-Part 2: Hydrophobicity variants. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 160: S. 134-142

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Murenu, Elisa; Kostidis, Sarantos; Lahiri, Shibojyoti; Geserich, Anna S.; Imhof, Axel; Giera, Martin und Michalakis, Stylianos (2021): Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice. In: International Journal of Molecular Sciences, Bd. 22, Nr. 5, 2345

Murenu, Elisa; Pavlou, Marina; Richter, Lisa; Rapti, Kleopatra; Just, Sabrina; Cehajic-Kapetanovic, Jasmina; Tafrishi, Neda; Hayes, Andrew; Scholey, Rachel; Lucas, Robert; Buening, Hildegard; Grimm, Dirk und Michalakis, Stylianos (2021): A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting. In: Molecular Therapy-Methods & Clinical Development, Bd. 20: S. 587-600

Müller, Martin; Gerndt, Susanne; Chao, Yu-Kai; Zisis, Themistoklis; Ong, Nam Phuong Nguyen; Gerwien, Aaron; Urban, Nicole; Müller, Christoph; Gegenfurtner, Florian A.; Geisslinger, Franz; Ortler, Carina; Chen, Cheng-Chang; Zahler, Stefan; Biel, Martin; Schäfer, Michael; Grimm, Christian; Bracher, Franz; Vollmar, Angelika M. und Bartel, Karin (2021): Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. In: Cell Chemical Biology, Bd. 28, Nr. 8: 1119-

Opolka-Hoffmann, Eugenia; Jordan, Gregor; Otteneder, Michael; Kieferle, Robin; Lechmann, Martin; Winter, Gerhard und Staack, Roland F. (2021): The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance. In: Mabs, Bd. 13, Nr. 1, e1995929

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Pasieka, Anna; Panek, Dawid; Jonczyk, Jakub; Godyn, Justyna; Szalaj, Natalia; Latacz, Gniewomir; Tabor, Julia; Mezeiova, Eva; Chantegreil, Fabien; Dias, Jose; Knez, Damijan; Lu, Junfeng; Pi, Rongbiao; Korabecny, Jan; Brazzolotto, Xavier; Gobec, Stanislav; Hoefner, Georg; Wanner, Klaus; Wieckowska, Anna und Malawska, Barbara (2021): Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters. In: European Journal of Medicinal Chemistry, Bd. 218, 113397

Passi, Mehak und Zahler, Stefan (2021): Mechano-Signaling Aspects of Hepatocellular Carcinoma. In: Journal of Cancer, Bd. 12, Nr. 21: S. 6411-6421

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Rieser, Ruth; Koch, Johanna; Faccioli, Greta; Richter, Klaus; Menzen, Tim; Biel, Martin; Winter, Gerhard und Michalakis, Stylianos (2021): Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors. In: Pharmaceutics, Bd. 13, Nr. 5, 748

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Rockinger, Ute; Müller, Christoph; Bracher, Franz; Funk, Martin und Winter, Gerhard (2021): DMSO as new, counterintuitive excipient for freeze-drying human keratinocytes. In: European Journal of Pharmaceutical Sciences, Bd. 160, 105746

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Rotzer, Rene D.; Brox, Verena F.; Hennis, Konstantin; Thalhammer, Stefan B.; Biel, Martin; Wahl-Schott, Christian und Fenske, Stefanie (2021): Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice. In: Jove-Journal of Visualized Experiments, Nr. 168, e62101

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Seifert, Ivonne und Frieß, Wolfgang (2021): The effect of residual moisture on a monoclonal antibody stability in L-arginine based lyophilisates. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 158: S. 53-61

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Trenkenschuh, Eduard und Friess, Wolfgang (2021): Freeze-thaw stability of aluminum oxide nanoparticles. In: International Journal of Pharmaceutics, Bd. 606, 120932

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Trenkenschuh, Eduard; Savsek, Ula und Frieß, Wolfgang (2021): Formulation, process, and storage strategies for lyophilizates of lipophilic nanoparticulate systems established based on the two models paliperidone palmitate and solid lipid nanoparticles. In: International Journal of Pharmaceutics, Bd. 606, 120929

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Wang, Shuaijun; Meixner, Maximilian; Yu, Lushuang; Zhuo, Ling; Karmann, Lisa; Kazmaier, Uli; Vollmar, Angelika M.; Antes, Iris und Zahler, Stefan (2021): Turning the Actin Nucleating Compound Miuraenamide into Nucleation Inhibitors. In: ACS Omega, Bd. 6, Nr. 34: S. 22165-22172

Yoluç, Yasemin; Logt, Erik van de und Kellner-Kaiser, Stefanie (2021): The Stress-Dependent Dynamics of Saccharomyces cerevisiae tRNA and rRNA Modification Profiles. In: Genes, Bd. 12, Nr. 9, 1344

Yuan, Yu; Kilpatrick, Bethan S.; Gerndt, Susanne; Bracher, Franz; Grimm, Christian; Schapira, Anthony H. und Patel, Sandip (2021): The lysosomotrope GPN mobilises Ca2+ from acidic organelles. In: Journal of Cell Science, Bd. 134, Nr. 6, jcs256578

Zaienne, Daniel; Willems, Sabine; Schierle, Simone; Heering, Jan und Merk, Daniel (2021): Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1. In: Journal of Medicinal Chemistry, Bd. 64, Nr. 20: S. 15126-15140

Zareba, Paula; Salat, Kinga; Höfner, Georg C.; Latka, Kamil; Bajda, Marek; Latacz, Gniewomir; Kotniewicz, Krzysztof; Rapacz, Anna; Podkowa, Adrian; Maj, Maciej; Jozwiak, Krzysztof; Filipek, Barbara; Wanner, Klaus T.; Malawska, Barbara und Kulig, Katarzyna (2021): Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity. In: European Journal of Medicinal Chemistry, Bd. 221, 113512

Zisis, Themistoklis; Schwarz, Jan; Balles, Miriam; Kretschmer, Maibritt; Nemethova, Maria; Chait, Remy; Hauschild, Robert; Lange, Janina; Guet, Calin; Sixt, Michael und Zahler, Stefan (2021): Sequential and Switchable Patterning for Studying Cellular Processes under Spatiotemporal Control. In: ACS Applied Materials & Interfaces, Bd. 13, Nr. 30: S. 35545-35560

2020

Ackermann, Thomas M.; Allmendinger, Lars; Höfner, Georg und Wanner, Klaus T. (2020): MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand. In: Chemmedchem, Bd. 16, Nr. 1: S. 199-215 [PDF, 2MB]

Andreß, Janina C.; Böck, Michael C.; Höfner, Georg und Wanner, Klaus T. (2020): Synthesis and biological evaluation of α- and β-hydroxy substituted amino acid derivatives as potential mGAT1-4 inhibitors. In: Medicinal Chemistry Research, Bd. 29, Nr. 8: S. 1321-1340 [PDF, 1MB]

Bao, Xuanwen; Shi, Run; Zhao, Tianyu und Wang, Yanfang (2020): Immune landscape and a novel immunotherapy-related gene signature associated with clinical outcome in early-stage lung adenocarcinoma. In: Journal of Molecular Medicine-Jmm, Bd. 98, Nr. 6: S. 805-818

Bao, Xuanwen; Shi, Run; Zhao, Tianyu und Wang, Yanfang (2020): Mast cell-based molecular subtypes and signature associated with clinical outcome in early-stage lung adenocarcinoma. In: Molecular Oncology, Bd. 14, Nr. 5: S. 917-932

Bluemel, Oliver; Buecheler, Jakob W.; Rodrigues, Miguel A.; Geraldes, Vitor; Hoelzl, Georg; Bechtold-Peters, Karoline und Friess, Wolfgang (2020): Cryoconcentration and 3D Temperature Profiles During Freezing of mAb Solutions in Large-Scale PET Bottles and a Novel Scale-Down Device. In: Pharmaceutical Research, Bd. 37, Nr. 9, 179

Boehm, Sybille; Splith, Victoria; Riedmayr, Lisa Maria; Rotzer, Rene Dominik; Gasparoni, Gilles; Nordstroem, Karl J. V.; Wagner, Johanna Elisabeth; Hinrichsmeyer, Klara Sonnie; Walter, Joern; Wahl-Schott, Christian; Fenske, Stefanie; Biel, Martin; Michalakis, Stylianos und Becirovic, Elvir (2020): A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation. In: Science Advances, Bd. 6, Nr. 34, eaba5614

Borowiak, Malgorzata; Kuellmer, Florian; Gegenfurtner, Florian; Peil, Sebastian; Nasufovic, Veselin; Zahler, Stefan; Thorn-Seshold, Oliver; Trauner, Dirk und Arndt, Hans-Dieter (2020): Optical Manipulation of F-Actin with Photoswitchable Small Molecules. In: Journal of the American Chemical Society, Bd. 142, Nr. 20: S. 9240-9249

Bracher, Franz (2020): Dimethylformamide Acetals and Bredereck's Reagent as Building Blocks in Natural Products Total Synthesis. In: Mini-Reviews in Organic Chemistry, Bd. 17, Nr. 1: S. 47-66

Böck, Michael C.; Höfner, Georg und Wanner, Klaus T. (2020): N‐Substituted Nipecotic Acids as (S )‐SNAP‐5114 Analogues with Modified Lipophilic Domains. In: ChemMedChem, Bd. 15, Nr. 9: S. 756-771 [PDF, 2MB]

Carfagna, Marco; Rosa, Monica; Lucke, Matthias; Hawe, Andrea und Friess, Wolfgang (2020): Heat flux sensor to create a design space for freeze-drying development. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 153: S. 84-94

Chen, Cheng; Liu, Li; Shu, Ya-Qiao; Jing, Ping; Lu, Yun; Zhang, Xiao-Xue; Zong, Xian-Gang; Guo, Lian-Jun und Li, Chang-Jun (2020): Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons. In: Neuroscience Bulletin, Bd. 36, Nr. 8: S. 875-894

Daerr, Markus; Allmendinger, Lars; Höfner, Georg und Wanner, Klaus T. (2020): Synthesis and biological evaluation of fluorescent GAT-ligands based on asymmetric substituted BODIPY dyes. In: Medicinal Chemistry Research, Bd. 29, Nr. 4: S. 767-782

Daerr, Markus; Pabel, Jörg; Höfner, Georg; Mayer, Peter und Wanner, Klaus T. (2020): Synthesis and biological evaluation of fluorescent GAT-ligands based on meso-substituted BODIPY dyes. In: Medicinal Chemistry Research, Bd. 29, Nr. 2: S. 301-327

Dahlem, Charlotte; Siow, Wei Xiong; Lopatniuk, Maria; Tse, William K. F.; Kessler, Sonja M.; Kirsch, Susanne H.; Hoppstaedter, Jessica; Vollmar, Angelika M.; Müller, Rolf; Luzhetskyy, Andriy; Bartel, Karin und Kiemer, Alexandra K. (2020): Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism. In: Cancers, Bd. 12, Nr. 5, 1288

Daller, Sarah; Friess, Wolfgang und Schroeder, Rudolf (2020): Energy Transfer in Vials Nested in a Rack System During Lyophilization. In: Pharmaceutics, Bd. 12, Nr. 1, 61

Darnet, Sylvain; Martin, Laetitia B. B.; Mercier, Pierre; Bracher, Franz; Geoffroy, Philippe und Schaller, Hubert (2020): Inhibition of Phytosterol Biosynthesis by Azasterols. In: Molecules, Bd. 25, Nr. 5, 1111

Dekel, Noa; Eisenberg-Domovich, Yael; Karlas, Alexander; Meyer, Thomas F.; Bracher, Franz; Lebendiker, Mario; Danieli, Tsafi und Livnah, Oded (2020): Expression, purification and crystallization of CLK1 kinase - A potential target for antiviral therapy. In: Protein Expression and Purification, Bd. 176, 105742

Derya, Sami M.; Spiegel, Holger; Hanisch, Franz-Georg; Morozov, Vasily; Schroten, Horst; Jennewein, Stefan und Parschat, Katja (2020): Biotechnologically produced fucosylated oligosaccharides inhibit the binding of human noroviruses to their natural receptors. In: Journal of Biotechnology, Bd. 318: S. 31-38

Domnowski, Martin; Jaehrling, Jan und Friess, Wolfgang (2020): Assessment of Antibody Self-Interaction by Bio-Layer-Interferometry as a Tool for Early Stage Formulation Development. In: Pharmaceutical Research, Bd. 37, Nr. 2, 29

Feldmann, Daniel P.; Heyza, Joshua; Zimmermann, Christoph M.; Patrick, Steve M. und Merkel, Olivia M. (2020): Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy. In: Molecules, Bd. 25, Nr. 8, 1994

Fenske, Stefanie; Hennis, Konstantin; Roetzer, Rene D.; Brox, Verena F.; Becirovic, Elvir; Scharr, Andreas; Gruner, Christian; Ziegler, Tilman; Mehlfeld, Verena; Brennan, Jaclyn; Efimov, Igor R.; Pauza, Audrys G.; Moser, Markus; Wotjak, Carsten T.; Kupatt, Christian; Goenner, Rasmus; Zhang, Rai; Zhang, Henggui; Zong, Xiangang; Biel, Martin und Wahl-Schott, Christian (2020): cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells. In: Nature Communications, Bd. 11, Nr. 1, 5555 [PDF, 10MB]

Fornara, Paolo; Madersbacher, Stephan; Vahlensieck, Winfried; Bracher, Franz; Romics, Imre und Kil, Paul (2020): Phytotherapy Adds to the Therapeutic Armamentarium for the Treatment of Mild-To-Moderate Lower Urinary Tract Symptoms in Men. In: Urologia Internationalis, Bd. 104: S. 333-342

Frank, James A.; Antonini, Marc-Joseph; Chiang, Po-Han; Canales, Andres; Konrad, David B.; Garwood, Indie C.; Rajic, Gabriela; Koehler, Florian; Fink, Yoel und Anikeeva, Polina (2020): In Vivo Photopharmacology Enabled by Multifunctional Fibers. In: ACS Chemical Neuroscience, Bd. 11, Nr. 22: S. 3802-3813

Gabriel, Jeurgen; Höfner, Georg und Wanner, Klaus T. (2020): Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1. In: European Journal of Medicinal Chemistry, Bd. 206, 112598

Geisslinger, Franz; Müller, Martin; Vollmar, Angelika M. und Bartel, Karin (Juli 2020): Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review. In: Frontiers in Oncology, Bd. 10, 1156: S. 1-7 [PDF, 717kB]

Geisslinger, Franz; Vollmar, Angelika M. und Bartel, Karin (2020): Cancer Patients Have a Higher Risk Regarding COVID-19-and Vice Versa? In: Pharmaceuticals, Bd. 13, Nr. 7, 143

Gentiluomo, Lorenzo; Roessner, Dierk und Friess, Wolfgang (2020): Application of machine learning to predict monomer retention of therapeutic proteins after long term storage. In: International Journal of Pharmaceutics, Bd. 577, 119039

Gentiluomo, Lorenzo; Roessner, Dierk; Streicher, Werner; Mahapatra, Sujata; Harris, Pernille und Friess, Wolfgang (2020): Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 443-451

Glas, Carina; Dietschreit, Johannes C. B.; Woessner, Nathalie; Urban, Lars; Ghazy, Ehab; Sippl, Wolfgang; Jung, Manfred; Ochsenfeld, Christian und Bracher, Franz (2020): Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations. In: European Journal of Medicinal Chemistry, Bd. 206, 112676

Grapentin, Christoph; Müller, Claudia; Kishore, Ravuri S. K.; Adler, Michael; ElBialy, Inas; Friess, Wolfgang; Huwyler, Jörg und Khan, Tarik A. (2020): Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 8: S. 2393-2404

Guenther, Ilka; Rimbach, Gerald; Mack, Carina; Weinert, Christoph H.; Danylec, Nicolas; Lueersen, Kai; Birringer, Marc; Bracher, Franz; Soukup, Sebastian T.; Kulling, Sabine E. und Pallauf, Kathrin (2020): The Putative Caloric Restriction Mimetic Resveratrol has Moderate Impact on Insulin Sensitivity, Body Composition, and the Metabolome in Mice. In: Molecular Nutrition & Food Research, Bd. 64, Nr. 6, 1901116

Haeuser, Christina; Goldbach, Pierre; Huwyler, Jörg; Friess, Wolfgang und Allmendinger, Andrea (2020): Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 807-817

Haeuser, Christina; Goldbach, Pierre; Huwyler, Jörg; Friess, Wolfgang und Allmendinger, Andrea (2020): Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 147: S. 45-56

Hartl, Natascha; Adams, Friederike und Merkel, Olivia M. (2020): From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood-Brain Barrier. In: Advanced Therapeutics, Bd. 4, Nr. 1, 2000092 [PDF, 2MB]

Heerdegen, Desiree; Reuter, Doreen; Kornmayer, Moritz M.; Kriegler, Katharina N.; Müller, Christoph; Mayer, Peter und Bracher, Franz (2020): Synthesis ofSeco-Analogues of the DHCR24 Inhibitor SH-42. In: European Journal of Organic Chemistry, Bd. 2020, Nr. 39: S. 6270-6288

Heerdegen, Desirée; Junker, Julia; Dittrich, Sebastian; Mayer, Peter und Bracher, Franz ORCID logoORCID: https://orcid.org/0000-0003-0009-8629 (2020): Traceless Isoprenylation of Aldehydes via N‐Boc‐N‐(1,1‐dimethylallyl)hydrazones. In: European Journal of Organic Chemistry, Bd. 2020, Nr. 24: S. 3680-3687 [PDF, 1MB]

Helbig, Constanze; Ammann, Gregor; Menzen, Tim; Friess, Wolfgang; Wuchner, Klaus und Hawe, Andrea (2020): Backgrounded Membrane Imaging (BMI) for High-Throughput Characterization of Subvisible Particles During Biopharmaceutical Drug Product Development. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 264-276

Hu, Xiaobo; Mandal, Pradeep K.; Kauffmann, Brice und Huc, Ivan (2020): Hybrid Sequences that Express both Aromatic Amide and α‐Peptidic Folding Features. In: ChemPlusChem, Bd. 85, Nr. 7: S. 1580-1586 [PDF, 1MB]

Kamlah, Alexandra und Bracher, Franz ORCID logoORCID: https://orcid.org/0000-0003-0009-8629 (2020): A Novel Approach to Highly Substituted β‐Carbolines via Reductive Ring Transformation of 2‐Acyl‐3‐isoxazolylindoles. In: European Journal of Organic Chemistry, Nr. 18: S. 2708-2719 [PDF, 1MB]

Kandil, Rima; Xie, Yuran; Mehta, Aditi und Merkel, Olivia (2020): A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases. In: Jain, Kewal K. (Hrsg.): Drug Delivery Systems. Methods in molecular biology, Bd. 2059. S. 155-166

Karg, Cornelia A.; Wang, Pengyu; Kluibenschedl, Florian; Müller, Thomas; Allmendinger, Lars; Vollmar, Angelika M. und Moser, Simone (2020): Phylloxanthobilins are Abundant Linear Tetrapyrroles from Chlorophyll Breakdown with Activities Against Cancer Cells. In: European Journal of Organic Chemistry, Bd. 2020, Nr. 29: S. 4499-4509 [PDF, 2MB]

Keil, Tobias W. M.; Baldassi, Domizia und Merkel, Olivia M. (2020): T‐cell targeted pulmonary siRNA delivery for the treatment of asthma. In: WIREs Nanomedicine and Nanobiotechnology, Bd. 12, Nr. 5, e1634 [PDF, 5MB]

Kraus, Yvonne; Glas, Carina; Melzer, Benedikt; Gao, Li; Heise, Constanze; Preusse, Monique; Ahlfeld, Julia; Bracher, Franz und Thorn-Seshold, Oliver (2020): Isoquinoline-based biaryls as a robust scaffold for microtubule inhibitors. In: European Journal of Medicinal Chemistry, Bd. 186, 111865

