Department of Pharmacy

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- Chemistry and Pharmacy (644)
  - Department of Pharmacy (644)

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Number of items at this level: 644.

2022

Baldassi, Domizia; Ngo, Thi My Hanh and Merkel, Olivia M. (2022): Optimization of Lung Surfactant Coating of siRNA Polyplexes for Pulmonary Delivery. In: Pharmaceutical Research [PDF, 6MB]

Becirovic, Elvir

(2022): Maybe you can turn me on: CRISPRa-based strategies for therapeutic applications. In: Cellular and Molecular Life Sciences, Vol. 79, No. 2, 130: pp. 1-9 [PDF, 2MB]

Berger, Simone

; Berger, Martin

; Bantz, Christoph; Maskos, Michael and Wagner, Ernst

(2022): Performance of nanoparticles for biomedical applications: The in vitro/in vivo discrepancy. In: Biophysics Reviews, Vol. 3, No. 1, 011303

Bindl, Daniel; Mandal, Pradeep K. and Huc, Ivan (2022): Generalizing the Aromatic delta-Amino Acid Foldamer Helix. In: Chemistry - A European Journal, Vol. 28, No. 31 [PDF, 1MB]

Dengler, Sebastian; Douat, Celine and Huc, Ivan (2022): Differential Peptide Multi-Macrocyclizations at the Surface of a Helical Foldamer Template. In: Angewandte Chemie International Edition, Vol. 61, No. 44 [PDF, 5MB]

Gabold, Bettina; Adams, Friederike; Brameyer, Sophie; Jung, Kirsten; Ried, Christian L.; Merdan, Thomas and Merkel, Olivia M. (2022): Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. In: Drug Delivery and Translational Research, Vol. 13, No. 3: pp. 822-838 [PDF, 2MB]

Hennis, Konstantin; Biel, Martin; Fenske, Stefanie and Wahl-Schott, Christian (2022): Paradigm shift: new concepts for HCN4 function in cardiac pacemaking. In: Pflugers Archiv-European Journal of Physiology, Vol. 474, No. 7: pp. 649-663 [PDF, 4MB]

Jin, Yao; Adams, Friederike; Moeller, Judith; Isert, Lorenz; Zimmermann, Christoph M. M.; Keul, David and Merkel, Olivia M. M. (2022): Synthesis and Application of Low Molecular Weight PEI-Based Copolymers for siRNA Delivery with Smart Polymer Blends. In: Macromolecular Bioscience, Vol. 23, No. 2 [PDF, 2MB]

Kajtna, Jacqueline; Tsang, Stephen H. and Koch, Susanne F. (2022): Late-stage rescue of visually guided behavior in the context of a significantly remodeled retinitis pigmentosa mouse model. In: Cellular and Molecular Life Sciences, Vol. 79, No. 3 [PDF, 13MB]

Karg, Cornelia A.; Parrakova, Lucia; Fuchs, Dietmar; Schennach, Harald; Kräutler, Bernhard; Moser, Simone and Gostner, Johanna M. (2022): A Chlorophyll-Derived Phylloxanthobilin Is a Potent Antioxidant That Modulates Immunometabolism in Human PBMC. In: Antioxidants, Vol. 11, No. 10 [PDF, 2MB]

Köhler, Bianca; Dubovik, Sviatlana; Hörterer, Elisa; Wilk, Ulrich; Stöckl, Jan Bernd; Tekarslan-Sahin, Hande; Ljepoja, Bojan; Paulitschke, Philipp; Fröhlich, Thomas; Wagner, Ernst and Roidl, Andreas (2022): Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification. In: Cancers, Vol. 14, No. 22 [PDF, 4MB]

Mandal, Pradeep K.; Collie, Gavin W.; Kauffmann, Brice and Huc, Ivan (2022): Racemic crystal structures of A-DNA duplexes. In: Acta Crystallographica Section D : Structural Biology, Vol. 78: pp. 709-715 [PDF, 683kB]

Müller, Markus; Niemeyer, Konstantin; Urban, Nicole; Ojha, Navin K.; Zufall, Frank; Leinders-Zufall, Trese; Schäfer, Michael and Thorn-Seshold, Oliver (2022): BTDAzo: A Photoswitchable TRPC5 Channel Activator. In: Angewandte Chemie International Edition, Vol. 61, No. 36 [PDF, 11MB]

Roche, Aisling; Gentiluomo, Lorenzo; Sibanda, Nicole; Roessner, Dierk; Friess, Wolfgang; Trainoff, Steven P. and Curtis, Robin (2022): Towards an improved prediction of concentrated antibody solution viscosity using the Huggins coefficient. In: Journal of Colloid and Interface Science, Vol. 607, No. 2: pp. 1813-1824

Steffens, Ricarda Carolin and Wagner, Ernst (2022): Directing the Way-Receptor and Chemical Targeting Strategies for Nucleic Acid Delivery. In: Pharmaceutical Research, Vol. 40, No. 1: pp. 47-76 [PDF, 2MB]

Wang, Jinhua; Wicher, Barbara; Maurizot, Victor and Huc, Ivan (2022): Directing the Self-Assembly of Aromatic Foldamer Helices using Acridine Appendages and Metal Coordination. In: Chemistry - A European Journal, Vol. 28, No. 62 [PDF, 2MB]

2021

Baldassi, Domizia; Gabold, Bettina and Merkel, Olivia M. (2021): Air-Liquid Interface Cultures of the Healthy and Diseased Human Respiratory Tract: Promises, Challenges, and Future Directions. In: Advanced Nanobiomed Research, Vol. 1, No. 6, 2000111

Benli-Hoppe, Teoman; Ozturk, Surhan Gol; Ozturk, Ozgur; Berger, Simone; Wagner, Ernst and Yazdi, Mina (2021): Transferrin Receptor Targeted Polyplexes Completely Comprised of Sequence-Defined Components. In: Macromolecular Rapid Communications, Vol. 43, No. 12, 2100602

Berger, Simone; Levacic, Ana Krhac; Hörterer, Elisa; Wilk, Ulrich; Benli-Hoppe, Teoman; Wang, Yanfang; Öztürk, Özgür; Luo, Jie and Wagner, Ernst (2021): Optimizing pDNA Lipo-polyplexes: A Balancing Act between Stability and Cargo Release. In: Biomacromolecules, Vol. 22, No. 3: pp. 1282-1296

Berner, Carolin; Menzen, Tim; Winter, Gerhard and Svilenov, Hristo L. (2021): Combining Unfolding Reversibility Studies and Molecular Dynamics Simulations to Select Aggregation-Resistant Antibodies. In: Molecular Pharmaceutics, Vol. 18, No. 6: pp. 2242-2253

Bindl, Daniel; Heinemann, Elisabeth; Mandal, Pradeep K. and Huc, Ivan (2021): Quantitative helix handedness bias through a single H vs. CH3 stereochemical differentiation. In: Chemical Communications, Vol. 57, No. 46: pp. 5662-5665

Bluemel, Oliver; Buecheler, Jakob W.; Hauptmann, Astrid; Hoelzl, Georg; Bechtold-Peters, Karoline and Frieß, Wolfgang (2021): Scaling Down Large-Scale Thawing of Monoclonal Antibody Solutions: 3D Temperature Profiles, Changes in Concentration, and Density Gradients. In: Pharmaceutical Research, Vol. 38, No. 11: pp. 1977-1989

Bornerie, Megane; Brion, Anais; Guichard, Gilles; Kichler, Antoine and Douat, Celine (2021): Delivery of siRNA by tailored cell-penetrating urea-based foldamers. In: Chemical Communications, Vol. 57, No. 12: pp. 1458-1461

Bouwknegt, Jonna; Wiersma, Sanne J.; Ortiz-Merino, Raul A.; Doornenbal, Eline S. R.; Buitenhuis, Petrik; Giera, Martin; Mueller, Christoph and Pronk, Jack T. (2021): A squalene-hopene cyclase in Schizosaccharomyces japonicus represents a eukaryotic adaptation to sterol-limited anaerobic environments. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 32, e2105225118

Büning, Hildegard; Fehse, Boris; Ivics, Zoltán; Kochanek, Stefan; Koehl, Ulrike; Kupatt, Christian; Mussolino, Claudio; Nettelbeck, Dirk M.; Schambach, Axel; Uckert, Wolfgang; Wagner, Ernst and Cathomen, Toni (2021): Gene Therapy “Made in Germany”: A Historical Perspective, Analysis of the Status Quo, and Recommendations for Action by the German Society for Gene Therapy. In: Human Gene Therapy, Vol. 32, No. 19-20: pp. 987-996

Daraosheh, Ahmad Q.; Abul-Futouh, Hassan; Abdel-Rahem, Rami A.; Goerls, Helmar; Stachel, Hans-Dietrich and Weigand, Wolfgang (2021): Synthesis and Electrochemical Investigations of the [FeFe]-Hydrogenase H-Cluster Mimics Mediated by Bicyclic Dithiols Derivative. In: Zeitschrift für Anorganische und Allgemeine Chemie, Vol. 647, No. 8: pp. 931-936

Deiringer, Natalie; Haase, Christian; Wieland, Karin; Zahler, Stefan; Haisch, Christoph and Frieß, Wolfgang (2021): Finding the Needle in the Haystack: High-Resolution Techniques for Characterization of Mixed Protein Particles Containing Shed Silicone Rubber Particles Generated During Pumping. In: Journal of Pharmaceutical Sciences, Vol. 110, No. 5: pp. 2093-2104

Dengler, Sebastian; Mandal, Pradeep K.; Allmendinger, Lars; Douat, Celine and Huc, Ivan (2021): Conformational interplay in hybrid peptide-helical aromatic foldamer macrocycles. In: Chemical Science, Vol. 12, No. 33: 11004-

Devaux, Floriane; Li, Xuesong; Sluysmans, Damien; Maurizot, Victor; Bakalis, Evangelos; Zerbetto, Francesco; Huc, Ivan and Duwez, Anne-Sophie (2021): Single-molecule mechanics of synthetic aromatic amide helices: Ultrafast and robust non-dissipative winding. In: Chem, Vol. 7, No. 5

Dobersch, Stephanie; Rubio, Karla; Singh, Indrabahadur; Guenther, Stefan; Graumann, Johannes; Cordero, Julio; Castillo-Negrete, Rafael; Huynh, Minh Bao; Mehta, Aditi; Braubach, Peter; Cabrera-Fuentes, Hector; Bernhagen, Jürgen; Chao, Cho-Ming; Bellusci, Saverio; Guenther, Andreas; Preissner, Klaus T.; Kugel, Sita; Dobreva, Gergana; Wygrecka, Malgorzata; Braun, Thomas; Papy-Garcia, Dulce and Barreto, Guillermo (2021): Positioning of nucleosomes containing gamma-H2AX precedes active DNA demethylation and transcription initiation. In: Nature Communications, Vol. 12, No. 1, 1072

Domnowski, Martin; Lo Presti, Ken; Binder, Jonas; Reindl, Josef; Lehmann, Lucille; Kummer, Felix; Wolber, Meike; Satzger, Marion; Dehling, Marco; Jaehrling, Jan and Frieß, Wolfgang (2021): Generation of mAb Variants with Less Attractive Self-Interaction but Preserved Target Binding by Well-Directed Mutation. In: Molecular Pharmaceutics, Vol. 18, No. 1: pp. 236-245

Domnowski, Martin; Maruno, Takahiro; Enomoto, Kanta; Kummer, Felix; Kulakova, Alina; Harris, Pernille; Uchiyama, Susumu; Jaehrling, Jan and Friess, Wolfgang (2021): A Multi-Method Approach to Assess the Self-Interaction Behavior of Infliximab. In: Journal of Pharmaceutical Sciences, Vol. 110, No. 5: pp. 1979-1988

Donthamsetti, Prashant; Konrad, David B.; Hetzler, Belinda; Fu, Zhu; Trauner, Dirk and Isacoff, Ehud Y. (2021): Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor. In: Journal of the American Chemical Society, Vol. 143, No. 24: pp. 8951-8956

Ehlers, Sarah; Frieß, Wolfgang and Schroeder, Rudolf (2021): Impact of chamber wall temperature on energy transfer during freeze-drying. In: International Journal of Pharmaceutics, Vol. 592, 120025

Ehlers, Sarah; Schroeder, Rudolf and Frieß, Wolfgang (2021): Trouble With the Neighbor During Freeze-Drying: Rivalry About Energy. In: Journal of Pharmaceutical Sciences, Vol. 110, No. 3: pp. 1219-1226

Ehlers, Sarah; Schröder, Rudolf and Frieß, Wolfgang (2021): Process optimization and transfer of freeze-drying in nested vial systems. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 159: pp. 143-150

Faudone, Giuseppe; Kilu, Whitney; Ni, Xiaomin; Chaikuad, Apirat; Sreeramulu, Sridhar; Heitel, Pascal; Schwalbe, Harald; Knapp, Stefan; Schubert-Zsilavecz, Manfred; Heering, Jan and Merk, Daniel (2021): The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines. In: ACS Pharmacology & Translational Science, Vol. 4, No. 6: pp. 1794-1807

Freitag, Franziska and Wagner, Ernst (2021): Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach. In: Advanced Drug Delivery Reviews, Vol. 168: pp. 30-54

Gerckens, Michael; Schorpp, Kenji; Pelizza, Francesco; Woegrath, Melanie; Reichau, Kora; Ma, Huilong; Dworsky, Armando-Marco; Sengupta, Arunima; Stoleriu, Mircea Gabriel; Heinzelmann, Katharina; Merl-Pham, Juliane; Irmler, Martin; Alsafadi, Hani N.; Trenkenschuh, Eduard; Sarnova, Lenka; Jirouskova, Marketa; Friess, Wolfgang; Hauck, Stefanie M.; Beckers, Johannes; Kneidinger, Nikolaus; Behr, Jürgen; Hilgendorff, Anne; Hadian, Kamyar; Lindner, Michael; Koenigshoff, Melanie; Eickelberg, Oliver; Gregor, Martin; Plettenburg, Oliver; Yildirim, Ali Oender and Burgstaller, Gerald (2021): Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics. In: Science Advances, Vol. 7, No. 52, eabb3673

Ghanawi, Hanaa; Hennlein, Luisa; Zare, Abdolhossein; Bader, Jakob; Salehi, Saeede; Hornburg, Daniel; Ji, Changhe; Sivadasan, Rajeeve; Drepper, Carsten; Meissner, Felix; Mann, Matthias; Jablonka, Sibylle; Briese, Michael and Sendtner, Michael (2021): Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin. In: Nucleic Acids Research, Vol. 49, No. 21: pp. 12284-12305

Glas, Carina; Wirawan, Ricky and Bracher, Franz (2021): A Short Approach to N-Aryl-1,2,3,4-tetrahydroisoquinolines from N-(2-Bromobenzyl)anilines via a Reductive Amination/Palladium-Catalyzed Ethoxyvinylation/Reductive N-Alkylation Sequence. In: Synthesis-Stuttgart, Vol. 53, No. 11: pp. 1943-1954

Groel, Sebastian; Menzen, Tim and Winter, Gerhard (2021): Calorimetric Investigation of the Relaxation Phenomena in Amorphous Lyophilized Solids. In: Pharmaceutics, Vol. 13, No. 10, 1735

Gryzlo, Beata; Zareba, Paula; Malawska, Katarzyna; Mazur, Gabriela; Rapacz, Anna; Latka, Kamil; Höfner, Georg C.; Latacz, Gniewomir; Bajda, Marek; Salat, Kinga; Wanner, Klaus T.; Malawska, Barbara and Kulig, Katarzyna (2021): Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity. In: ACS Chemical Neuroscience, Vol. 12, No. 16: pp. 3073-3100

Hennis, Konstantin; Biel, Martin; Wahl-Schott, Christian and Fenske, Stefanie (2021): Beyond pacemaking: HCN channels in sinoatrial node function. In: Progress in Biophysics & Molecular Biology, Vol. 166: pp. 51-60

Hennis, Konstantin; Roetzer, Rene D.; Piantoni, Chiara; Biel, Martin; Wahl-Schott, Christian and Fenske, Stefanie (2021): Speeding Up the Heart? Traditional and New Perspectives on HCN4 Function. In: Frontiers in Physiology, Vol. 12, 669029

Härdter, Nicole; Menzen, Tim and Winter, Gerhard (2021): Minimizing Oxidation of Freeze-Dried Monoclonal Antibodies in Polymeric Vials Using a Smart Packaging Approach. In: Pharmaceutics, Vol. 13, No. 10, 1695

Joos, Markus; Schneider, Christian; Münchinger, Andreas; Moudrakovski, Igor; Usiskin, Robert; Maier, Joachim and Lotsch, Bettina V. (2021): Impact of hydration on ion transport in Li2Sn2S5 center dot xH(2)O. In: Journal of Materials Chemistry A, Vol. 9, No. 30: pp. 16532-16544

Jourjine, Ilya A. P.; Zeisel, Lukas; Krauß, Jürgen and Bracher, Franz (2021): Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone. In: Beilstein Journal of Organic Chemistry, Vol. 17: pp. 2668-2679

Junker, Julia; Kamp, Frits; Winkler, Edith; Steiner, Harald; Bracher, Franz and Müller, Christoph (2021): Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS. In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 211, 105880

Karg, Cornelia A.; Doppler, Christian; Schilling, Charlotte; Jakobs, Franziska; Dal Colle, Marlene C. S.; Frey, Nadine; Bernhard, David; Vollmar, Angelika M. and Moser, Simone (2021): A yellow chlorophyll catabolite in leaves of Urtica dioica L.: An overlooked phytochemical that contributes to health benefits of stinging nettle. In: Food Chemistry, Vol. 359, 129906

Karg, Cornelia A.; Neubig, Christina M.; Roosen, Jutta and Moser, Simone (2021): Rising levels of antioxidative phyllobilins in stored agricultural produce and their impact on consumer acceptance. In: Npj Science of Food, Vol. 5, No. 1, 19

Karg, Cornelia A.; Wang, Shuaijun; Al Danaf, Nader; Pemberton, Ryan P.; Bernard, Denzil; Kretschmer, Maibritt; Schneider, Sabine; Zisis, Themistoklis; Vollmar, Angelika M.; Lamb, Don C.; Zahler, Stefan and Moser, Simone (2021): Tetrapyrrolic Pigments from Heme- and Chlorophyll Breakdown are Actin-Targeting Compounds. In: Angewandte Chemie-International Edition, Vol. 60, No. 41: pp. 22578-22584

Keil, Tobias W. M. and Merkel, Olivia M. (2021): Characterization of positively charged polyplexes by tunable resistive pulse sensing. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 158: pp. 359-364

Keil, Tobias W. M.; Zimmermann, Christoph; Baldassi, Domizia; Adams, Friederike; Frieß, Wolfgang; Mehta, Aditi and Merkel, Olivia M. (2021): Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano-in-Microparticles. In: Advanced Therapeutics, Vol. 4, No. 6, 2100073

Keller, Marco; Sauvageot-Witzku, Karl; Geisslinger, Franz; Urban, Nicole; Schaefer, Michael; Bartel, Karin and Bracher, Franz (2021): The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet-Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids. In: Beilstein Journal of Organic Chemistry, Vol. 17: pp. 2716-2725

Koch, Mirja; Scheel, Constanze; Ma, Hongwei; Yang, Fan; Stadlmeier, Michael; Glück, Andrea F.; Murenu, Elisa; Traube, Franziska R.; Carell, Thomas; Biel, Martin; Ding, Xi-Qin and Michalakis, Stylianos (2021): The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia. In: International Journal of Molecular Sciences, Vol. 22, No. 1, 52

Krauß, Jürgen; Müller, Christoph; Klimt, Monika; Valero, Leandro Jorquera; Martinez, Jose Francisco; Müller, Martin; Bartel, Karin; Binder, Ulrike and Bracher, Franz (2021): Synthesis, Biological Evaluation, and Structure-Activity Relationships of 4-Aminopiperidines as Novel Antifungal Agents Targeting Ergosterol Biosynthesis. In: Molecules, Vol. 26, No. 23, 7208

Krishnathas, G. Melissa; Strödke, Benjamin; Mittmann, Laura; Zech, Thomas; Berger, Lena M.; Reichel, Christoph A.; Rösser, Silvia; Schmid, Tobias; Knapp, Stefan; Müller, Susanne; Bracher, Franz; Fürst, Robert and Bischoff-Kont, Iris (2021): C81-evoked inhibition of the TNFR1-NF kappa B pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes. In: Faseb Journal, Vol. 35, No. 6, e21656

Lang, Alisa; Isigkeit, Laura; Schubert-Zsilavecz, Manfred and Merk, Daniel (2021): The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators. In: Journal of Medicinal Chemistry, Vol. 64, No. 23: pp. 16956-16973

Leser, Charlotte; Keller, Marco; Gerndt, Susanne; Urban, Nicole; Chen, Cheng-Chang; Schaefer, Michael; Grimm, Christian and Bracher, Franz (2021): Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. In: European Journal of Medicinal Chemistry, Vol. 210, 112966

Li, Yanfen; Schoen, Christian; Chen, Cheng-Chang; Yang, Zhuo; Liegl, Raffael; Murenu, Elisa; Schworm, Benedikt; Klugbauer, Norbert; Grimm, Christian; Wahl-Schott, Christian; Michalakis, Stylianos and Biel, Martin (2021): TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration. In: Life Science Alliance, Vol. 4, No. 8, e202101047

Lo Presti, Ken and Frieß, Wolfgang (2021): Adjustment of specific residual moisture levels in completely freeze-dried protein formulations by controlled spiking of small water volumes. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 169: pp. 292-296

Loy, Dominik M.; Krzyszton, Rafal; Lächelt, Ulrich; Rädler, Joachim O. and Wagner, Ernst (2021): Controlling Nanoparticle Formulation: A Low-Budget Prototype for the Automation of a Microfluidic Platform. In: Processes, Vol. 9, No. 1, 129

Löbbert, Arnelle; Schanzer, Sonja; Krehenwinkel, Henrik; Bracher, Franz and Müller, Christoph (2021): Determination of multi pesticide residues in leaf and needle samples using a modified QuEChERS approach and gas chromatography-tandem mass spectrometry. In: Analytical Methods, Vol. 13, No. 9: pp. 1138-1146