Krieg, Dennis; Svilenov, Hristo; Gitter, Julian H. und Winter, Gerhard (2020): Overcoming challenges in co-formulation of proteins with contradicting stability profiles - EPO plus G-CSF. In: European Journal of Pharmaceutical Sciences, Bd. 141, 105073

Kuhn, Jasmin; Lin, Yi; Levacic, Ana Krhac; Al Danaf, Nader; Peng, Lun; Hoehn, Miriam; Lamb, Don C.; Wagner, Ernst und Laechelt, Ulrich (2020): Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides. In: Bioconjugate Chemistry, Bd. 31, Nr. 3: S. 729-742

Kulakova, Alina; Indrakumar, Sowmya; Sonderby, Pernille; Gentiluomo, Lorenzo; Streicher, Werner; Roessner, Dierk; Friess, Wolfgang; Peters, Guenther H. J. und Harris, Pernille (2020): Small angle X-ray scattering and molecular dynamic simulations provide molecular insight for stability of recombinant human transferrin. In: Journal of Structural Biology-X, Bd. 4, 100017

Little, Hunter; Wang, Jingqi; Duhamel, Jean; Li, Xuesong; Markandeya, Nagula; Maurizot, Victor und Huc, Ivan (2020): Simplification in the Acquisition and Analysis of Fluorescence Decays Acquired with Polarized Emission for Time-Resolved Fluorescence Anisotropy Measurements. In: Analytical Chemistry, Bd. 92, Nr. 1: S. 668-673

Martos, Ariadna; Berger, Michelle; Kranz, Wendelin; Spanopoulou, Anna; Menzen, Tim; Friess, Wolfgang; Wuchner, Klaus und Hawe, Andrea (2020): Novel High-Throughput Assay for Polysorbate Quantification in Biopharmaceutical Products by Using the Fluorescent Dye DiI. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 646-655

Mateus, Pedro; Chandramouli, Nagula; Mackereth, Cameron D.; Kauffmann, Brice; Ferrand, Yann und Huc, Ivan (2020): Allosteric Recognition of Homomeric and Heteromeric Pairs of Monosaccharides by a Foldamer Capsule. In: Angewandte Chemie-International Edition, Bd. 59, Nr. 14: S. 5797-5805 [PDF, 5MB]

Mathaes, Roman; Manning, Mark Cornell; Winter, Gerhard; Engert, Julia und Wilson, Glenn A. (2020): Shape Characterization of Subvisible Particles Using Dynamic Imaging Analysis. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 375-379

Mazzier, Daniela; De, Soumen; Wicher, Barbara; Maurizot, Victor und Huc, Ivan (2020): Parallel Homochiral and Anti‐Parallel Heterochiral Hydrogen‐Bonding Interfaces in Multi‐Helical Abiotic Foldamers. In: Angewandte Chemie-International Edition, Bd. 59, Nr. 4: S. 1606-1610 [PDF, 2MB]

Meena, Chhuttan L.; Singh, Dharmendra; Weinmueller, Michael; Reichart, Florian; Dangi, Abha; Marelli, Udaya Kiran; Zahler, Stefan und Sanjayan, Gangadhar J. (2020): Novel cilengitide-based cyclic RGD peptides as alpha nu beta(3) integrin inhibitors. In: Bioorganic & Medicinal Chemistry Letters, Bd. 30, Nr. 8, 127039

Mehta, Aditi und Merkel, Olivia M. (2020): Immunogenicity of Cas9 Protein. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 62-67

Merkel, Olivia M. ORCID logoORCID: https://orcid.org/0000-0002-4151-3916 und Mehta, Aditi (20. Oktober 2020): Characterization techniques for studying the properties of nanocarriers for systemic delivery. In: Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Bd. 13. Cham: Springer. S. 57-86 [PDF, 1MB]

Messner, Martina; Schmitt, Sabine; Ardelt, Maximilian A.; Fröhlich, Thomas; Müller, Martin; Pein, Helmut; Huber-Cantonati, Petra; Ortler, Carina; König, Lars M.; Zobel, Lena; Koeberle, Andreas; Arnold, Georg J.; Rothenfusser, Simon; Kiemer, Alexandra K.; Gerbes, Alexander L.; Zischka, Hans; Vollmar, Angelika M. und Pachmayr, Johanna (2020): Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma. In: FASEB Journal, Bd. 34, Nr. 9: S. 11860-11882

Meunier, Antoine; Singleton, Michael L.; Kauffmann, Brice; Granier, Thierry; Lautrette, Guillaume; Ferrand, Yann und Huc, Ivan (2020): Aromatic foldamers as scaffolds for metal second coordination sphere design. In: Chemical Science, Bd. 11, Nr. 44: S. 12178-12186

Müller-Deku, Adrian; Meiring, Joyce C. M.; Loy, Kristina; Kraus, Yvonne; Heise, Constanze; Bingham, Rebekkah; Jansen, Klara I.; Qu, Xiaoyi; Bartolini, Francesca; Kapitein, Lukas C.; Akhmanova, Anna; Ahlfeld, Julia; Trauner, Dirk und Thorn-Seshold, Oliver (2020): Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton. In: Nature communications, Bd. 11, Nr. 1, 4640 [PDF, 7MB]

Panagiotopoulos, Anna-Lena; Karguth, Nina; Pavlou, Marina; Boehm, Sybille; Gasparoni, Gilles; Walter, Joern; Graf, Alexander; Blum, Helmut; Biel, Martin; Riedmayr, Lisa Maria und Becirovic, Elvir (2020): Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation. In: Molecular Therapy-Nucleic Acids, Bd. 21: S. 1050-1061

Panossian, Alexander G.; Efferth, Thomas; Shikov, Alexander N.; Pozharitskaya, Olga N.; Kuchta, Kenny; Mukherjee, Pulok K.; Banerjee, Subhadip; Heinrich, Michael; Wu, Wanying; Guo, De-an und Wagner, Hildebert (2020): Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases. In: Medicinal Research Reviews, Bd. 41, Nr. 1: S. 630-703

Pappas, Charalampos G.; Mandal, Pradeep K.; Liu, Bin; Kauffmann, Brice; Miao, Xiaoming; Komaromy, David; Hoffmann, Waldemar; Manz, Christian; Chang, Rayoon; Liu, Kai; Pagel, Kevin; Huc, Ivan und Otto, Sijbren (2020): Emergence of low-symmetry foldamers from single monomers. In: Nature Chemistry, Bd. 12, Nr. 12: S. 1180-1186

Pohl, Christin; Zalar, Matja; El Bialy, Inas; Indrakumar, Sowmya; Peters, Gunther H. J.; Friess, Wolfgang; Golovanov, Alexander P.; Streicher, Werner W.; Noergaard, Allan und Harris, Pernille (2020): The Effect of Point Mutations on the Biophysical Properties of an Antimicrobial Peptide: Development of a Screening Protocol for Peptide Stability Screening. In: Molecular Pharmaceutics, Bd. 17, Nr. 9: S. 3298-3313

Riedmayr, Lisa M. (2020): SMaRT for Therapeutic Purposes. In: Li, Hui und Elfman, Justin (Hrsg.): Chimeric RNA. Methods in molecular biology : Methods and Protocols, Bd. 2079. New York, NY: Springer Nature. S. 219-232

Riedmayr, Lisa M.; Boehm, Sybille; Biel, Martin und Becirovic, Elvir (2020): Enigmatic rhodopsin mutation creates an exceptionally strong splice acceptor site. In: Human Molecular Genetics, Bd. 29, Nr. 2: S. 295-304

Ritt, Nicolas; Berger, Simone; Wagner, Ernst und Zentel, Rudolf (2020): Versatile, Multifunctional Block Copolymers for the Self-Assembly of Well-Defined, Nontoxic pDNA Polyplexes. In: ACS Applied Polymer Materials, Bd. 2, Nr. 12: S. 5469-5481

Rudy, Heinrich‐Karl A.; Mayer, Peter und Wanner, Klaus T. (2020): Synthesis of 1,5‐Ring‐Fused Imidazoles from Cyclic Imines and TosMIC – Identification of in situ Generated N‐Methyleneformamide as a Catalyst in the van Leusen Imidazole Synthesis. In: European Journal of Organic Chemistry, Bd. 2020, Nr. 24: S. 3599-3612 [PDF, 2MB]

Schroeder, Martin; Bullock, Alex N.; Fedorov, Oleg; Bracher, Franz; Chaikuad, Apirat und Knapp, Stefan (2020): DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. In: Journal of Medicinal Chemistry, Bd. 63, Nr. 18: S. 10224-10234

Schuetz, Ramona; Meixner, Maximilian; Antes, Iris und Bracher, Franz (2020): A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine. In: Organic & Biomolecular Chemistry, Bd. 18, Nr. 16: S. 3047-3068

Schütz, Ramona; Müller, Martin; Geisslinger, Franz; Vollmar, Angelika; Bartel, Karin und Bracher, Franz (2020): Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. In: European Journal of Medicinal Chemistry, Bd. 207, 112810

Schütz, Ramona; Müller, Martin; Gerndt, Susanne; Bartel, Karin und Bracher, Franz ORCID logoORCID: https://orcid.org/0000-0003-0009-8629 (2020): Racemic total synthesis and evaluation of the biological activities of the isoquinoline–benzylisoquinoline alkaloid muraricine. In: Archiv der Pharmazie, Bd. 353, Nr. 7, 2000106 [PDF, 1MB]

Seifert, Ivonne; Bregolin, Alessandro; Fissore, Davide und Friess, Wolfgang (2020): Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 153: S. 36-42

Seifert, Ivonne und Friess, Wolfgang (2020): Freeze concentration during freezing: How does the maximally freeze concentrated solution influence protein stability? In: International Journal of Pharmaceutics, Bd. 589, 119810

Seifert, Ivonne und Friess, Wolfgang (2020): Improvement of arginine hydrochloride based antibody lyophilisates. In: International Journal of Pharmaceutics, Bd. 589, 119859

Skelbaek-Pedersen, Anne Linnet; Anuschek, Moritz; Vilhelmsen, Thomas Kvistgaard; Rantanen, Jukka und Zeitler, J. Axel (2020): Non-destructive quantification of fragmentation within tablets after compression from scattering analysis of terahertz transmission measurements. In: International Journal of Pharmaceutics, Bd. 588, 119769

Strack, Patrick; Kuelzer, Raimund; Sommer, Florian; Bretschneider, Tom; Merkel, Olivia M. und Grube, Achim (2020): A smart approach to enable preclinical studies in pharmaceutical industry: PLGA-based extended release formulation platform for subcutaneous applications. In: Drug Development and Industrial Pharmacy, Bd. 46, Nr. 4: S. 635-645

Stulz, Anja; Breitsamer, Michaela; Winter, Gerhard und Heerklotz, Heiko (2020): Primary and Secondary Binding of Exenatide to Liposomes. In: Biophysical Journal, Bd. 118, Nr. 3: S. 600-611

Svilenov, Hristo ORCID logoORCID: https://orcid.org/0000-0001-5863-9569; Kulakova, Alina; Zalar, Matja; Golovanov, Alexander P.; Harris, Pernille und Winter, Gerhard (Januar 2020): Orthogonal Techniques to Study the Effect of pH, Sucrose, and Arginine Salts on Monoclonal Antibody Physical Stability and Aggregation During Long-Term Storage. In: Journal of Pharmaceutical Sciences, Bd. 109, Nr. 1: S. 584-594 [PDF, 2MB]

Svilenov, Hristo ORCID logoORCID: https://orcid.org/0000-0001-5863-9569 und Winter, Gerhard (April 2020): Formulations that suppress aggregation during long-term storage of a bispecific antibody are characterized by high refoldability and colloidal stability. In: Journal of Pharmaceutical Sciences [PDF, 4MB]

Svilenov, Hristo L.; Menzen, Tim; Richter, Klaus und Winter, Gerhard (2020): Modulated Scanning Fluorimetry Can Quickly Assess Thermal Protein Unfolding Reversibility in Microvolume Samples. In: Molecular Pharmaceutics, Bd. 17, Nr. 7: S. 2638-2647

Theisen, Ulrike; Ernst, Alexander U.; Heyne, Ronja L. S.; Ring, Tobias P.; Thorn-Seshold, Oliver und Koster, Reinhard W. (2020): Microtubules and motor proteins support zebrafish neuronal migration by directing cargo. In: Journal of Cell Biology, Bd. 219, Nr. 10, e201908040

Tosstorff, Andreas ORCID logoORCID: https://orcid.org/0000-0002-4969-3667; Menzen, Tim und Winter, Gerhard ORCID logoORCID: https://orcid.org/0000-0002-7413-6627 (Januar 2020): Exploring Chemical Space for new Substances to stabilize a therapeutic Monoclonal Antibody. In: Journal of Pharmaceutical Sciences [PDF, 1MB]

Tosstorff, Andreas ORCID logoORCID: https://orcid.org/0000-0002-4969-3667; Peters, Günther H. J. und Winter, Gerhard ORCID logoORCID: https://orcid.org/0000-0002-7413-6627 (April 2020): Study of the interaction between a novel, protein stabilizing dipeptide and Interferon-alpha-2a by construction of a Markov State Model from Molecular Dynamics simulations. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 149: S. 105-112 [PDF, 1MB]

Traub-Hoffmann, Kerstin; Gegenfurtner, Katrin; Kraft, Kay-Uwe und Friess, Wolfgang (2020): Spray congealed solid lipid microparticles as a sustained release delivery system for Gonadorelin [6-D-Phe]: Production, optimization and in vitro release behavior. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 154: S. 18-32

Tsiamantas, Christos; Kwon, Sunbum; Rogers, Joseph M.; Douat, Céline; Huc, Ivan und Suga, Hiroaki (2020): Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages. In: Angewandte Chemie - International Edition, Bd. 59, Nr. 12: S. 4860-4864 [PDF, 1MB]

Untergehrer, Martin und Bracher, Franz (2020): A short divergent approach to highly substituted carbazoles and beta-carbolines via in situ-generated diketoindoles. In: Tetrahedron Letters, Bd. 61, Nr. 12, 151597

Unzue, Andrea; Jessen-Trefzer, Claudia; Spiliotopoulos, Dimitrios; Gaudio, Eugenio; Tarantelli, Chiara; Dong, Jing; Zhao, Hongtao; Pachmayr, Johanna; Zahler, Stefan; Bernasconi, Elena; Sartori, Giulio; Cascione, Luciano; Bertoni, Francesco; Sledz, Pawel; Caflisch, Amedeo und Nevado, Cristina (2020): Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors. In: Rsc Medicinal Chemistry, Bd. 11, Nr. 6: S. 665-675

Wang, Jinhua; Wicher, Barbara; Maurizot, Victor und Huc, Ivan (2020): Oligo-Quinolylene-Vinylene Foldamers. In: Chemistry-A European Journal, Bd. 27, Nr. 3: S. 1031-1038

Wang, Yanfang und Wagner, Ernst (2020): Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization. In: Pharmaceutics, Bd. 12, Nr. 9, 888

Wathoni, Nasrul; An Ny, Nguyen; Rusdin, Agus; Umar, Abd Kakhar; Mohammed, Ahmed Fouad Abdelwahab; Motoyama, Keiichi; Joni, I. Made und Muchtaridi, Muchtaridi (2020): Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System. In: Drug Design Development and Therapy, Bd. 14: S. 4387-4405

Wollnitzke, Philipp; Essig, Sebastian; Goelz, Jan Philipp; Schwarzenberg, Karin von und Menche, Dirk (2020): Total Synthesis of Ajudazol A by a Modular Oxazole Diversification Strategy. In: Organic Letters, Bd. 22, Nr. 16: S. 6344-6348

Woortman, Dirk Volker; Jürgens, Sophie; Untergehrer, Martin; Rechenberger, Julia; Fuchs, Monika; Mehlmer, Norbert; Qoura, Farah; Eckel, Georg; Stoehr, Michael; Osswald, Patrick; Le Clercq, Patrick; Hintermann, Lukas; Weuster-Botz, Dirk; Bracher, Franz und Brueck, Thomas (2020): Greener aromatic antioxidants for aviation and beyond. In: Sustainable Energy & Fuels, Bd. 4, Nr. 5: S. 2153-2163

Wurzlbauer, Anne; Rueben, Katharina; Guerdal, Ece; Chaikuad, Apirat; Knapp, Stefan; Sippl, Wolfgang; Becker, Walter und Bracher, Franz (2020): How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine. In: Molecules, Bd. 25, Nr. 24, 5962

Xie, Ying; Hang, Yu; Wang, Yazhe; Sleightholm, Richard; Prajapati, Dipakkumar R.; Bader, Johannes; Yu, Ao; Tang, Weimin; Jaramillo, Lee; Li, Jing; Singh, Rakesh K. und Oupicky, David (2020): Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. In: ACS Nano, Bd. 14, Nr. 1: S. 255-271

Zahler, Stefan (2020): Nuclear actin in cancer biology. In: International review of cell and molecular biology, Bd. 355: S. 53-66

Zareba, Paula; Gryzlo, Beata; Malawska, Katarzyna; Salat, Kinga; Höfner, Georg C.; Nowaczyk, Alicja; Fijalkowski, Lukasz; Rapacz, Anna; Podkowa, Adrian; Furgala, Anna; Zmudzki, Pawel; Wanner, Klaus T.; Malawska, Barbara und Kulig, Katarzyna (2020): Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. In: European Journal of Medicinal Chemistry, Bd. 188, 111920

Zhong, Yulong; Kauffmann, Brice; Xu, Wenwu; Lu, Zhong-Lin; Ferrand, Yann; Huc, Ivan; Zeng, Xiao Cheng; Liu, Rui und Gong, Bing (2020): Multiturn Hollow Helices: Synthesis and Folding of Long Aromatic Oligoamides. In: Organic Letters, Bd. 22, Nr. 17: S. 6938-6942

Zwillinger, Marton; Reddy, Post Sai; Wicher, Barbara; Mandal, Pradeep K.; Csekei, Marton; Fischer, Lucile; Kotschy, Andras und Huc, Ivan (2020): Aromatic Foldamer Helices as alpha-Helix Extended Surface Mimetics. In: Chemistry-A European Journal, Bd. 26, Nr. 72: S. 17366-17370

2019

Ackermann, Thomas M.; Bhokare, Karuna; Hoefner, Georg und Wanner, Klaus T. (2019): MS binding assays for GlyT1 based on Org24598 as nonlabelled reporter ligand. In: Neuropharmacology, Bd. 161, 107561

Alex, Jimi M.; Corvaglia, Valentina; Hu, Xiaobo; Engilberge, Sylvain; Huc, Ivan und Crowley, Peter B. (2019): Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution. In: Chemical Communications, Bd. 55, Nr. 74: S. 11087-11090

Ardelt, Maximilian A.; Fröhlich, Thomas; Martini, Emanuele; Müller, Martin; Kanitz, Veronika; Atzberger, Carina; Cantonati, Petra; Messner, Martina; Posselt, Laura; Lehr, Thorsten; Wojtyniak, Jan-Georg; Ulrich, Melanie; Arnold, Georg J.; König, Lars; Parazzoli, Dario; Zahler, Stefan; Rothenfusser, Simon; Mayr, Doris; Gerbes, Alexander; Scita, Giorgio; Vollmar, Angelika M. und Pachmayr, Johanna (2019): Inhibition of Cyclin-Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy. In: Hepatology, Bd. 69, Nr. 1: S. 376-393

Augustijn, Dillen; Mahapatra, Sujata; Streicher, Werner; Svilenov, Hristo; Kulakova, Ahna; Pohl, Christin und Rinnan, Asmund (2019): Novel non-linear curve fitting to resolve protein unfolding transitions in intrinsic fluorescence differential scanning fluorimetry. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 142: S. 506-517

Bao, Maode; Shi, Run; Zhang, Kai; Zhao, Yanbo; Wang, Yanfang und Bao, Xuanwen (2019): Development of a membrane lipid metabolism-based signature to predict overall survival for personalized medicine in ccRCC patients. In: Epma Journal, Bd. 10, Nr. 4: S. 383-393

Bao, Xuanwen; Anastasov, Natasa; Wang, Yanfang und Rosemann, Michael (2019): A novel epigenetic signature for overall survival prediction in patients with breast cancer. In: Journal of Translational Medicine, Bd. 17, Nr. 1, 380

Bao, Xuanwen; Shi, Run; Zhang, Kai; Xin, Shan; Li, Xin; Zhao, Yanbo und Wang, Yanfang (18. September 2019): Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature. In: Frontiers in Oncology, Bd. 9, 903: S. 1-15 [PDF, 2MB]

Bartel, Karin; Müller, Rolf und Schwarzenberg, Karin von (2019): Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells. In: Journal of Biological Chemistry, Bd. 294, Nr. 46: S. 17239-17248

Bartel, Karin; Pein, Helmut; Popper, Bastian; Schmitt, Sabine; Janaki-Raman, Sudha; Schulze, Almut; Lengauer, Florian; Koeberle, Andreas; Werz, Oliver; Zischka, Hans; Müller, Rolf; Vollmar, Angelika M. und Schwarzenberg, Karin von (2019): Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death. In: Cell Communication and Signaling, Bd. 17, 87

Blassmann, Ute; Hope, William; Roehr, Anka C.; Frey, Otto R.; Vetter-Kerkhoff, Cornelia; Thon, Niklas; Briegel, Josef und Huge, Volker (2019): CSF penetration of vancomycin in critical care patients with proven or suspected ventriculitis: a prospective observational study. In: Journal of Antimicrobial Chemotherapy, Bd. 74, Nr. 4: S. 991-996

Borland, Kayla; Diesend, Jan; Ito-Kureha, Taku; Heissmeyer, Vigo; Hammann, Christian; Buck, Amy H.; Michalakis, Stylianos und Kellner, Stefanie (2019): Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis. In: Genes, Bd. 10, Nr. 1, 26

Breitsamer, Michaela; Stulz, Anja; Heerklotz, Heiko H. und Winter, Gerhard (2019): Do interactions between protein and phospholipids influence the release behavior from lipid-based exenatide depot systems? In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 142: S. 61-69

Breitsamer, Michaela und Winter, Gerhard (2019): Vesicular phospholipid gels as drug delivery systems for small molecular weight drugs, peptides and proteins: State of the art review. In: International Journal of Pharmaceutics, Bd. 557: S. 1-8

Bryce, Nicole S.; Failes, Tim W.; Stehn, Justine R.; Baker, Karen; Zahler, Stefan; Arzhaeva, Yulia; Bischof, Leanne; Lyons, Ciaran; Dedova, Irina; Arndt, Greg M.; Gaus, Katharina; Goult, Benjamin T.; Hardeman, Edna C.; Gunning, Peter W. und Lock, John G. (2019): High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained. In: Cell Systems, Bd. 9, Nr. 5

Chiu, Joy E.; Thekkiniath, Jose; Mehta, Sameet; Müller, Christoph; Bracher, Franz und Ben Mamoun, Choukri (2019): The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors. In: Journal of Biological Chemistry, Bd. 294, Nr. 40: S. 14757-14767

Choi, Jae Eun; Verhaegen, Monique E.; Yazdani, Sahr; Malik, Rohit; Harms, Paul W.; Mangelberger, Doris; Tien, Jean; Cao, Xuhong; Wang, Yuping; Cieslik, Marcin; Gurkan, Jonathan; Yazdani, Mishaal; Jing, Xiaojun; Juckette, Kristin; Su, Fengyun; Wang, Rui; Zhou, Bing; Apel, Ingrid J.; Wang, Shaomeng; Dlugosz, Andrzej A. und Chinnaiyan, Arul M. (2019): Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma. In: Neoplasia, Bd. 21, Nr. 3: S. 322-330

Corvaglia, Valentina; Carbajo, Daniel; Prabhakaran, Panchami; Ziach, Krzysztof; Mandal, Pradeep Kumar; Dos Santos, Victor; Legeay, Carole; Vogel, Rachel; Parissi, Vincent; Pourquier, Philippe und Huc, Ivan (2019): Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins. In: Nucleic Acids Research, Bd. 47, Nr. 11: S. 5511-5521

De Meyer, Laurens; Lammens, Joris; Vanbillemont, Brecht; Van Bockstal, Pieter Jan; Corver, Jos; Vervaet, Chris; Friess, Wolfgang und De Beer, Thomas (2019): Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying. In: International Journal of Pharmaceutics, Bd. 570, 118631

Douat, Celine; Bornerie, Megane; Antunes, Stephanie; Guichard, Gilles und Kichler, Antoine (2019): Hybrid Cell-Penetrating Foldamer with Superior Intracellular Delivery Properties and Serum Stability. In: Bioconjugate Chemistry, Bd. 30, Nr. 4: S. 1133-1139

Duerr, Corinna und Friess, Wolfgang (2019): Antibody-drug conjugates- stability and formulation. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 139: S. 168-176

Gabriel, Jürgen; Hoefner, Georg und Wanner, Klaus T. (4. Oktober 2019): A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry. In: Frontiers in Chemistry, Bd. 7, 665: S. 1-18 [PDF, 2MB]

Gadelha, Ana Paula R.; Bravim, Barbara; Vidal, Juliana; Reignault, Lissa Catherine; Cosme, Bruno; Huber, Kilian; Bracher, Franz und de Souza, Wanderley (2019): Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor. In: International Journal of Medical Microbiology, Bd. 309, Nr. 2: S. 130-142

Geh, K. J.; Stelzl, A.; Grone, A.; Wagner, L.; Forster, B. und Winter, G. (2019): Development of a sprayable hydrogel formulation for the skin application of therapeutic antibodies. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 142: S. 123-132

Geiger, Florian; Rüdiger, Daniel; Zahler, Stefan und Engelke, Hanna (2019): Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels.
In: PLOS One 14(11), e0225215 [PDF, 2MB]

Gentiluomo, Lorenzo; Roessner, Dierk; Augustijn, Dillen; Svilenov, Hristo ORCID logoORCID: https://orcid.org/0000-0001-5863-9569; Kulakova, Alina; Mahapatra, Sujata; Winter, Gerhard; Streicher, Werner; Rinnan, Asmund; Peters, Günther; Harris, Pernille und Friess, Wolfgang (August 2019): Application of interpretable artificial neural networks to early monoclonal antibodies development. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 141: S. 81-89 [PDF, 1MB]

Gentiluomo, Lorenzo; Schneider, Vanessa; Roessner, Dierk und Frieß, Wolfgang (2019): Coupling Multi-Angle Light Scattering to Reverse-Phase Ultra-High-Pressure Chromatography (RP-UPLC-MALS) for the characterization monoclonal antibodies. In: Scientific Reports, Bd. 9, 14965 [PDF, 3MB]

Gitter, Julian Hendryk; Geidobler, Raimund; Presser, Ingo und Winter, Gerhard (2019): Microwave-Assisted Freeze-Drying of Monoclonal Antibodies: Product Quality Aspects and Storage Stability. In: Pharmaceutics, Bd. 11, Nr. 12, 674

Glas, Carina und Bracher, Franz (2019): General Method for the Preparation of Indole-2-Weinreb Amides. In: Synthesis-Stuttgart, Bd. 51, Nr. 3, UNSP ss-2018-t0494-op: S. 757-768

Gleissner, Carolin M. -L.; Pyka, Carolin L.; Heydenreuter, Wolfgang; Gronauer, Thomas F.; Atzberger, Carina; Korotkov, Vadim S.; Cheng, Weiting; Hacker, Stephan M.; Vollmar, Angelika M.; Braig, Simone und Sieber, Stephan A. (2019): Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT-1 Controlled Pathways. In: ACS Central Science, Bd. 5, Nr. 7: S. 1170-1178

Gole, Bappaditya; Kauffmann, Brice; Maurizot, Victor; Huc, Ivan und Ferrand, Yann (2019): Light-Controlled Conformational Switch of an Aromatic Oligoamide Foldamer. In: Angewandte Chemie-International Edition, Bd. 58, Nr. 24: S. 8063-8067

Haeuser, Christina; Goldbach, Pierre; Huwyler, Jörg; Friess, Wolfgang und Allmendinger, Andrea (2019): Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations. In: Pharmaceutics, Bd. 11, Nr. 11, 616

Hammelmann, Verena; Stieglitz, Marc Sebastian; Huelle, Henrik; Le Meur, Karim; Kass, Jennifer; Bruemmer, Manuela; Gruner, Christian; Roetzer, Rene Dominik; Fenske, Stefanie; Hartmann, Jana; Zott, Benedikt; Luthi, Anita; Spahn, Saskia; Moser, Markus; Isbrandt, Dirk; Ludwig, Andreas; Konnerth, Arthur; Wahl-Schott, Christian und Biel, Martin (2019): Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures. In: Jci Insight, Bd. 4, Nr. 9, e126418

Haryadi, Bernard Manuel; Hafner, Daniel; Amin, Ihsan; Schubel, Rene; Jordan, Rainer; Winter, Gerhard ORCID logoORCID: https://orcid.org/0000-0002-7413-6627 und Engert, Julia (September 2019): Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting. In: Advanced Healthcare Materials, Bd. 8, Nr. 18, 1900352 [PDF, 2MB]

Hauke, Tobias J.; Hoefner, Georg und Wanner, Klaus T. (2019): Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4. In: Bioorganic & Medicinal Chemistry, Bd. 27, Nr. 1: S. 144-152

Hauke, Tobias J.; Hoefner, Georg und Wanner, Klaus T. (2019): MS-Based Screening of 5-Substituted Nipecotic Acid Derived Hydrazone Libraries as Ligands of the GABA Transporter 1. In: Chemmedchem, Bd. 14, Nr. 5: S. 583-593

Higel, Fabian; Sandl, Theresa; Kao, Chi-Ya; Pechinger, Nicole; Soergel, Fritz; Friess, Wolfgang; Wolschin, Florian und Seidl, Andreas (2019): N-glycans of complex glycosylated biopharmaceuticals and their impact on protein clearance. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 139: S. 123-131

Hoffmann, Eugenia; Jordan, Gregor; Lauer, Matthias; Ringler, Philippe; Kusznir, Eric A.; Rufer, Arne C.; Huber, Sylwia; Jochner, Anton; Winter, Gerhard und Staack, Roland F. (2019): Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies. In: Pharmaceutical Research, Bd. 36, Nr. 9, UNSP 129

Holm, Regina; Schwiertz, David; Weber, Benjamin; Schultze, Jennifer; Kuhn, Jasmin; Koynov, Kaloian; Laechelt, Ulrich und Barz, Matthias (2019): Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential. In: Macromolecular Bioscience, Bd. 20, Nr. 1, 1900152

Horn, Jacqueline; Jena, Sampeeti; Aksan, Alptekin und Friess, Wolfgang (2019): Freeze/thaw of IGG solutions. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 134: S. 185-189

Huber, Simone K.; Hoefner, Georg und Wanner, Klaus T. (2019): Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of gamma-aminobutyric acid transporter 1 (GAT1). In: Bioorganic & Medicinal Chemistry, Bd. 27, Nr. 13: S. 2753-2763

Junker, Julia; Chong, Isabelle; Kamp, Frits; Steiner, Harald; Giera, Martin; Müller, Christoph und Bracher, Franz (2019): Comparison of Strategies for the Determination of Sterol Sulfates via GC-MS Leading to a Novel Deconjugation-Derivatization Protocol. In: Molecules, Bd. 24, Nr. 13, 2353

Kamlah, Alexandra und Bracher, Franz (2019): A Short Synthesis of the Plant Alkaloid 4-Methyl-2,6-naphthyridine. In: Letters in Organic Chemistry, Bd. 16, Nr. 12: S. 931-934

Kandil, Rima und Merkel, Olivia M. (2019): Recent progress of polymeric nanogels for gene delivery. In: Current Opinion in Colloid & Interface Science, Bd. 39: S. 11-23

Karg, Cornelia A.; Schilling, Charlotte M.; Allmendinger, Lars und Moser, Simone (2019): Isolation, characterization, and antioxidative activity of a dioxobilin-type phylloxanthobilin from savoy cabbage. In: Journal of Porphyrins and Phthalocyanines, Bd. 23, Nr. 7-8: S. 881-888

Karg, Cornelia A.; Wang, Pengyu; Vollmar, Angelika M. und Moser, Simone (2019): Re-opening the stage for Echinacea research - Characterization of phylloxanthobilins as a novel anti-oxidative compound class in Echinacea purpurea. In: Phytomedicine, Bd. 60, UNSP 152969

Karthik, S.; Mandal, P. K.; Thirugnanasambandam, A. und Gautham, N. (2019): Crystal structures of disordered Z-type helices. In: Nucleosides Nucleotides & Nucleic Acids, Bd. 38, Nr. 4: S. 279-293

Keil, Tobias W. M.; Feldmann, Daniel P.; Costabile, Gabriella; Zhong, Qian; da Rocha, Sandro und Merkel, Olivia M. (2019): Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 143: S. 61-69

Kern, Felix und Wanner, Klaus T. (2019): Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors gamma-aminobutyric acid transporter 1. In: Bioorganic & Medicinal Chemistry, Bd. 27, Nr. 7: S. 1232-1245

Kern, Sarah; Truebenbach, Ines; Hoehn, Miriam; Gorges, Jan; Kazmaier, Uli; Zahler, Stefan; Vollmar, Angelika M. und Wagner, Ernst (2019): Combined antitumoral effects of pretubulysin and methotrexate. In: Pharmacology Research & Perspectives, Bd. 7, Nr. 1, UNSP e00460

Kirsch, Volker C.; Orgler, Christina; Braig, Simone; Jeremias, Irmela; Auerbach, David; Müller, Rolf; Vollmar, Angelika M. und Sieber, Stephan A. (2019): The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, which is Essential for Ribosome Biogenesis. In: Angewandte Chemie-International Edition, Bd. 59, Nr. 4: S. 1595-1600

Koczian, Fabian; Naglo, Olga; Vomacka, Jan; Vick, Binje; Servatius, Phil; Zisis, Themistoklis; Hettich, Britta; Kazmaier, Uli; Sieber, Stephan A.; Jeremias, Irmela; Zahler, Stefan und Braig, Simone (2019): Targeting the endoplasmic reticulum-mitochondria interface sensitizes leukemia cells to cytostatics. In: Haematologica, Bd. 104, Nr. 3: S. 546-555

Koerner, Andreas; Zhou, Enchen; Muller, Christoph; Mohammed, Yassene; Herceg, Sandra; Bracher, Franz; Rensen, Patrick C. N.; Wang, Yanan; Mirakaj, Valbona und Giera, Martin (2019): Inhibition of Delta 24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution. In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 116, Nr. 41: S. 20623-20634

Kraus, Teresa; Lubitz, Annika; Schliesser, Ulrike; Giese, Christoph; Reuschel, Jana; Brecht, Rene; Engert, Julia und Winter, Gerhard (2019): Evaluation of a 3D Human Artificial Lymph Node as Test Model for the Assessment of Immunogenicity of Protein Aggregates. In: Journal of Pharmaceutical Sciences, Bd. 108, Nr. 7: S. 2358-2366

Kraus, Teresa; Winter, Gerhard und Engert, Julia (2019): Test models for the evaluation of immunogenicity of protein aggregates. In: International Journal of Pharmaceutics, Bd. 559: S. 192-200

Krauss, Jürgen; Klimt, Monika; Luber, Markus; Mayer, Peter und Bracher, Franz (2019): Characterization of two new degradation products of atorvastatin calcium formed upon treatment with strong acids. In: Beilstein Journal of Organic Chemistry, Bd. 15: S. 2085-2091

Krogsaeter, Einar K.; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian (2019): The protein interaction networks of mucolipins and two-pore channels. In: Biochimica et Biophysica Acta-Molecular Cell Research, Bd. 1866, Nr. 7: S. 1111-1123

Kuhn, Jasmin; Klein, Philipp M.; Danaf, Nader al; Nordin, Joel Z.; Reinhard, Sören; Loy, Dominik M.; Höhn, Miriam; Andaloussi, Samir el; Lamb, Don C.; Wagner, Ernst; Aoki, Yoshitsugu; Lehto, Taavi und Lächelt, Ulrich (2019): Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles. In: Advanced Functional Materials, Bd. 29, Nr. 48, 1906432 [PDF, 1MB]

Lainez, Sergio; Tsantoulas, Christoforos; Biel, Martin und McNaughton, Peter A. (2019): HCN3 ion channels: roles in sensory neuronal excitability and pain. In: Journal of Physiology-London, Bd. 597, Nr. 17: S. 4661-4675

Ljepoja, Bojan; Schreiber, Christoph; Gegenfurtner, Florian A.; Garcia-Roman, Jonathan; Köhler, Bianca; Zahler, Stefan; Rädler, Joachim O.; Wagner, Ernst und Roidl, Andreas (2019): Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A.
In: PLOS One 14(11), e0224314 [PDF, 2MB]

Ljepoja, Bojan; Garcia-Roman, Jonathan; Sommer, Ann-Katrin; Wagner, Ernst und Roidl, Andreas (2019): MiRNA-27a sensitizes breast cancer cells to treatment with Selective Estrogen Receptor Modulators. In: Breast, Bd. 43: S. 31-38

Lohrer, Bernhard und Bracher, Franz (2019): Novel access to 2-substituted quinolin-4-ones by nickel boride-mediated reductive ring transformation of 5-(2-nitrophenyl)isoxazoles. In: Tetrahedron Letters, Bd. 60, Nr. 51, 151327

Luo, Jie; Hoehn, Miriam; Reinhard, Soeren; Loy, Dominik M.; Klein, Philipp Michael und Wagner, Ernst (2019): IL4-Receptor-Targeted Dual Antitumoral Apoptotic Peptide-siRNA Conjugate Lipoplexes. In: Advanced Functional Materials, Bd. 29, Nr. 25, 1900697

Mastrella, Giorgia; Hou, Mengzhuo; Li, Min; Stöcklein, Veit M.; Zdouc, Nina; Vomar, Marie N. M.; Miletic, Hrvoje; Reinhard, Soeren; Herold-Mende, Christel C.; Kleber, Susanne; Eisenhut, Katharina; Gargiulo, Gaetano; Synowitz, Michael; Vescovi, Angelo L.; Harter, Patrick N.; Penninger, Josef M.; Wagner, Ernst; Mittelbronn, Michel; Bjerkvig, Rolf; Hambardzumyan, Dolores; Schueller, Ulrich; Tonn, Jörg-Christian; Radke, Josefine; Glass, Rainer und Kaelin, Roland E. (2019): Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma. In: Cancer Research, Bd. 79, Nr. 9: S. 2298-2313

Mazzier, Daniela; De, Soumen; Wicher, Barbara; Maurizot, Victor und Huc, Ivan (2019): Interplay of secondary and tertiary folding in abiotic foldamers. In: Chemical Science, Bd. 10, Nr. 29: S. 6984-6991

Mehta, Aditi; Vedove, Elena Dalle; Isert, Lorenz und Merkel, Olivia M. (2019): Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles. In: Pharmaceutical Research, Bd. 36, Nr. 9, UNSP 133

Meinhold, Sarah; Bauer, Daniela; Huber, Jonas; Merkel, Ulrich; Weissl, Andreas; Zoldak, Gabriel und Rief, Matthias (2019): An Active, Ligand-Responsive Pulling Geometry Reports on Internal Signaling between Subdomains of the DnaK Nucleotide-Binding Domain in Single-Molecule Mechanical Experiments. In: Biochemistry, Bd. 58, Nr. 47: S. 4744-4750