Mahapatra, Sujata; Polimeni, Marco; Gentiluomo, Lorenzo; Roessner, Dierk; Friess, Wolfgang; Peters, Guenther H. J.; Streicher, Werner W.; Lund, Mikael and Harris, Pernille (2021): Self-Interactions of Two Monoclonal Antibodies: Small-Angle X-ray Scattering, Light Scattering, and Coarse-Grained Modeling. In: Molecular Pharmaceutics, Vol. 19, No. 2: pp. 508-519

Marschall, Christoph; Graf, Gesche; Witt, Madlen; Hauptmeier, Bernhard and Friess, Wolfgang (2021): Preparation of high concentration protein powder suspensions by milling of lyophilizates. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 166: pp. 75-86

Mateus, Pedro; Jacquet, Antoine; Mendez-Ardoy, Alejandro; Boulloy, Alice; Kauffmann, Brice; Pecastaings, Gilles; Buffeteau, Thierry; Ferrand, Yann; Bassani, Dario M. and Huc, Ivan (2021): Sensing a binding event through charge transport variations using an aromatic oligoamide capsule. In: Chemical Science, Vol. 12, No. 10: pp. 3743-3750

Mbianda, Johanne; Bakail, May; Andre, Christophe; Moal, Gwenaelle; Perrin, Marie E.; Pinna, Guillaume; Guerois, Raphael; Becher, Francois; Legrand, Pierre; Traore, Seydou; Douat, Celine; Guichard, Gilles and Ochsenbein, Francoise (2021): Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity. In: Science Advances, Vol. 7, No. 12, eabd9153

Mehta, Aditi; Michler, Thomas and Merkel, Olivia M. (2021): siRNA Therapeutics against Respiratory Viral Infections-What Have We Learned for Potential COVID-19 Therapies? In: Advanced Healthcare Materials, Vol. 10, No. 7, 2001650

Messner, Martina; Mandl, Melanie M.; Hackl, Mathias W.; Reinhardt, Till; Ardelt, Maximilian A.; Szczepanowska, Karolina; Fraedrich, Julian E.; Waschke, Jens; Jeremias, Irmela; Fux, Anja; Stahl, Matthias; Vollmar, Angelika M.; Sieber, Stephan A. and Pachmayr, Johanna (2021): Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers. In: Scientific Reports, Vol. 11, No. 1, 11185

Meyer, Robina M.; Berger, Lukas; Nerkamp, Jörg; Scheler, Stefan; Nehring, Sebastian and Frieß, Wolfgang (2021): Identification of monoclonal antibody variants involved in aggregate formation -Part 1: Charge variants. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 158: pp. 123-131

Meyer, Robina M.; Berger, Lukas; Nerkamp, Jörg; Scheler, Stefan; Nehring, Sebastian and Frieß, Wolfgang (2021): Identification of monoclonal antibody variants involved in aggregate formation-Part 2: Hydrophobicity variants. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 160: pp. 134-142

Mueller, Susanne; Ackloo, Suzanne; Al Chawaf, Arij; Al-Lazikani, Bissan; Antolin, Albert; Baell, Jonathan B.; Beck, Hartmut; Beedie, Shaunna; Betz, Ulrich A. K.; Bezerra, Gustavo Arruda; Brennan, Paul E.; Brown, David; Brown, Peter J.; Bullock, Alex N.; Carter, Adrian J.; Chaikuad, Apirat; Chaineau, Mathilde; Ciulli, Alessio; Collins, Ian; Dreher, Jan; Drewry, David; Edfeldt, Kristina; Edwards, Aled M.; Egner, Ursula; Frye, Stephen V.; Fuchs, Stephen M.; Hall, Matthew D.; Hartung, Ingo V.; Hillisch, Alexander; Hitchcock, Stephen H.; Homan, Evert; Kannan, Natarajan; Kiefer, James R.; Knapp, Stefan; Kostic, Milka; Kubicek, Stefan; Leach, Andrew R.; Lindemann, Sven; Marsden, Brian D.; Matsui, Hisanori; Meier, Jordan L.; Merk, Daniel; Michel, Maurice; Morgan, Maxwell R.; Mueller-Fahrnow, Anke; Owen, Dafydd R.; Perry, Benjamin G.; Rosenberg, Saul H.; Saikatendu, Kumar Singh; Schapira, Matthieu; Scholten, Cora; Sharma, Sujata; Simeonov, Anton; Sundstrom, Michael; Superti-Furga, Giulio; Todd, Matthew H.; Tredup, Claudia; Vedadi, Masoud; Delft, Frank von; Willson, Timothy M.; Winter, Georg E.; Workman, Paul and Arrowsmith, Cheryl H. (2021): Target 2035-update on the quest for a probe for every protein. In: Rsc Medicinal Chemistry, Vol. 13, No. 1: pp. 13-21

Murenu, Elisa; Kostidis, Sarantos; Lahiri, Shibojyoti; Geserich, Anna S.; Imhof, Axel; Giera, Martin and Michalakis, Stylianos (2021): Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice. In: International Journal of Molecular Sciences, Vol. 22, No. 5, 2345

Murenu, Elisa; Pavlou, Marina; Richter, Lisa; Rapti, Kleopatra; Just, Sabrina; Cehajic-Kapetanovic, Jasmina; Tafrishi, Neda; Hayes, Andrew; Scholey, Rachel; Lucas, Robert; Buening, Hildegard; Grimm, Dirk and Michalakis, Stylianos (2021): A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting. In: Molecular Therapy-Methods & Clinical Development, Vol. 20: pp. 587-600

Müller, Martin; Gerndt, Susanne; Chao, Yu-Kai; Zisis, Themistoklis; Ong, Nam Phuong Nguyen; Gerwien, Aaron; Urban, Nicole; Müller, Christoph; Gegenfurtner, Florian A.; Geisslinger, Franz; Ortler, Carina; Chen, Cheng-Chang; Zahler, Stefan; Biel, Martin; Schäfer, Michael; Grimm, Christian; Bracher, Franz; Vollmar, Angelika M. and Bartel, Karin (2021): Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. In: Cell Chemical Biology, Vol. 28, No. 8: 1119-

Opolka-Hoffmann, Eugenia; Jordan, Gregor; Otteneder, Michael; Kieferle, Robin; Lechmann, Martin; Winter, Gerhard and Staack, Roland F. (2021): The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance. In: Mabs, Vol. 13, No. 1, e1995929

Palabiyik-Yucelik, Saziye Sezin; Moser, Simone; Becker, Kathrin; Halici, Zekai; Bayir, Yasin; Stonig, Marlies; Schennach, Harald; Fuchs, Dietmar; Gostner, Johanna M. and Kurz, Katharina (2021): Oxyresveratrol modulates the immune response in vitro. In: Pteridines, Vol. 32, No. 1: pp. 70-78

Pasieka, Anna; Panek, Dawid; Jonczyk, Jakub; Godyn, Justyna; Szalaj, Natalia; Latacz, Gniewomir; Tabor, Julia; Mezeiova, Eva; Chantegreil, Fabien; Dias, Jose; Knez, Damijan; Lu, Junfeng; Pi, Rongbiao; Korabecny, Jan; Brazzolotto, Xavier; Gobec, Stanislav; Hoefner, Georg; Wanner, Klaus; Wieckowska, Anna and Malawska, Barbara (2021): Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters. In: European Journal of Medicinal Chemistry, Vol. 218, 113397

Passi, Mehak and Zahler, Stefan (2021): Mechano-Signaling Aspects of Hepatocellular Carcinoma. In: Journal of Cancer, Vol. 12, No. 21: pp. 6411-6421

Pramanik, Susnata; Kauffmann, Brice; Hecht, Stefan; Ferrand, Yann and Huc, Ivan (2021): Light-mediated chiroptical switching of an achiral foldamer host in presence of a carbohydrate guest. In: Chemical Communications, Vol. 57, No. 1: pp. 93-96

Reynders, Martin and Trauner, Dirk (2021): Optical control of targeted protein degradation. In: Cell Chemical Biology, Vol. 28, No. 7: pp. 969-986

Rieser, Ruth; Koch, Johanna; Faccioli, Greta; Richter, Klaus; Menzen, Tim; Biel, Martin; Winter, Gerhard and Michalakis, Stylianos (2021): Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors. In: Pharmaceutics, Vol. 13, No. 5, 748

Roche, Aisling; Gentiluomo, Lorenzo; Sibanda, Nicole; Roessner, Dierk; Friess, Wolfgang; Trainoff, Steven P. and Curtis, Robin (2021): Towards an improved prediction of concentrated antibody solution viscosity using the Huggins coefficient. In: Journal of Colloid and Interface Science, Vol. 607: pp. 1813-1824

Rockinger, Ute; Funk, Martin and Winter, Gerhard (2021): Current Approaches of Preservation of Cells During (freeze-) Drying. In: Journal of Pharmaceutical Sciences, Vol. 110, No. 8: pp. 2873-2893

Rockinger, Ute; Müller, Christoph; Bracher, Franz; Funk, Martin and Winter, Gerhard (2021): DMSO as new, counterintuitive excipient for freeze-drying human keratinocytes. In: European Journal of Pharmaceutical Sciences, Vol. 160, 105746

Rospiccio, Marcello; Arsiccio, Andrea; Winter, Gerhard and Pisano, Roberto (2021): The Role of Cyclodextrins against Interface-Induced Denaturation in Pharmaceutical Formulations: A Molecular Dynamics Approach. In: Molecular Pharmaceutics, Vol. 18, No. 6: pp. 2322-2333

Rotzer, Rene D.; Brox, Verena F.; Hennis, Konstantin; Thalhammer, Stefan B.; Biel, Martin; Wahl-Schott, Christian and Fenske, Stefanie (2021): Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice. In: Jove-Journal of Visualized Experiments, No. 168, e62101

Rudy, Heinrich-Karl A.; Höfner, Georg and Wanner, Klaus T. (2021): Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with tricyclic cage structures in the lipophilic domain as GABA uptake inhibitors. In: Medicinal Chemistry Research, Vol. 30, No. 3: pp. 586-609 [PDF, 1MB]

Rühl, Philipp; Rosato, Anna Scotto; Urban, Nicole; Gerndt, Susanne; Tang, Rachel; Abrahamian, Carla; Leser, Charlotte; Sheng, Jiansong; Jha, Archana; Vollmer, Günter; Schaefer, Michael; Bracher, Franz

and Grimm, Christian (2021): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. In: Scientific reports, Vol. 11, No. 1, 8313 [PDF, 7MB]

Sailer, Alexander; Meiring, Joyce C. M.; Heise, Constanze; Pettersson, Linda N.; Akhmanova, Anna; Thorn-Seshold, Julia and Thorn-Seshold, Oliver (2021): Pyrrole Hemithioindigo Antimitotics with Near-Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single-Cell Precision**. In: Angewandte Chemie-International Edition, Vol. 60, No. 44: pp. 23695-23704

Sauer, Fabian; Haas, Maren; Sydow, Constanze; Siegle, Alexander F.; Lauer, Christoph A. and Trapp, Oliver (2021): From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth. In: Nature Communications, Vol. 12, No. 1, 7182

Schanzer, Sonja; Kröner, Egbert; Wibbelt, Gudrun; Koch, Martin; Kiefer, Andreas; Bracher, Franz and Müller, Christoph (2021): Miniaturized multiresidue method for the analysis of pesticides and persistent organic pollutants in non-target wildlife animal liver tissues using GC-MS/MS. In: Chemosphere, Vol. 279, 130434

Seifert, Ivonne; Bregolin, Alessandro; Fissore, Davide and Frieß, Wolfgang (2021): The Influence of Arginine and Counter-Ions: Antibody Stability during Freeze-Drying. In: Journal of Pharmaceutical Sciences, Vol. 110, No. 5: pp. 2017-2027

Seifert, Ivonne and Frieß, Wolfgang (2021): The effect of residual moisture on a monoclonal antibody stability in L-arginine based lyophilisates. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 158: pp. 53-61

Sobiech, Thomas A.; Zhong, Yulong; Sanchez, Laura S. B.; Kauffmann, Brice; McGrath, Jillian K.; Scalzo, Christina; Miller, Daniel P.; Huc, Ivan; Zurek, Eva; Ferrand, Yann and Gong, Bing (2021): Stable pseudo[3]rotaxanes with strong positive binding cooperativity based on shape-persistent aromatic oligoamide macrocycles. In: Chemical Communications, Vol. 57, No. 88: pp. 11645-11648

Trenkenschuh, Eduard and Friess, Wolfgang (2021): Freeze-thaw stability of aluminum oxide nanoparticles. In: International Journal of Pharmaceutics, Vol. 606, 120932

Trenkenschuh, Eduard and Frieß, Wolfgang (2021): Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process optimization. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 165: pp. 345-360

Trenkenschuh, Eduard; Savsek, Ula and Frieß, Wolfgang (2021): Formulation, process, and storage strategies for lyophilizates of lipophilic nanoparticulate systems established based on the two models paliperidone palmitate and solid lipid nanoparticles. In: International Journal of Pharmaceutics, Vol. 606, 120929

Urushibara, Ko; Ferrand, Yann; Liu, Zhiwei; Katagiri, Kosuke; Kawahata, Masatoshi; Morvan, Estelle; D'Elia, Ryan; Pophristic, Vojislava; Tanatani, Aya and Huc, Ivan (2021): Accessing Improbable Foldamer Shapes with Strained Macrocycles. In: Chemistry - A European Journal, Vol. 27, No. 43: pp. 11205-11215

Wang, Jinhua; Wicher, Barbara; Mendez-Ardoy, Alejandro; Li, Xuesong; Pecastaings, Gilles; Buffeteau, Thierry; Bassani, Dario M.; Maurizot, Victor and Huc, Ivan (2021): Loading Linear Arrays of Cu-II Inside Aromatic Amide Helices. In: Angewandte Chemie-International Edition, Vol. 60, No. 34: pp. 18461-18466

Wang, Pengyu; Karg, Cornelia A.; Frey, Nadine; Frädrich, Julian; Vollmar, Angelika M. and Moser, Simone (2021): Phyllobilins as a challenging diverse natural product class: Exploration of pharmacological activities. In: Archiv der Pharmazie, Vol. 354, No. 10, e2100061

Wang, Shuaijun; Meixner, Maximilian; Yu, Lushuang; Zhuo, Ling; Karmann, Lisa; Kazmaier, Uli; Vollmar, Angelika M.; Antes, Iris and Zahler, Stefan (2021): Turning the Actin Nucleating Compound Miuraenamide into Nucleation Inhibitors. In: ACS Omega, Vol. 6, No. 34: pp. 22165-22172

Yoluç, Yasemin; Logt, Erik van de and Kellner-Kaiser, Stefanie (2021): The Stress-Dependent Dynamics of Saccharomyces cerevisiae tRNA and rRNA Modification Profiles. In: Genes, Vol. 12, No. 9, 1344

Yuan, Yu; Kilpatrick, Bethan S.; Gerndt, Susanne; Bracher, Franz; Grimm, Christian; Schapira, Anthony H. and Patel, Sandip (2021): The lysosomotrope GPN mobilises Ca2+ from acidic organelles. In: Journal of Cell Science, Vol. 134, No. 6, jcs256578

Zaienne, Daniel; Willems, Sabine; Schierle, Simone; Heering, Jan and Merk, Daniel (2021): Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1. In: Journal of Medicinal Chemistry, Vol. 64, No. 20: pp. 15126-15140

Zareba, Paula; Salat, Kinga; Höfner, Georg C.; Latka, Kamil; Bajda, Marek; Latacz, Gniewomir; Kotniewicz, Krzysztof; Rapacz, Anna; Podkowa, Adrian; Maj, Maciej; Jozwiak, Krzysztof; Filipek, Barbara; Wanner, Klaus T.; Malawska, Barbara and Kulig, Katarzyna (2021): Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity. In: European Journal of Medicinal Chemistry, Vol. 221, 113512

Zisis, Themistoklis; Schwarz, Jan; Balles, Miriam; Kretschmer, Maibritt; Nemethova, Maria; Chait, Remy; Hauschild, Robert; Lange, Janina; Guet, Calin; Sixt, Michael and Zahler, Stefan (2021): Sequential and Switchable Patterning for Studying Cellular Processes under Spatiotemporal Control. In: ACS Applied Materials & Interfaces, Vol. 13, No. 30: pp. 35545-35560

2020

Ackermann, Thomas M.; Allmendinger, Lars; Höfner, Georg and Wanner, Klaus T. (2020): MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand. In: Chemmedchem, Vol. 16, No. 1: pp. 199-215 [PDF, 2MB]

Andreß, Janina C.; Böck, Michael C.; Höfner, Georg and Wanner, Klaus T. (2020): Synthesis and biological evaluation of α- and β-hydroxy substituted amino acid derivatives as potential mGAT1-4 inhibitors. In: Medicinal Chemistry Research, Vol. 29, No. 8: pp. 1321-1340 [PDF, 1MB]

Bao, Xuanwen; Shi, Run; Zhao, Tianyu and Wang, Yanfang (2020): Immune landscape and a novel immunotherapy-related gene signature associated with clinical outcome in early-stage lung adenocarcinoma. In: Journal of Molecular Medicine-Jmm, Vol. 98, No. 6: pp. 805-818

Bao, Xuanwen; Shi, Run; Zhao, Tianyu and Wang, Yanfang (2020): Mast cell-based molecular subtypes and signature associated with clinical outcome in early-stage lung adenocarcinoma. In: Molecular Oncology, Vol. 14, No. 5: pp. 917-932

Bluemel, Oliver; Buecheler, Jakob W.; Rodrigues, Miguel A.; Geraldes, Vitor; Hoelzl, Georg; Bechtold-Peters, Karoline and Friess, Wolfgang (2020): Cryoconcentration and 3D Temperature Profiles During Freezing of mAb Solutions in Large-Scale PET Bottles and a Novel Scale-Down Device. In: Pharmaceutical Research, Vol. 37, No. 9, 179

Boehm, Sybille; Splith, Victoria; Riedmayr, Lisa Maria; Rotzer, Rene Dominik; Gasparoni, Gilles; Nordstroem, Karl J. V.; Wagner, Johanna Elisabeth; Hinrichsmeyer, Klara Sonnie; Walter, Joern; Wahl-Schott, Christian; Fenske, Stefanie; Biel, Martin; Michalakis, Stylianos and Becirovic, Elvir (2020): A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation. In: Science Advances, Vol. 6, No. 34, eaba5614

Borowiak, Malgorzata; Kuellmer, Florian; Gegenfurtner, Florian; Peil, Sebastian; Nasufovic, Veselin; Zahler, Stefan; Thorn-Seshold, Oliver; Trauner, Dirk and Arndt, Hans-Dieter (2020): Optical Manipulation of F-Actin with Photoswitchable Small Molecules. In: Journal of the American Chemical Society, Vol. 142, No. 20: pp. 9240-9249

Bracher, Franz (2020): Dimethylformamide Acetals and Bredereck's Reagent as Building Blocks in Natural Products Total Synthesis. In: Mini-Reviews in Organic Chemistry, Vol. 17, No. 1: pp. 47-66

Böck, Michael C.; Höfner, Georg and Wanner, Klaus T. (2020): N‐Substituted Nipecotic Acids as (S )‐SNAP‐5114 Analogues with Modified Lipophilic Domains. In: ChemMedChem, Vol. 15, No. 9: pp. 756-771 [PDF, 2MB]

Carfagna, Marco; Rosa, Monica; Lucke, Matthias; Hawe, Andrea and Friess, Wolfgang (2020): Heat flux sensor to create a design space for freeze-drying development. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 153: pp. 84-94

Chen, Cheng; Liu, Li; Shu, Ya-Qiao; Jing, Ping; Lu, Yun; Zhang, Xiao-Xue; Zong, Xian-Gang; Guo, Lian-Jun and Li, Chang-Jun (2020): Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons. In: Neuroscience Bulletin, Vol. 36, No. 8: pp. 875-894

Daerr, Markus; Allmendinger, Lars; Höfner, Georg and Wanner, Klaus T. (2020): Synthesis and biological evaluation of fluorescent GAT-ligands based on asymmetric substituted BODIPY dyes. In: Medicinal Chemistry Research, Vol. 29, No. 4: pp. 767-782

Daerr, Markus; Pabel, Jörg; Höfner, Georg; Mayer, Peter and Wanner, Klaus T. (2020): Synthesis and biological evaluation of fluorescent GAT-ligands based on meso-substituted BODIPY dyes. In: Medicinal Chemistry Research, Vol. 29, No. 2: pp. 301-327

Dahlem, Charlotte; Siow, Wei Xiong; Lopatniuk, Maria; Tse, William K. F.; Kessler, Sonja M.; Kirsch, Susanne H.; Hoppstaedter, Jessica; Vollmar, Angelika M.; Müller, Rolf; Luzhetskyy, Andriy; Bartel, Karin and Kiemer, Alexandra K. (2020): Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism. In: Cancers, Vol. 12, No. 5, 1288

Daller, Sarah; Friess, Wolfgang and Schroeder, Rudolf (2020): Energy Transfer in Vials Nested in a Rack System During Lyophilization. In: Pharmaceutics, Vol. 12, No. 1, 61

Darnet, Sylvain; Martin, Laetitia B. B.; Mercier, Pierre; Bracher, Franz; Geoffroy, Philippe and Schaller, Hubert (2020): Inhibition of Phytosterol Biosynthesis by Azasterols. In: Molecules, Vol. 25, No. 5, 1111

Dekel, Noa; Eisenberg-Domovich, Yael; Karlas, Alexander; Meyer, Thomas F.; Bracher, Franz; Lebendiker, Mario; Danieli, Tsafi and Livnah, Oded (2020): Expression, purification and crystallization of CLK1 kinase - A potential target for antiviral therapy. In: Protein Expression and Purification, Vol. 176, 105742

Derya, Sami M.; Spiegel, Holger; Hanisch, Franz-Georg; Morozov, Vasily; Schroten, Horst; Jennewein, Stefan and Parschat, Katja (2020): Biotechnologically produced fucosylated oligosaccharides inhibit the binding of human noroviruses to their natural receptors. In: Journal of Biotechnology, Vol. 318: pp. 31-38

Domnowski, Martin; Jaehrling, Jan and Friess, Wolfgang (2020): Assessment of Antibody Self-Interaction by Bio-Layer-Interferometry as a Tool for Early Stage Formulation Development. In: Pharmaceutical Research, Vol. 37, No. 2, 29