Melzer, Benedikt C.; Plodek, Alois und Bracher, Franz (2019): Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogues of pyridoacridine alkaloids. In: Beilstein Journal of Organic Chemistry, Bd. 15: S. 2304-2310

Moser, Simone und Kraeutler, Bernhard (2019): In Search of Bioactivity - Phyllobilins, an Unexplored Class of Abundant Heterocyclic Plant Metabolites from Breakdown of Chlorophyll. In: Israel Journal of Chemistry, Bd. 59, Nr. 5: S. 420-431

Müller, Christoph; Junker, Julia; Bracher, Franz und Giera, Martin (2019): A gas chromatography-mass spectrometry-based whole-cell screening assay for target identification in distal cholesterol biosynthesis. In: Nature Protocols, Bd. 14, Nr. 8: S. 2546-2570

Müller, Christoph; Wagner, Antonie L.; Rockinger, Ute; Winter, Gerhard und Bracher, Franz (2019): Development of a convenient method for the determination of dimethyl sulfoxide in lyophilised pharmaceuticals by static headspace gas chromatography-mass spectrometry. In: Analytical Methods, Bd. 11, Nr. 16: S. 2119-2122

Pallauf, Kathrin; Chin, Dawn; Guenther, Ilka; Birringer, Marc; Lueerseni, Kai; Schultheiss, Gerald; Vieten, Sarah; Krauss, Jürgen; Bracher, Franz; Danylec, Nicolas; Soukup, Sebastian T.; Kulling, Sabine E. und Rimbach, Gerald (2019): Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice. In: Scientific Reports, Bd. 9, 4445 [PDF, 1MB]

Pavlou, M.; Shah, M.; Gikas, P.; Briggs, T.; Roberts, S. J. und Cheema, U. (2019): Osteomimetic matrix components alter cell migration and drug response in a 3D tumour-engineered osteosarcoma model. In: Acta Biomaterialia, Bd. 96: S. 247-257

Peng, Lun und Wagner, Ernst (2019): Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions. In: Biomacromolecules, Bd. 20, Nr. 10: S. 3613-3626

Petersen-Jones, Simon M.; Occelli, Laurence M.; Biel, Martin und Michalakis, Stylianos (2019): Advancing Gene Therapy for PDE6A Retinitis Pigmentosa. In: Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, Bd. 1185: S. 103-107

Pfitzer, Lisa; Moser, Christina; Gegenfurtner, Florian; Arner, Anja; Foerster, Florian; Atzberger, Carina; Zisis, Themistoklis; Kubisch-Dohmen, Rebekka; Busse, Johanna; Smith, Rebecca; Timinszky, Gyula; Kalinina, Olga V.; Müller, Rolf; Wagner, Ernst; Vollmar, Angelika M. und Zahler, Stefan (2019): Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy. In: Cell Death & Disease, Bd. 10, UNSP 302

Reddy, Post Sai; d'Estaintot, Beatrice Langlois; Granier, Thierry; Mackereth, Cameron D.; Fischer, Lucile und Huc, Ivan (2019): Structure Elucidation of Helical Aromatic Foldamer-Protein Complexes with Large Contact Surface Areas. In: Chemistry-A European Journal, Bd. 25, Nr. 47: S. 11042-11047

Rodrigues, Leticia; Schneider, Fabian; Zhang, Xiaohan; Larsson, Elin; Moodie, Lindon W. K.; Dietz, Hendrik; Papadakis, Christine M.; Winter, Gerhard; Lundmark, Richard und Hubert, Madlen (2019): Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries. In: Journal of Colloid and Interface Science, Bd. 553: S. 820-833

Rubio, Karla; Singh, Indrabahadur; Dobersch, Stephanie; Sarvari, Pouya; Guenther, Stefan; Cordero, Julio; Mehta, Aditi; Wujak, Lukasz; Cabrera-Fuentes, Hector; Chao, Cho-Ming; Braubach, Peter; Bellusci, Saverio; Seeger, Werner; Guenther, Andreas; Preissner, Klaus T.; Wygrecka, Malgorzata; Savai, Rajkumar; Papy-Garcia, Dulce; Dobreva, Gergana; Heikenwalder, Mathias; Savai-Pullamsetti, Soni; Braun, Thomas und Barreto, Guillermo (2019): Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. In: Nature Communications, Bd. 10, 2229 [PDF, 3MB]

Rudy, Heinrich-Karl A. und Wanner, Klaus T. (2019): Accessing Tricyclic Imines Comprising a 2-Azabicyclo[2.2.2]octane Scaffold by Intramolecular Hetero-Diels-Alder Reaction of 4-Alkenyl-Substituted N-Silyl-1,4-dihydropyridines. In: Synthesis-Stuttgart, Bd. 51, Nr. 22: S. 4296-4310

Sailer, Alexander; Ermer, Franziska; Kraus, Yvonne; Lutter, Ferdinand H.; Donau, Carsten; Bremerich, Maximilian; Ahlfeld, Julia und Thorn-Seshold, Oliver (2019): Hemithioindigos for Cellular Photopharmacology: Desymmetrised Molecular Switch Scaffolds Enabling Design Control over the Isomer-Dependency of Potent Antimitotic Bioactivity. In: Chembiochem, Bd. 20, Nr. 10: S. 1305-1314

Santos-Ferreira, Tiago; Herbig, Maik; Otto, Oliver; Carido, Madalena; Karl, Mike O.; Michalakis, Stylianos; Guck, Jochen und Ader, Marius (2019): Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry. In: Cytometry Part A, Bd. 95, Nr. 11: S. 1145-1157

Schaarschmidt, Maren; Hoefner, Georg und Wanner, Klaus T. (2019): Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3-Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1. In: Chemmedchem, Bd. 14, Nr. 12: S. 1135-1151

Schepmann, Dirk; Neue, Christina; Westphaelinger, Stefanie; Müller, Christoph; Bracher, Franz; Lange, Carsten; Bednarski, Patrick; Almansa, Carmen; Friedland, Kristina; Raebiger, Vivien; Duefer, Martina und Wuensch, Bernhard (2019): Pharmacological characterization of high-affinity sigma(1) receptor ligands with spirocyclic thienopyran and thienofuran scaffold. In: Journal of Pharmacy and Pharmacology, Bd. 72, Nr. 2: S. 236-248

Scherer, Nicole; Marcsekova, Klaudia; Posset, Tobias und Winter, Gerhard (2019): New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics. In: International Journal of Pharmaceutics, Bd. 555: S. 404-419

Schnitzler, Lukas G.; Junger, Stefanie; Loy, Dominik M.; Wagner, Ernst; Wixforth, Achim; Hoerner, Andreas; Laechelt, Ulrich und Westerhausen, Christoph (2019): Size tunable nanoparticle formation employing droplet fusion by acoustic streaming applied to polyplexes. In: Journal of Physics D-Applied Physics, Bd. 52, Nr. 24, 244002

Schug, Christina; Kitzberger, Carolin; Sievert, Wolfgang; Spellerberg, Rebekka; Tutter, Mariella; Schmohl, Kathrin A.; Eberlein, Bernadette; Biedermann, Tilo; Steiger, Katja; Zach, Christian; Schwaiger, Markus; Multhoff, Gabriele; Wagner, Ernst; Nelson, Peter J. und Spitzweg, Christine (2019): Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell-Mediated Sodium Iodide Symporter (NIS) Gene I-131 Therapy. In: Clinical Cancer Research, Bd. 25, Nr. 19: S. 5997-6008

Schug, Christina; Urnauer, Sarah; Jaeckel, Carsten; Schmohl, Kathrin A.; Tutter, Mariella; Steiger, Katja; Schwenk, Nathalie; Schwaiger, Markus; Wagner, Ernst; Nelson, Peter J. und Spitzweg, Christine (2019): TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer. In: Endocrine-Related Cancer, Bd. 26, Nr. 1: S. 89-101

Siepmann, Jürgen; Faham, Amina; Clas, Sophie-Dorothee; Boyd, Ben J.; Jannin, Vincent; Bernkop-Schnuerch, Andreas; Zhao, Hang; Lecommandoux, Sebastien; Evans, James C.; Allen, Christine; Merkel, Olivia M.; Costabile, Gabriella; Alexander, Morgan R.; Wildman, Ricky D.; Roberts, Clive J. und Leroux, Jean-Christophe (2019): Lipids and polymers in pharmaceutical technology: Lifelong companions. In: International Journal of Pharmaceutics, Bd. 558: S. 128-142

Sommer, Ann-Katrin; Falcenberg, Mathias; Ljepoja, Bojan; Fröhlich, Thomas; Arnold, Georg J.; Wagner, Ernst und Roidl, Andreas (2019): Downregulation of GRK5 hampers the migration of breast cancer cells. In: Scientific Reports, Bd. 9, 15548 [PDF, 5MB]

Steinborn, Benjamin; Hirschle, Patrick; Höhn, Miriam; Bauer, Tobias; Barz, Matthias; Wuttke, Stefan; Wagner, Ernst und Lächelt, Ulrich (2019): Core‐Shell Functionalized Zirconium‐Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content. In: Advanced Therapeutics, Bd. 2, Nr. 11 [PDF, 7MB]

Stieglitz, David; Lamm, Susanne; Braig, Simone; Feuerer, Lena; Kuphal, Silke; Dietrich, Peter; Arndt, Stephanie; Echtenacher, Bernd; Hellerbrand, Claus; Karrer, Sigrid und Bosserhoff, Anja-Katrin (2019): BMP6-induced modulation of the tumor micro-milieu. In: Oncogene, Bd. 38, Nr. 5: S. 609-621

Stoeckelhuber, Markus; Pluym, Nikola; Bracher, Franz; Leibold, Edgar; Scherer, Gerhard und Scherer, Max (2019): A validated UPLC-MS/MS method for the determination of urinary metabolites of Uvinul (R) A plus. In: Analytical and Bioanalytical Chemistry, Bd. 411, Nr. 30: S. 8143-8152

Svilenov, Hristo ORCID logoORCID: https://orcid.org/0000-0001-5863-9569 und Winter, Gerhard (1. Mai 2019): Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations Is there a correlation? In: International Journal of Pharmaceutics, Bd. 562: S. 42-50 [PDF, 1MB]

Svilenov, Hristo ORCID logoORCID: https://orcid.org/0000-0001-5863-9569 und Winter, Gerhard (April 2019): The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 137: S. 131-139 [PDF, 2MB]

Tobias, Peters; Philipp, Seitz Immanuel; Stylianos, Michalakis; Martin, Biel; Barbara, Wilhelm; Felix, Reichel; Alexander, Ochakovski Guy; Eberhart, Zrenner; Marius, Ueffing; Birgit, Korbmacher; Sven, Korte; Ulrich, Bartz-Schmidt Karl; Dominik, Fischer Manuel; Bartz-Schmidt, Karl Ulrich; Bolz, Sylvia; Fischer, Dominik; Kohl, Susanne; Kuehlewein, Laura; Muehlfriedel, Regine; Neubauer, Jonas; Ochakovski, Alex; Paquet-Durand, Francois; Seeliger, Mathias; Sothilingam, Vithiyanjali; Ueffing, Marius; Weisschuh, Nicole; Wissinger, Bernd; Zhour, Ahmad; Zobor, Ditta; Zrenner, Eberhart; Biel, Martin; Michalakis, Stylianos; Schön, Christian; Kahle, Nadine; Peters, Tobias; Wilhelm, Barbara; Tsang, Steven und Gloeckner, Christian Johannes (2019): Safety and Toxicology of Ocular Gene Therapy with Recombinant AAV Vector rAAV.hCNGA3 in Nonhuman Primates. In: Human Gene Therapy Clinical Development, Bd. 30, Nr. 2: S. 50-56

Tosstorff, Andreas ORCID logoORCID: https://orcid.org/0000-0002-4969-3667; Svilenov, Hristo ORCID logoORCID: https://orcid.org/0000-0001-5863-9569; Peters, Günther H. J.; Harris, Pernille und Winter, Gerhard ORCID logoORCID: https://orcid.org/0000-0002-7413-6627 (12. September 2019): Structure-based Discovery of a new Protein-Aggregation Breaking Excipient. In: European Journal of Pharmaceutics and Biopharmaceutics [HTML, 1MB]

Toth, Krisztian; Hoefner, Georg und Wanner, Klaus T. (2019): Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors. In: Bioorganic & Medicinal Chemistry, Bd. 27, Nr. 5: S. 822-831

Truebenbach, Ines; Kern, Sarah; Loy, Dominik M.; Hoehn, Miriam; Gorges, Jan; Kazmaier, Uli und Wagner, Ernst (2019): Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles. In: Molecular Pharmaceutics, Bd. 16, Nr. 6: S. 2405-2417

Truebenbach, Ines; Zhang, Wei; Wang, Yanfang; Kern, Sarah; Hoehn, Miriam; Reinhard, Soeren; Gorges, Jan; Kazmaier, Uli und Wagner, Ernst (2019): Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells. In: International Journal of Pharmaceutics, Bd. 569, 118570

Tsiamantas, Christos; Kwon, Sunbum; Douat, Celine; Huc, Ivan und Suga, Hiroaki (2019): Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation. In: Chemical Communications, Bd. 55, Nr. 51: S. 7366-7369

Urnauer, Sarah; Schmohl, Kathrin A.; Tutter, Mariella; Schug, Christina; Schwenk, Nathalie; Morys, Stephan; Ziegler, Sibylle; Bartenstein, Peter; Clevert, Dirk-Andre; Wagner, Ernst und Spitzweg, Christine (2019): Dual-targeted NIS polyplexes-a theranostic strategy toward tumors with heterogeneous receptor expression. In: Gene Therapy, Bd. 26, Nr. 3-4: S. 93-108

Vallade, MaeIle; Jewginski, Michal; Fischer, Lucile; Buratto, Jeremie; Bathany, Katell; Schmitter, Jean-Marie; Stupfel, Marine; Godde, Frederic; Mackereth, Cameron D. und Huc, Ivan (2019): Assessing Interactions between Helical Aromatic Oligoamide Foldamers and Protein Surfaces: A Tethering Approach. In: Bioconjugate Chemistry, Bd. 30, Nr. 1: S. 54-62

Voegerl, Katharina; Ong, Nghia; Senger, Johanna; Herp, Daniel; Schmidtkunz, Karin; Marek, Martin; Müller, Martin; Bartel, Karin; Shaik, Tajith B.; Porter, Nicholas J.; Robaa, Dina; Christianson, David W.; Romier, Christophe; Sippl, Wolfgang; Jung, Manfred und Bracher, Franz (2019): Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors. In: Journal of Medicinal Chemistry, Bd. 62, Nr. 3: S. 1138-1166

Vollrath, Ilona; Friess, Wolfgang; Freitag, Angelika; Hawe, Andrea und Winter, Gerhard (2019): Comparison of ice fog methods and monitoring of controlled nucleation success after freeze-drying. In: International Journal of Pharmaceutics, Bd. 558: S. 18-28

Wang, Shuaijun; Crevenna, Alvaro H.; Ugur, Ilke; Marion, Antoine; Antes, Iris; Kazmaier, Uli; Hoyer, Maria; Lamb, Don C.; Gegenfurtner, Florian; Kliesmetes, Zane; Ziegenhain, Christoph; Enard, Wolfgang; Vollmar, Angelika und Zahler, Stefan (2019): Actin stabilizing compounds show specific biological effects due to their binding mode. In: Scientific Reports, Bd. 9, 9731 [PDF, 5MB]

Wang, Shuaijun; Gegenfurtner, Florian A.; Crevenna, Alvaro H.; Ziegenhain, Christoph; Kliesmete, Zane; Enard, Wolfgang; Müller, Rolf; Vollmar, Angelika M.; Schneider, Sabine und Zahler, Stefan (2019): Chivosazole A Modulates Protein Protein Interactions of Actin. In: Journal of Natural Products, Bd. 82, Nr. 7: S. 1961-1970

Wang, Xiang; Gan, Quan; Wicher, Barbara; Ferrand, Yann und Huc, Ivan (2019): Directional Threading and Sliding of a Dissymmetrical Foldamer Helix on Dissymmetrical Axles. In: Angewandte Chemie-International Edition, Bd. 58, Nr. 13: S. 4205-4209

Wang, Yanfang; Xin, Shan; Zhang, Kai; Shi, Run und Bao, Xuanwen (2019): Low GAS5 Levels as a Predictor of Poor Survival in Patients with Lower-Grade Gliomas. In: Journal of Oncology, Bd. 2019, 1785042 [PDF, 9MB]

Wang, Yanfang; Zhang, Quanli; Gao, Zhaojia; Xin, Shan; Zhao, Yando; Zhang, Kai; Shi, Run und Bao, Xuanwen (2019): A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis. In: Cancer Cell International, Bd. 19, 100

Wein, Thomas; Wanner, Klaus T.; Rappenglueck, Sebastian; Sichler, Sonja; Niessen, Karin; Seeger, Thomas; Worek, Franz und Thiermann, Horst (2019): New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling. In: Current Computer-Aided Drug Design, Bd. 15, Nr. 1: S. 104-109

Weippert, Valentin und Johrendt, Dirk (2019): High-pressure synthesis and crystal structure of SrGa4As4. In: Acta Crystallographica Section E-Crystallographic Communications, Bd. 75

Werner, Benjamin Patrick; Schoneich, Christian und Winter, Gerhard (2019): Silicone Oil-Free Polymer Syringes for the Storage of Therapeutic Proteins. In: Journal of Pharmaceutical Sciences, Bd. 108, Nr. 3: S. 1148-1160

Yoneda, Saki; Niederleitner, Bertram; Wiggenhorn, Michael; Koga, Hiroki; Totoki, Shinichiro; Krayukhina, Elena; Friess, Wolfgang und Uchiyama, Susumu (2019): Quantitative Laser Diffraction for Quantification of Protein Aggregates: Comparison With Resonant Mass Measurement, Nanoparticle Tracking Analysis, Flow Imaging, and Light Obscuration. In: Journal of Pharmaceutical Sciences, Bd. 108, Nr. 1: S. 755-762

2018

Andima, Moses; Costabile, Gabriella; Isert, Lorenz; Ndakala, Albert J.; Derese, Solomon und Merkel, Olivia M. (2018): Evaluation of beta-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity. In: Pharmaceutics, Bd. 10, Nr. 4, 232 [PDF, 3MB]

Berger, Karin; Schopohl, Dorothee; Bollig, Antonia; Strobach, Dorothea; Rieger, Christina; Rublee, Dale und Ostermann, Helmut (2018): Burden of Oral Mucositis: A Systematic Review and Implications for Future Research. In: Oncology Research and Treatment, Bd. 41, Nr. 6: S. 399-405

Blank, Thomas; Goldmann, Tobias; Koch, Mirja; Amann, Lukas; Schön, Christian; Bonin, Michael; Pang, Shengru; Prinz, Marco; Burnet, Michael; Wagner, Johanna E.; Biel, Martin und Michalakis, Stylianos (2018): Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa. In: Frontiers in Immunology, Bd. 8, 1930 [PDF, 7MB]

Bracher, Franz ORCID logoORCID: https://orcid.org/0000-0003-0009-8629 (2018): Methods for Arylethylation of Amines and Heteroarenes. In: Synopen, Bd. 2, Nr. 2: S. 96-104 [PDF, 2MB]

Braig, Simone (2018): Chemical genetics in tumor lipogenesis. In: Biotechnology Advances, Bd. 36, Nr. 6: S. 1724-1729