Feldmann, Daniel P.; Heyza, Joshua; Zimmermann, Christoph M.; Patrick, Steve M. and Merkel, Olivia M. (2020): Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy. In: Molecules, Vol. 25, No. 8, 1994

Fenske, Stefanie; Hennis, Konstantin; Roetzer, Rene D.; Brox, Verena F.; Becirovic, Elvir; Scharr, Andreas; Gruner, Christian; Ziegler, Tilman; Mehlfeld, Verena; Brennan, Jaclyn; Efimov, Igor R.; Pauza, Audrys G.; Moser, Markus; Wotjak, Carsten T.; Kupatt, Christian; Goenner, Rasmus; Zhang, Rai; Zhang, Henggui; Zong, Xiangang; Biel, Martin and Wahl-Schott, Christian (2020): cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells. In: Nature Communications, Vol. 11, No. 1, 5555 [PDF, 10MB]

Fornara, Paolo; Madersbacher, Stephan; Vahlensieck, Winfried; Bracher, Franz; Romics, Imre and Kil, Paul (2020): Phytotherapy Adds to the Therapeutic Armamentarium for the Treatment of Mild-To-Moderate Lower Urinary Tract Symptoms in Men. In: Urologia Internationalis, Vol. 104: pp. 333-342

Frank, James A.; Antonini, Marc-Joseph; Chiang, Po-Han; Canales, Andres; Konrad, David B.; Garwood, Indie C.; Rajic, Gabriela; Koehler, Florian; Fink, Yoel and Anikeeva, Polina (2020): In Vivo Photopharmacology Enabled by Multifunctional Fibers. In: ACS Chemical Neuroscience, Vol. 11, No. 22: pp. 3802-3813

Gabriel, Jeurgen; Höfner, Georg and Wanner, Klaus T. (2020): Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1. In: European Journal of Medicinal Chemistry, Vol. 206, 112598

Geisslinger, Franz; Müller, Martin; Vollmar, Angelika M. and Bartel, Karin (July 2020): Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review. In: Frontiers in Oncology, Vol. 10, 1156: pp. 1-7 [PDF, 717kB]

Geisslinger, Franz; Vollmar, Angelika M. and Bartel, Karin (2020): Cancer Patients Have a Higher Risk Regarding COVID-19-and Vice Versa? In: Pharmaceuticals, Vol. 13, No. 7, 143

Gentiluomo, Lorenzo; Roessner, Dierk and Friess, Wolfgang (2020): Application of machine learning to predict monomer retention of therapeutic proteins after long term storage. In: International Journal of Pharmaceutics, Vol. 577, 119039

Gentiluomo, Lorenzo; Roessner, Dierk; Streicher, Werner; Mahapatra, Sujata; Harris, Pernille and Friess, Wolfgang (2020): Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction. In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1: pp. 443-451

Glas, Carina; Dietschreit, Johannes C. B.; Woessner, Nathalie; Urban, Lars; Ghazy, Ehab; Sippl, Wolfgang; Jung, Manfred; Ochsenfeld, Christian and Bracher, Franz (2020): Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations. In: European Journal of Medicinal Chemistry, Vol. 206, 112676

Grapentin, Christoph; Müller, Claudia; Kishore, Ravuri S. K.; Adler, Michael; ElBialy, Inas; Friess, Wolfgang; Huwyler, Jörg and Khan, Tarik A. (2020): Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188. In: Journal of Pharmaceutical Sciences, Vol. 109, No. 8: pp. 2393-2404

Guenther, Ilka; Rimbach, Gerald; Mack, Carina; Weinert, Christoph H.; Danylec, Nicolas; Lueersen, Kai; Birringer, Marc; Bracher, Franz; Soukup, Sebastian T.; Kulling, Sabine E. and Pallauf, Kathrin (2020): The Putative Caloric Restriction Mimetic Resveratrol has Moderate Impact on Insulin Sensitivity, Body Composition, and the Metabolome in Mice. In: Molecular Nutrition & Food Research, Vol. 64, No. 6, 1901116

Haeuser, Christina; Goldbach, Pierre; Huwyler, Jörg; Friess, Wolfgang and Allmendinger, Andrea (2020): Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations. In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1: pp. 807-817

Haeuser, Christina; Goldbach, Pierre; Huwyler, Jörg; Friess, Wolfgang and Allmendinger, Andrea (2020): Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 147: pp. 45-56

Hartl, Natascha; Adams, Friederike and Merkel, Olivia M. (2020): From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood-Brain Barrier. In: Advanced Therapeutics, Vol. 4, No. 1, 2000092 [PDF, 2MB]

Heerdegen, Desiree; Reuter, Doreen; Kornmayer, Moritz M.; Kriegler, Katharina N.; Müller, Christoph; Mayer, Peter and Bracher, Franz (2020): Synthesis ofSeco-Analogues of the DHCR24 Inhibitor SH-42. In: European Journal of Organic Chemistry, Vol. 2020, No. 39: pp. 6270-6288

Heerdegen, Desirée; Junker, Julia; Dittrich, Sebastian; Mayer, Peter and Bracher, Franz

(2020): Traceless Isoprenylation of Aldehydes via N‐Boc‐N‐(1,1‐dimethylallyl)hydrazones. In: European Journal of Organic Chemistry, Vol. 2020, No. 24: pp. 3680-3687 [PDF, 1MB]

Helbig, Constanze; Ammann, Gregor; Menzen, Tim; Friess, Wolfgang; Wuchner, Klaus and Hawe, Andrea (2020): Backgrounded Membrane Imaging (BMI) for High-Throughput Characterization of Subvisible Particles During Biopharmaceutical Drug Product Development. In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1: pp. 264-276

Hu, Xiaobo; Mandal, Pradeep K.; Kauffmann, Brice and Huc, Ivan (2020): Hybrid Sequences that Express both Aromatic Amide and α‐Peptidic Folding Features. In: ChemPlusChem, Vol. 85, No. 7: pp. 1580-1586 [PDF, 1MB]

Kamlah, Alexandra and Bracher, Franz

(2020): A Novel Approach to Highly Substituted β‐Carbolines via Reductive Ring Transformation of 2‐Acyl‐3‐isoxazolylindoles. In: European Journal of Organic Chemistry, No. 18: pp. 2708-2719 [PDF, 1MB]

Kandil, Rima; Xie, Yuran; Mehta, Aditi and Merkel, Olivia (2020): A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases. In: Jain, Kewal K. (ed.) : Drug Delivery Systems. Methods in molecular biology, Vol. 2059. pp. 155-166

Karg, Cornelia A.; Wang, Pengyu; Kluibenschedl, Florian; Müller, Thomas; Allmendinger, Lars; Vollmar, Angelika M. and Moser, Simone (2020): Phylloxanthobilins are Abundant Linear Tetrapyrroles from Chlorophyll Breakdown with Activities Against Cancer Cells. In: European Journal of Organic Chemistry, Vol. 2020, No. 29: pp. 4499-4509 [PDF, 2MB]

Keil, Tobias W. M.; Baldassi, Domizia and Merkel, Olivia M. (2020): T‐cell targeted pulmonary siRNA delivery for the treatment of asthma. In: WIREs Nanomedicine and Nanobiotechnology, Vol. 12, No. 5, e1634 [PDF, 5MB]

Koelbel, J.; Anuschek, M. L.; Seifert, I; Friess, W. and Zeitler, J. A. (2020): Stability of Protein-Sugar Lyophilizates Investigated with Terahertz Spectroscopy. In: 2020 45th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THZ)

Kraus, Yvonne; Glas, Carina; Melzer, Benedikt; Gao, Li; Heise, Constanze; Preusse, Monique; Ahlfeld, Julia; Bracher, Franz and Thorn-Seshold, Oliver (2020): Isoquinoline-based biaryls as a robust scaffold for microtubule inhibitors. In: European Journal of Medicinal Chemistry, Vol. 186, 111865

Krieg, Dennis; Svilenov, Hristo; Gitter, Julian H. and Winter, Gerhard (2020): Overcoming challenges in co-formulation of proteins with contradicting stability profiles - EPO plus G-CSF. In: European Journal of Pharmaceutical Sciences, Vol. 141, 105073

Kuhn, Jasmin; Lin, Yi; Levacic, Ana Krhac; Al Danaf, Nader; Peng, Lun; Hoehn, Miriam; Lamb, Don C.; Wagner, Ernst and Laechelt, Ulrich (2020): Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides. In: Bioconjugate Chemistry, Vol. 31, No. 3: pp. 729-742

Kulakova, Alina; Indrakumar, Sowmya; Sonderby, Pernille; Gentiluomo, Lorenzo; Streicher, Werner; Roessner, Dierk; Friess, Wolfgang; Peters, Guenther H. J. and Harris, Pernille (2020): Small angle X-ray scattering and molecular dynamic simulations provide molecular insight for stability of recombinant human transferrin. In: Journal of Structural Biology-X, Vol. 4, 100017

Little, Hunter; Wang, Jingqi; Duhamel, Jean; Li, Xuesong; Markandeya, Nagula; Maurizot, Victor and Huc, Ivan (2020): Simplification in the Acquisition and Analysis of Fluorescence Decays Acquired with Polarized Emission for Time-Resolved Fluorescence Anisotropy Measurements. In: Analytical Chemistry, Vol. 92, No. 1: pp. 668-673

Martos, Ariadna; Berger, Michelle; Kranz, Wendelin; Spanopoulou, Anna; Menzen, Tim; Friess, Wolfgang; Wuchner, Klaus and Hawe, Andrea (2020): Novel High-Throughput Assay for Polysorbate Quantification in Biopharmaceutical Products by Using the Fluorescent Dye DiI. In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1: pp. 646-655

Mateus, Pedro; Chandramouli, Nagula; Mackereth, Cameron D.; Kauffmann, Brice; Ferrand, Yann and Huc, Ivan (2020): Allosteric Recognition of Homomeric and Heteromeric Pairs of Monosaccharides by a Foldamer Capsule. In: Angewandte Chemie-International Edition, Vol. 59, No. 14: pp. 5797-5805 [PDF, 5MB]

Mathaes, Roman; Manning, Mark Cornell; Winter, Gerhard; Engert, Julia and Wilson, Glenn A. (2020): Shape Characterization of Subvisible Particles Using Dynamic Imaging Analysis. In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1: pp. 375-379

Mazzier, Daniela; De, Soumen; Wicher, Barbara; Maurizot, Victor and Huc, Ivan (2020): Parallel Homochiral and Anti‐Parallel Heterochiral Hydrogen‐Bonding Interfaces in Multi‐Helical Abiotic Foldamers. In: Angewandte Chemie-International Edition, Vol. 59, No. 4: pp. 1606-1610 [PDF, 2MB]

Meena, Chhuttan L.; Singh, Dharmendra; Weinmueller, Michael; Reichart, Florian; Dangi, Abha; Marelli, Udaya Kiran; Zahler, Stefan and Sanjayan, Gangadhar J. (2020): Novel cilengitide-based cyclic RGD peptides as alpha nu beta(3) integrin inhibitors. In: Bioorganic & Medicinal Chemistry Letters, Vol. 30, No. 8, 127039

Mehta, Aditi and Merkel, Olivia M. (2020): Immunogenicity of Cas9 Protein. In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1: pp. 62-67

Merkel, Olivia M.

and Mehta, Aditi (20. October 2020): Characterization techniques for studying the properties of nanocarriers for systemic delivery. In: Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Vol. 13. Cham: Springer. pp. 57-86 [PDF, 1MB]

Messner, Martina; Schmitt, Sabine; Ardelt, Maximilian A.; Fröhlich, Thomas; Müller, Martin; Pein, Helmut; Huber-Cantonati, Petra; Ortler, Carina; König, Lars M.; Zobel, Lena; Koeberle, Andreas; Arnold, Georg J.; Rothenfusser, Simon; Kiemer, Alexandra K.; Gerbes, Alexander L.; Zischka, Hans; Vollmar, Angelika M. and Pachmayr, Johanna (2020): Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma. In: FASEB Journal, Vol. 34, No. 9: pp. 11860-11882

Meunier, Antoine; Singleton, Michael L.; Kauffmann, Brice; Granier, Thierry; Lautrette, Guillaume; Ferrand, Yann and Huc, Ivan (2020): Aromatic foldamers as scaffolds for metal second coordination sphere design. In: Chemical Science, Vol. 11, No. 44: pp. 12178-12186

Müller-Deku, Adrian; Meiring, Joyce C. M.; Loy, Kristina; Kraus, Yvonne; Heise, Constanze; Bingham, Rebekkah; Jansen, Klara I.; Qu, Xiaoyi; Bartolini, Francesca; Kapitein, Lukas C.; Akhmanova, Anna; Ahlfeld, Julia; Trauner, Dirk and Thorn-Seshold, Oliver (2020): Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton. In: Nature communications, Vol. 11, No. 1, 4640 [PDF, 7MB]

Panagiotopoulos, Anna-Lena; Karguth, Nina; Pavlou, Marina; Boehm, Sybille; Gasparoni, Gilles; Walter, Joern; Graf, Alexander; Blum, Helmut; Biel, Martin; Riedmayr, Lisa Maria and Becirovic, Elvir (2020): Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation. In: Molecular Therapy-Nucleic Acids, Vol. 21: pp. 1050-1061

Panossian, Alexander G.; Efferth, Thomas; Shikov, Alexander N.; Pozharitskaya, Olga N.; Kuchta, Kenny; Mukherjee, Pulok K.; Banerjee, Subhadip; Heinrich, Michael; Wu, Wanying; Guo, De-an and Wagner, Hildebert (2020): Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases. In: Medicinal Research Reviews, Vol. 41, No. 1: pp. 630-703

Pappas, Charalampos G.; Mandal, Pradeep K.; Liu, Bin; Kauffmann, Brice; Miao, Xiaoming; Komaromy, David; Hoffmann, Waldemar; Manz, Christian; Chang, Rayoon; Liu, Kai; Pagel, Kevin; Huc, Ivan and Otto, Sijbren (2020): Emergence of low-symmetry foldamers from single monomers. In: Nature Chemistry, Vol. 12, No. 12: pp. 1180-1186

Pohl, Christin; Zalar, Matja; El Bialy, Inas; Indrakumar, Sowmya; Peters, Gunther H. J.; Friess, Wolfgang; Golovanov, Alexander P.; Streicher, Werner W.; Noergaard, Allan and Harris, Pernille (2020): The Effect of Point Mutations on the Biophysical Properties of an Antimicrobial Peptide: Development of a Screening Protocol for Peptide Stability Screening. In: Molecular Pharmaceutics, Vol. 17, No. 9: pp. 3298-3313

Riedmayr, Lisa M. (2020): SMaRT for Therapeutic Purposes. In: Li, Hui and Elfman, Justin (eds.) : Chimeric RNA. Methods in molecular biology : Methods and Protocols, Vol. 2079. New York, NY: Springer Nature. pp. 219-232

Riedmayr, Lisa M.; Boehm, Sybille; Biel, Martin and Becirovic, Elvir (2020): Enigmatic rhodopsin mutation creates an exceptionally strong splice acceptor site. In: Human Molecular Genetics, Vol. 29, No. 2: pp. 295-304

Ritt, Nicolas; Berger, Simone; Wagner, Ernst and Zentel, Rudolf (2020): Versatile, Multifunctional Block Copolymers for the Self-Assembly of Well-Defined, Nontoxic pDNA Polyplexes. In: ACS Applied Polymer Materials, Vol. 2, No. 12: pp. 5469-5481

Rudy, Heinrich‐Karl A.; Mayer, Peter and Wanner, Klaus T. (2020): Synthesis of 1,5‐Ring‐Fused Imidazoles from Cyclic Imines and TosMIC – Identification of in situ Generated N‐Methyleneformamide as a Catalyst in the van Leusen Imidazole Synthesis. In: European Journal of Organic Chemistry, Vol. 2020, No. 24: pp. 3599-3612 [PDF, 2MB]

Schroeder, Martin; Bullock, Alex N.; Fedorov, Oleg; Bracher, Franz; Chaikuad, Apirat and Knapp, Stefan (2020): DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. In: Journal of Medicinal Chemistry, Vol. 63, No. 18: pp. 10224-10234

Schuetz, Ramona; Meixner, Maximilian; Antes, Iris and Bracher, Franz (2020): A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine. In: Organic & Biomolecular Chemistry, Vol. 18, No. 16: pp. 3047-3068

Schütz, Ramona; Müller, Martin; Geisslinger, Franz; Vollmar, Angelika; Bartel, Karin and Bracher, Franz (2020): Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. In: European Journal of Medicinal Chemistry, Vol. 207, 112810

Schütz, Ramona; Müller, Martin; Gerndt, Susanne; Bartel, Karin and Bracher, Franz

(2020): Racemic total synthesis and evaluation of the biological activities of the isoquinoline–benzylisoquinoline alkaloid muraricine. In: Archiv der Pharmazie, Vol. 353, No. 7, 2000106 [PDF, 1MB]

Seifert, Ivonne; Bregolin, Alessandro; Fissore, Davide and Friess, Wolfgang (2020): Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 153: pp. 36-42

Seifert, Ivonne and Friess, Wolfgang (2020): Freeze concentration during freezing: How does the maximally freeze concentrated solution influence protein stability? In: International Journal of Pharmaceutics, Vol. 589, 119810

Seifert, Ivonne and Friess, Wolfgang (2020): Improvement of arginine hydrochloride based antibody lyophilisates. In: International Journal of Pharmaceutics, Vol. 589, 119859

Skelbaek-Pedersen, Anne Linnet; Anuschek, Moritz; Vilhelmsen, Thomas Kvistgaard; Rantanen, Jukka and Zeitler, J. Axel (2020): Non-destructive quantification of fragmentation within tablets after compression from scattering analysis of terahertz transmission measurements. In: International Journal of Pharmaceutics, Vol. 588, 119769

Strack, Patrick; Kuelzer, Raimund; Sommer, Florian; Bretschneider, Tom; Merkel, Olivia M. and Grube, Achim (2020): A smart approach to enable preclinical studies in pharmaceutical industry: PLGA-based extended release formulation platform for subcutaneous applications. In: Drug Development and Industrial Pharmacy, Vol. 46, No. 4: pp. 635-645

Stulz, Anja; Breitsamer, Michaela; Winter, Gerhard and Heerklotz, Heiko (2020): Primary and Secondary Binding of Exenatide to Liposomes. In: Biophysical Journal, Vol. 118, No. 3: pp. 600-611

Svilenov, Hristo

; Kulakova, Alina; Zalar, Matja; Golovanov, Alexander P.; Harris, Pernille and Winter, Gerhard (January 2020): Orthogonal Techniques to Study the Effect of pH, Sucrose, and Arginine Salts on Monoclonal Antibody Physical Stability and Aggregation During Long-Term Storage. In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1: pp. 584-594 [PDF, 2MB]

Svilenov, Hristo

and Winter, Gerhard (April 2020): Formulations that suppress aggregation during long-term storage of a bispecific antibody are characterized by high refoldability and colloidal stability. In: Journal of Pharmaceutical Sciences [PDF, 4MB]

Svilenov, Hristo L.; Menzen, Tim; Richter, Klaus and Winter, Gerhard (2020): Modulated Scanning Fluorimetry Can Quickly Assess Thermal Protein Unfolding Reversibility in Microvolume Samples. In: Molecular Pharmaceutics, Vol. 17, No. 7: pp. 2638-2647

Theisen, Ulrike; Ernst, Alexander U.; Heyne, Ronja L. S.; Ring, Tobias P.; Thorn-Seshold, Oliver and Koster, Reinhard W. (2020): Microtubules and motor proteins support zebrafish neuronal migration by directing cargo. In: Journal of Cell Biology, Vol. 219, No. 10, e201908040

Tosstorff, Andreas

; Menzen, Tim and Winter, Gerhard

(January 2020): Exploring Chemical Space for new Substances to stabilize a therapeutic Monoclonal Antibody. In: Journal of Pharmaceutical Sciences [PDF, 1MB]

Tosstorff, Andreas

; Peters, Günther H. J. and Winter, Gerhard

(April 2020): Study of the interaction between a novel, protein stabilizing dipeptide and Interferon-alpha-2a by construction of a Markov State Model from Molecular Dynamics simulations. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 149: pp. 105-112 [PDF, 1MB]

Traub-Hoffmann, Kerstin; Gegenfurtner, Katrin; Kraft, Kay-Uwe and Friess, Wolfgang (2020): Spray congealed solid lipid microparticles as a sustained release delivery system for Gonadorelin [6-D-Phe]: Production, optimization and in vitro release behavior. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 154: pp. 18-32

Tsiamantas, Christos; Kwon, Sunbum; Rogers, Joseph M.; Douat, Céline; Huc, Ivan and Suga, Hiroaki (2020): Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages. In: Angewandte Chemie - International Edition, Vol. 59, No. 12: pp. 4860-4864 [PDF, 1MB]

Untergehrer, Martin and Bracher, Franz (2020): A short divergent approach to highly substituted carbazoles and beta-carbolines via in situ-generated diketoindoles. In: Tetrahedron Letters, Vol. 61, No. 12, 151597

Unzue, Andrea; Jessen-Trefzer, Claudia; Spiliotopoulos, Dimitrios; Gaudio, Eugenio; Tarantelli, Chiara; Dong, Jing; Zhao, Hongtao; Pachmayr, Johanna; Zahler, Stefan; Bernasconi, Elena; Sartori, Giulio; Cascione, Luciano; Bertoni, Francesco; Sledz, Pawel; Caflisch, Amedeo and Nevado, Cristina (2020): Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors. In: Rsc Medicinal Chemistry, Vol. 11, No. 6: pp. 665-675

Wang, Jinhua; Wicher, Barbara; Maurizot, Victor and Huc, Ivan (2020): Oligo-Quinolylene-Vinylene Foldamers. In: Chemistry-A European Journal, Vol. 27, No. 3: pp. 1031-1038

Wang, Yanfang and Wagner, Ernst (2020): Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization. In: Pharmaceutics, Vol. 12, No. 9, 888

Wathoni, Nasrul; An Ny, Nguyen; Rusdin, Agus; Umar, Abd Kakhar; Mohammed, Ahmed Fouad Abdelwahab; Motoyama, Keiichi; Joni, I. Made and Muchtaridi, Muchtaridi (2020): Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System. In: Drug Design Development and Therapy, Vol. 14: pp. 4387-4405

Wollnitzke, Philipp; Essig, Sebastian; Goelz, Jan Philipp; Schwarzenberg, Karin von and Menche, Dirk (2020): Total Synthesis of Ajudazol A by a Modular Oxazole Diversification Strategy. In: Organic Letters, Vol. 22, No. 16: pp. 6344-6348

Woortman, Dirk Volker; Jürgens, Sophie; Untergehrer, Martin; Rechenberger, Julia; Fuchs, Monika; Mehlmer, Norbert; Qoura, Farah; Eckel, Georg; Stoehr, Michael; Osswald, Patrick; Le Clercq, Patrick; Hintermann, Lukas; Weuster-Botz, Dirk; Bracher, Franz and Brueck, Thomas (2020): Greener aromatic antioxidants for aviation and beyond. In: Sustainable Energy & Fuels, Vol. 4, No. 5: pp. 2153-2163

Wurzlbauer, Anne; Rueben, Katharina; Guerdal, Ece; Chaikuad, Apirat; Knapp, Stefan; Sippl, Wolfgang; Becker, Walter and Bracher, Franz (2020): How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine. In: Molecules, Vol. 25, No. 24, 5962

Xie, Ying; Hang, Yu; Wang, Yazhe; Sleightholm, Richard; Prajapati, Dipakkumar R.; Bader, Johannes; Yu, Ao; Tang, Weimin; Jaramillo, Lee; Li, Jing; Singh, Rakesh K. and Oupicky, David (2020): Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. In: ACS Nano, Vol. 14, No. 1: pp. 255-271

Zahler, Stefan (2020): Nuclear actin in cancer biology. In: International review of cell and molecular biology, Vol. 355: pp. 53-66

Zareba, Paula; Gryzlo, Beata; Malawska, Katarzyna; Salat, Kinga; Höfner, Georg C.; Nowaczyk, Alicja; Fijalkowski, Lukasz; Rapacz, Anna; Podkowa, Adrian; Furgala, Anna; Zmudzki, Pawel; Wanner, Klaus T.; Malawska, Barbara and Kulig, Katarzyna (2020): Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. In: European Journal of Medicinal Chemistry, Vol. 188, 111920

Zhong, Yulong; Kauffmann, Brice; Xu, Wenwu; Lu, Zhong-Lin; Ferrand, Yann; Huc, Ivan; Zeng, Xiao Cheng; Liu, Rui and Gong, Bing (2020): Multiturn Hollow Helices: Synthesis and Folding of Long Aromatic Oligoamides. In: Organic Letters, Vol. 22, No. 17: pp. 6938-6942

Zwillinger, Marton; Reddy, Post Sai; Wicher, Barbara; Mandal, Pradeep K.; Csekei, Marton; Fischer, Lucile; Kotschy, Andras and Huc, Ivan (2020): Aromatic Foldamer Helices as alpha-Helix Extended Surface Mimetics. In: Chemistry-A European Journal, Vol. 26, No. 72: pp. 17366-17370

2019

Ackermann, Thomas M.; Bhokare, Karuna; Hoefner, Georg and Wanner, Klaus T. (2019): MS binding assays for GlyT1 based on Org24598 as nonlabelled reporter ligand. In: Neuropharmacology, Vol. 161, 107561

Alex, Jimi M.; Corvaglia, Valentina; Hu, Xiaobo; Engilberge, Sylvain; Huc, Ivan and Crowley, Peter B. (2019): Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution. In: Chemical Communications, Vol. 55, No. 74: pp. 11087-11090

Ardelt, Maximilian A.; Fröhlich, Thomas; Martini, Emanuele; Müller, Martin; Kanitz, Veronika; Atzberger, Carina; Cantonati, Petra; Messner, Martina; Posselt, Laura; Lehr, Thorsten; Wojtyniak, Jan-Georg; Ulrich, Melanie; Arnold, Georg J.; König, Lars; Parazzoli, Dario; Zahler, Stefan; Rothenfusser, Simon; Mayr, Doris; Gerbes, Alexander; Scita, Giorgio; Vollmar, Angelika M. and Pachmayr, Johanna (2019): Inhibition of Cyclin-Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy. In: Hepatology, Vol. 69, No. 1: pp. 376-393

Augustijn, Dillen; Mahapatra, Sujata; Streicher, Werner; Svilenov, Hristo; Kulakova, Ahna; Pohl, Christin and Rinnan, Asmund (2019): Novel non-linear curve fitting to resolve protein unfolding transitions in intrinsic fluorescence differential scanning fluorimetry. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 142: pp. 506-517

Bao, Maode; Shi, Run; Zhang, Kai; Zhao, Yanbo; Wang, Yanfang and Bao, Xuanwen (2019): Development of a membrane lipid metabolism-based signature to predict overall survival for personalized medicine in ccRCC patients. In: Epma Journal, Vol. 10, No. 4: pp. 383-393

Bao, Xuanwen; Anastasov, Natasa; Wang, Yanfang and Rosemann, Michael (2019): A novel epigenetic signature for overall survival prediction in patients with breast cancer. In: Journal of Translational Medicine, Vol. 17, No. 1, 380

Bao, Xuanwen; Shi, Run; Zhang, Kai; Xin, Shan; Li, Xin; Zhao, Yanbo and Wang, Yanfang (18. September 2019): Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature. In: Frontiers in Oncology, Vol. 9, 903: pp. 1-15 [PDF, 2MB]

Bartel, Karin; Müller, Rolf and Schwarzenberg, Karin von (2019): Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells. In: Journal of Biological Chemistry, Vol. 294, No. 46: pp. 17239-17248

Bartel, Karin; Pein, Helmut; Popper, Bastian; Schmitt, Sabine; Janaki-Raman, Sudha; Schulze, Almut; Lengauer, Florian; Koeberle, Andreas; Werz, Oliver; Zischka, Hans; Müller, Rolf; Vollmar, Angelika M. and Schwarzenberg, Karin von (2019): Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death. In: Cell Communication and Signaling, Vol. 17, 87

Blassmann, Ute; Hope, William; Roehr, Anka C.; Frey, Otto R.; Vetter-Kerkhoff, Cornelia; Thon, Niklas; Briegel, Josef and Huge, Volker (2019): CSF penetration of vancomycin in critical care patients with proven or suspected ventriculitis: a prospective observational study. In: Journal of Antimicrobial Chemotherapy, Vol. 74, No. 4: pp. 991-996

Borland, Kayla; Diesend, Jan; Ito-Kureha, Taku; Heissmeyer, Vigo; Hammann, Christian; Buck, Amy H.; Michalakis, Stylianos and Kellner, Stefanie (2019): Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis. In: Genes, Vol. 10, No. 1, 26

Breitsamer, Michaela; Stulz, Anja; Heerklotz, Heiko H. and Winter, Gerhard (2019): Do interactions between protein and phospholipids influence the release behavior from lipid-based exenatide depot systems? In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 142: pp. 61-69

Breitsamer, Michaela and Winter, Gerhard (2019): Vesicular phospholipid gels as drug delivery systems for small molecular weight drugs, peptides and proteins: State of the art review. In: International Journal of Pharmaceutics, Vol. 557: pp. 1-8

Bryce, Nicole S.; Failes, Tim W.; Stehn, Justine R.; Baker, Karen; Zahler, Stefan; Arzhaeva, Yulia; Bischof, Leanne; Lyons, Ciaran; Dedova, Irina; Arndt, Greg M.; Gaus, Katharina; Goult, Benjamin T.; Hardeman, Edna C.; Gunning, Peter W. and Lock, John G. (2019): High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained. In: Cell Systems, Vol. 9, No. 5

Chiu, Joy E.; Thekkiniath, Jose; Mehta, Sameet; Müller, Christoph; Bracher, Franz and Ben Mamoun, Choukri (2019): The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors. In: Journal of Biological Chemistry, Vol. 294, No. 40: pp. 14757-14767

Choi, Jae Eun; Verhaegen, Monique E.; Yazdani, Sahr; Malik, Rohit; Harms, Paul W.; Mangelberger, Doris; Tien, Jean; Cao, Xuhong; Wang, Yuping; Cieslik, Marcin; Gurkan, Jonathan; Yazdani, Mishaal; Jing, Xiaojun; Juckette, Kristin; Su, Fengyun; Wang, Rui; Zhou, Bing; Apel, Ingrid J.; Wang, Shaomeng; Dlugosz, Andrzej A. and Chinnaiyan, Arul M. (2019): Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma. In: Neoplasia, Vol. 21, No. 3: pp. 322-330

Corvaglia, Valentina; Carbajo, Daniel; Prabhakaran, Panchami; Ziach, Krzysztof; Mandal, Pradeep Kumar; Dos Santos, Victor; Legeay, Carole; Vogel, Rachel; Parissi, Vincent; Pourquier, Philippe and Huc, Ivan (2019): Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins. In: Nucleic Acids Research, Vol. 47, No. 11: pp. 5511-5521

De Meyer, Laurens; Lammens, Joris; Vanbillemont, Brecht; Van Bockstal, Pieter Jan; Corver, Jos; Vervaet, Chris; Friess, Wolfgang and De Beer, Thomas (2019): Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying. In: International Journal of Pharmaceutics, Vol. 570, 118631

Douat, Celine; Bornerie, Megane; Antunes, Stephanie; Guichard, Gilles and Kichler, Antoine (2019): Hybrid Cell-Penetrating Foldamer with Superior Intracellular Delivery Properties and Serum Stability. In: Bioconjugate Chemistry, Vol. 30, No. 4: pp. 1133-1139

Duerr, Corinna and Friess, Wolfgang (2019): Antibody-drug conjugates- stability and formulation. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 139: pp. 168-176

Gabriel, Jürgen; Hoefner, Georg and Wanner, Klaus T. (4. October 2019): A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry. In: Frontiers in Chemistry, Vol. 7, 665: pp. 1-18 [PDF, 2MB]

Gadelha, Ana Paula R.; Bravim, Barbara; Vidal, Juliana; Reignault, Lissa Catherine; Cosme, Bruno; Huber, Kilian; Bracher, Franz and de Souza, Wanderley (2019): Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor. In: International Journal of Medical Microbiology, Vol. 309, No. 2: pp. 130-142

Geh, K. J.; Stelzl, A.; Grone, A.; Wagner, L.; Forster, B. and Winter, G. (2019): Development of a sprayable hydrogel formulation for the skin application of therapeutic antibodies. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 142: pp. 123-132

Geiger, Florian; Rüdiger, Daniel; Zahler, Stefan and Engelke, Hanna (2019): Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels.
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Gentiluomo, Lorenzo; Roessner, Dierk; Augustijn, Dillen; Svilenov, Hristo

; Kulakova, Alina; Mahapatra, Sujata; Winter, Gerhard; Streicher, Werner; Rinnan, Asmund; Peters, Günther; Harris, Pernille and Friess, Wolfgang (August 2019): Application of interpretable artificial neural networks to early monoclonal antibodies development. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 141: pp. 81-89 [PDF, 1MB]

Gentiluomo, Lorenzo; Schneider, Vanessa; Roessner, Dierk and Frieß, Wolfgang (2019): Coupling Multi-Angle Light Scattering to Reverse-Phase Ultra-High-Pressure Chromatography (RP-UPLC-MALS) for the characterization monoclonal antibodies. In: Scientific Reports, Vol. 9, 14965 [PDF, 3MB]

Gitter, Julian Hendryk; Geidobler, Raimund; Presser, Ingo and Winter, Gerhard (2019): Microwave-Assisted Freeze-Drying of Monoclonal Antibodies: Product Quality Aspects and Storage Stability. In: Pharmaceutics, Vol. 11, No. 12, 674

Glas, Carina and Bracher, Franz (2019): General Method for the Preparation of Indole-2-Weinreb Amides. In: Synthesis-Stuttgart, Vol. 51, No. 3, UNSP ss-2018-t0494-op: pp. 757-768

Gleissner, Carolin M. -L.; Pyka, Carolin L.; Heydenreuter, Wolfgang; Gronauer, Thomas F.; Atzberger, Carina; Korotkov, Vadim S.; Cheng, Weiting; Hacker, Stephan M.; Vollmar, Angelika M.; Braig, Simone and Sieber, Stephan A. (2019): Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT-1 Controlled Pathways. In: ACS Central Science, Vol. 5, No. 7: pp. 1170-1178

Gole, Bappaditya; Kauffmann, Brice; Maurizot, Victor; Huc, Ivan and Ferrand, Yann (2019): Light-Controlled Conformational Switch of an Aromatic Oligoamide Foldamer. In: Angewandte Chemie-International Edition, Vol. 58, No. 24: pp. 8063-8067

Haeuser, Christina; Goldbach, Pierre; Huwyler, Jörg; Friess, Wolfgang and Allmendinger, Andrea (2019): Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations. In: Pharmaceutics, Vol. 11, No. 11, 616

Hammelmann, Verena; Stieglitz, Marc Sebastian; Huelle, Henrik; Le Meur, Karim; Kass, Jennifer; Bruemmer, Manuela; Gruner, Christian; Roetzer, Rene Dominik; Fenske, Stefanie; Hartmann, Jana; Zott, Benedikt; Luthi, Anita; Spahn, Saskia; Moser, Markus; Isbrandt, Dirk; Ludwig, Andreas; Konnerth, Arthur; Wahl-Schott, Christian and Biel, Martin (2019): Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures. In: Jci Insight, Vol. 4, No. 9, e126418

Haryadi, Bernard Manuel; Hafner, Daniel; Amin, Ihsan; Schubel, Rene; Jordan, Rainer; Winter, Gerhard

and Engert, Julia (September 2019): Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting. In: Advanced Healthcare Materials, Vol. 8, No. 18, 1900352 [PDF, 2MB]

Hauke, Tobias J.; Hoefner, Georg and Wanner, Klaus T. (2019): Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4. In: Bioorganic & Medicinal Chemistry, Vol. 27, No. 1: pp. 144-152

Hauke, Tobias J.; Hoefner, Georg and Wanner, Klaus T. (2019): MS-Based Screening of 5-Substituted Nipecotic Acid Derived Hydrazone Libraries as Ligands of the GABA Transporter 1. In: Chemmedchem, Vol. 14, No. 5: pp. 583-593

Higel, Fabian; Sandl, Theresa; Kao, Chi-Ya; Pechinger, Nicole; Soergel, Fritz; Friess, Wolfgang; Wolschin, Florian and Seidl, Andreas (2019): N-glycans of complex glycosylated biopharmaceuticals and their impact on protein clearance. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 139: pp. 123-131

Hoffmann, Eugenia; Jordan, Gregor; Lauer, Matthias; Ringler, Philippe; Kusznir, Eric A.; Rufer, Arne C.; Huber, Sylwia; Jochner, Anton; Winter, Gerhard and Staack, Roland F. (2019): Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies. In: Pharmaceutical Research, Vol. 36, No. 9, UNSP 129

Holm, Regina; Schwiertz, David; Weber, Benjamin; Schultze, Jennifer; Kuhn, Jasmin; Koynov, Kaloian; Laechelt, Ulrich and Barz, Matthias (2019): Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential. In: Macromolecular Bioscience, Vol. 20, No. 1, 1900152

Horn, Jacqueline; Jena, Sampeeti; Aksan, Alptekin and Friess, Wolfgang (2019): Freeze/thaw of IGG solutions. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 134: pp. 185-189

Huber, Simone K.; Hoefner, Georg and Wanner, Klaus T. (2019): Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of gamma-aminobutyric acid transporter 1 (GAT1). In: Bioorganic & Medicinal Chemistry, Vol. 27, No. 13: pp. 2753-2763

Junker, Julia; Chong, Isabelle; Kamp, Frits; Steiner, Harald; Giera, Martin; Müller, Christoph and Bracher, Franz (2019): Comparison of Strategies for the Determination of Sterol Sulfates via GC-MS Leading to a Novel Deconjugation-Derivatization Protocol. In: Molecules, Vol. 24, No. 13, 2353

Kamlah, Alexandra and Bracher, Franz (2019): A Short Synthesis of the Plant Alkaloid 4-Methyl-2,6-naphthyridine. In: Letters in Organic Chemistry, Vol. 16, No. 12: pp. 931-934

Kandil, Rima and Merkel, Olivia M. (2019): Recent progress of polymeric nanogels for gene delivery. In: Current Opinion in Colloid & Interface Science, Vol. 39: pp. 11-23

Karg, Cornelia A.; Schilling, Charlotte M.; Allmendinger, Lars and Moser, Simone (2019): Isolation, characterization, and antioxidative activity of a dioxobilin-type phylloxanthobilin from savoy cabbage. In: Journal of Porphyrins and Phthalocyanines, Vol. 23, No. 7-8: pp. 881-888

Karg, Cornelia A.; Wang, Pengyu; Vollmar, Angelika M. and Moser, Simone (2019): Re-opening the stage for Echinacea research - Characterization of phylloxanthobilins as a novel anti-oxidative compound class in Echinacea purpurea. In: Phytomedicine, Vol. 60, UNSP 152969

Karthik, S.; Mandal, P. K.; Thirugnanasambandam, A. and Gautham, N. (2019): Crystal structures of disordered Z-type helices. In: Nucleosides Nucleotides & Nucleic Acids, Vol. 38, No. 4: pp. 279-293

Keil, Tobias W. M.; Feldmann, Daniel P.; Costabile, Gabriella; Zhong, Qian; da Rocha, Sandro and Merkel, Olivia M. (2019): Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 143: pp. 61-69

Kern, Felix and Wanner, Klaus T. (2019): Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors gamma-aminobutyric acid transporter 1. In: Bioorganic & Medicinal Chemistry, Vol. 27, No. 7: pp. 1232-1245

Kern, Sarah; Truebenbach, Ines; Hoehn, Miriam; Gorges, Jan; Kazmaier, Uli; Zahler, Stefan; Vollmar, Angelika M. and Wagner, Ernst (2019): Combined antitumoral effects of pretubulysin and methotrexate. In: Pharmacology Research & Perspectives, Vol. 7, No. 1, UNSP e00460

Kirsch, Volker C.; Orgler, Christina; Braig, Simone; Jeremias, Irmela; Auerbach, David; Müller, Rolf; Vollmar, Angelika M. and Sieber, Stephan A. (2019): The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, which is Essential for Ribosome Biogenesis. In: Angewandte Chemie-International Edition, Vol. 59, No. 4: pp. 1595-1600

Koczian, Fabian; Naglo, Olga; Vomacka, Jan; Vick, Binje; Servatius, Phil; Zisis, Themistoklis; Hettich, Britta; Kazmaier, Uli; Sieber, Stephan A.; Jeremias, Irmela; Zahler, Stefan and Braig, Simone (2019): Targeting the endoplasmic reticulum-mitochondria interface sensitizes leukemia cells to cytostatics. In: Haematologica, Vol. 104, No. 3: pp. 546-555

Koerner, Andreas; Zhou, Enchen; Muller, Christoph; Mohammed, Yassene; Herceg, Sandra; Bracher, Franz; Rensen, Patrick C. N.; Wang, Yanan; Mirakaj, Valbona and Giera, Martin (2019): Inhibition of Delta 24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 41: pp. 20623-20634

Kraus, Teresa; Lubitz, Annika; Schliesser, Ulrike; Giese, Christoph; Reuschel, Jana; Brecht, Rene; Engert, Julia and Winter, Gerhard (2019): Evaluation of a 3D Human Artificial Lymph Node as Test Model for the Assessment of Immunogenicity of Protein Aggregates. In: Journal of Pharmaceutical Sciences, Vol. 108, No. 7: pp. 2358-2366

Kraus, Teresa; Winter, Gerhard and Engert, Julia (2019): Test models for the evaluation of immunogenicity of protein aggregates. In: International Journal of Pharmaceutics, Vol. 559: pp. 192-200

Krauss, Jürgen; Klimt, Monika; Luber, Markus; Mayer, Peter and Bracher, Franz (2019): Characterization of two new degradation products of atorvastatin calcium formed upon treatment with strong acids. In: Beilstein Journal of Organic Chemistry, Vol. 15: pp. 2085-2091

Krogsaeter, Einar K.; Biel, Martin; Wahl-Schott, Christian and Grimm, Christian (2019): The protein interaction networks of mucolipins and two-pore channels. In: Biochimica et Biophysica Acta-Molecular Cell Research, Vol. 1866, No. 7: pp. 1111-1123

Kuhn, Jasmin; Klein, Philipp M.; Danaf, Nader al; Nordin, Joel Z.; Reinhard, Sören; Loy, Dominik M.; Höhn, Miriam; Andaloussi, Samir el; Lamb, Don C.; Wagner, Ernst; Aoki, Yoshitsugu; Lehto, Taavi and Lächelt, Ulrich (2019): Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles. In: Advanced Functional Materials, Vol. 29, No. 48, 1906432 [PDF, 1MB]

Lainez, Sergio; Tsantoulas, Christoforos; Biel, Martin and McNaughton, Peter A. (2019): HCN3 ion channels: roles in sensory neuronal excitability and pain. In: Journal of Physiology-London, Vol. 597, No. 17: pp. 4661-4675

Ljepoja, Bojan; Schreiber, Christoph; Gegenfurtner, Florian A.; Garcia-Roman, Jonathan; Köhler, Bianca; Zahler, Stefan; Rädler, Joachim O.; Wagner, Ernst and Roidl, Andreas (2019): Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A.
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Ljepoja, Bojan; Garcia-Roman, Jonathan; Sommer, Ann-Katrin; Wagner, Ernst and Roidl, Andreas (2019): MiRNA-27a sensitizes breast cancer cells to treatment with Selective Estrogen Receptor Modulators. In: Breast, Vol. 43: pp. 31-38

Lohrer, Bernhard and Bracher, Franz (2019): Novel access to 2-substituted quinolin-4-ones by nickel boride-mediated reductive ring transformation of 5-(2-nitrophenyl)isoxazoles. In: Tetrahedron Letters, Vol. 60, No. 51, 151327

Luo, Jie; Hoehn, Miriam; Reinhard, Soeren; Loy, Dominik M.; Klein, Philipp Michael and Wagner, Ernst (2019): IL4-Receptor-Targeted Dual Antitumoral Apoptotic Peptide-siRNA Conjugate Lipoplexes. In: Advanced Functional Materials, Vol. 29, No. 25, 1900697