Burkard, Markus; Kohl, Susanne; Kratzig, Timm; Tanimoto, Naoyuki; Brennenstuhl, Christina; Bausch, Anne E.; Junger, Katrin; Reuter, Peggy; Sothilingam, Vithiyanjali; Beck, Susanne C.; Huber, Gesine; Ding, Xi-Qin; Mayer, Anja K.; Baumann, Britta; Weisschuh, Nicole; Zobor, Ditta; Hahn, Gesa-Astrid; Kellner, Ulrich; Venturelli, Sascha; Becirovic, Elvir; Charbel Issa, Peter; Koenekoop, Robert K.; Rudolph, Gunther; Heckenlively, John; Sieving, Paul; Weleber, Richard G.; Hamel, Christian; Zong, Xiangang; Biel, Martin; Lukowski, Robert; Seeliger, Matthias W.; Michalakis, Stylianos; Wissinger, Bernd und Ruth, Peter (2018): Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy. In: The Journal of Clinical Investigation, Bd. 128, Nr. 12: S. 5663-5675

Chatzopoulou, E. I.; Raharja-Liu, P.; Murschhauser, A.; Sekhavati, F.; Buggenthin, F.; Vollmar, A. M.; Marr, C. und Rädler, Joachim O. (2018): A single-cell micro-trench platform for automatic monitoring of cell division and apoptosis after chemotherapeutic drug administration. In: Scientific Reports, Bd. 8, 18042 [PDF, 1MB]

Costabile, Gabriella; Gasteyer, Kathrin I.; Nadithe, Venkatereddy; Denburgh, Katherine van; Lin, Qian; Sharma, Shiv; Reineke, Joshua J.; Firestine, Steven M. und Merkel, Olivia M. (2018): Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles. In: Aaps Pharmscitech, Bd. 19, Nr. 8: S. 3561-3570

Deglmann, Claus J.; Blazkow-Schmalzbauer, Katarzyna; Moorkamp, Sarah; Wallmichrath, Jens; Giunta, Riccardo E.; Rogach, Andrey L.; Wagner, Ernst; Baumeister, Rüdiger G. und Ogris, Manfred (2018): In vivo tracking of adipose tissue grafts with cadmium-tel-luride quantum dots. In: Archives of Plastic Surgery-Aps, Bd. 45, Nr. 2: S. 111-117 [PDF, 1MB]

Dileep, Kalarickal V.; Remya, Chandran; Tintu, Ignatius; Mandal, Pradeep K.; Karthe, Ponnuraj; Haridas, Madathilkovilakathu und Sadasivan, Chittalakkottu (2018): Crystal structure of phospholipase A(2) in complex with 1-naphthaleneacetic acid. In: Iubmb Life, Bd. 70, Nr. 10: S. 995-1001

Engelke, Laura; Winter, Gerhard und Engert, Julia (2018): Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 128: S. 119-130

Engert, Julia; Anamur, Cihad; Engelke, Laura; Fellner, Christian; Lell, Peter; Henke, Stefan; Stadler, Julia; Zoels, Susanne; Ritzmann, Mathias und Winter, Gerhard (2018): A pilot study using a novel pyrotechnically driven prototype applicator for epidermal powder immunization in piglets. In: International Journal of Pharmaceutics, Bd. 545, Nr. 1-2: S. 215-228

Falk, Nathalie; Kessler, Kristin; Schramm, Sinja-Fee; Boldt, Karsten; Becirovic, Elvir; Michalakis, Stylianos; Regus-Leidig, Hanna; Noegel, Angelika A.; Ueffing, Marius; Thiel, Christian T.; Roepman, Ronald; Brandstaetter, Johann Helmut und Giessl, Andreas (2018): Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis. In: Journal of Cell Science, Bd. 131, Nr. 16

Feldmann, Daniel P.; Cheng, Yilong; Kandil, Rima; Xie, Yuran; Mohammadi, Mariam; Harz, Hartmann; Sharma, Akhil; Peeler, David J.; Moszczynska, Anna; Leonhardt, Heinrich; Pun, Suzie H. und Merkel, Olivia M. (2018): In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. In: Journal of Controlled Release, Bd. 276: S. 50-58

Ferrand, Yann und Huc, Ivan (2018): Designing Helical Molecular Capsules Based on Folded Aromatic Amide Oligomers. In: Accounts of Chemical Research, Bd. 51, Nr. 4: S. 970-977

Gegenfurtner, Florian A.; Jahn, Berenice; Wagner, Helga; Ziegenhain, Christoph; Enard, Wolfgang; Geistlinger, Ludwig; Rädler, Joachim O.; Vollmar, Angelika M. und Zahler, Stefan (2018): Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing. In: Journal of Cell Science, Bd. 131, Nr. 10

Gegenfurtner, Florian A.; Zisis, Themistoklis; Al Danaf, Nader; Schrimpf, Waldemar; Kliesmete, Zane; Ziegenhain, Christoph; Enard, Wolfgang; Kazmaier, Uli; Lamb, Don C.; Vollmar, Angelika M. und Zahler, Stefan (2018): Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone. In: Cellular and Molecular Life Sciences, Bd. 75, Nr. 24: S. 4539-4555

Geh, Katharina J.; Hubert, Madlen und Winter, Gerhard (2018): Progress in formulation development and sterilisation of freeze-dried oligodeoxynucleotide-loaded gelatine nanoparticles. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 129: S. 10-20

Gemechu, Jickssa M.; Sharma, Akhil; Yu, Dongyue; Xie, Yuran; Merkel, Olivia M. und Moszczynska, Anna (2018): Characterization of Dopaminergic System in the Striatum of Young Adult Park2(-/-) Knockout Rats. In: Scientific Reports, Bd. 8, 1517 [PDF, 2MB]

Gitter, Julian H.; Geidobler, Raimund; Presser, Ingo und Winter, Gerhard (2018): A Comparison of Controlled Ice Nucleation Techniques for Freeze-Drying of a Therapeutic Antibody. In: Journal of Pharmaceutical Sciences, Bd. 107, Nr. 11: S. 2748-2754

Gitter, Julian H.; Geidobler, Raimund; Presser, Ingo und Winter, Gerhard (2018): Significant Drying Time Reduction Using Microwave- Assisted Freeze- Drying for a Monoclonal Antibody. In: Journal of Pharmaceutical Sciences, Bd. 107, Nr. 10: S. 2538-2543

Gronauer, Thomas F.; Mandl, Melanie M.; Lakemeyer, Markus; Hackl, Mathias W.; Messner, Martina; Korotkov, Vadim S.; Pachmayr, Johanna und Sieber, Stephan A. (2018): Design and synthesis of tailored human caseinolytic protease P inhibitors. In: Chemical Communications, Bd. 54, Nr. 70: S. 9833-9836

Haeuser, Christina; Goldbach, Pierre; Huwyler, Jörg; Friess, Wolfgang und Allmendinger, Andrea (2018): Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products. In: Journal of Pharmaceutical Sciences, Bd. 107, Nr. 11: S. 2810-2822

Hager, Simone und Wagner, Ernst (2018): Bioresponsive polyplexes - chemically programmed for nucleic acid delivery. In: Expert Opinion on Drug Delivery, Bd. 15, Nr. 11: S. 1067-1083

Hauke, Tobias J.; Wein, Thomas; Hofner, Georg und Wanner, Klaus T. (2018): Novel Allosteric Ligands of gamma-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries. In: Journal of Medicinal Chemistry, Bd. 61, Nr. 22: S. 10310-10332

Hirschberger, Kristin; Jarzebinska, Anita; Kessel, Eva; Kretzschmann, Verena; Aneja, Manish K.; Dohmen, Christian; Herrmann-Janson, Annika; Wagner, Ernst; Plank, Christian und Rudolph, Carsten (2018): Exploring Cytotoxic mRNAs as a Novel Class of Anti-cancer Biotherapeutics. In: Molecular Therapy-Methods & Clinical Development, Bd. 8: S. 141-151 [PDF, 1MB]

Horn, Jacqueline und Friess, Wolfgang (2018): Detection of Collapse and Crystallization of Saccharide, Protein, and Mannitol Formulations by Optical Fibers in Lyophilization. In: Frontiers in Chemistry, Bd. 6, 4 [PDF, 1MB]

Horn, Jacqueline; Schanda, Julia und Friess, Wolfgang (2018): Impact of fast and conservative freeze-drying on product quality of protein-mannitol-sucrose-glycerol lyophilizates. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 127: S. 342-354

Horn, Jacqueline; Tolardo, Eleonora; Fissore, Davide und Friess, Wolfgang (2018): Crystallizing amino acids as bulking agents in freeze-drying. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 132: S. 70-82

Huber, Simone K.; Höfner, Georg und Wanner, Klaus T. (2018): Identification of Pyrrolidine-3-acetic Acid Derived Oximes as Potent Inhibitors of gamma-Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays. In: Chemmedchem, Bd. 13, Nr. 23: S. 2488-2503

Hubler, Zita; Allimuthu, Dharmaraja; Bederman, Ilya; Elitt, Matthew S.; Madhavan, Mayur; Allan, Kevin C.; Shick, H. Elizabeth; Garrison, Eric; Karl, Molly T.; Factor, Daniel C.; Nevin, Zachary S.; Sax, Joel L.; Thompson, Matthew A.; Fedorov, Yuriy; Jin, Jing; Wilson, William K.; Giera, Martin; Bracher, Franz; Miller, Robert H.; Tesar, Paul J. und Adams, Drew J. (2018): Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. In: Nature, Bd. 560, Nr. 7718: S. 372-376

Jones, Steven K.; Douglas, Kirk; Shields, Anthony F. und Merkel, Olivia M. (2018): Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model. In: Biomaterials, Bd. 178: S. 183-192

Kappler, Sarah; Karmann, Lisa; Prudel, Cynthia; Herrmann, Jennifer; Caddeu, Giulia; Müller, Rolf; Vollmar, Angelika M.; Zahler, Stefan und Kazmaier, Uli (2018): Synthesis and Biological Evaluation of Modified Miuraenamides. In: European Journal of Organic Chemistry, Nr. 48: S. 6952-6965

Kiesel, Esther Katharina; Hopf, Yvonne Marina und Drey, Michael (2018): An anticholinergic burden score for German prescribers: score development. In: BMC Geriatrics 18:239 [PDF, 1MB]

Klein, D.; Kessler, W.; Pütz, C.; Semder, B.; Kirchinger, W.; Langsch, A.; Gries, W.; Otter, R.; Gallien, A. K. E.; Wurzenberger, X. und Filser, J. G. (2018): Single ingestion of di-(2-propylheptyl) phthalate (DPHP) by male volunteers: DPHP in blood and its metabolites in blood and urine. In: Toxicology Letters, Bd. 294: S. 105-115

Klein, Philipp Michael; Kern, Sarah; Lee, Dian-Jang; Schmaus, Johannes; Hoehn, Miriam; Gorges, Jan; Kazmaier, Uli und Wagner, Ernst (2018): Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo. In: Biomaterials, Bd. 178: S. 630-642

Klein, Philipp Michael; Klinker, Kristina; Zhang, Wei; Kern, Sarah; Kessel, Eva; Wagner, Ernst und Barz, Matthias (2018): Efficient Shielding of Polyplexes Using Heterotelechelic Polysarcosines. In: Polymers, Bd. 10, Nr. 6, 689 [PDF, 2MB]

Klier, John; Geis, Sabine; Steuer, Jeanette; Geh, Katharina; Reese, Sven; Fuchs, Sebastian; Müller, Ralf S.; Winter, Gerhard und Gehlen, Heidrun (2018): A comparison of nanoparticullate CpG immunotherapy with and without allergens in spontaneously equine asthma-affected horses, an animal model. In: Immunity Inflammation and Disease, Bd. 6, Nr. 1: S. 81-96

Koepf, Ellen; Eisele, Simon; Schröder, Rudolf; Brezesinski, Gerald und Friess, Wolfgang (2018): Notorious but not understood: How liquid-air interfacial stress triggers protein aggregation. In: International Journal of Pharmaceutics, Bd. 537, Nr. 1-2: S. 202-212

Koepf, Ellen; Richert, Manuela; Braunschweig, Björn; Schröder, Rudolf; Brezesinski, Gerald und Friess, Wolfgang (2018): Impact of formulation pH on physicochemical protein characteristics at the liquid-air interface. In: International Journal of Pharmaceutics, Bd. 541, Nr. 1-2: S. 234-245

Koepf, Ellen; Schröder, Rudolf; Brezesinski, Gerald und Friess, Wolfgang (2018): The missing piece in the puzzle: Prediction of aggregation via the protein-protein interaction parameter A(2)*. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 128: S. 200-209

Krauß, Jürgen und Bracher, Franz (2018): Pharmacokinetic Enhancers (Boosters)-Escort for Drugs against Degrading Enzymes and Beyond. In: Scientia Pharmaceutica, Bd. 86, Nr. 4 [PDF, 8MB]

Lachenmayr, Sarah J.; Berking, Sophie; Horns, Heidi; Strobach, Dorothea; Ostermann, Helmut und Berger, Karin (2018): Antifungal treatment in haematological and oncological patients: Need for quality assessment in routine care. In: Mycoses, Bd. 61, Nr. 7: S. 464-471

Larkin, Caroline M.; Breen, Eamon P.; Tomaszewski, Krzysztof A.; Eisele, Simon; Radomski, Marek W.; Ryan, Thomas A. und Santos-Martinez, Maria-Jose (2018): Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology. In: Platelets, Bd. 29, Nr. 3: S. 301-304

Larkin, Caroline M.; Hante, Nadhim Kamil; Breen, Eamon P.; Tomaszewski, Krzysztof A.; Eisele, Simon; Radomski, Marek W.; Ryan, Thomas A. und Santos-Martinez, Maria-Jose (2018): Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia.
In: PLOS One 13(5), e0196478 [PDF, 3MB]

Lin, Hsiao-Chun Amy; Dean-Ben, Xose Luis; Reiss, Michael; Schöttle, Verena; Wahl-Schott, Christian A.; Efimov, Igor R. und Razansky, Daniel (2018): Ultrafast Volumetric Optoacoustic Imaging of Whole Isolated Beating Mouse Heart. In: Scientific Reports, Bd. 8, 14132 [PDF, 2MB]

Ljepoja, Bojan; Garcia-Roman, Jonathan; Sommer, Ann-Katrin; Frohlich, Thomas; Arnold, Georg J.; Wagner, Ernst und Roidl, Andreas (2018): A proteomic analysis of an in vitro knock-out of miR-200c. In: Scientific Reports, Bd. 8, 6927 [PDF, 3MB]

Lohrer, B. und Bracher, F. (2018): A convenient identification of carbamate-derived drug substances. In: Pharmazie, Bd. 73, Nr. 10: S. 555-558

Lohrer, Bernhard und Bracher, Franz (2018): A short and divergent route to 2-alkenyl-4-quinolones. In: Tetrahedron Letters, Bd. 59, Nr. 40: S. 3632-3635

Lucke, Matthias; Mottas, Ines; Herbst, Tina; Hotz, Christian; Roemer, Lin; Schierling, Martina; Herold, Heike M.; Slotta, Ute; Spinetti, Thibaud; Scheibel, Thomas; Winter, Gerhard; Bourquin, Carole und Engert, Julia (2018): Engineered hybrid spider silk particles as delivery system for peptide vaccines. In: Biomaterials, Bd. 172: S. 105-115

Lutz, Toni; Wein, Thomas; Höfner, Georg; Pabel, Jörg; Eder, Matthias; Dine, Julien und Wanner, Klaus T. (2018): Development of New Photoswitchable Azobenzene Based gamma-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation. In: Journal of Medicinal Chemistry, Bd. 61, Nr. 14: S. 6211-6235

Maiaru, Maria; Morgan, Oakley B.; Mao, Tianqi; Breitsamer, Michaela; Bamber, Harry; Poehlmann, Max; Schmidt, Mathias V.; Winter, Gerhard; Hausch, Felix und Geranton, Sandrine M. (2018): The stress regulator FKBP51: a novel and promising druggable target for the treatment of persistent pain states across sexes. In: Pain, Bd. 159, Nr. 7: S. 1224-1234

Mateus, Pedro; Wicher, Barbara; Ferrand, Yann und Huc, Ivan (2018): Carbohydrate binding through first- and second-sphere coordination within aromatic oligoamide metallofoldamers. In: Chemical Communications, Bd. 54, Nr. 40: S. 5078-5081

Mehta, Aditi und Barreto, Guillermo (2018): Non-invasive approaches for lung cancer diagnosis. In: Indian Journal of Thoracic and Cardiovascular Surgery, Bd. 34, Nr. Suppl. 1: S. 11-19

Melzer, Benedikt C.; Felber, Jan G. und Bracher, Franz (2018): Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines - a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline. In: Beilstein Journal of Organic Chemistry, Bd. 14: S. 130-134 [PDF, 261kB]

Moustakim, Moses; Riedel, Kerstin; Schuller, Marion; Gehring, Andre P.; Monteiro, Octovia P.; Martin, Sarah P.; Fedorov, Oleg; Heer, Jag; Dixon, Darren J.; Elkins, Jonathan M.; Knapp, Stefan; Bracher, Franz und Brennan, Paul E. (2018): Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. In: Bioorganic & Medicinal Chemistry, Bd. 26, Nr. 11: S. 2965-2972

Müller, Christoph; Neugebauer, Thomas; Zill, Patrizia; Lass-Floerl, Cornelia; Bracher, Franz und Binder, Ulrike (2018): Sterol Composition of Clinically Relevant Mucorales and Changes Resulting from Posaconazole Treatment. In: Molecules, Bd. 23, Nr. 5, 1218 [PDF, 1MB]

Neiens, Patrick; De Simone, Angela; Höfner, Georg und Wanner, Klaus T. (2018): Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters. In: Chemmedchem, Bd. 13, Nr. 5: S. 453-463

Neiens, Patrick; De Simone, Angela; Ramershoven, Anna; Höfner, Georg; Allmendinger, Lars und Wanner, Klaus T. (2018): Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET. In: Biomedical Chromatography, Bd. 32, Nr. 7, e4231

Niessen, K. V.; Seeger, T.; Rappenglück, S.; Wein, T.; Höfner, G.; Wanner, K. T.; Thiermann, H. und Worek, F. (2018): In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2-and 3-regioisomers. In: Toxicology Letters, Bd. 293: S. 190-197

Plesch, Eva; Chen, Cheng-Chang; Butz, Elisabeth; Rosato, Anna Scotto; Krogsaeter, Einar K.; Yinan, Hua; Bartel, Karin; Keller, Marco; Robaa, Dina; Teupser, Daniel; Holdt, Lesca M.; Vollmar, Angelika M.; Sippl, Wolfgang; Puertollano, Rosa; Medina, Diego; Biel, Martin; Wahl-Schott, Christian; Bracher, Franz und Grimm, Christian (2018): Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells. In: eLife, Bd. 7, e39720 [PDF, 4MB]

Pöhlmann, Max L.; Häusl, Alexander S.; Harbich, Daniela; Balsevich, Georgia; Engelhardt, Clara; Feng, Xixi; Breitsamer, Michaela; Hausch, Felix; Winter, Gerhard und Schmidt, Mathias V. (2018): Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs. In: Frontiers in Behavioral Neuroscience, Bd. 12, 262 [PDF, 1MB]

Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T. (2018): Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor. In: Chemmedchem, Bd. 13, Nr. 24: S. 2653-2663

Rappenglück, Sebastian; Sichler, Sonja; Höfner, Georg; Wein, Thomas; Niessen, Karin V.; Seeger, Thomas; Paintner, Franz F.; Worek, Franz; Thiermann, Horst und Wanner, Klaus T. (2018): Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor. In: Chemmedchem, Bd. 13, Nr. 17: S. 1806-1816

Rarova, Lucie; Sedlak, David; Oklestkova, Jana; Steigerova, Jana; Liebl, Johanna; Zahler, Stefan; Bartunek, Petr; Kolar, Zdenek; Kohout, Ladislav; Kvasnica, Miroslav und Strnad, Miroslav (2018): The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitro. In: Journal of Steroid Biochemistry and Molecular Biology, Bd. 178: S. 263-271

Reinhard, Sören; Wang, Yanfang; Dengler, Sebastian und Wagner, Ernst (2018): Precise Enzymatic Cleavage Sites for Improved Bioactivity of siRNA Lipo-Polyplexes. In: Bioconjugate Chemistry, Bd. 29, Nr. 11: S. 3649-3657

Riedmayr, Lisa Maria; Böhm, Sybille; Michalakis, Stylianos und Becirovic, Elvir (2018): Construction and Cloning of Minigenes for in vivo Analysis of Potential Splice Mutations. In: Bio-Protocol, Bd. 8, Nr. 5, e2760

Rodrigues, Leticia; Raftopoulos, Konstantinos N.; Schmidt, Signe Tandrup; Schneider, Fabian; Dietz, Hendrik; Rades, Thomas; Franzyk, Henrik; Pedersen, Anders Elm; Papadakis, Christine M.; Christensen, Dennis; Winter, Gerhard; Foged, Camilla und Hubert, Madlen (2018): Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein. In: Journal of Controlled Release, Bd. 285: S. 12-22

Rogers, Joseph M.; Kwon, Sunbum; Dawson, Simon J.; Mandal, Pradeep K.; Suga, Hiroaki und Huc, Ivan (2018): Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids. In: Nature Chemistry, Bd. 10, Nr. 4: S. 405-412

Saha, Subrata; Kauffmann, Brice; Ferrand, Yann und Huc, Ivan (2018): Selective Encapsulation of Disaccharide Xylobiose by an Aromatic Foldamer Helical Capsule. In: Angewandte Chemie-International Edition, Bd. 57, Nr. 41: S. 13542-13546

Saller, Verena; Hediger, Constanze; Matilainen, Julia; Grauschopf, Ulla; Bechtold-Peters, Karoline; Mahler, Hanns-Christian und Friess, Wolfgang (2018): Influence of particle shedding from silicone tubing on antibody stability. In: Journal of Pharmacy and Pharmacology, Bd. 70, Nr. 5: S. 675-685

Schargus, Marc; Werner, Benjamin P.; Geerling, Gerd und Winter, Gerhard ORCID logoORCID: https://orcid.org/0000-0002-7413-6627 (2018): Contamination of anti-vegf drugs for intravitreal injection. How Do Repackaging and Newly Developed Syringes Affect the Amount of Silicone Oil Droplets and Protein Aggregates? In: Retina-the Journal of Retinal and Vitreous Diseases, Bd. 38, Nr. 10: S. 2088-2095 [PDF, 307kB]

Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas (2018): Counteracting desensitization of human alpha 7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning. In: Toxicology Letters, Bd. 293: S. 149-156

Scheffel, Corinna; Niessen, Karin V.; Rappenglück, Sebastian; Wanner, Klaus. T.; Thiermann, Horst; Worek, Franz und Seeger, Thomas (2018): Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human alpha 7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. In: Toxicology Letters, Bd. 293: S. 157-166

Scherer, Nicole; Marcsekova, Klaudia; Posset, Tobias und Winter, Gerhard (2018): Evaluation of stir-bar sorptive extraction coupled with thermal desorption GC-MS for the detection of leachables from polymer single use systems to drugs. In: Journal of Pharmaceutical and Biomedical Analysis, Bd. 152: S. 66-73

Schug, Christina; Sievert, Wolfgang; Urnauer, Sarah; Müller, Andrea M.; Schmohl, Kathrin A.; Wechselberger, Alexandra; Schwenk, Nathalie; Lauber, Kirsten; Schwaiger, Markus; Multhoff, Gabriele; Wagner, Ernst; Nelson, Peter J. und Spitzweg, Christine (2018): External Beam Radiation Therapy Enhances Mesenchymal Stem Cell-Mediated Sodium-Iodide Symporter Gene Delivery. In: Human Gene Therapy, Bd. 29, Nr. 11: S. 1287-1300

Sichler, S.; Höfner, G.; Rappenglück, S.; Wein, T.; Niessen, V.; Seeger, T.; Worek, F.; Thiermann, H.; Paintner, F. und Wanner, K. T. (2018): Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor. In: Toxicology Letters, Bd. 293: S. 172-183

Singh, Amrita; Saha, Tanumoy; Begemann, Isabell; Ricker, Andrea; Nuesse, Harald; Thorn-Seshold, Oliver; Klingauf, Jürgen; Galic, Milos und Matis, Maja (2018): Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis. In: Nature Cell Biology, Bd. 20, Nr. 10: S. 1126-1133

Sommer, Ann-Katrin; Hermawan, Adam; Ljepoja, Bojan; Fröhlich, Thomas; Arnold, Georg J.; Wagner, Ernst und Roidl, Andreas (2018): A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF-7 breast cancer cells. In: International Journal of Molecular Medicine, Bd. 42, Nr. 4: S. 1987-1997

Steinborn, Benjamin; Truebenbach, Ines; Morys, Stephan; Laechelt, Ulrich; Wagner, Ernst und Zhang, Wei (2018): Epidermal growth factor receptor targeted methotrexate and small interfering RNA co-delivery. In: Journal of Gene Medicine, Bd. 20, Nr. 7-8, e3041

Stieglitz, Marc S.; Fenske, Stefanie; Hammelmann, Verena; Becirovic, Elvir; Schöttle, Verena; Delorme, James E.; Schöll-Weidinger, Martha; Mader, Robert; Deussing, Jan; Wolfer, David P.; Seeliger, Mathias W.; Albrecht, Urs; Wotjak, Carsten T.; Biel, Martin; Michalakis, Stylianos und Wahl-Schott, Christian (2018): Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice. In: Frontiers in Molecular Neuroscience, Bd. 10, 436 [PDF, 4MB]

Svilenov, Hristo ORCID logoORCID: https://orcid.org/0000-0001-5863-9569; Gentiluomo, Lorenzo; Friess, Wolfgang; Roessner, Dierk und Winter, Gerhard (Dezember 2018): A New Approach to Study the Physical Stability of Monoclonal Antibody Formulations Dilution From a Denaturant. In: Journal of Pharmaceutical Sciences, Bd. 107, Nr. 12: S. 3007-3013 [PDF, 1MB]

Svilenov, Hristo ORCID logoORCID: https://orcid.org/0000-0001-5863-9569; Markoja, Uros und Winter, Gerhard (April 2018): Isothermal chemical denaturation as a complementary tool to overcome limitations of thermal differential scanning fluorimetry in predicting physical stability of protein formulations. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 125: S. 106-113 [PDF, 1MB]

Thauvin, Cedric; Schwarz, Bettina; Delie, Florence und Allemann, Eric (2018): Functionalized PLA polymers to control loading and/or release properties of drug-loaded nanoparticles. In: International Journal of Pharmaceutics, Bd. 548, Nr. 2: S. 771-777

Toth, Krisztian; Höfner, Georg und Wanner, Klaus T. (2018): Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors. In: Bioorganic & Medicinal Chemistry, Bd. 26, Nr. 22: S. 5944-5961

Toth, Krisztian; Höfner, Georg und Wanner, Klaus T. (2018): Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors. In: Bioorganic & Medicinal Chemistry, Bd. 26, Nr. 12: S. 3668-3687

Urushibara, Ko; Ferrand, Yann; Liu, Zhiwei; Masu, Hyuma; Pophristic, Vojislava; Tanatani, Aya und Huc, Ivan (2018): Frustrated Helicity: Joining the Diverging Ends of a Stable Aromatic Amide Helix to Form a Fluxional Macrocycle. In: Angewandte Chemie-International Edition, Bd. 57, Nr. 26: S. 7888-7892

Vallade, Maelle; Reddy, Post Sai; Fischer, Lucile und Huc, Ivan (2018): Enhancing Aromatic Foldamer Helix Dynamics to Probe Interactions with Protein Surfaces. In: European Journal of Organic Chemistry, Nr. 40: S. 5489-5498

Vedove, Elena Dalle; Costabile, Gabriella und Merkel, Olivia M. (2018): Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy. In: Advanced Healthcare Materials, Bd. 7, Nr. 14, 1701398

Vlugt, Lucien E. P. M. van der; Eger, Katrien; Müller, Christoph; Ninaber, Dennis K.; Zarcone, Maria C.; Amatngalim, Gimano D.; Bracher, Franz; Mutius, Erika von; Smits, Hermelijn H. und Hiemstra, Pieter S. (2018): Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses. In: Journal of Allergy and Clinical Immunology, Bd. 141, Nr. 5: S. 1949-1952

Voegerl, Katharina; Ong, Duc Nghia und Bracher, Franz (2018): Reductive N-Arylethylation of Aromatic Amines and N-Heterocycles with Enol Ethers. In: Synthesis-Stuttgart, Bd. 50, Nr. 6: S. 1323-1330

Vollrath, Ilona; Friess, Wolfgang; Freitag, Angelika; Hawe, Andrea und Winter, Gerhard (2018): Does controlled nucleation impact the properties and stability of lyophilized monoclonal antibody formulations? In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 129: S. 134-144

Vollrath, Moritz; Engert, Julia und Winter, Gerhard (2018): New insights into process understanding of solid lipid extrusion (SLE) of extruded lipid implants for sustained protein delivery. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 130: S. 11-21

Wang, Bifeng und Friess, Wolfgang (2018): Lipid-coated mannitol core microparticles for sustained release of protein. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 128: S. 91-97

Wang, Ji; Wang, Jing; Zhang, Kai; Wang, Yanfang und Bao, Xuanwen (2018): Bayesian Network Meta-Analysis of the Effectiveness of Various Interventions for Nontraumatic Osteonecrosis of the Femoral Head. In: Biomed Research International, Bd. 2018, 2790163 [PDF, 2MB]

Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst und Wanner, Klaus T. (2018): Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor. In: Toxicology Letters, Bd. 293: S. 184-189

Werner, Benjamin Patrick und Winter, Gerhard (2018): Expanding Bedside Filtration-A Powerful Tool to Protect Patients From Protein Aggregates. In: Journal of Pharmaceutical Sciences, Bd. 107, Nr. 11: S. 2775-2788

West, Lorna Marie; Vetter-Kerkhoff, Cornelia; Miljkovic, Nenad und Frontini, Roberto (2018): Is there a need for a hospital pharmacy common training framework? Review of the literature on the impact of educational interventions on health outcome. In: European Journal of Hospital Pharmacy-Science and Practice, Bd. 25, Nr. 1: S. 6-9

Yordanova, Yordanka; Vanderlinden, Willem; Stoll, Raphael; Rüdiger, Daniel; Tosstorff, Andreas; Zaremba, Wolfgang; Winter, Gerhard; Zahler, Stefan und Friess, Wolfgang (2018): Zn2+-triggered self-assembly of Gonadorelin [6-D-Phe] to produce nanostructures and fibrils. In: Scientific Reports, Bd. 8, 11280 [PDF, 3MB]

Zhang, Xiaohan; Chytil, Petr; Etrych, Tomas; Liu, Weiwei; Rodrigues, Leticia; Winter, Gerhard; Filippov, Sergey K. und Papadakis, Christine M. (2018): Binding of HSA to Macromolecular rho HPMA Based Nanoparticles for Drug Delivery: An Investigation Using Fluorescence Methods. In: Langmuir, Bd. 34, Nr. 27: S. 7998-8006

Ziach, Krzysztof; Chollet, Celine; Parissi, Vincent; Prabhakaran, Panchami; Marchivie, Mathieu; Corvaglia, Valentina; Bose, Partha Pratim; Laxmi-Reddy, Katta; Godde, Frederic; Schmitter, Jean-Marie; Chaignepain, Stephane; Pourquier, Philippe und Huc, Ivan (2018): Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA. In: Nature Chemistry, Bd. 10, Nr. 5: S. 511-518

2017

Agostini, Elisa; Winter, Gerhard und Engert, Julia (2017): Scale-up of water-based spider silk film casting using a film applicator. In: International Journal of Pharmaceutics, Bd. 532, Nr. 1: S. 13-20

Arlt, E.; Arndt, L.; Breit, A.; Wennemuth, G.; Biel, M.; Wahl, C.; Gudermann, T.; Klugbauer, N. und Boekhoff, I. (2017): Two-pore channel protein 1 contributes to NAADP triggered acrosome reaction in spermatozoa. In: Reproduction in Domestic Animals, Bd. 52: S. 6-7

Balsevich, Georgia; Häusl, Alexander S.; Meyer, Carola W.; Karamihalev, Stoyo; Feng, Xixi; Poehlmann, Max L.; Dournes, Carine; Uribe-Marino, Andres; Santarelli, Sara; Labermaier, Christiana; Hafner, Kathrin; Mao, Tianqi; Breitsamer, Michaela; Theodoropoulou, Marily; Namendorf, Christian; Uhr, Manfred; Paez-Pereda, Marcelo; Winter, Gerhard; Hausch, Felix; Chen, Alon; Tschöp, Matthias H.; Rein, Theo; Gassen, Nils C. und Schmidt, Mathias V. (2017): Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. In: Nature Communications, Bd. 8, 1725 [PDF, 1MB]

Bartel, Karin; Winzi, Maria; Ulrich, Melanie; Koeberle, Andreas; Menche, Dirk; Werz, Oliver; Müller, Rolf; Guck, Jochen; Vollmar, Angelika M. und Schwarzenberg, Karin von (2017): V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy. In: Oncotarget, Bd. 8, Nr. 6: S. 9476-9487

Biel, M. (2017): Endolysosomal two-pore channels: from genes to function. In: Acta Physiologica, Bd. 221: S. 8

Bobak, Nicole; Feliciangeli, Sylvain; Chen, Cheng-Chang; Ben Soussia, Ismail; Bittner, Stefan; Pagnotta, Sophie; Ruck, Tobias; Biel, Martin; Wahl-Schott, Christian; Grimm, Christian; Meuth, Sven G. und Lesage, Florian (2017): Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels. In: Scientific Reports, Bd. 7, 649 [PDF, 11MB]

Bracher, Franz und Tremmel, Tim (2017): From Lead to Drug Utilizing a Mannich Reaction: The Topotecan Story. In: Archiv der Pharmazie, Bd. 350, Nr. 7, e1600236

Bracher, Franz und Tremmel, Tim (2017): The Chemistry of the Canthin-4-ones. In: Mini-Reviews in Organic Chemistry, Bd. 14, Nr. 2: S. 92-98

Breitsamer, Michaela und Winter, Gerhard (2017): Needle-Free Injection of Vesicular Phospholipid Gels-A Novel Approach to Overcome an Administration Hurdle for Semisolid Depot Systems. In: Journal of Pharmaceutical Sciences, Bd. 106, Nr. 4: S. 968-972

Butler, Michael R.; Ma, Hongwei; Yang, Fan; Belcher, Joshua; Le, Yun-Zheng; Mikoshiba, Katsuhiko; Biel, Martin; Michalakis, Stylianos; Iuso, Anthony; Krizaj, David und Ding, Xi-Qin (2017): Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. In: Journal of Biological Chemistry, Bd. 292, Nr. 27: S. 11189-11205

Böhm, Sybille; Riedmayr, Lisa M.; Nguyen, O. N. Phuong; Giessl, Andreas; Liebscher, Toni; Butz, Elisabeth S.; Schön, Christian; Michalakis, Stylianos; Wahl-Schott, Christian; Biel, Martin und Becirovic, Elvir (2017): Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. In: Scientific Reports, Bd. 7, 2321 [PDF, 3MB]

Castonguay, Jan; Orth, Joachim H. C.; Müller, Thomas; Sleman, Faten; Grimm, Christian; Wahl-Schott, Christian; Biel, Martin; Mallmann, Robert Theodor; Bildl, Wolfgang; Schulte, Uwe und Klugbauer, Norbert (2017): The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. In: Scientific Reports, Bd. 7, 10038 [PDF, 4MB]

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Schuller, Marion; Höfner, Georg und Wanner, Klaus T. (2017): Simultaneous Multiple MS Binding Assays Addressing D-1 and D-2 Dopamine Receptors. In: ChemMedChem, Bd. 12, Nr. 19: S. 1585-1594

Schuller, Marion; Riede, Kerstin; Gibbs-Seymour, Ian; Uth, Kristin; Sieg, Christian; Gehring, Andre P.; Ahel, Ivan; Bracher, Franz; Kessler, Benedikt M.; Elkins, Jonathan M. und Knapp, Stefan (2017): Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. In: ACS Chemical Biology, Bd. 12, Nr. 11: S. 2866-2874

Schön, Christian; Sothilingam, Vithiyanjali; Mühlfriedel, Regine; Garrido, Marina Garcia; Beck, Susanne C.; Tanimoto, Naoyuki; Wissinger, Bernd; Paquet-Durand, Francois; Biel, Martin; Michalakis, Stylianos und Seeliger, Mathias W. (2017): Gene Therapy Successfully Delays Degeneration in a Mouse Model of PDE6A-Linked Retinitis Pigmentosa (RP43). In: Human Gene therapy, Bd. 28, Nr. 12: S. 1180-1188

Sibbing, Dirk; Aradi, Daniel; Jacobshagen, Claudius; Gross, Lisa; Trenk, Dietmar; Geisler, Tobias; Orban, Martin; Gori, Tommaso; Hadamitzky, Martin; Merkely, Bela; Kiss, Robert Gabor; Komocsi, Andras; Dersi, Csaba A.; Thalmeier, Andreas; Loew, Anja; Holdt, Lesca; Teupser, Daniel; Ince, Hueseyin; Felix, Stephan B.; Parma, Radoslaw; Malek, Lukasz; Horstkotte, Jan; Bay-lacher, Monika; Schwinger, Robert; Rieber, Johannes; Mudra, Harald; Hausleiter, Jörg; Huber, Kurt; Neumann, Franz-Josef; Koltowski, Lukasz; Huczek, Zenon; Mehilli, Julinda und Massberg, Steffen (2017): A randomised trial on platelet function-guided de-escalation of antiplatelet treatment in ACS patients undergoing PCI Rationale and design of the Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes (TROPICAL-ACS) Trial. In: Thrombosis and Haemostasis, Bd. 117, Nr. 1: S. 188-195

Strüver, Kay; Friess, Wolfgang und Hedtrich, Sarah (2017): Development of a Perfusion Platform for Dynamic Cultivation of in vitro Skin Models. In: Skin Pharmacology and Physiology, Bd. 30, Nr. 4: S. 180-189

Stöckelhuber, M.; Müller, C.; Vetter, F.; Mingo, V.; Lötters, S.; Wagner, N. und Bracher, F. (2017): Determination of Pesticides Adsorbed on Arthropods and Gastropods by a Micro-QuEChERS Approach and GC-MS/MS. In: Chromatographia, Bd. 80, Nr. 5: S. 825-829

Trübenbach, Ines; Gorges, Jan; Kuhn, Jasmin; Kern, Sarah; Baratti, Emanuele; Kazmaier, Uli; Wagner, Ernst und Lächelt, Ulrich (2017): Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy. In: Macromolecular Bioscience, Bd. 17, Nr. 10, 1600520

Urnauer, Sarah; Klutz, Kathrin; Grünwald, Geoffrey K.; Morys, Stephan; Schwenk, Nathalie; Zach, Christian; Gildehaus, Franz-Josef; Rödl, Wolfgang; Ogris, Manfred; Wagner, Ernst und Spitzweg, Christine (2017): Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes. In: Journal of Gene Medicine, Bd. 19, Nr. 5, e2957