Mastrella, Giorgia; Hou, Mengzhuo; Li, Min; Stöcklein, Veit M.; Zdouc, Nina; Vomar, Marie N. M.; Miletic, Hrvoje; Reinhard, Soeren; Herold-Mende, Christel C.; Kleber, Susanne; Eisenhut, Katharina; Gargiulo, Gaetano; Synowitz, Michael; Vescovi, Angelo L.; Harter, Patrick N.; Penninger, Josef M.; Wagner, Ernst; Mittelbronn, Michel; Bjerkvig, Rolf; Hambardzumyan, Dolores; Schueller, Ulrich; Tonn, Jörg-Christian; Radke, Josefine; Glass, Rainer and Kaelin, Roland E. (2019): Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma. In: Cancer Research, Vol. 79, No. 9: pp. 2298-2313

Mazzier, Daniela; De, Soumen; Wicher, Barbara; Maurizot, Victor and Huc, Ivan (2019): Interplay of secondary and tertiary folding in abiotic foldamers. In: Chemical Science, Vol. 10, No. 29: pp. 6984-6991

Mehta, Aditi; Vedove, Elena Dalle; Isert, Lorenz and Merkel, Olivia M. (2019): Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles. In: Pharmaceutical Research, Vol. 36, No. 9, UNSP 133

Meinhold, Sarah; Bauer, Daniela; Huber, Jonas; Merkel, Ulrich; Weissl, Andreas; Zoldak, Gabriel and Rief, Matthias (2019): An Active, Ligand-Responsive Pulling Geometry Reports on Internal Signaling between Subdomains of the DnaK Nucleotide-Binding Domain in Single-Molecule Mechanical Experiments. In: Biochemistry, Vol. 58, No. 47: pp. 4744-4750

Melzer, Benedikt C.; Plodek, Alois and Bracher, Franz (2019): Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogues of pyridoacridine alkaloids. In: Beilstein Journal of Organic Chemistry, Vol. 15: pp. 2304-2310

Moser, Simone and Kraeutler, Bernhard (2019): In Search of Bioactivity - Phyllobilins, an Unexplored Class of Abundant Heterocyclic Plant Metabolites from Breakdown of Chlorophyll. In: Israel Journal of Chemistry, Vol. 59, No. 5: pp. 420-431

Müller, Christoph; Junker, Julia; Bracher, Franz and Giera, Martin (2019): A gas chromatography-mass spectrometry-based whole-cell screening assay for target identification in distal cholesterol biosynthesis. In: Nature Protocols, Vol. 14, No. 8: pp. 2546-2570

Müller, Christoph; Wagner, Antonie L.; Rockinger, Ute; Winter, Gerhard and Bracher, Franz (2019): Development of a convenient method for the determination of dimethyl sulfoxide in lyophilised pharmaceuticals by static headspace gas chromatography-mass spectrometry. In: Analytical Methods, Vol. 11, No. 16: pp. 2119-2122

Pallauf, Kathrin; Chin, Dawn; Guenther, Ilka; Birringer, Marc; Lueerseni, Kai; Schultheiss, Gerald; Vieten, Sarah; Krauss, Jürgen; Bracher, Franz; Danylec, Nicolas; Soukup, Sebastian T.; Kulling, Sabine E. and Rimbach, Gerald (2019): Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice. In: Scientific Reports, Vol. 9, 4445 [PDF, 1MB]

Pavlou, M.; Shah, M.; Gikas, P.; Briggs, T.; Roberts, S. J. and Cheema, U. (2019): Osteomimetic matrix components alter cell migration and drug response in a 3D tumour-engineered osteosarcoma model. In: Acta Biomaterialia, Vol. 96: pp. 247-257

Peng, Lun and Wagner, Ernst (2019): Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions. In: Biomacromolecules, Vol. 20, No. 10: pp. 3613-3626

Petersen-Jones, Simon M.; Occelli, Laurence M.; Biel, Martin and Michalakis, Stylianos (2019): Advancing Gene Therapy for PDE6A Retinitis Pigmentosa. In: Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, Vol. 1185: pp. 103-107

Pfitzer, Lisa; Moser, Christina; Gegenfurtner, Florian; Arner, Anja; Foerster, Florian; Atzberger, Carina; Zisis, Themistoklis; Kubisch-Dohmen, Rebekka; Busse, Johanna; Smith, Rebecca; Timinszky, Gyula; Kalinina, Olga V.; Müller, Rolf; Wagner, Ernst; Vollmar, Angelika M. and Zahler, Stefan (2019): Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy. In: Cell Death & Disease, Vol. 10, UNSP 302

Reddy, Post Sai; d'Estaintot, Beatrice Langlois; Granier, Thierry; Mackereth, Cameron D.; Fischer, Lucile and Huc, Ivan (2019): Structure Elucidation of Helical Aromatic Foldamer-Protein Complexes with Large Contact Surface Areas. In: Chemistry-A European Journal, Vol. 25, No. 47: pp. 11042-11047

Rodrigues, Leticia; Schneider, Fabian; Zhang, Xiaohan; Larsson, Elin; Moodie, Lindon W. K.; Dietz, Hendrik; Papadakis, Christine M.; Winter, Gerhard; Lundmark, Richard and Hubert, Madlen (2019): Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries. In: Journal of Colloid and Interface Science, Vol. 553: pp. 820-833

Rubio, Karla; Singh, Indrabahadur; Dobersch, Stephanie; Sarvari, Pouya; Guenther, Stefan; Cordero, Julio; Mehta, Aditi; Wujak, Lukasz; Cabrera-Fuentes, Hector; Chao, Cho-Ming; Braubach, Peter; Bellusci, Saverio; Seeger, Werner; Guenther, Andreas; Preissner, Klaus T.; Wygrecka, Malgorzata; Savai, Rajkumar; Papy-Garcia, Dulce; Dobreva, Gergana; Heikenwalder, Mathias; Savai-Pullamsetti, Soni; Braun, Thomas and Barreto, Guillermo (2019): Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. In: Nature Communications, Vol. 10, 2229 [PDF, 3MB]

Rudy, Heinrich-Karl A. and Wanner, Klaus T. (2019): Accessing Tricyclic Imines Comprising a 2-Azabicyclo[2.2.2]octane Scaffold by Intramolecular Hetero-Diels-Alder Reaction of 4-Alkenyl-Substituted N-Silyl-1,4-dihydropyridines. In: Synthesis-Stuttgart, Vol. 51, No. 22: pp. 4296-4310

Sailer, Alexander; Ermer, Franziska; Kraus, Yvonne; Lutter, Ferdinand H.; Donau, Carsten; Bremerich, Maximilian; Ahlfeld, Julia and Thorn-Seshold, Oliver (2019): Hemithioindigos for Cellular Photopharmacology: Desymmetrised Molecular Switch Scaffolds Enabling Design Control over the Isomer-Dependency of Potent Antimitotic Bioactivity. In: Chembiochem, Vol. 20, No. 10: pp. 1305-1314

Santos-Ferreira, Tiago; Herbig, Maik; Otto, Oliver; Carido, Madalena; Karl, Mike O.; Michalakis, Stylianos; Guck, Jochen and Ader, Marius (2019): Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry. In: Cytometry Part A, Vol. 95, No. 11: pp. 1145-1157

Schaarschmidt, Maren; Hoefner, Georg and Wanner, Klaus T. (2019): Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3-Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1. In: Chemmedchem, Vol. 14, No. 12: pp. 1135-1151

Schepmann, Dirk; Neue, Christina; Westphaelinger, Stefanie; Müller, Christoph; Bracher, Franz; Lange, Carsten; Bednarski, Patrick; Almansa, Carmen; Friedland, Kristina; Raebiger, Vivien; Duefer, Martina and Wuensch, Bernhard (2019): Pharmacological characterization of high-affinity sigma(1) receptor ligands with spirocyclic thienopyran and thienofuran scaffold. In: Journal of Pharmacy and Pharmacology, Vol. 72, No. 2: pp. 236-248

Scherer, Nicole; Marcsekova, Klaudia; Posset, Tobias and Winter, Gerhard (2019): New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics. In: International Journal of Pharmaceutics, Vol. 555: pp. 404-419

Schnitzler, Lukas G.; Junger, Stefanie; Loy, Dominik M.; Wagner, Ernst; Wixforth, Achim; Hoerner, Andreas; Laechelt, Ulrich and Westerhausen, Christoph (2019): Size tunable nanoparticle formation employing droplet fusion by acoustic streaming applied to polyplexes. In: Journal of Physics D-Applied Physics, Vol. 52, No. 24, 244002

Schug, Christina; Kitzberger, Carolin; Sievert, Wolfgang; Spellerberg, Rebekka; Tutter, Mariella; Schmohl, Kathrin A.; Eberlein, Bernadette; Biedermann, Tilo; Steiger, Katja; Zach, Christian; Schwaiger, Markus; Multhoff, Gabriele; Wagner, Ernst; Nelson, Peter J. and Spitzweg, Christine (2019): Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell-Mediated Sodium Iodide Symporter (NIS) Gene I-131 Therapy. In: Clinical Cancer Research, Vol. 25, No. 19: pp. 5997-6008

Schug, Christina; Urnauer, Sarah; Jaeckel, Carsten; Schmohl, Kathrin A.; Tutter, Mariella; Steiger, Katja; Schwenk, Nathalie; Schwaiger, Markus; Wagner, Ernst; Nelson, Peter J. and Spitzweg, Christine (2019): TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer. In: Endocrine-Related Cancer, Vol. 26, No. 1: pp. 89-101

Siepmann, Jürgen; Faham, Amina; Clas, Sophie-Dorothee; Boyd, Ben J.; Jannin, Vincent; Bernkop-Schnuerch, Andreas; Zhao, Hang; Lecommandoux, Sebastien; Evans, James C.; Allen, Christine; Merkel, Olivia M.; Costabile, Gabriella; Alexander, Morgan R.; Wildman, Ricky D.; Roberts, Clive J. and Leroux, Jean-Christophe (2019): Lipids and polymers in pharmaceutical technology: Lifelong companions. In: International Journal of Pharmaceutics, Vol. 558: pp. 128-142

Sommer, Ann-Katrin; Falcenberg, Mathias; Ljepoja, Bojan; Fröhlich, Thomas; Arnold, Georg J.; Wagner, Ernst and Roidl, Andreas (2019): Downregulation of GRK5 hampers the migration of breast cancer cells. In: Scientific Reports, Vol. 9, 15548 [PDF, 5MB]

Steinborn, Benjamin; Hirschle, Patrick; Höhn, Miriam; Bauer, Tobias; Barz, Matthias; Wuttke, Stefan; Wagner, Ernst and Lächelt, Ulrich (2019): Core‐Shell Functionalized Zirconium‐Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content. In: Advanced Therapeutics, Vol. 2, No. 11 [PDF, 7MB]

Stieglitz, David; Lamm, Susanne; Braig, Simone; Feuerer, Lena; Kuphal, Silke; Dietrich, Peter; Arndt, Stephanie; Echtenacher, Bernd; Hellerbrand, Claus; Karrer, Sigrid and Bosserhoff, Anja-Katrin (2019): BMP6-induced modulation of the tumor micro-milieu. In: Oncogene, Vol. 38, No. 5: pp. 609-621

Stoeckelhuber, Markus; Pluym, Nikola; Bracher, Franz; Leibold, Edgar; Scherer, Gerhard and Scherer, Max (2019): A validated UPLC-MS/MS method for the determination of urinary metabolites of Uvinul (R) A plus. In: Analytical and Bioanalytical Chemistry, Vol. 411, No. 30: pp. 8143-8152

Svilenov, Hristo

and Winter, Gerhard (1. May 2019): Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations Is there a correlation? In: International Journal of Pharmaceutics, Vol. 562: pp. 42-50 [PDF, 1MB]

Svilenov, Hristo

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Tobias, Peters; Philipp, Seitz Immanuel; Stylianos, Michalakis; Martin, Biel; Barbara, Wilhelm; Felix, Reichel; Alexander, Ochakovski Guy; Eberhart, Zrenner; Marius, Ueffing; Birgit, Korbmacher; Sven, Korte; Ulrich, Bartz-Schmidt Karl; Dominik, Fischer Manuel; Bartz-Schmidt, Karl Ulrich; Bolz, Sylvia; Fischer, Dominik; Kohl, Susanne; Kuehlewein, Laura; Muehlfriedel, Regine; Neubauer, Jonas; Ochakovski, Alex; Paquet-Durand, Francois; Seeliger, Mathias; Sothilingam, Vithiyanjali; Ueffing, Marius; Weisschuh, Nicole; Wissinger, Bernd; Zhour, Ahmad; Zobor, Ditta; Zrenner, Eberhart; Biel, Martin; Michalakis, Stylianos; Schön, Christian; Kahle, Nadine; Peters, Tobias; Wilhelm, Barbara; Tsang, Steven and Gloeckner, Christian Johannes (2019): Safety and Toxicology of Ocular Gene Therapy with Recombinant AAV Vector rAAV.hCNGA3 in Nonhuman Primates. In: Human Gene Therapy Clinical Development, Vol. 30, No. 2: pp. 50-56

Tosstorff, Andreas

; Svilenov, Hristo

; Peters, Günther H. J.; Harris, Pernille and Winter, Gerhard

(12. September 2019): Structure-based Discovery of a new Protein-Aggregation Breaking Excipient. In: European Journal of Pharmaceutics and Biopharmaceutics [HTML, 1MB]

Toth, Krisztian; Hoefner, Georg and Wanner, Klaus T. (2019): Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors. In: Bioorganic & Medicinal Chemistry, Vol. 27, No. 5: pp. 822-831

Truebenbach, Ines; Kern, Sarah; Loy, Dominik M.; Hoehn, Miriam; Gorges, Jan; Kazmaier, Uli and Wagner, Ernst (2019): Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles. In: Molecular Pharmaceutics, Vol. 16, No. 6: pp. 2405-2417

Truebenbach, Ines; Zhang, Wei; Wang, Yanfang; Kern, Sarah; Hoehn, Miriam; Reinhard, Soeren; Gorges, Jan; Kazmaier, Uli and Wagner, Ernst (2019): Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells. In: International Journal of Pharmaceutics, Vol. 569, 118570

Tsiamantas, Christos; Kwon, Sunbum; Douat, Celine; Huc, Ivan and Suga, Hiroaki (2019): Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation. In: Chemical Communications, Vol. 55, No. 51: pp. 7366-7369

Urnauer, Sarah; Schmohl, Kathrin A.; Tutter, Mariella; Schug, Christina; Schwenk, Nathalie; Morys, Stephan; Ziegler, Sibylle; Bartenstein, Peter; Clevert, Dirk-Andre; Wagner, Ernst and Spitzweg, Christine (2019): Dual-targeted NIS polyplexes-a theranostic strategy toward tumors with heterogeneous receptor expression. In: Gene Therapy, Vol. 26, No. 3-4: pp. 93-108

Vallade, MaeIle; Jewginski, Michal; Fischer, Lucile; Buratto, Jeremie; Bathany, Katell; Schmitter, Jean-Marie; Stupfel, Marine; Godde, Frederic; Mackereth, Cameron D. and Huc, Ivan (2019): Assessing Interactions between Helical Aromatic Oligoamide Foldamers and Protein Surfaces: A Tethering Approach. In: Bioconjugate Chemistry, Vol. 30, No. 1: pp. 54-62

Voegerl, Katharina; Ong, Nghia; Senger, Johanna; Herp, Daniel; Schmidtkunz, Karin; Marek, Martin; Müller, Martin; Bartel, Karin; Shaik, Tajith B.; Porter, Nicholas J.; Robaa, Dina; Christianson, David W.; Romier, Christophe; Sippl, Wolfgang; Jung, Manfred and Bracher, Franz (2019): Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors. In: Journal of Medicinal Chemistry, Vol. 62, No. 3: pp. 1138-1166

Vollrath, Ilona; Friess, Wolfgang; Freitag, Angelika; Hawe, Andrea and Winter, Gerhard (2019): Comparison of ice fog methods and monitoring of controlled nucleation success after freeze-drying. In: International Journal of Pharmaceutics, Vol. 558: pp. 18-28

Wang, Shuaijun; Crevenna, Alvaro H.; Ugur, Ilke; Marion, Antoine; Antes, Iris; Kazmaier, Uli; Hoyer, Maria; Lamb, Don C.; Gegenfurtner, Florian; Kliesmetes, Zane; Ziegenhain, Christoph; Enard, Wolfgang; Vollmar, Angelika and Zahler, Stefan (2019): Actin stabilizing compounds show specific biological effects due to their binding mode. In: Scientific Reports, Vol. 9, 9731 [PDF, 5MB]

Wang, Shuaijun; Gegenfurtner, Florian A.; Crevenna, Alvaro H.; Ziegenhain, Christoph; Kliesmete, Zane; Enard, Wolfgang; Müller, Rolf; Vollmar, Angelika M.; Schneider, Sabine and Zahler, Stefan (2019): Chivosazole A Modulates Protein Protein Interactions of Actin. In: Journal of Natural Products, Vol. 82, No. 7: pp. 1961-1970

Wang, Xiang; Gan, Quan; Wicher, Barbara; Ferrand, Yann and Huc, Ivan (2019): Directional Threading and Sliding of a Dissymmetrical Foldamer Helix on Dissymmetrical Axles. In: Angewandte Chemie-International Edition, Vol. 58, No. 13: pp. 4205-4209

Wang, Yanfang; Xin, Shan; Zhang, Kai; Shi, Run and Bao, Xuanwen (2019): Low GAS5 Levels as a Predictor of Poor Survival in Patients with Lower-Grade Gliomas. In: Journal of Oncology, Vol. 2019, 1785042 [PDF, 9MB]

Wang, Yanfang; Zhang, Quanli; Gao, Zhaojia; Xin, Shan; Zhao, Yando; Zhang, Kai; Shi, Run and Bao, Xuanwen (2019): A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis. In: Cancer Cell International, Vol. 19, 100

Wein, Thomas; Wanner, Klaus T.; Rappenglueck, Sebastian; Sichler, Sonja; Niessen, Karin; Seeger, Thomas; Worek, Franz and Thiermann, Horst (2019): New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling. In: Current Computer-Aided Drug Design, Vol. 15, No. 1: pp. 104-109

Weippert, Valentin and Johrendt, Dirk (2019): High-pressure synthesis and crystal structure of SrGa4As4. In: Acta Crystallographica Section E-Crystallographic Communications, Vol. 75

Werner, Benjamin Patrick; Schoneich, Christian and Winter, Gerhard (2019): Silicone Oil-Free Polymer Syringes for the Storage of Therapeutic Proteins. In: Journal of Pharmaceutical Sciences, Vol. 108, No. 3: pp. 1148-1160

Yoneda, Saki; Niederleitner, Bertram; Wiggenhorn, Michael; Koga, Hiroki; Totoki, Shinichiro; Krayukhina, Elena; Friess, Wolfgang and Uchiyama, Susumu (2019): Quantitative Laser Diffraction for Quantification of Protein Aggregates: Comparison With Resonant Mass Measurement, Nanoparticle Tracking Analysis, Flow Imaging, and Light Obscuration. In: Journal of Pharmaceutical Sciences, Vol. 108, No. 1: pp. 755-762

2018

Andima, Moses; Costabile, Gabriella; Isert, Lorenz; Ndakala, Albert J.; Derese, Solomon and Merkel, Olivia M. (2018): Evaluation of beta-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity. In: Pharmaceutics, Vol. 10, No. 4, 232 [PDF, 3MB]

Berger, Karin; Schopohl, Dorothee; Bollig, Antonia; Strobach, Dorothea; Rieger, Christina; Rublee, Dale and Ostermann, Helmut (2018): Burden of Oral Mucositis: A Systematic Review and Implications for Future Research. In: Oncology Research and Treatment, Vol. 41, No. 6: pp. 399-405

Blank, Thomas; Goldmann, Tobias; Koch, Mirja; Amann, Lukas; Schön, Christian; Bonin, Michael; Pang, Shengru; Prinz, Marco; Burnet, Michael; Wagner, Johanna E.; Biel, Martin and Michalakis, Stylianos (2018): Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa. In: Frontiers in Immunology, Vol. 8, 1930 [PDF, 7MB]

Bracher, Franz

(2018): Methods for Arylethylation of Amines and Heteroarenes. In: Synopen, Vol. 2, No. 2: pp. 96-104 [PDF, 2MB]

Braig, Simone (2018): Chemical genetics in tumor lipogenesis. In: Biotechnology Advances, Vol. 36, No. 6: pp. 1724-1729

Burkard, Markus; Kohl, Susanne; Kratzig, Timm; Tanimoto, Naoyuki; Brennenstuhl, Christina; Bausch, Anne E.; Junger, Katrin; Reuter, Peggy; Sothilingam, Vithiyanjali; Beck, Susanne C.; Huber, Gesine; Ding, Xi-Qin; Mayer, Anja K.; Baumann, Britta; Weisschuh, Nicole; Zobor, Ditta; Hahn, Gesa-Astrid; Kellner, Ulrich; Venturelli, Sascha; Becirovic, Elvir; Charbel Issa, Peter; Koenekoop, Robert K.; Rudolph, Gunther; Heckenlively, John; Sieving, Paul; Weleber, Richard G.; Hamel, Christian; Zong, Xiangang; Biel, Martin; Lukowski, Robert; Seeliger, Matthias W.; Michalakis, Stylianos; Wissinger, Bernd and Ruth, Peter (2018): Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy. In: The Journal of Clinical Investigation, Vol. 128, No. 12: pp. 5663-5675

Chatzopoulou, E. I.; Raharja-Liu, P.; Murschhauser, A.; Sekhavati, F.; Buggenthin, F.; Vollmar, A. M.; Marr, C. and Rädler, Joachim O. (2018): A single-cell micro-trench platform for automatic monitoring of cell division and apoptosis after chemotherapeutic drug administration. In: Scientific Reports, Vol. 8, 18042 [PDF, 1MB]

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Deglmann, Claus J.; Blazkow-Schmalzbauer, Katarzyna; Moorkamp, Sarah; Wallmichrath, Jens; Giunta, Riccardo E.; Rogach, Andrey L.; Wagner, Ernst; Baumeister, Rüdiger G. and Ogris, Manfred (2018): In vivo tracking of adipose tissue grafts with cadmium-tel-luride quantum dots. In: Archives of Plastic Surgery-Aps, Vol. 45, No. 2: pp. 111-117 [PDF, 1MB]

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Geh, Katharina J.; Hubert, Madlen and Winter, Gerhard (2018): Progress in formulation development and sterilisation of freeze-dried oligodeoxynucleotide-loaded gelatine nanoparticles. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 129: pp. 10-20

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Maiaru, Maria; Morgan, Oakley B.; Mao, Tianqi; Breitsamer, Michaela; Bamber, Harry; Poehlmann, Max; Schmidt, Mathias V.; Winter, Gerhard; Hausch, Felix and Geranton, Sandrine M. (2018): The stress regulator FKBP51: a novel and promising druggable target for the treatment of persistent pain states across sexes. In: Pain, Vol. 159, No. 7: pp. 1224-1234

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Vollrath, Moritz; Engert, Julia and Winter, Gerhard (2018): New insights into process understanding of solid lipid extrusion (SLE) of extruded lipid implants for sustained protein delivery. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 130: pp. 11-21

Wang, Bifeng and Friess, Wolfgang (2018): Lipid-coated mannitol core microparticles for sustained release of protein. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 128: pp. 91-97

Wang, Ji; Wang, Jing; Zhang, Kai; Wang, Yanfang and Bao, Xuanwen (2018): Bayesian Network Meta-Analysis of the Effectiveness of Various Interventions for Nontraumatic Osteonecrosis of the Femoral Head. In: Biomed Research International, Vol. 2018, 2790163 [PDF, 2MB]

Wein, Thomas; Höfner, Georg; Rappenglück, Sebastian; Sichler, Sonja; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst and Wanner, Klaus T. (2018): Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor. In: Toxicology Letters, Vol. 293: pp. 184-189

Werner, Benjamin Patrick and Winter, Gerhard (2018): Expanding Bedside Filtration-A Powerful Tool to Protect Patients From Protein Aggregates. In: Journal of Pharmaceutical Sciences, Vol. 107, No. 11: pp. 2775-2788

West, Lorna Marie; Vetter-Kerkhoff, Cornelia; Miljkovic, Nenad and Frontini, Roberto (2018): Is there a need for a hospital pharmacy common training framework? Review of the literature on the impact of educational interventions on health outcome. In: European Journal of Hospital Pharmacy-Science and Practice, Vol. 25, No. 1: pp. 6-9

Yordanova, Yordanka; Vanderlinden, Willem; Stoll, Raphael; Rüdiger, Daniel; Tosstorff, Andreas; Zaremba, Wolfgang; Winter, Gerhard; Zahler, Stefan and Friess, Wolfgang (2018): Zn2+-triggered self-assembly of Gonadorelin [6-D-Phe] to produce nanostructures and fibrils. In: Scientific Reports, Vol. 8, 11280 [PDF, 3MB]

Zhang, Xiaohan; Chytil, Petr; Etrych, Tomas; Liu, Weiwei; Rodrigues, Leticia; Winter, Gerhard; Filippov, Sergey K. and Papadakis, Christine M. (2018): Binding of HSA to Macromolecular rho HPMA Based Nanoparticles for Drug Delivery: An Investigation Using Fluorescence Methods. In: Langmuir, Vol. 34, No. 27: pp. 7998-8006

Ziach, Krzysztof; Chollet, Celine; Parissi, Vincent; Prabhakaran, Panchami; Marchivie, Mathieu; Corvaglia, Valentina; Bose, Partha Pratim; Laxmi-Reddy, Katta; Godde, Frederic; Schmitter, Jean-Marie; Chaignepain, Stephane; Pourquier, Philippe and Huc, Ivan (2018): Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA. In: Nature Chemistry, Vol. 10, No. 5: pp. 511-518

2017

Agostini, Elisa; Winter, Gerhard and Engert, Julia (2017): Scale-up of water-based spider silk film casting using a film applicator. In: International Journal of Pharmaceutics, Vol. 532, No. 1: pp. 13-20

Arlt, E.; Arndt, L.; Breit, A.; Wennemuth, G.; Biel, M.; Wahl, C.; Gudermann, T.; Klugbauer, N. and Boekhoff, I. (2017): Two-pore channel protein 1 contributes to NAADP triggered acrosome reaction in spermatozoa. In: Reproduction in Domestic Animals, Vol. 52: pp. 6-7

Balsevich, Georgia; Häusl, Alexander S.; Meyer, Carola W.; Karamihalev, Stoyo; Feng, Xixi; Poehlmann, Max L.; Dournes, Carine; Uribe-Marino, Andres; Santarelli, Sara; Labermaier, Christiana; Hafner, Kathrin; Mao, Tianqi; Breitsamer, Michaela; Theodoropoulou, Marily; Namendorf, Christian; Uhr, Manfred; Paez-Pereda, Marcelo; Winter, Gerhard; Hausch, Felix; Chen, Alon; Tschöp, Matthias H.; Rein, Theo; Gassen, Nils C. and Schmidt, Mathias V. (2017): Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. In: Nature Communications, Vol. 8, 1725 [PDF, 1MB]

Bartel, Karin; Winzi, Maria; Ulrich, Melanie; Koeberle, Andreas; Menche, Dirk; Werz, Oliver; Müller, Rolf; Guck, Jochen; Vollmar, Angelika M. and Schwarzenberg, Karin von (2017): V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy. In: Oncotarget, Vol. 8, No. 6: pp. 9476-9487

Biel, M. (2017): Endolysosomal two-pore channels: from genes to function. In: Acta Physiologica, Vol. 221: p. 8

Bobak, Nicole; Feliciangeli, Sylvain; Chen, Cheng-Chang; Ben Soussia, Ismail; Bittner, Stefan; Pagnotta, Sophie; Ruck, Tobias; Biel, Martin; Wahl-Schott, Christian; Grimm, Christian; Meuth, Sven G. and Lesage, Florian (2017): Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels. In: Scientific Reports, Vol. 7, 649 [PDF, 11MB]

Bracher, Franz and Tremmel, Tim (2017): From Lead to Drug Utilizing a Mannich Reaction: The Topotecan Story. In: Archiv der Pharmazie, Vol. 350, No. 7, e1600236

Bracher, Franz and Tremmel, Tim (2017): The Chemistry of the Canthin-4-ones. In: Mini-Reviews in Organic Chemistry, Vol. 14, No. 2: pp. 92-98

Breitsamer, Michaela and Winter, Gerhard (2017): Needle-Free Injection of Vesicular Phospholipid Gels-A Novel Approach to Overcome an Administration Hurdle for Semisolid Depot Systems. In: Journal of Pharmaceutical Sciences, Vol. 106, No. 4: pp. 968-972

Butler, Michael R.; Ma, Hongwei; Yang, Fan; Belcher, Joshua; Le, Yun-Zheng; Mikoshiba, Katsuhiko; Biel, Martin; Michalakis, Stylianos; Iuso, Anthony; Krizaj, David and Ding, Xi-Qin (2017): Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. In: Journal of Biological Chemistry, Vol. 292, No. 27: pp. 11189-11205

Böhm, Sybille; Riedmayr, Lisa M.; Nguyen, O. N. Phuong; Giessl, Andreas; Liebscher, Toni; Butz, Elisabeth S.; Schön, Christian; Michalakis, Stylianos; Wahl-Schott, Christian; Biel, Martin and Becirovic, Elvir (2017): Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. In: Scientific Reports, Vol. 7, 2321 [PDF, 3MB]

Castonguay, Jan; Orth, Joachim H. C.; Müller, Thomas; Sleman, Faten; Grimm, Christian; Wahl-Schott, Christian; Biel, Martin; Mallmann, Robert Theodor; Bildl, Wolfgang; Schulte, Uwe and Klugbauer, Norbert (2017): The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. In: Scientific Reports, Vol. 7, 10038 [PDF, 4MB]

Chao, Yu-Kai; Schludi, Verena; Chen, Cheng-Chang; Butz, Elisabeth; Nguyen, O. N. Phuong; Müller, Martin; Krüger, Jens; Kammerbauer, Claudia; Ben-Johny, Manu; Vollmar, Angelika M.; Berking, Carola; Biel, Martin; Wahl-Schott, Christian A. and Grimm, Christian (2017): TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 41, E8595-E8602

Chen, Cheng-Chang; Butz, Elisabeth S.; Chao, Yu-Kai; Grishchuk, Yulia; Becker, Lars; Heller, Stefan; Slaugenhaupt, Susan A.; Biel, Martin; Wahl-Schott, Christian and Grimm, Christian (2017): Small Molecules for Early Endosome-Specific Patch Clamping. In: Cell Chemical Biology, Vol. 24, No. 7: pp. 907-916

Chen, Cheng-Chang; Cang, Chunlei; Fenske, Stefanie; Butz, Elisabeth; Chao, Yu-Kai; Biel, Martin; Ren, Dejian; Wahl-Schott, Christian and Grimm, Christian (2017): Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes. In: Nature Protocols, Vol. 12, No. 8: pp. 1639-1658

Decembrini, Sarah; Martin, Catherine; Sennlaub, Florian; Chemtob, Sylvain; Bie, Martin; Samardzija, Marijana; Moulin, Alexandre; Behar-Cohen, Francine and Arsenijevic, Yvan (2017): Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation. In: Molecular therapy, Vol. 25, No. 3: pp. 634-653

Deglmann, Claus J.; Błażków-Schmalzbauer, Katarzyna; Moorkamp, Sarah; Susha, Andrei S.; Herrler, Tanja; Giunta, Riccardo E.; Wagner, Ernst; Rogach, Andrey L.; Baumeister, Ruediger G. and Ogris, Manfred (2017): Cadmium Telluride Quantum Dots as a Fluorescence Marker for Adipose Tissue Grafts. In: Annals of Plastic Surgery, Vol. 78, No. 2: pp. 217-222 [PDF, 586kB]

Ellwart, Mario; Höfner, Georg; Gerwien, Aaron; Wanner, Klaus T. and Knochel, Paul (2017): Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives. In: Synthesis-Stuttgart, Vol. 49, No. 23: pp. 5159-5166

Even, Marie-Paule; Bobbala, Sharan; Gibson, Blake; Hook, Sarah; Winter, Gerhard and Engert, Julia (2017): Twin-screw extruded lipid implants containing TRP2 peptide for tumour therapy. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 114: pp. 79-87

Fanter, Lena; Müller, Christoph; Schepmann, Dirk; Bracher, Franz and Wünsch, Bernhard (2017): Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel sigma(1) receptor ligands. In: Bioorganic & Medicinal Chemistry, Vol. 25, No. 17: pp. 4778-4799

Farias Vercoza, Brunno Renato; Prado Godinho, Joseane Lima; Teixeira de Macedo-Silva, Sara; Huber, Kilian; Bracher, Franz; Souza, Wanderley de and Fernandes Rodrigues, Juliany Cola (2017): KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis. In: Apoptosis, Vol. 22, No. 9: pp. 1169-1188

Feldmann, Daniel P.; Xie, Yuran; Jones, Steven K.; Yu, Dongyue; Moszczynska, Anna and Merkel, Olivia M. (2017): The impact of microfluidic mixing of triblock micelleplexes on in vitro/in vivo gene silencing and intracellular trafficking. In: Nanotechnology, Vol. 28, No. 22, 224001

Fuchs, Simone; Bischoff, Iris; Willer, Elisabeth A.; Bräutigam, Jacqueline; Bubik, Martin F.; Erdelmeier, Clemens A. J.; Koch, Egon; Faleschini, Maria T.; Mieri, Maria de; Bauhart, Milena; Zahler, Stefan; Hensel, Andreas; Hamburger, Matthias; Potterat, Olivier and Fürst, Robert (2017): The Dual Edema-Preventing Molecular Mechanism of the Crataegus Extract WS 1442 Can Be Assigned to Distinct Phytochemical Fractions. In: Planta Medica, Vol. 83, No. 8: pp. 701-709

Grimm, Christian; Butz, Elisabeth; Chen, Cheng-Chang; Wahl-Schott, Christian and Biel, Martin (2017): From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease. In: Cell Calcium, Vol. 67: pp. 148-155

Grimm, Christian; Chen, Cheng-Chang; Wahl-Schott, Christian and Biel, Martin (February 2017): Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function. In: Frontiers in Pharmacology, Vol. 8, 45 [PDF, 662kB]

Hall, Arnaldur; Lächelt, Ulrich; Bartek, Jiri; Wagner, Ernst and Moghimi, Seyed Moein (2017): Polyplex Evolution: Understanding Biology, Optimizing Performance. In: Molecular therapy, Vol. 25, No. 7: pp. 1476-1490

Hammink, Roel; Eggermont, Loek J.; Zisis, Themistoklis; Tel, Jurjen; Figdor, Carl G.; Rowan, Alan E. and Blank, Kerstin G. (2017): Affinity-Based Purification of Polyisocyanopeptide Bioconjugates. In: Bioconjugate Chemistry, Vol. 28, No. 10: pp. 2560-2568

Hauke, Tobias J. and Herzig, Volker (2017): Dangerous arachnids-Fake news or reality? In: Toxicon, Vol. 138: pp. 173-183

Heissig, Philipp; Schrimpf, Waldemar; Hadwiger, Philipp; Wagner, Ernst and Lamb, Don C. (2017): Monitoring integrity and localization of modified single-stranded RNA oligonucleotides using ultrasensitive fluorescence methods.
In: PLOS One 12(3), e0173401 [PDF, 3MB]

Heller, Philipp; Hobernik, Dominika; Lächelt, Ulrich; Schinnerer, Meike; Weber, Benjamin; Schmidt, Manfred; Wagner, Ernst; Bros, Matthias and Barz, Matthias (2017): Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines. In: Journal of Controlled Release, Vol. 258: pp. 146-160

Herms, Jochen and Schön, Christian (2017): In vivo imaging of retinal neurodegeneration at the single cell level in humans. In: Brain, Vol. 140: pp. 1542-1543

Herrmann, Stefan; Rajab, Hamsa; Christ, Irina; Schirdewahn, Christoph; Höfler, Daniel; Fischer, Michael J. M.; Bruno, Ariane; Fenske, Stefanie; Gruner, Christian; Kramer, Felix; Wachsmann, Tassilo; Wahl-Schott, Christian; Stieber, Juliane; Biel, Martin and Ludwig, Andreas (2017): Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons. In: Pain, Vol. 158, No. 10: pp. 2012-2024

Jena, Sampreeti; Horn, Jacqueline; Suryanarayanan, Raj; Friess, Wolfgang and Aksan, Alptekin (2017): Effects of Excipient Interactions on the State of the Freeze-Concentrate and Protein Stability. In: Pharmaceutical Research, Vol. 34, No. 2: pp. 462-478

Jones, Steven K.; Sarkar, Anwesha; Feldmann, Daniel P.; Hoffmann, Peter and Merkel, Olivia M. (2017): Revisiting the value of competition assays in folate receptor-mediated drug delivery. In: Biomaterials, Vol. 138: pp. 35-45

Khan, Arif O.; Becirovic, Elvir; Betz, Christian; Neuhaus, Christine; Altmüller, Janine; Riedmayr, Lisa Maria; Motameny, Susanne; Nürnberg, Gudrun; Nürnberg, Peter and Bolz, Hanno J. (2017): A deep intronic CLRN1 (USH3A) founder mutation generates an aberrant exon and underlies severe Usher syndrome on the Arabian Peninsula. In: Scientific Reports, Vol. 7, 1411 [PDF, 2MB]

Klein, Philipp M.; Reinhard, Sören; Zhang, Wei; Klinker, Kristina; Kern, Sarah; Kessel, Eva; Barz, Matthias and Wagner, Ernst (2017): Novel Poly(Sarcosine) Click Shielding Agents Improve Circulation of Redox-Sensitive siRNA Lipo-Polyplexes In Vivo. In: Molecular therapy, Vol. 25, No. 5: p. 144

Knappmann, Inga; Lehmkuhl, Kirstin; Köhler, Jens; Schepmann, Dirk; Giera, Martin; Bracher, Franz and Wünsch, Bernhard (2017): Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomerically pure a ligands with 2-benzopyran structure. In: Bioorganic & Medicinal Chemistry, Vol. 25, No. 13: pp. 3384-3395

Koch, Susanne F.; Duong, Jimmy K.; Hsu, Chun-Wei; Tsai, Yi-Ting; Lin, Chyuan-Sheng; Wahl-Schott, Christian A. and Tsang, Stephen H. (2017): Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 20: pp. 5259-5264

Koczian, F.; Vomacka, J.; Vick, B.; Hettich, B.; Kazmaier, U.; Sieber, S.; Jeremias, I.; Vollmar, A. and Braig, S. (2017): Targeting the ER-Mitochondrial Interface of Cell Death Sensitizes Leukemia Cells towards Cytostatics. In: Annals of Hematology, Vol. 96: S73-S73

Korpus, Christoph and Friess, Wolfgang (2017): Evaluation of Different Holder Devices for Freeze-Drying in Dual-Chamber Cartridges With a Focus on Energy Transfer. In: Journal of Pharmaceutical Sciences, Vol. 106, No. 4: pp. 1092-1101

Korpus, Christoph and Friess, Wolfgang (2017): Lyophilization Cycle Design for Dual Chamber Cartridges and a Method for Online Process Control: The "DCC LyoMate" Procedure. In: Journal of Pharmaceutical Sciences, Vol. 106, No. 8: pp. 2077-2087

Krauss, Jürgen; Stadler, Martina and Bracher, Franz (2017): Synthesis and Structure-Activity Relationships of Novel Benzylamine-Type Antifungals as Butenafine-Related Antimycotics. In: Archiv der Pharmazie, Vol. 350, No. 5, e1600342

Kreitmeyr, Katharina; Both, Ulrich von; Pecar, Alenka; Borde, Johannes P.; Mikolajczyk, Rafael and Hübner, Johannes (2017): Pediatric antibiotic stewardship: successful interventions to reduce broad-spectrum antibiotic use on general pediatric wards. In: Infection, Vol. 45, No. 4: pp. 493-504

Köpf, Ellen; Schröder, Rudolf; Brezesinski, Gerald and Friess, Wolfgang (2017): The film tells the story: Physical-chemical characteristics of IgG at the liquid-air interface. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 119: pp. 396-407

Lacaille-Dubois, Marie-Aleth and Wagner, Hildebert (2017): New perspectives for natural triterpene glycosides as potential adjuvants. In: Phytomedicine, Vol. 37: pp. 49-57

Lamouroux, Arthur; Sebaoun, Laure; Wicher, Barbara; Kauffmann, Brice; Ferrand, Yann; Maurizot, Victor and Huc, Ivan (2017): Controlling Dipole Orientation through Curvature: Aromatic Foldamer Bent beta-Sheets and Helix-Sheet-Helix Architectures. In: Journal of the American Chemical Society, Vol. 139, No. 41: pp. 14668-14675

Laprell, Laura; Tochitsky, Ivan; Kaur, Kuldeep; Manookin, Michael B.; Stein, Marco; Barber, David M.; Schön, Christian; Michalakis, Stylianos; Biel, Martin; Kramer, Richard H.; Sumser, Martin P.; Trauner, Dirk and Gelder, Russell N. van (2017): Photopharmacological control of bipolar cells restores visual function in blind mice. In: Journal of Clinical investigation, Vol. 127, No. 7: pp. 2598-2611

Lee, Dian-Jang; Kessel, Eva; Lehto, Taavi; Liu, Xueying; Yoshinaga, Naoto; Padari, Kart; Chen, Ying-Chen; Kempter, Susanne; Uchida, Satoshi; Rädler, Joachim O.; Pooga, Margus; Sheu, Ming-Thau; Kataoka, Kazunori and Wagner, Ernst (2017): Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia. In: Bioconjugate Chemistry, Vol. 28, No. 9: pp. 2393-2409

Levacic, Ana Krhac; Morys, Stephan; Kempter, Susanne; Lächelt, Ulrich and Wagner, Ernst (2017): Minicircle Versus Plasmid DNA Delivery by Receptor-Targeted Polyplexes. In: Human Gene therapy, Vol. 28, No. 10: pp. 862-874

Liu, Xiaowen; Zhang, Peng; Rodl, Wolfgang; Maier, Kevin; Lächelt, Ulrich and Wagner, Ernst (2017): Toward Artificial Immunotoxins: Traceless Reversible Conjugation of RNase A with Receptor Targeting and Endosomal Escape Domains. In: Molecular Pharmaceutics, Vol. 14, No. 5: pp. 1439-1449

Lutz, Toni; Wein, Thomas; Höfner, Georg and Wanner, Klaus T. (2017): Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents. In: ChemMedChem, Vol. 12, No. 5: pp. 362-371

Mailaender-Sanchez, Daniela; Braunsdorf, Christina; Grumaz, Christian; Müller, Christoph; Lorenz, Stefan; Stevens, Philip; Wagener, Jeanette; Hebecker, Betty; Hube, Bernhard; Bracher, Franz; Sohn, Kai and Schaller, Martin (2017): Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion.
In: PLOS One 12(10), e0184438 [PDF, 5MB]

Mandl, Melanie M.; Zhang, Siwei; Ulrich, Melanie; Schmöckel, Elisa; Mayr, Doris; Vollmar, Angelika M. and Liebl, Johanna (2017): Inhibition of Cdk5 induces cell death of tumor-initiating cells. In: British Journal of Cancer, Vol. 116, No. 7: pp. 912-922

Martos, Ariadna; Koch, Wendelin; Jiskoot, Wim; Wuchner, Klaus; Winter, Gerhard; Friess, Wolfgang and Hawe, Andrea (2017): Trends on Analytical Characterization of Polysorbates and Their Degradation Products in Biopharmaceutical Formulations. In: Journal of Pharmaceutical Sciences, Vol. 106, No. 7: pp. 1722-1735

Meier, Christopher; Steinhauer, Tamara N.; Koczian, Fabian; Plitzko, Birte; Jarolim, Katharina; Girreser, Ulrich; Braig, Simone; Marko, Doris; Vollmar, Angelika M. and Clement, Bernd (2017): A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment. In: ChemMedChem, Vol. 12, No. 5: pp. 347-352

Meier, Christopher; Steinhauer, Tamara N.; Koczian, Fabian; Plitzko, Birte; Jarolim, Katharina; Girreser, Ulrich; Braig, Simone; Marko, Doris; Vollmar, Angelika M. and Clement, Bernd (2017): Cover Picture: A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment (ChemMedChem 5/2017). In: ChemMedChem, Vol. 12, No. 5: p. 346