Urnauer, Sarah; Müller, Andrea M.; Schug, Christina; Schmohl, Kathrin A.; Tutter, Mariella; Schwenk, Nathalie; Rödl, Wolfgang; Morys, Stephan; Ingrisch, Michäl; Bertram, Jens; Bartenstein, Peter; Clevert, Dirk-André; Wagner, Ernst und Spitzweg, Christine (2017): EGFR-targeted nonviral NIS gene transfer for bioimaging and therapy of disseminated colon cancer metastases. In: Oncotarget, Bd. 8, Nr. 54: S. 92195-92208

Utzinger, Maximilian; Jarzebinska, Anita; Haag, Nicolas; Schweizer, Martin; Winter, Gerhard; Dohmen, Christian; Rudolph, Carsten und Plank, Christian (2017): cmRNA/lipoplex encapsulation in PLGA microspheres enables transfection via calcium phosphate cement (CPC)/PLGA composites. In: Journal of Controlled Release, Bd. 249: S. 143-149

Vetter, F.; Müller, C.; Stöckelhuber, M. und Bracher, F. (2017): Determination of coumarin in seasonal bakery products using QuEChERS and GC-MS. In: Pharmazie, Bd. 72, Nr. 6: S. 313-316

Vollrath, Ilona; Pauli, Victoria; Friess, Wolfgang; Freitag, Angelika; Hawe, Andrea und Winter, Gerhard (2017): Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying. In: Journal of Pharmaceutical Sciences, Bd. 106, Nr. 5: S. 1249-1257

Vollrath, Moritz; Engert, Julia und Winter, Gerhard (2017): Long-term release and stability of pharmaceutical proteins delivered from solid lipid implants. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 117: S. 244-255

Wagner, I.; Geh, K. J.; Hubert, M.; Winter, G.; Weber, K.; Classen, J.; Klinger, C. und Müller, R. S. (2017): Preliminary evaluation of cytosine-phosphate-guanine oligodeoxynucleotides bound to gelatine nanoparticles as immunotherapy for canine atopic dermatitis. In: Veterinary Record, Bd. 181, Nr. 5

Wagner, J. E.; Schön, C.; O'Riordan, C. R.; Scaria, A.; Cheng, S. H.; Biel, M. und Michalakis, S. (2017): Preclinical evaluation of rAAV.CNGB1 in the Cngb1 knockout mouse model of retinitis pigmentosa. In: Human Gene therapy, Bd. 28, Nr. 12: A78-A79

Wang, Bifeng und Friess, Wolfgang (2017): Spray drying of silica microparticles for sustained release application with a new sol-gel precursor. In: International Journal of Pharmaceutics, Bd. 532, Nr. 1: S. 281-288

Wang, Shanshan; Li, Chengyi; Qian, Min; Jiang, Huiling; Shi, Wei; Chen, Jian; Lächelt, Ulrich; Wagner, Ernst; Lu, Weiyue; Wang, Yi und Huang, Rongqin (2017): Augmented glioma-targeted theranostics using multifunctional polymer-coated carbon nanodots. In: Biomaterials, Bd. 141: S. 29-39

Wanner, Randy; Breitsprecher, Dennis; Duhr, Stefan; Baaske, Philipp und Winter, Gerhard (2017): Thermo-Optical Protein Characterization for Straightforward Preformulation Development. In: Journal of Pharmaceutical Sciences, Bd. 106, Nr. 10: S. 2955-2958

Wuttke, Stefan; Zimpel, Andreas; Bein, Thomas; Braig, Simone; Stoiber, Katharina; Vollmar, Angelika; Müller, Dominik; Haastert-Talini, Kirsten; Schaeske, Jörn; Stiesch, Meike; Zahn, Gesa; Mohmeyer, Alexander; Behrens, Peter; Eickelberg, Oliver; Bölükbas, Deniz A. und Meiners, Silke (2017): Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications. In: Advanced Healthcare Materials, Bd. 6, Nr. 2, 1600818

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Zhang, Peng und Wagner, Ernst (2017): History of Polymeric Gene Delivery Systems. In: Topics in Current Chemistry, Bd. 375, Nr. 2, 26

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Alamri, Ahmad M.; Kang, Keunsoo; Groeneveld, Svenja; Wang, Weisheng; Zhong, Xiaogang; Kallakury, Bhaskar; Hennighausen, Lothar; Liu, Xuefeng und Furth, Priscilla A. (2016): Primary cancer cell culture: mammary-optimized vs conditional reprogramming. In: Endocrine-Related Cancer, Bd. 23, Nr. 7: S. 535-554

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Beck, Simon; Henß, Lisa; Weidner, Tatjana; Herrmann, Jennifer; Müller, Rolf; Chao, Yu-Kai; Grimm, Christian; Weber, Christopher; Sliva, Katja und Schnierle, Barbara S. (2016): Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library. In: Antiviral Research, Bd. 132: S. 85-91

Bischoff, I.; Dai, B.; Stroedke, B.; Knapp, S.; Bracher, F. und Fuerst, R. (2016): First insights into the action of the carbazole derivative C81 and the role of its primary target BMP2K in the activated vascular endothelium. In: Naunyn-Schmiedebergs Archives of Pharmacology, Bd. 389, Nr. 1: S6-S6

Bischoff, Iris; Hornburger, Michael C.; Mayer, Bettina A.; Beyerle, Andrea; Wegener, Joachim und Fürst, Robert (2016): Pitfalls in assessing microvascular endothelial barrier function: impedance-based devices versus the classic macromolecular tracer assay. In: Scientific Reports, Bd. 6, 23671 [PDF, 1MB]

Capasso, Cristian; Cardella, Davide; Müller, Martin; Garofalo, Mariangela; Kuryk, Lukasz; Peltonen, Karita und Cerullo, Vincenzo (2016): Oncolytic Vaccines in Combination with PD-L1 Blockade for the Treatment of Melanoma. In: Molecular therapy, Bd. 24: S161-S162

Cattaneo, Giulia; Ubiali, Daniela; Calleri, Enrica; Rabuffetti, Marco; Höfner, Georg C.; Wanner, Klaus T.; Moraes, Marcela C. de; Martinelli, Leonardo K. B.; Santiago Santos, Diógenes; Speranza, Giovanna und Massolini, Gabriella (2016): Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase. In: Analytica Chimica Acta, Bd. 943: S. 89-97

Chen, Dong-Sheng; Wu, Yi-Quan; Zhang, Wei; Jiang, San-Jie und Chen, Shan-Ze (2016): Horizontal gene transfer events reshape the global landscape of arm race between viruses and homo sapiens. In: Scientific Reports, Bd. 6, 26934 [PDF, 1MB]

Fenske, Stefanie; Pröbstle, Rasmus; Auer, Franziska; Hassan, Sami; Marks, Vanessa; Pauza, Danius H.; Biel, Martin und Wahl-Schott, Christian (2016): Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology. In: Nature Protocols, Bd. 11, Nr. 1: S. 61-86

Fischer, M. Dominik; Wilhelm, Barbara; Michalakis, Stylianos; Zobor, Ditta; Kohl, Susanne; Seeliger, Matthias; Zrenner, Eberhart; Ueffing, Marius; Wissinger, Bernd; Biel, Martin und Bartz-Schmidt, Karl Ulrich (2016): Successful delivery of rAAV8.CNGA3 in a patient with CNGA3 achromatopsia. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Foerster, Florian; Chen, Tao; Altmann, Karl-Heinz und Vollmar, Angelika M. (2016): Actin-binding doliculide causes premature senescence in p53 wild type cells. In: Bioorganic & Medicinal Chemistry, Bd. 24, Nr. 2: S. 123-129

Funke, Stefanie; Matilainen, Julia; Nalenz, Heiko; Bechtold-Peters, Karoline; Mahler, Hanns-Christian und Friess, Wolfgang (2016): Optimization of the bake-on siliconization of cartridges. Part I: Optimization of the spray-on parameters. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 104: S. 200-215

Funke, Stefanie; Matilainen, Julia; Nalenz, Heiko; Bechtold-Peters, Karoline; Mahler, Hanns-Christian und Friess, Wolfgang (2016): Silicone Migration From Baked-on Silicone Layers. Particle Characterization in Placebo and Protein Solutions. In: Journal of Pharmaceutical Sciences, Bd. 105, Nr. 12: S. 3520-3531

Funke, Stefanie; Matilainen, Julia; Nalenz, Heiko; Bechtold-Peters, Karoline; Mahler, Hanns-Christian; Vetter, Florian; Müller, Christoph; Bracher, Franz und Friess, Wolfgang (2016): Optimization of the bake-on siliconization of cartridges. Part II: Investigations into burn-in time and temperature. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 105: S. 209-222

Geh, Katharina J.; Hubert, Madlen und Winter, Gerhard (2016): Optimisation of one-step desolvation and scale-up of gelatine nanoparticle production. In: Journal of Microencapsulation, Bd. 33, Nr. 7: S. 595-604

Grimm, Christian; Barben, Maya; Ail, Divya; Kast, Brigitt; Schori, Christian; Giger-Lange, Christina; Michalakis, Stylianos und Samardzija, Marijana (2016): Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD? In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

He, Dongsheng; Müller, Katharina; Levacic, Ana Krhac; Kos, Petra; Lächelt, Ulrich und Wagner, Ernst (2016): Combinatorial Optimization of Sequence-Defined Oligo(ethanamino)amides for Folate Receptor-Targeted pDNA and siRNA Delivery. In: Bioconjugate Chemistry, Bd. 27, Nr. 3: S. 647-659

Heissig, Philipp; Klein, Philipp M.; Hadwiger, Philipp und Wagner, Ernst (2016): DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization. In: Molecular Therapy - Nucleic Acids, Bd. 5, e288 [PDF, 1MB]

Hellenbrand, Tim; Höfner, Georg; Wein, Thomas und Wanner, Klaus T. (2016): Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors. In: Bioorganic & Medicinal Chemistry, Bd. 24, Nr. 9: S. 2072-2096

Hermawan, Adam; Wagner, Ernst und Roidl, Andreas (2016): Consecutive salinomycin treatment reduces doxorubicin resistance of breast tumor cells by diminishing drug efflux pump expression and activity. In: Oncology Reports, Bd. 35, Nr. 3: S. 1732-1740

Herzog, Julia; Ehrlich, Sandra M.; Pfitzer, Lisa; Liebl, Johanna; Fröhlich, Thomas; Arnold, Georg J.; Mikulits, Wolfgang; Haider, Christine; Vollmar, Angelika M. und Zahler, Stefan (2016): Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1 alpha: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma. In: Oncotarget, Bd. 7, Nr. 19: S. 27108-27121

Hesbacher, Sonja; Pfitzer, Lisa; Wiedorfer, Katharina; Angermeyer, Sabrina; Borst, Andreas; Haferkamp, Sebastian; Scholz, Claus-Jürgen; Wobser, Marion; Schrama, David und Houben, Roland (2016): RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells. In: Oncotarget, Bd. 7, Nr. 22: S. 32956-32968

Higel, Fabian; Seidl, Andreas; Sörgel, Fritz und Friess, Wolfgang (2016): N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins. In: European Journal of Pharmaceutics and Biopharmaceutics, Bd. 100: S. 94-100

Hildebrandt, Christian; Mathaes, Roman; Saedler, Rainer und Winter, Gerhard (2016): Origin of Aggregate Formation in Antibody Crystal Suspensions Containing PEG. In: Journal of Pharmaceutical Sciences, Bd. 105, Nr. 3: S. 1059-1065

Jiang, Qian; Yue, Dong; Nie, Yu; Xu, Xianghui; He, Yiyan; Zhang, Shiyong; Wagner, Ernst und Gu, Zhongwei (2016): Specially-Made Lipid-Based Assemblies for Improving Transmembrane Gene Delivery: Comparison of Basic Amino Acid Residue Rich Periphery. In: Molecular Pharmaceutics, Bd. 13, Nr. 6: S. 1809-1821

Jones, S. K. und Merkel, O. M. (2016): Tackling breast cancer chemoresistance with nano-formulated siRNA. In: Gene therapy, Bd. 23, Nr. 12: S. 821-828

Kamlah, Alexandra; Lirk, Florian und Bracher, Franz (2016): A new approach to 1-substituted β-carbolines and isoquinolines utilizing tributyl[(Z)-2-ethoxyvinyl]stannane as a C-3,C-4 building block. In: Tetrahedron, Bd. 72, Nr. 6: S. 837-845

Karimova, Madina; Splith, Victoria; Karpinski, Janet; Pisabarro, M. Teresa und Buchholz, Frank (2016): Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering. In: Scientific Reports, Bd. 6, 30130 [PDF, 1MB]

Keller, Marco; Wolfgardt, Annette; Müller, Christoph; Wilcken, Rainer; Böckler, Frank M.; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Balliano, Gianni und Bracher, Franz (2016): Arylpiperidines as a new class of oxidosqualene cyclase inhibitors. In: European Journal of Medicinal Chemistry, Bd. 109: S. 13-22

Kerscher-Hack, Silke; Renukappa-Gutke, Thejavathi; Höfner, Georg und Wanner, Klaus T. (2016): Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. In: European Journal of Medicinal Chemistry, Bd. 124: S. 852-880

Kibat, Janek; Schirrmann, Thomas; Knape, Matthias J.; Helmsing, Saskia; Meier, Doris; Hust, Michael; Schröder, Christoph; Bertinetti, Daniela; Winter, Gerhard; Pardes, Khalid; Funk, Mia; Vala, Andrea; Giese, Nathalia; Herberg, Friedrich W.; Dübel, Stefan und Hoheisel, Jörg D. (2016): Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality. In: New Biotechnology, Bd. 33, Nr. 5: S. 574-581

Kick, Kerstin; Nekolla, Katharina; Rehberg, Markus; Vollmar, Angelika M. und Zahler, Stefan (2016): New View on Endothelial Cell Migration Switching Modes of Migration Based on Matrix Composition. In: Arteriosclerosis thrombosis and Vascular Biology, Bd. 36, Nr. 12: S. 2346-2357

Kilpatrick, Bethan S.; Yates, Elizabeth; Grimm, Christian; Schapira, Anthony H. und Patel, Sandip (2016): Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx. In: Journal of Cell Science, Bd. 129, Nr. 20: S. 3859-3867

Kirmeier, Thomas; Gopalakrishnan, Ranganath; Gormanns, Vanessa; Werner, Anna M.; Cuboni, Serena; Rudolf, Georg C.; Höfner, Georg; Wanner, Klaus T.; Sieber, Stephan A.; Schmidt, Ulrike; Holsboer, Florian; Rein, Theo und Hausch, Felix (2016): Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores.
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Korpus, Christoph; Pikal, Michael und Friess, Wolfgang (2016): Heat Transfer Analysis of an Optimized, Flexible Holder System for Freeze-Drying in Dual Chamber Cartridges Using Different State-of-the-Art PAT Tools. In: Journal of Pharmaceutical Sciences, Bd. 105, Nr. 11: S. 3304-3313

Kostic, Corinne; Crippa, Sylvain V.; Martin, Catherine; Kardon, Randy H.; Biel, Martin; Arsenijevic, Yvan und Kawasaki, Aki (2016): Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 6: S. 2501-2508

Köse, Meryem; Schiedel, Anke C.; Bauer, Alexander Andreas; Poschenrieder, Hermann; Burbiel, Joachim C.; Akkinepally, Raghuram Rao; Stachef, Hans-Dietrich und Müller, Christa E. (2016): Focused screening to identify new adenosine kinase inhibitors. In: Bioorganic & Medicinal Chemistry, Bd. 24, Nr. 21: S. 5127-5133

Lee, Dian-Jang; He, Dongsheng; Kessel, Eva; Padari, Kärt; Kempter, Susanne; Lächelt, Ulrich; Rädler, Joachim O.; Pooga, Margus und Wagner, Ernst (2016): Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes. In: Journal of Controlled Release, Bd. 244: S. 280-291

Lee, Dian-Jang; Kessel, Eva; Edinger, Daniel; He, Dongsheng; Klein, Philipp M.; Voith von Voithenberg, Lena; Lamb, Don C.; Lächelt, Ulrich; Lehto, Taavi und Wagner, Ernst (2016): Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand. In: Biomaterials, Bd. 77: S. 98-110

Liebl, Johanna (2016): Cyclin dependent kinase 5-a novel target to enhance the antitumor immune response. In: Translational Cancer Research, Bd. 5: S587-S589

Liu, Xiaowen; Zhang, Peng; He, Dongsheng; Rödl, Wolfgang; Preiß, Tobias; Rädler, Joachim O.; Wagner, Ernst und Lächelt, Ulrich (2016): pH-Reversible Cationic RNase A Conjugates for Enhanced Cellular Delivery and Tumor Cell Killing. In: Biomacromolecules, Bd. 17, Nr. 1: S. 173-182

Lutz, Toni A.; Spanner, Patrick und Wanner, Klaus T. (2016): A general approach to substituted diphenyldiazenes. In: Tetrahedron, Bd. 72, Nr. 12: S. 1579-1589

Lächelt, Ulrich; Levacic, Ana Krhac; Wendel, Dominik und Wagner, Ernst (2016): Nonviral Gene Transfer by Sequence-Defined Proton-Sponges with Combined Nucleic Acid Binding and Endosomal Buffering: Balancing Basicities. In: Molecular therapy, Bd. 24: S195-S195

Merk, Henriette; Zhang, Siwei; Lehr, Thorsten; Müller, Christoph; Ulrich, Melanie; Bibb, James A.; Adams, Ralf H.; Bracher, Franz; Zahler, Stefan; Vollmar, Angelika M. und Liebl, Johanna (2016): Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. In: Oncotarget, Bd. 7, Nr. 5: S. 6088-6104

Michalakis, Stylianos; Koch, Mirwa; Ma, Hongwei; Ding, Xi-Qin und Biel, Martin (2016): cGMP-cGKII signalling contributes to cone photoreceptor degeneration in achromatopsia. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Mohammadi, Mariam; Li, Ying; Abebe, Daniel G.; Xie, Yuran; Kandil, Rima; Kraus, Teresa; Gomez-Lopez, Nardhy; Fujiwara, Tomoko und Merkel, Olivia M. (2016): Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. In: Journal of Controlled Release, Bd. 244: S. 269-279

Molokhia, Sarah; Burr, Randon M.; Flood, Maggie; Vallrath, Moritz; Winter, Gerhard und Ambati, Balamurali Krishna (2016): Lens Capsule Biodegradable Lipid Implant for Sustained-Release Anti-VEGF Therapy of Neovascular AMD. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Mosion, Jan; Rauscher, Alexander; Willi, Taylor; Lang, Donna; Vertinsky, Talia; Vila-Rodriguez, Fidel; Kames, Christian; Panenka, William; Jarrett, Mike; Honer, William und Barr, Alasdair (2016): A Longitudinal Characterization of Cerebral Microbleeds in a Marginalized Population with High Rates of Mental Illness, Substance Abuse and Viral Infection. In: Neurology, Bd. 86

Movassaghian, Sara; Xie, Yuran; Hildebrandt, Claudia; Rosati, Rayna; Li, Ying; Kim, Na Hyung; Conti, Denise S.; Rocha, Sandro R. P. da; Yang, Zeng-Quan und Merkel, Olivia M. (2016): Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles. In: Molecular Pharmaceutics, Bd. 13, Nr. 8: S. 2605-2621

Müller, Katharina; Klein, Philipp M.; Heissig, Philipp; Roidl, Andreas und Wagner, Ernst (2016): EGF receptor targeted lipo-oligocation polyplexes for antitumoral siRNA and miRNA delivery. In: Nanotechnology, Bd. 27, Nr. 46, 464001

Müller, Katherina; Kessel, Eva; Klein, Philipp M.; Höhn, Miriam und Wagner, Ernst (2016): Post-PEGylation of siRNA Lipo-oligoamino Amide Polyplexes Using Tetra-glutamylated Folic Acid as Ligand for Receptor-Targeted Delivery. In: Molecular Pharmaceutics, Bd. 13, Nr. 7: S. 2332-2345