Melzer, Benedikt C. and Bracher, Franz (2017): A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines. In: Beilstein Journal of Organic Chemistry, Vol. 13: pp. 1564-1571

Michalakis, Stylianos; Fischer, M. Dominik; Schön, Christian; Wilhelm, Barbara; Zobor, Ditta; Muhlfriedel, Regine; Sothilingam, Vithiyanjali; Kohl, Susanne; Peters, Tobias; Zrenner, Eberhart; Bartz-Schmidt, Karl Ulrich; Üffing, Marius; Wissinger, Bernd; Seeliger, Mathias and Biel, Martin (2017): Gene Supplementation Therapy for CNGA3-Linked Achromatopsia. In: Molecular therapy, Vol. 25, No. 5: p. 354

Michalakis, Stylianos; Schön, Christian; Becirovic, Elvir and Biel, Martin (2017): Gene therapy for achromatopsia. In: Journal of Gene Medicine, Vol. 19, No. 3, e2944

Michalakis, Stylianos; Shaltiel, Lior; Sothilingam, Vithiyanjali; Koch, Susanne; Schludi, Verena; Krause, Stefanie; Zeitz, Christina; Audo, Isabelle; Lancelot, Marie-Elise; Hamel, Christian; Meunier, Isabelle; Preising, Markus N.; Friedburg, Christoph; Lorenz, Birgit; Zabouri, Nawal; Haverkamp, Silke; Garcia Garrido, Marina; Tanimoto, Naoyuki; Seeliger, Mathias W.; Biel, Martin and Wahl-Schott, Christian A. (2017): Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2 (vol 23, pg 1538, 2014). In: Human Molecular Genetics, Vol. 26, No. 2: p. 466

Misslinger, Matthias; Gsaller, Fabio; Hortschansky, Peter; Müller, Christoph; Bracher, Franz; Bromley, Michael J. and Haas, Hubertus (2017): The cytochrome b(5) CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus. In: Metallomics, Vol. 9, No. 11: pp. 1655-1665

Moghimi, S. Moein and Wagner, Ernst (2017): Nanoparticle Technology: Having Impact, but Needing Further Optimization. In: Molecular therapy, Vol. 25, No. 7: pp. 1461-1463

Moser, Christina; Rüdiger, Daniel; Foerster, Florian; Blume, Julia von; Yu, Peng; Kuster, Bernhard; Kazmaier, Uli; Vollmar, Angelika M. and Zahler, Stefan (2017): Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer. In: Scientific Reports, Vol. 7, 16407 [PDF, 1MB]

Mühlfriedel, Regine; Tanimoto, Naoyuki; Schön, Christian; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Beck, Susanne C.; Huber, Gesine; Biel, Martin; Seeliger, Mathias W. and Michalakis, Stylianos (2017): AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects. In: Frontiers in Neuroscience, Vol. 11, 292 [PDF, 5MB]

Müller, C.; Neugebauer, T.; Zill, P.; Lass-Flörl, C.; Bracher, F. and Binder, U. (2017): Changes in sterol composition of clinically relevant Mucorales due to posaconazole treatment. In: Mycoses, Vol. 60: p. 29

Müller, Christoph; Binder, Ulrike; Bracher, Franz and Giera, Martin (2017): Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chromatography-mass spectrometry. In: Nature Protocols, Vol. 12, No. 5: pp. 947-963

Müller, Christoph; Hemmers, Sandra; Bartl, Nicholas; Plodek, Alois; Körner, Andreas; Mirakaj, Valbona; Giera, Martin and Bracher, Franz (2017): New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. In: European Journal of Medicinal Chemistry, Vol. 140: pp. 305-320

Nadrigny, F.; Meur, Karim le; Schomburg, E. D.; Safavi-Abbasi, S. and Dibaj, P. (2017): Two-Photon Laser-Scanning Microscopy for Single and Repetitive Imaging of Dorsal and Lateral Spinal White Matter In Vivo. In: Physiological Research, Vol. 66, No. 3: pp. 531-537

Nasiri, Hamid R.; Hohmann, Katharina; Hatemler, Melissa G.; Plodek, Alois; Bracher, Franz and Schwalbe, Harald (2017): In vitro production of reactive oxygen species (ROS) by sampangine. In: Medicinal Chemistry Research, Vol. 26, No. 6: pp. 1170-1175

Neiens, Patrick; Höfner, Georg and Wanner, Klaus T. (2017): Determination of the enantiomeric purity of the selective dopamine transporter inhibitor (+)-R,R-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol. In: Chirality, Vol. 29, No. 6: pp. 294-303

Nguyen, Ong Nam Phuong; Grimm, Christian; Schneider, Lina S.; Chao, Yu-Kai; Atzberger, Carina; Bartel, Karin; Watermann, Anna; Ulrich, Melanie; Mayr, Doris; Wahl-Schott, Christian; Biel, Martin and Vollmar, Angelika M. (2017): Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells. In: Cancer Research, Vol. 77, No. 6: pp. 1427-1438

Nino-Pariente, Amaya; Arminan, Ana; Reinhard, Sören; Scholz, Claudia; Kos, Petra; Wagner, Ernst and Vicent, Maria J. (2017): Design of Poly-l-Glutamate-Based Complexes for pDNA Delivery (vol 10, 1700029, 2017). In: Macromolecular Bioscience, Vol. 17, No. 10, 1700245

Nino-Pariente, Amaya; Arminan, Ana; Reinhard, Sören; Scholz, Claudia; Wagner, Ernst and Vicent, Maria J. (2017): Design of Poly-l-Glutamate-Based Complexes for pDNA Delivery. In: Macromolecular Bioscience, Vol. 17, No. 10, 1700029

Occelli, Laurence M.; Schön, Christian; Seeliger, Mathias W.; Biel, Martin; Michalakis, Stylianos and Petersen-Jones, Simon M. (2017): Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human PDE6A-Retinitis Pigmentosa. In: Human Gene therapy, Vol. 28, No. 12: pp. 1189-1201

Ochakovski, G. Alex; Peters, Tobias; Michalakis, Stylianos; Wilhelm, Barbara; Wissinger, Bernd; Bie, Martin; Bartz-Schmidt, K. Ulrich and Fischer, M. Dominik (2017): Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae. In: Investigative Ophthalmology & Visual Science, Vol. 58, No. 10: pp. 4155-4160

Ong, Duc Nghia; Dittrich, Sebastian; Swyter, Sören; Jung, Manfred and Bracher, Franz (2017): Synthesis of highly substituted 3-arylideneindolin-2-ones. In: Tetrahedron, Vol. 73, No. 38: pp. 5668-5679

Patel, Sajal Manubhai; Nail, Steven L.; Pikal, Michael J.; Geidobler, Raimund; Winter, Gerhard; Hawe, Andrea; Davagnino, Juan and Gupta, Shailaja Rambhatla (2017): Lyophilized Drug Product Cake Appearance: What Is Acceptable? In: Journal of Pharmaceutical Sciences, Vol. 106, No. 7: pp. 1706-1721

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Pozo, Karine; Ishimatsu, Keisuke; Telange, Rahul; Takahashi, Masaya; Oltmann, Sarah; Zahler, Stefan and Bibb, James (2017): Novel Combinatorial Drug Therapy for MTC. In: Pancreas, Vol. 46, No. 3: pp. 428-429

Pöhlmann, M. L.; Hartmann, J.; Harbich, D.; Schmid, B.; Häusl, A. S.; Dedic, N.; Feng, X.; Hausch, F.; Breitsamer, M.; Winter, G.; Deussing, J. and Schmidt, M. V. (2017): Unraveling the functional contribution of FKBP-51 in monoaminergic brain areas to stress vulnerability in mice. In: European Neuropsychopharmacology, Vol. 27: S39-S39

Rappenglück, Sebastian; Niessen, Karin V.; Seeger, Thomas; Worek, Franz; Thiermann, Horst and Wanner, Klaus T. (2017): Regioselective and Transition-Metal-Free Addition of tert-Butyl Magnesium Reagents to Pyridine Derivatives: A Convenient Method for the Synthesis of 3-Substituted 4-tert-Butylpyridine Derivatives. In: Synthesis-Stuttgart, Vol. 49, No. 17: pp. 4055-4064

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Reinhard, Sören and Wagner, Ernst (2017): How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amides. In: Macromolecular Bioscience, Vol. 17, No. 1, 1600152

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Saller, Verena; Matilainen, Julia; Rothkopf, Christian; Serafin, Daniel; Bechtold-Peters, Karoline; Mahler, Hanns-Christian and Friess, Wolfgang (2017): Preservative loss from silicone tubing during filling processes. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 112: pp. 109-118

Sałat, Kinga; Podkowa, Adrian; Malikowska, Natalia; Kern, Felix; Pabel, Jörg; Wojcieszak, Ewelina; Kulig, Katarzyna; Wanner, Klaus T.; Strach, Beata and Wyska, Elżbieta (2017): Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. In: Neuropharmacology, Vol. 113: pp. 331-342

Schaarschmidt, Maren and Wanner, Klaus T. (2017): Synthesis of Allene Substituted Nipecotic Acids by Allenylation of Terminal Alkynes. In: Journal of Organic Chemistry, Vol. 82, No. 16: pp. 8371-8388

Schmidt, Simone K.; Höfner, Georg and Wanner, Klaus T. (2017): Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives. In: Chirality, Vol. 29, No. 1: pp. 48-56

Schmohl, Kathrin A.; Dolp, Patrick; Schug, Christina; Knoop, Kerstin; Klutz, Kathrin; Schwenk, Nathalie; Bartenstein, Peter; Nelson, Peter J.; Ogris, Manfred; Wagner, Ernst and Spitzweg, Christine (2017): Reintroducing the Sodium-Iodide Symporter to Anaplastic Thyroid Carcinoma. In: Thyroid, Vol. 27, No. 12: pp. 1534-1543

Schreiber, C.; Segerer, F. J.; Wagner, E.; Roidl, A. and Rädler, Joachim O. (2017): Characterizing single cell migration and transitions to different substrate coatings. In: European Biophysics Journal With Biophysics Letters, Vol. 46: S323-S323

Schuller, Marion; Höfner, Georg and Wanner, Klaus T. (2017): Simultaneous Multiple MS Binding Assays Addressing D-1 and D-2 Dopamine Receptors. In: ChemMedChem, Vol. 12, No. 19: pp. 1585-1594

Schuller, Marion; Riede, Kerstin; Gibbs-Seymour, Ian; Uth, Kristin; Sieg, Christian; Gehring, Andre P.; Ahel, Ivan; Bracher, Franz; Kessler, Benedikt M.; Elkins, Jonathan M. and Knapp, Stefan (2017): Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. In: ACS Chemical Biology, Vol. 12, No. 11: pp. 2866-2874

Schön, Christian; Sothilingam, Vithiyanjali; Mühlfriedel, Regine; Garrido, Marina Garcia; Beck, Susanne C.; Tanimoto, Naoyuki; Wissinger, Bernd; Paquet-Durand, Francois; Biel, Martin; Michalakis, Stylianos and Seeliger, Mathias W. (2017): Gene Therapy Successfully Delays Degeneration in a Mouse Model of PDE6A-Linked Retinitis Pigmentosa (RP43). In: Human Gene therapy, Vol. 28, No. 12: pp. 1180-1188

Sibbing, Dirk; Aradi, Daniel; Jacobshagen, Claudius; Gross, Lisa; Trenk, Dietmar; Geisler, Tobias; Orban, Martin; Gori, Tommaso; Hadamitzky, Martin; Merkely, Bela; Kiss, Robert Gabor; Komocsi, Andras; Dersi, Csaba A.; Thalmeier, Andreas; Loew, Anja; Holdt, Lesca; Teupser, Daniel; Ince, Hueseyin; Felix, Stephan B.; Parma, Radoslaw; Malek, Lukasz; Horstkotte, Jan; Bay-lacher, Monika; Schwinger, Robert; Rieber, Johannes; Mudra, Harald; Hausleiter, Jörg; Huber, Kurt; Neumann, Franz-Josef; Koltowski, Lukasz; Huczek, Zenon; Mehilli, Julinda and Massberg, Steffen (2017): A randomised trial on platelet function-guided de-escalation of antiplatelet treatment in ACS patients undergoing PCI Rationale and design of the Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes (TROPICAL-ACS) Trial. In: Thrombosis and Haemostasis, Vol. 117, No. 1: pp. 188-195

Strüver, Kay; Friess, Wolfgang and Hedtrich, Sarah (2017): Development of a Perfusion Platform for Dynamic Cultivation of in vitro Skin Models. In: Skin Pharmacology and Physiology, Vol. 30, No. 4: pp. 180-189

Stöckelhuber, M.; Müller, C.; Vetter, F.; Mingo, V.; Lötters, S.; Wagner, N. and Bracher, F. (2017): Determination of Pesticides Adsorbed on Arthropods and Gastropods by a Micro-QuEChERS Approach and GC-MS/MS. In: Chromatographia, Vol. 80, No. 5: pp. 825-829

Trübenbach, Ines; Gorges, Jan; Kuhn, Jasmin; Kern, Sarah; Baratti, Emanuele; Kazmaier, Uli; Wagner, Ernst and Lächelt, Ulrich (2017): Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy. In: Macromolecular Bioscience, Vol. 17, No. 10, 1600520

Urnauer, Sarah; Klutz, Kathrin; Grünwald, Geoffrey K.; Morys, Stephan; Schwenk, Nathalie; Zach, Christian; Gildehaus, Franz-Josef; Rödl, Wolfgang; Ogris, Manfred; Wagner, Ernst and Spitzweg, Christine (2017): Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes. In: Journal of Gene Medicine, Vol. 19, No. 5, e2957

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Utzinger, Maximilian; Jarzebinska, Anita; Haag, Nicolas; Schweizer, Martin; Winter, Gerhard; Dohmen, Christian; Rudolph, Carsten and Plank, Christian (2017): cmRNA/lipoplex encapsulation in PLGA microspheres enables transfection via calcium phosphate cement (CPC)/PLGA composites. In: Journal of Controlled Release, Vol. 249: pp. 143-149

Vetter, F.; Müller, C.; Stöckelhuber, M. and Bracher, F. (2017): Determination of coumarin in seasonal bakery products using QuEChERS and GC-MS. In: Pharmazie, Vol. 72, No. 6: pp. 313-316

Vollrath, Ilona; Pauli, Victoria; Friess, Wolfgang; Freitag, Angelika; Hawe, Andrea and Winter, Gerhard (2017): Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying. In: Journal of Pharmaceutical Sciences, Vol. 106, No. 5: pp. 1249-1257

Vollrath, Moritz; Engert, Julia and Winter, Gerhard (2017): Long-term release and stability of pharmaceutical proteins delivered from solid lipid implants. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 117: pp. 244-255

Wagner, I.; Geh, K. J.; Hubert, M.; Winter, G.; Weber, K.; Classen, J.; Klinger, C. and Müller, R. S. (2017): Preliminary evaluation of cytosine-phosphate-guanine oligodeoxynucleotides bound to gelatine nanoparticles as immunotherapy for canine atopic dermatitis. In: Veterinary Record, Vol. 181, No. 5

Wagner, J. E.; Schön, C.; O'Riordan, C. R.; Scaria, A.; Cheng, S. H.; Biel, M. and Michalakis, S. (2017): Preclinical evaluation of rAAV.CNGB1 in the Cngb1 knockout mouse model of retinitis pigmentosa. In: Human Gene therapy, Vol. 28, No. 12: A78-A79

Wang, Bifeng and Friess, Wolfgang (2017): Spray drying of silica microparticles for sustained release application with a new sol-gel precursor. In: International Journal of Pharmaceutics, Vol. 532, No. 1: pp. 281-288

Wang, Shanshan; Li, Chengyi; Qian, Min; Jiang, Huiling; Shi, Wei; Chen, Jian; Lächelt, Ulrich; Wagner, Ernst; Lu, Weiyue; Wang, Yi and Huang, Rongqin (2017): Augmented glioma-targeted theranostics using multifunctional polymer-coated carbon nanodots. In: Biomaterials, Vol. 141: pp. 29-39

Wanner, Randy; Breitsprecher, Dennis; Duhr, Stefan; Baaske, Philipp and Winter, Gerhard (2017): Thermo-Optical Protein Characterization for Straightforward Preformulation Development. In: Journal of Pharmaceutical Sciences, Vol. 106, No. 10: pp. 2955-2958

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Zenker, J.; White, M. D.; Templin, R. M.; Parton, R. G.; Thorn-Seshold, O.; Bissiere, S. and Plachta, N. (2017): A microtubule-organizing center directing intracellular transport in the early mouse embryo. In: Science, Vol. 357, No. 6354: pp. 925-928

Zhang, Peng and Wagner, Ernst (2017): History of Polymeric Gene Delivery Systems. In: Topics in Current Chemistry, Vol. 375, No. 2, 26

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Cattaneo, Giulia; Ubiali, Daniela; Calleri, Enrica; Rabuffetti, Marco; Höfner, Georg C.; Wanner, Klaus T.; Moraes, Marcela C. de; Martinelli, Leonardo K. B.; Santiago Santos, Diógenes; Speranza, Giovanna and Massolini, Gabriella (2016): Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase. In: Analytica Chimica Acta, Vol. 943: pp. 89-97

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Foerster, Florian; Chen, Tao; Altmann, Karl-Heinz and Vollmar, Angelika M. (2016): Actin-binding doliculide causes premature senescence in p53 wild type cells. In: Bioorganic & Medicinal Chemistry, Vol. 24, No. 2: pp. 123-129

Funke, Stefanie; Matilainen, Julia; Nalenz, Heiko; Bechtold-Peters, Karoline; Mahler, Hanns-Christian and Friess, Wolfgang (2016): Optimization of the bake-on siliconization of cartridges. Part I: Optimization of the spray-on parameters. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 104: pp. 200-215

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Grimm, Christian; Barben, Maya; Ail, Divya; Kast, Brigitt; Schori, Christian; Giger-Lange, Christina; Michalakis, Stylianos and Samardzija, Marijana (2016): Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD? In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

He, Dongsheng; Müller, Katharina; Levacic, Ana Krhac; Kos, Petra; Lächelt, Ulrich and Wagner, Ernst (2016): Combinatorial Optimization of Sequence-Defined Oligo(ethanamino)amides for Folate Receptor-Targeted pDNA and siRNA Delivery. In: Bioconjugate Chemistry, Vol. 27, No. 3: pp. 647-659

Heissig, Philipp; Klein, Philipp M.; Hadwiger, Philipp and Wagner, Ernst (2016): DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization. In: Molecular Therapy - Nucleic Acids, Vol. 5, e288 [PDF, 1MB]

Hellenbrand, Tim; Höfner, Georg; Wein, Thomas and Wanner, Klaus T. (2016): Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors. In: Bioorganic & Medicinal Chemistry, Vol. 24, No. 9: pp. 2072-2096

Hermawan, Adam; Wagner, Ernst and Roidl, Andreas (2016): Consecutive salinomycin treatment reduces doxorubicin resistance of breast tumor cells by diminishing drug efflux pump expression and activity. In: Oncology Reports, Vol. 35, No. 3: pp. 1732-1740

Herzog, Julia; Ehrlich, Sandra M.; Pfitzer, Lisa; Liebl, Johanna; Fröhlich, Thomas; Arnold, Georg J.; Mikulits, Wolfgang; Haider, Christine; Vollmar, Angelika M. and Zahler, Stefan (2016): Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1 alpha: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma. In: Oncotarget, Vol. 7, No. 19: pp. 27108-27121

Hesbacher, Sonja; Pfitzer, Lisa; Wiedorfer, Katharina; Angermeyer, Sabrina; Borst, Andreas; Haferkamp, Sebastian; Scholz, Claus-Jürgen; Wobser, Marion; Schrama, David and Houben, Roland (2016): RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells. In: Oncotarget, Vol. 7, No. 22: pp. 32956-32968

Higel, Fabian; Seidl, Andreas; Sörgel, Fritz and Friess, Wolfgang (2016): N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins. In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 100: pp. 94-100

Hildebrandt, Christian; Mathaes, Roman; Saedler, Rainer and Winter, Gerhard (2016): Origin of Aggregate Formation in Antibody Crystal Suspensions Containing PEG. In: Journal of Pharmaceutical Sciences, Vol. 105, No. 3: pp. 1059-1065

Jiang, Qian; Yue, Dong; Nie, Yu; Xu, Xianghui; He, Yiyan; Zhang, Shiyong; Wagner, Ernst and Gu, Zhongwei (2016): Specially-Made Lipid-Based Assemblies for Improving Transmembrane Gene Delivery: Comparison of Basic Amino Acid Residue Rich Periphery. In: Molecular Pharmaceutics, Vol. 13, No. 6: pp. 1809-1821

Jones, S. K. and Merkel, O. M. (2016): Tackling breast cancer chemoresistance with nano-formulated siRNA. In: Gene therapy, Vol. 23, No. 12: pp. 821-828

Kamlah, Alexandra; Lirk, Florian and Bracher, Franz (2016): A new approach to 1-substituted β-carbolines and isoquinolines utilizing tributyl[(Z)-2-ethoxyvinyl]stannane as a C-3,C-4 building block. In: Tetrahedron, Vol. 72, No. 6: pp. 837-845

Karimova, Madina; Splith, Victoria; Karpinski, Janet; Pisabarro, M. Teresa and Buchholz, Frank (2016): Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering. In: Scientific Reports, Vol. 6, 30130 [PDF, 1MB]

Keller, Marco; Wolfgardt, Annette; Müller, Christoph; Wilcken, Rainer; Böckler, Frank M.; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Balliano, Gianni and Bracher, Franz (2016): Arylpiperidines as a new class of oxidosqualene cyclase inhibitors. In: European Journal of Medicinal Chemistry, Vol. 109: pp. 13-22

Kerscher-Hack, Silke; Renukappa-Gutke, Thejavathi; Höfner, Georg and Wanner, Klaus T. (2016): Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. In: European Journal of Medicinal Chemistry, Vol. 124: pp. 852-880