Nguyen, O. N. Phuong; Böhm, Sybille; Gießl, Andreas; Butz, Elisabeth S.; Wolfrum, Uwe; Brandstätter, Johann H.; Wahl-Schott, Christian; Biel, Martin und Becirovic, Elvir (2016): Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. In: Human Molecular Genetics, Bd. 25, Nr. 12: S. 2367-2377

Niessen, K. V.; Muschik, S.; Langguth, F.; Rappenglück, S.; Seeger, T.; Thiermann, H. und Worek, F. (2016): Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology. In: Toxicology Letters, Bd. 247: S. 1-10

Petrera, Marilena; Wein, Thomas; Allmendinger, Lars; Sindelar, Miriam; Pabel, Jörg; Höfner, Georg und Wanner, Klaus T. (2016): Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions. In: ChemMedChem, Bd. 11, Nr. 5: S. 519-538

Pivodová, V.; Zahler, S.; Karas, D.; Valentová, K. und Ulrichova, J. (2016): In vitro study of 2,3-dehydrosilybin and its galloyl esters as potential inhibitors of angiogenesis. In: Pharmazie, Bd. 71, Nr. 8: S. 478-483

Plodek, Alois und Bracher, Franz (2016): New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids. In: Marine Drugs, Bd. 14, Nr. 2, 26 [PDF, 6MB]

Podkowa, A.; Sałat, K.; Malikowska, N.; Kern, F.; Pabel, J.; Kulig, K.; Wanner, K. T.; Wojcieszak, E. und Furgala, A. (2016): Anticonvulsant activity of a novel gamma-aminobutyric acid transporter subtype 1 inhibitor in mice. In: European Neuropsychopharmacology, Bd. 26: S286-S286

Popp, Tobias A.; Tallant, Cynthia; Rogers, Catherine; Fedorov, Oleg; Brennan, Paul E.; Müller, Susanne; Knapp, Stefan und Bracher, Franz (2016): Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors. In: Journal of Medicinal Chemistry, Bd. 59, Nr. 19: S. 8889-8912

Popp, Tobias Alexander; Uhl, Edgar; Ong, Duc Nghia; Dittrich, Sebastian und Bracher, Franz (2016): A new approach to monoprotected 1,4-benzodiazepines via a one-pot N-deprotection/reductive cyclization procedure. In: Tetrahedron, Bd. 72, Nr. 13: S. 1668-1674

Reichel, Felix Friedrich; Peters, Tobias; Muehlfriedel, Regine; Biel, Martin; Paquet-Durand, Francois; Ueffing, Marius; Wissinger, Bernd; Bartz-Schmidt, Karl Ulrich; Fischer, M. Dominik und Michalakis, Stylianos (2016): Humoral immune response to subretinal AAV8 in non-human primates. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Rodrigues, Leticia; Kyriakos, Konstantinos; Schneider, Fabian; Dietz, Hendrik; Winter, Gerhard; Papadakis, Christine M. und Hubert, Madlen (2016): Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers. In: Molecular Pharmaceutics, Bd. 13, Nr. 11: S. 3945-3954

Santos-Ferreira, Tiago; Völkner, Manuela; Borsch, Oliver; Haas, Jochen; Cimalla, Peter; Vasudevan, Praveen; Carmeliet, Peter; Corbeil, Denis; Michalakis, Stylianos; Koch, Edmund; Karl, Mike O. und Ader, Marius (2016): Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 13: S. 5336-5337

Scheffel, C.; Rappenglck, S.; Niessen, K.; Worek, F.; Thiermann, H.; Wanner, K. und Seeger, T. (2016): Electrophysiological drug-screening of bispyridinium-non-oxime-compounds on human nicotinic alpha 7 acetylcholine receptors - an alternative approach for the treatment of nerve agent poisoning -. In: Naunyn-Schmiedebergs Archives of Pharmacology, Bd. 389, Nr. 1: S42-S42

Schneider, Lina S.; Ulrich, Melanie; Lehr, Thorsten; Menche, Dirk; Müller, Rolf und Schwarzenberg, Karin von (2016): MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition. In: Molecular Oncology, Bd. 10, Nr. 7: S. 1054-1062

Schuster, Simon L.; Segerer, Felix J.; Gegenfurtner, Florian A.; Kick, Kerstin; Schreiber, Christoph; Albert, Max; Vollmar, Angelika M.; Rädler, Joachim O. und Zahler, Stefan (2016): Contractility as a global regulator of cellular morphology, velocity, and directionality in low-adhesive fibrillary micro-environments. In: Biomaterials, Bd. 102: S. 137-147

Schön, Christian; Asteriti, Sabrina; Koch, Susanne; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Tanimoto, Naoyuki; Herms, Jochen; Seeliger, Mathias W.; Cangiano, Lorenzo; Biel, Martin und Michalakis, Stylianos (2016): Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. In: Human Molecular Genetics, Bd. 25, Nr. 6: S. 1165-1175

Schön, Christian; Paquet-Durand, Francois und Michalakis, Stylianos (2016): Ca(v)1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice.
In: PLOS ONE 11(6), e0156974 [PDF, 1MB]

Seitz, Immanuel Philipp; Fischer, M. Dominik; Michalakis, Stylianos; Wilhelm, Barbara; Kahle, Nadine; Zrenner, Eberhart; Ueffing, Marius; Bartz-Schmidt, Karl Ulrich; Biel, Martin; Wissinger, Bernd und Peters, Tobias (2016): rAAV8 biodistribution and shedding after subretinal injection in non-human primates. In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Sohail, Azmat; Jayaraman, Kumaresan; Venkatesan, Santhoshkannan; Gotfryd, Kamil; Daerr, Markus; Gether, Ulrik; Loland, Claus J.; Wanner, Klaus T.; Freissmuth, Michael; Sitte, Harald H.; Sandtner, Walter und Stockner, Thomas (2016): The Environment Shapes the Inner Vestibule of LeuT.
In: PLOS Computational Biology 12(11), e1005197 [PDF, 5MB]

Sothilingam, Vithiyanjali; Michalakis, Stylianos; Garrido, Marina Garcia; Biel, Martin; Tanimoto, Naoyuki und Seeliger, Mathias W. (2016): HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.
In: PLOS ONE 11(1), e0147728 [PDF, 1MB]

Tanimoto, Naoyuki; Michalakis, Stylianos; Weber, Bernhard H. F.; Wahl-Schott, Christian A.; Hammes, Hans-Peter und Seeliger, Mathias W. (2016): In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination. In: Retinal Degenerative Diseases: Mechanisms and Experimental therapy, Bd. 854: S. 619-625

Tremmel, Tim; Puzik, Andreas; Gehring, André P. und Bracher, Franz (2016): Canthin-4-ones as Novel Antibacterial Agents. In: Archiv Der Pharmazie, Bd. 349, Nr. 9: S. 710-723

Unzue, Andrea; Lafleur, Karine; Zhao, Hongtao; Zhou, Ting; Dong, Jing; Kolb, Peter; Liebl, Johanna; Zahler, Stefan; Caflisch, Amedeo und Nevado, Cristina (2016): Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation. In: European Journal of Medicinal Chemistry, Bd. 112: S. 347-366

Wagner, Hildebert; Bauer, Rudolf und Melchart, Dieter (2016): New Analytical Monographs on TCM Herbal Drugs for Quality Proof. In: Forschende Komplementarmedizin, Bd. 23: S. 16-20 [PDF, 219kB]

Wagner, I; Geh, K.; Winter, G.; Weber, K. und Mueller, R. S. (2016): Immunotherapy of canine atopic dermatitis with CpG oligodeoxynucleotides bound to gelatine nanoparticles. In: Allergy, Bd. 71: S. 69

Wein, Thomas; Petrera, Marilena; Allmendinger, Lars; Höfner, Georg; Pabel, Jörg und Wanner, Klaus T. (2016): Different Binding Modes of Small and Large Binders of GAT1. In: ChemMedChem, Bd. 11, Nr. 5: S. 509-518

Westerhausen, Christoph; Schnitzler, Lukas G.; Wendel, Dominik; Krzyszton, Rafal; Lächelt, Ulrich; Wagner, Ernst; Rädler, Joachim O. und Wixforth, Achim (2016): Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles. In: Micromachines, Bd. 7, Nr. 9, 150 [PDF, 4MB]

Xie, Yuran; Killinger, Bryan; Moszczynska, Anna und Merkel, Olivia M. (2016): Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine. In: Molecules, Bd. 21, Nr. 10, 1334 [PDF, 2MB]

Xie, Yuran; Kim, Na Hyung; Nadithe, Venkatareddy; Schalk, Dana; Thakur, Archana; Kılıç, Ayşe; Lum, Lawrence G.; Bassett, David J. P. und Merkel, Olivia M. (2016): Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma. In: Journal of Controlled Release, Bd. 229: S. 120-129

Zhang, S.; Ulrich, M.; Gromnicka, A.; Havlíček, L.; Kryštof, V.; Jorda, R.; Strnad, M.; Vollmar, A. M. und Zahler, S. (2016): Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold. In: British Journal of Pharmacology, Bd. 173, Nr. 17: S. 2645-2656

Zhang, Wei; Müller, Katharina; Kessel, Eva; Reinhard, Sören; He, Dongsheng; Klein, Philipp M.; Höhn, Miriam; Rödl, Wolfgang; Kempter, Susanne und Wagner, Ernst (2016): Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nanocore with an Influenza Peptide and Transferrin Shell. In: Advanced Healthcare Materials, Bd. 5, Nr. 12: S. 1493-1504

Zhong, Qian; Merkel, Olivia M.; Reineke, Joshua J. und Rocha, Sandro R. P. da (2016): Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution. In: Molecular Pharmaceutics, Bd. 13, Nr. 6: S. 1866-1878

2015

Arends, Fabienna; Nowald, Constantin; Pflieger, Kerstin; Boettcher, Kathrin; Zahler, Stefan und Lieleg, Oliver (2015): The Biophysical Properties of Basal Lamina Gels Depend on the Biochemical Composition of the Gel.
In: PLOS ONE 10(2), e0118090 [PDF, 2MB]

Bender, Julia; Engeholm, Maik; Ederer, Marion S.; Breu, Johannes; Moller, Thor C.; Michalakis, Stylianos; Rasko, Tamas; Wanker, Erich E.; Biel, Martin; Martinez, Karen L.; Wurst, Wolfgang und Deussing, Jan M. (2015): Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
In: PLOS ONE 10(9), e0136768 [PDF, 20MB]

Braig, Simone; Schmidt, B. U. Sebastian; Stoiber, Katharina; Haendel, Chris; Moehn, Till; Werz, Oliver; Mueller, Rolf; Zahler, Stefan; Koeberle, Andreas; Kaes, Josef A. und Vollmar, Angelika M. (2015): Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion. In: New Journal of Physics, Bd. 17, 083007 [PDF, 1MB]

Buchmann, Stefan; Sandmann, Gunther H.; Walz, Lars; Reichel, Thomas; Beitzel, Knut; Wexel, Gabriele; Tian, Weiwei; Battmann, Achim; Vogt, Stephan; Winter, Gerhard und Imhoff, Andreas B. (2015): Growth factor release by vesicular phospholipid gels: in-vitro results and application for rotator cuff repair in a rat model. In: BMC Musculoskeletal Disorders 16:82 [PDF, 1MB]

Feodorova, Yana; Koch, Mirja; Bultman, Sebastian; Michalakis, Stylianos und Solovei, Irina (2015): Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice. In: Methodsx, Bd. 2: S. 39-46

Fuchs, Simone; Hsieh, Louise T.; Saarberg, Werner; Erdelmeier, Clemens A. J.; Wichelhaus, Thomas A.; Schaefer, Liliana; Koch, Egon und Fuerst, Robert (2015): Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo. In: Journal of Cellular and Molecular Medicine, Bd. 19, Nr. 5: S. 1021-1032 [PDF, 718kB]

Liebl, Johanna; Zhang, Siwei; Moser, Markus; Agalarov, Yan; Demir, Cansaran Saygili; Hager, Bianca; Bibb, James A.; Adams, Ralf H.; Kiefer, Friedemann; Miura, Naoyuki; Petrova, Tatiana V.; Vollmar, Angelika M. und Zahler, Stefan (2015): Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. In: Nature Communications, Bd. 6, 7274 [PDF, 2MB]

Reichel, Christoph A.; Hessenauer, Maximilian E. T.; Pflieger, Kerstin; Rehberg, Markus; Kanse, Sandip M.; Zahler, Stefan; Krombach, Fritz; Berghaus, Alexander und Strieth, Sebastian (2015): Components of the Plasminogen Activation System Promote Engraftment of Porous Polyethylene Biomaterial via Common and Distinct Effects.
In: PLOS ONE 10(2), e0116883 [PDF, 4MB]

Rüben, Katharina; Wurzlbauer, Anne; Walte, Agnes; Sippl, Wolfgang; Bracher, Franz und Becker, Walter (2015): Selectivity Profiling and Biological Activity of Novel beta-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.
In: PLOS ONE 10(7), e0132453 [PDF, 4MB]

Schmitt, Andreas; Rödel, Philipp; Anamur, Cihad; Seeliger, Claudine; Imhoff, Andreas B.; Herbst, Elmar; Vogt, Stephan; Griensven, Martijn van; Winter, Gerhard und Engert, Julia (2015): Calcium Alginate Gels as Stem Cell Matrix - Making Paracrine Stem Cell Activity Available for Enhanced Healing after Surgery.
In: PLOS ONE 10(3), e0118937 [PDF, 1MB]

Tanimoto, Naoyuki; Sothilingam, Vithiyanjali; Kondo, Mineo; Biel, Martin; Humphries, Peter und Seeliger, Mathias W. (2015): Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice. In: Scientific Reports, Bd. 5, 10731 [PDF, 960kB]

2014

Arango-Gonzalez, Blanca; Trifunović, Dragana; Sahaboglu, Ayse; Kranz, Katharina; Michalakis, Stylianos; Farinelli, Pietro; Koch, Susanne; Koch, Fred; Cottet, Sandra; Janssen-Bienhold, Ulrike; Dedek, Karin; Biel, Martin; Zrenner, Eberhart; Euler, Thomas; Ekstrom, Per; Ueffing, Marius und Paquet-Durand, François (2014): Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration.
In: PLOS ONE 9(11), e112142 [PDF, 1MB]

Braig, S.; Wiedmann, R. M.; Liebl, J.; Singer, M.; Kubisch, R.; Schreiner, L.; Abhari, B. A.; Wagner, E.; Kazmaier, U.; Fulda, S. und Vollmar, Angelika M. (2014): Pretubulysin: a new option for the treatment of metastatic cancer. In: Cell Death & Disease, Bd. 5, e1001

Chen, Cheng-Chang; Keller, Marco; Hess, Martin; Schiffmann, Raphael; Urban, Nicole; Wolfgardt, Annette; Schaefer, Michael; Bracher, Franz; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian (2014): A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. In: Nature Communications, Bd. 5, 4681 [PDF, 1MB]

Farinelli, P.; Perera, A.; Arango-Gonzalez, B.; Trifunovic, D.; Wagner, M.; Carell, T.; Biel, M.; Zrenner, E.; Michalakis, S.; Paquet-Durand, F. und Ekström, P. A. R. (2014): DNA methylation and differential gene regulation in photoreceptor cell death. In: Cell Death & Disease, Bd. 5, e1558 [PDF, 5MB]

Foerster, F.; Braig, S.; Moser, C.; Kubisch, R.; Busse, J.; Wagner, E.; Schmoeckel, E.; Mayr, D.; Schmitt, S.; Huettel, S.; Zischka, H.; Mueller, R. und Vollmar, Angelika M. (2014): Targeting the actin cytoskeleton: selective antitumor action via trapping PKCε. In: Cell Death & Disease, Bd. 5, e1398 [PDF, 3MB]

Grimm, Christian; Holdt, Lesca M.; Chen, Cheng-Chang; Hassan, Sami; Müller, Christoph; Jörs, Simone; Cuny, Hartmut; Kissing, Sandra; Schröder, Bernd; Butz, Elisabeth; Northoff, Bernd; Castonguay, Jan; Luber, Christian A.; Moser, Markus; Spahn, Saskia; Luellmann-Rauch, Renate; Fendel, Christina; Klugbauer, Norbert; Griesbeck, Oliver; Haas, Albert; Mann, Matthias; Bracher, Franz; Teupser, Daniel; Saftig, Paul; Biel, Martin und Wahl-Schott, Christian (2014): High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. In: Nature Communications, Bd. 5, 4699 [PDF, 3MB]

Kern, Selina; Agarwal, Shruti; Huber, Kilian; Gehring, André P.; Strödke, Benjamin; Wirth, Christine C.; Brügl, Thomas; Abodo, Liliane Onambele; Dandekar, Thomas; Doerig, Christian; Fischer, Rainer; Tobin, Andrew B.; Alam, Mahmood M.; Bracher, Franz und Pradel, Gabriele (2014): Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission.
In: PLOS ONE 9(9), e105732 [PDF, 3MB]

Kneidl, Barbara; Peller, Michael; Winter, Gerhard; Lindner, Lars H. und Hossann, Martin (2014): Thermosensitive liposomal drug delivery systems: state of the art review. In: International Journal of Nanomedicine, Bd. 9: S. 4387-4398 [PDF, 4MB]

Kos, Petra; Lächelt, Ulrich; Herrmann, Annika; Mickler, Frauke M.; Krhač Levačić, Ana; Morys, Stephan; Bräuchle, Christoph und Wagner, Ernst (2014): Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer. In: Nanoscale, Bd. 7, Nr. 12: S. 5350-5362 [PDF, 0B]

Neuner, Johanna; Filser, Severin; Michalakis, Stylianos; Biel, Martin und Herms, Jochen (2014): A30P alpha-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network. In: Scientific Reports, Bd. 4, 3931 [PDF, 11MB]

Soltysinska, Ewa; Bentzen, Bo Hjorth; Barthmes, Maria; Hattel, Helle; Thrush, A. Brianne; Harper, Mary-Ellen; Qvortrup, Klaus; Larsen, Filip J.; Schiffer, Tomas A.; Losa-Reyna, Jose; Straubinger, Julia; Kniess, Angelina; Thomsen, Morten Bækgaard; Brüggemann, Andrea; Fenske, Stefanie; Biel, Martin; Ruth, Peter; Wahl-Schott, Christian; Boushel, Robert Christopher; Olesen, Søren-Peter und Lukowski, Robert (2014): KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury.
In: PLOS ONE 9(7), e103402 [PDF, 1MB]

2012

Herrmann, Jennifer; Elnakady, Yasser A.; Wiedmann, Romina M.; Ullrich, Angelika; Rohde, Manfred; Kazmaier, Uli; Vollmar, Angelika M. und Müller, Rolf (2012): Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy.
In: PLOS ONE 7(5), e37416 [PDF, 1MB]

Kopp, Florian; Oak, Prajakta S.; Wagner, Ernst und Roidl, Andreas (2012): miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression.
In: PLOS ONE 7(11), e50469 [PDF, 700kB]

2011

Dussmann, Philipp; Pagel, Judith I.; Vogel, Sabina; Magnusson, Terese; Zimmermann, Rene; Wagner, Ernst; Schaper, Wolfgang; Ogris, Manfred und Deindl, Elisabeth (2011): Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing. In: BMC Developmental Biology 11:28 [PDF, 2MB]

1994

Maass, Gerd; Zatloukal, Kurt; Schmidt, Walter; Berger, M.; Cotten, Matt; Wagner, Ernst; Birnstiel, Max L. und Buschle, M. (1994): The generation of tumor vaccines by adenovirus-enhanced transfection of cytokine genes into tumor cells. In: Skouteris, George G. (Hrsg.): Liver carcinogenesis. Berlin u.a.: Springer. S. 467-479 [PDF, 1MB]

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