Kibat, Janek; Schirrmann, Thomas; Knape, Matthias J.; Helmsing, Saskia; Meier, Doris; Hust, Michael; Schröder, Christoph; Bertinetti, Daniela; Winter, Gerhard; Pardes, Khalid; Funk, Mia; Vala, Andrea; Giese, Nathalia; Herberg, Friedrich W.; Dübel, Stefan and Hoheisel, Jörg D. (2016): Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality. In: New Biotechnology, Vol. 33, No. 5: pp. 574-581

Kick, Kerstin; Nekolla, Katharina; Rehberg, Markus; Vollmar, Angelika M. and Zahler, Stefan (2016): New View on Endothelial Cell Migration Switching Modes of Migration Based on Matrix Composition. In: Arteriosclerosis thrombosis and Vascular Biology, Vol. 36, No. 12: pp. 2346-2357

Kilpatrick, Bethan S.; Yates, Elizabeth; Grimm, Christian; Schapira, Anthony H. and Patel, Sandip (2016): Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx. In: Journal of Cell Science, Vol. 129, No. 20: pp. 3859-3867

Kirmeier, Thomas; Gopalakrishnan, Ranganath; Gormanns, Vanessa; Werner, Anna M.; Cuboni, Serena; Rudolf, Georg C.; Höfner, Georg; Wanner, Klaus T.; Sieber, Stephan A.; Schmidt, Ulrike; Holsboer, Florian; Rein, Theo and Hausch, Felix (2016): Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores.
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Korpus, Christoph; Pikal, Michael and Friess, Wolfgang (2016): Heat Transfer Analysis of an Optimized, Flexible Holder System for Freeze-Drying in Dual Chamber Cartridges Using Different State-of-the-Art PAT Tools. In: Journal of Pharmaceutical Sciences, Vol. 105, No. 11: pp. 3304-3313

Kostic, Corinne; Crippa, Sylvain V.; Martin, Catherine; Kardon, Randy H.; Biel, Martin; Arsenijevic, Yvan and Kawasaki, Aki (2016): Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 6: pp. 2501-2508

Köse, Meryem; Schiedel, Anke C.; Bauer, Alexander Andreas; Poschenrieder, Hermann; Burbiel, Joachim C.; Akkinepally, Raghuram Rao; Stachef, Hans-Dietrich and Müller, Christa E. (2016): Focused screening to identify new adenosine kinase inhibitors. In: Bioorganic & Medicinal Chemistry, Vol. 24, No. 21: pp. 5127-5133

Lee, Dian-Jang; He, Dongsheng; Kessel, Eva; Padari, Kärt; Kempter, Susanne; Lächelt, Ulrich; Rädler, Joachim O.; Pooga, Margus and Wagner, Ernst (2016): Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes. In: Journal of Controlled Release, Vol. 244: pp. 280-291

Lee, Dian-Jang; Kessel, Eva; Edinger, Daniel; He, Dongsheng; Klein, Philipp M.; Voith von Voithenberg, Lena; Lamb, Don C.; Lächelt, Ulrich; Lehto, Taavi and Wagner, Ernst (2016): Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand. In: Biomaterials, Vol. 77: pp. 98-110

Liebl, Johanna (2016): Cyclin dependent kinase 5-a novel target to enhance the antitumor immune response. In: Translational Cancer Research, Vol. 5: S587-S589

Liu, Xiaowen; Zhang, Peng; He, Dongsheng; Rödl, Wolfgang; Preiß, Tobias; Rädler, Joachim O.; Wagner, Ernst and Lächelt, Ulrich (2016): pH-Reversible Cationic RNase A Conjugates for Enhanced Cellular Delivery and Tumor Cell Killing. In: Biomacromolecules, Vol. 17, No. 1: pp. 173-182

Lutz, Toni A.; Spanner, Patrick and Wanner, Klaus T. (2016): A general approach to substituted diphenyldiazenes. In: Tetrahedron, Vol. 72, No. 12: pp. 1579-1589

Lächelt, Ulrich; Levacic, Ana Krhac; Wendel, Dominik and Wagner, Ernst (2016): Nonviral Gene Transfer by Sequence-Defined Proton-Sponges with Combined Nucleic Acid Binding and Endosomal Buffering: Balancing Basicities. In: Molecular therapy, Vol. 24: S195-S195

Merk, Henriette; Zhang, Siwei; Lehr, Thorsten; Müller, Christoph; Ulrich, Melanie; Bibb, James A.; Adams, Ralf H.; Bracher, Franz; Zahler, Stefan; Vollmar, Angelika M. and Liebl, Johanna (2016): Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. In: Oncotarget, Vol. 7, No. 5: pp. 6088-6104

Michalakis, Stylianos; Koch, Mirwa; Ma, Hongwei; Ding, Xi-Qin and Biel, Martin (2016): cGMP-cGKII signalling contributes to cone photoreceptor degeneration in achromatopsia. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Mohammadi, Mariam; Li, Ying; Abebe, Daniel G.; Xie, Yuran; Kandil, Rima; Kraus, Teresa; Gomez-Lopez, Nardhy; Fujiwara, Tomoko and Merkel, Olivia M. (2016): Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. In: Journal of Controlled Release, Vol. 244: pp. 269-279

Molokhia, Sarah; Burr, Randon M.; Flood, Maggie; Vallrath, Moritz; Winter, Gerhard and Ambati, Balamurali Krishna (2016): Lens Capsule Biodegradable Lipid Implant for Sustained-Release Anti-VEGF Therapy of Neovascular AMD. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Mosion, Jan; Rauscher, Alexander; Willi, Taylor; Lang, Donna; Vertinsky, Talia; Vila-Rodriguez, Fidel; Kames, Christian; Panenka, William; Jarrett, Mike; Honer, William and Barr, Alasdair (2016): A Longitudinal Characterization of Cerebral Microbleeds in a Marginalized Population with High Rates of Mental Illness, Substance Abuse and Viral Infection. In: Neurology, Vol. 86

Movassaghian, Sara; Xie, Yuran; Hildebrandt, Claudia; Rosati, Rayna; Li, Ying; Kim, Na Hyung; Conti, Denise S.; Rocha, Sandro R. P. da; Yang, Zeng-Quan and Merkel, Olivia M. (2016): Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles. In: Molecular Pharmaceutics, Vol. 13, No. 8: pp. 2605-2621

Müller, Katharina; Klein, Philipp M.; Heissig, Philipp; Roidl, Andreas and Wagner, Ernst (2016): EGF receptor targeted lipo-oligocation polyplexes for antitumoral siRNA and miRNA delivery. In: Nanotechnology, Vol. 27, No. 46, 464001

Müller, Katherina; Kessel, Eva; Klein, Philipp M.; Höhn, Miriam and Wagner, Ernst (2016): Post-PEGylation of siRNA Lipo-oligoamino Amide Polyplexes Using Tetra-glutamylated Folic Acid as Ligand for Receptor-Targeted Delivery. In: Molecular Pharmaceutics, Vol. 13, No. 7: pp. 2332-2345

Nguyen, O. N. Phuong; Böhm, Sybille; Gießl, Andreas; Butz, Elisabeth S.; Wolfrum, Uwe; Brandstätter, Johann H.; Wahl-Schott, Christian; Biel, Martin and Becirovic, Elvir (2016): Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. In: Human Molecular Genetics, Vol. 25, No. 12: pp. 2367-2377

Niessen, K. V.; Muschik, S.; Langguth, F.; Rappenglück, S.; Seeger, T.; Thiermann, H. and Worek, F. (2016): Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology. In: Toxicology Letters, Vol. 247: pp. 1-10

Petrera, Marilena; Wein, Thomas; Allmendinger, Lars; Sindelar, Miriam; Pabel, Jörg; Höfner, Georg and Wanner, Klaus T. (2016): Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions. In: ChemMedChem, Vol. 11, No. 5: pp. 519-538

Pivodová, V.; Zahler, S.; Karas, D.; Valentová, K. and Ulrichova, J. (2016): In vitro study of 2,3-dehydrosilybin and its galloyl esters as potential inhibitors of angiogenesis. In: Pharmazie, Vol. 71, No. 8: pp. 478-483

Plodek, Alois and Bracher, Franz (2016): New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids. In: Marine Drugs, Vol. 14, No. 2, 26 [PDF, 6MB]

Podkowa, A.; Sałat, K.; Malikowska, N.; Kern, F.; Pabel, J.; Kulig, K.; Wanner, K. T.; Wojcieszak, E. and Furgala, A. (2016): Anticonvulsant activity of a novel gamma-aminobutyric acid transporter subtype 1 inhibitor in mice. In: European Neuropsychopharmacology, Vol. 26: S286-S286

Popp, Tobias A.; Tallant, Cynthia; Rogers, Catherine; Fedorov, Oleg; Brennan, Paul E.; Müller, Susanne; Knapp, Stefan and Bracher, Franz (2016): Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors. In: Journal of Medicinal Chemistry, Vol. 59, No. 19: pp. 8889-8912

Popp, Tobias Alexander; Uhl, Edgar; Ong, Duc Nghia; Dittrich, Sebastian and Bracher, Franz (2016): A new approach to monoprotected 1,4-benzodiazepines via a one-pot N-deprotection/reductive cyclization procedure. In: Tetrahedron, Vol. 72, No. 13: pp. 1668-1674

Reichel, Felix Friedrich; Peters, Tobias; Muehlfriedel, Regine; Biel, Martin; Paquet-Durand, Francois; Ueffing, Marius; Wissinger, Bernd; Bartz-Schmidt, Karl Ulrich; Fischer, M. Dominik and Michalakis, Stylianos (2016): Humoral immune response to subretinal AAV8 in non-human primates. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Rodrigues, Leticia; Kyriakos, Konstantinos; Schneider, Fabian; Dietz, Hendrik; Winter, Gerhard; Papadakis, Christine M. and Hubert, Madlen (2016): Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers. In: Molecular Pharmaceutics, Vol. 13, No. 11: pp. 3945-3954

Santos-Ferreira, Tiago; Völkner, Manuela; Borsch, Oliver; Haas, Jochen; Cimalla, Peter; Vasudevan, Praveen; Carmeliet, Peter; Corbeil, Denis; Michalakis, Stylianos; Koch, Edmund; Karl, Mike O. and Ader, Marius (2016): Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 13: pp. 5336-5337

Scheffel, C.; Rappenglck, S.; Niessen, K.; Worek, F.; Thiermann, H.; Wanner, K. and Seeger, T. (2016): Electrophysiological drug-screening of bispyridinium-non-oxime-compounds on human nicotinic alpha 7 acetylcholine receptors - an alternative approach for the treatment of nerve agent poisoning -. In: Naunyn-Schmiedebergs Archives of Pharmacology, Vol. 389, No. 1: S42-S42

Schneider, Lina S.; Ulrich, Melanie; Lehr, Thorsten; Menche, Dirk; Müller, Rolf and Schwarzenberg, Karin von (2016): MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition. In: Molecular Oncology, Vol. 10, No. 7: pp. 1054-1062

Schuster, Simon L.; Segerer, Felix J.; Gegenfurtner, Florian A.; Kick, Kerstin; Schreiber, Christoph; Albert, Max; Vollmar, Angelika M.; Rädler, Joachim O. and Zahler, Stefan (2016): Contractility as a global regulator of cellular morphology, velocity, and directionality in low-adhesive fibrillary micro-environments. In: Biomaterials, Vol. 102: pp. 137-147

Schön, Christian; Asteriti, Sabrina; Koch, Susanne; Sothilingam, Vithiyanjali; Garrido, Marina Garcia; Tanimoto, Naoyuki; Herms, Jochen; Seeliger, Mathias W.; Cangiano, Lorenzo; Biel, Martin and Michalakis, Stylianos (2016): Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. In: Human Molecular Genetics, Vol. 25, No. 6: pp. 1165-1175

Schön, Christian; Paquet-Durand, Francois and Michalakis, Stylianos (2016): Ca(v)1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice.
In: PLOS ONE 11(6), e0156974 [PDF, 1MB]

Seitz, Immanuel Philipp; Fischer, M. Dominik; Michalakis, Stylianos; Wilhelm, Barbara; Kahle, Nadine; Zrenner, Eberhart; Ueffing, Marius; Bartz-Schmidt, Karl Ulrich; Biel, Martin; Wissinger, Bernd and Peters, Tobias (2016): rAAV8 biodistribution and shedding after subretinal injection in non-human primates. In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 12

Sohail, Azmat; Jayaraman, Kumaresan; Venkatesan, Santhoshkannan; Gotfryd, Kamil; Daerr, Markus; Gether, Ulrik; Loland, Claus J.; Wanner, Klaus T.; Freissmuth, Michael; Sitte, Harald H.; Sandtner, Walter and Stockner, Thomas (2016): The Environment Shapes the Inner Vestibule of LeuT.
In: PLOS Computational Biology 12(11), e1005197 [PDF, 5MB]

Sothilingam, Vithiyanjali; Michalakis, Stylianos; Garrido, Marina Garcia; Biel, Martin; Tanimoto, Naoyuki and Seeliger, Mathias W. (2016): HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.
In: PLOS ONE 11(1), e0147728 [PDF, 1MB]

Tanimoto, Naoyuki; Michalakis, Stylianos; Weber, Bernhard H. F.; Wahl-Schott, Christian A.; Hammes, Hans-Peter and Seeliger, Mathias W. (2016): In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination. In: Retinal Degenerative Diseases: Mechanisms and Experimental therapy, Vol. 854: pp. 619-625

Tremmel, Tim; Puzik, Andreas; Gehring, André P. and Bracher, Franz (2016): Canthin-4-ones as Novel Antibacterial Agents. In: Archiv Der Pharmazie, Vol. 349, No. 9: pp. 710-723

Unzue, Andrea; Lafleur, Karine; Zhao, Hongtao; Zhou, Ting; Dong, Jing; Kolb, Peter; Liebl, Johanna; Zahler, Stefan; Caflisch, Amedeo and Nevado, Cristina (2016): Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation. In: European Journal of Medicinal Chemistry, Vol. 112: pp. 347-366

Wagner, Hildebert; Bauer, Rudolf and Melchart, Dieter (2016): New Analytical Monographs on TCM Herbal Drugs for Quality Proof. In: Forschende Komplementarmedizin, Vol. 23: pp. 16-20 [PDF, 219kB]

Wagner, I; Geh, K.; Winter, G.; Weber, K. and Mueller, R. S. (2016): Immunotherapy of canine atopic dermatitis with CpG oligodeoxynucleotides bound to gelatine nanoparticles. In: Allergy, Vol. 71: p. 69

Wein, Thomas; Petrera, Marilena; Allmendinger, Lars; Höfner, Georg; Pabel, Jörg and Wanner, Klaus T. (2016): Different Binding Modes of Small and Large Binders of GAT1. In: ChemMedChem, Vol. 11, No. 5: pp. 509-518

Westerhausen, Christoph; Schnitzler, Lukas G.; Wendel, Dominik; Krzyszton, Rafal; Lächelt, Ulrich; Wagner, Ernst; Rädler, Joachim O. and Wixforth, Achim (2016): Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles. In: Micromachines, Vol. 7, No. 9, 150 [PDF, 4MB]

Xie, Yuran; Killinger, Bryan; Moszczynska, Anna and Merkel, Olivia M. (2016): Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine. In: Molecules, Vol. 21, No. 10, 1334 [PDF, 2MB]

Xie, Yuran; Kim, Na Hyung; Nadithe, Venkatareddy; Schalk, Dana; Thakur, Archana; Kılıç, Ayşe; Lum, Lawrence G.; Bassett, David J. P. and Merkel, Olivia M. (2016): Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma. In: Journal of Controlled Release, Vol. 229: pp. 120-129

Zhang, S.; Ulrich, M.; Gromnicka, A.; Havlíček, L.; Kryštof, V.; Jorda, R.; Strnad, M.; Vollmar, A. M. and Zahler, S. (2016): Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold. In: British Journal of Pharmacology, Vol. 173, No. 17: pp. 2645-2656

Zhang, Wei; Müller, Katharina; Kessel, Eva; Reinhard, Sören; He, Dongsheng; Klein, Philipp M.; Höhn, Miriam; Rödl, Wolfgang; Kempter, Susanne and Wagner, Ernst (2016): Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nanocore with an Influenza Peptide and Transferrin Shell. In: Advanced Healthcare Materials, Vol. 5, No. 12: pp. 1493-1504

Zhong, Qian; Merkel, Olivia M.; Reineke, Joshua J. and Rocha, Sandro R. P. da (2016): Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution. In: Molecular Pharmaceutics, Vol. 13, No. 6: pp. 1866-1878

2015

Arends, Fabienna; Nowald, Constantin; Pflieger, Kerstin; Boettcher, Kathrin; Zahler, Stefan and Lieleg, Oliver (2015): The Biophysical Properties of Basal Lamina Gels Depend on the Biochemical Composition of the Gel.
In: PLOS ONE 10(2), e0118090 [PDF, 2MB]

Bender, Julia; Engeholm, Maik; Ederer, Marion S.; Breu, Johannes; Moller, Thor C.; Michalakis, Stylianos; Rasko, Tamas; Wanker, Erich E.; Biel, Martin; Martinez, Karen L.; Wurst, Wolfgang and Deussing, Jan M. (2015): Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
In: PLOS ONE 10(9), e0136768 [PDF, 20MB]

Braig, Simone; Schmidt, B. U. Sebastian; Stoiber, Katharina; Haendel, Chris; Moehn, Till; Werz, Oliver; Mueller, Rolf; Zahler, Stefan; Koeberle, Andreas; Kaes, Josef A. and Vollmar, Angelika M. (2015): Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion. In: New Journal of Physics, Vol. 17, 083007 [PDF, 1MB]

Buchmann, Stefan; Sandmann, Gunther H.; Walz, Lars; Reichel, Thomas; Beitzel, Knut; Wexel, Gabriele; Tian, Weiwei; Battmann, Achim; Vogt, Stephan; Winter, Gerhard and Imhoff, Andreas B. (2015): Growth factor release by vesicular phospholipid gels: in-vitro results and application for rotator cuff repair in a rat model. In: BMC Musculoskeletal Disorders 16:82 [PDF, 1MB]

Feodorova, Yana; Koch, Mirja; Bultman, Sebastian; Michalakis, Stylianos and Solovei, Irina (2015): Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice. In: Methodsx, Vol. 2: pp. 39-46

Fuchs, Simone; Hsieh, Louise T.; Saarberg, Werner; Erdelmeier, Clemens A. J.; Wichelhaus, Thomas A.; Schaefer, Liliana; Koch, Egon and Fuerst, Robert (2015): Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo. In: Journal of Cellular and Molecular Medicine, Vol. 19, No. 5: pp. 1021-1032 [PDF, 718kB]

Liebl, Johanna; Zhang, Siwei; Moser, Markus; Agalarov, Yan; Demir, Cansaran Saygili; Hager, Bianca; Bibb, James A.; Adams, Ralf H.; Kiefer, Friedemann; Miura, Naoyuki; Petrova, Tatiana V.; Vollmar, Angelika M. and Zahler, Stefan (2015): Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. In: Nature Communications, Vol. 6, 7274 [PDF, 2MB]

Reichel, Christoph A.; Hessenauer, Maximilian E. T.; Pflieger, Kerstin; Rehberg, Markus; Kanse, Sandip M.; Zahler, Stefan; Krombach, Fritz; Berghaus, Alexander and Strieth, Sebastian (2015): Components of the Plasminogen Activation System Promote Engraftment of Porous Polyethylene Biomaterial via Common and Distinct Effects.
In: PLOS ONE 10(2), e0116883 [PDF, 4MB]

Rüben, Katharina; Wurzlbauer, Anne; Walte, Agnes; Sippl, Wolfgang; Bracher, Franz and Becker, Walter (2015): Selectivity Profiling and Biological Activity of Novel beta-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.
In: PLOS ONE 10(7), e0132453 [PDF, 4MB]

Schmitt, Andreas; Rödel, Philipp; Anamur, Cihad; Seeliger, Claudine; Imhoff, Andreas B.; Herbst, Elmar; Vogt, Stephan; Griensven, Martijn van; Winter, Gerhard and Engert, Julia (2015): Calcium Alginate Gels as Stem Cell Matrix - Making Paracrine Stem Cell Activity Available for Enhanced Healing after Surgery.
In: PLOS ONE 10(3), e0118937 [PDF, 1MB]

Tanimoto, Naoyuki; Sothilingam, Vithiyanjali; Kondo, Mineo; Biel, Martin; Humphries, Peter and Seeliger, Mathias W. (2015): Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice. In: Scientific Reports, Vol. 5, 10731 [PDF, 960kB]

2014

Arango-Gonzalez, Blanca; Trifunović, Dragana; Sahaboglu, Ayse; Kranz, Katharina; Michalakis, Stylianos; Farinelli, Pietro; Koch, Susanne; Koch, Fred; Cottet, Sandra; Janssen-Bienhold, Ulrike; Dedek, Karin; Biel, Martin; Zrenner, Eberhart; Euler, Thomas; Ekstrom, Per; Ueffing, Marius and Paquet-Durand, François (2014): Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration.
In: PLOS ONE 9(11), e112142 [PDF, 1MB]

Braig, S.; Wiedmann, R. M.; Liebl, J.; Singer, M.; Kubisch, R.; Schreiner, L.; Abhari, B. A.; Wagner, E.; Kazmaier, U.; Fulda, S. and Vollmar, Angelika M. (2014): Pretubulysin: a new option for the treatment of metastatic cancer. In: Cell Death & Disease, Vol. 5, e1001

Chen, Cheng-Chang; Keller, Marco; Hess, Martin; Schiffmann, Raphael; Urban, Nicole; Wolfgardt, Annette; Schaefer, Michael; Bracher, Franz; Biel, Martin; Wahl-Schott, Christian and Grimm, Christian (2014): A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. In: Nature Communications, Vol. 5, 4681 [PDF, 1MB]

Farinelli, P.; Perera, A.; Arango-Gonzalez, B.; Trifunovic, D.; Wagner, M.; Carell, T.; Biel, M.; Zrenner, E.; Michalakis, S.; Paquet-Durand, F. and Ekström, P. A. R. (2014): DNA methylation and differential gene regulation in photoreceptor cell death. In: Cell Death & Disease, Vol. 5, e1558 [PDF, 5MB]

Foerster, F.; Braig, S.; Moser, C.; Kubisch, R.; Busse, J.; Wagner, E.; Schmoeckel, E.; Mayr, D.; Schmitt, S.; Huettel, S.; Zischka, H.; Mueller, R. and Vollmar, Angelika M. (2014): Targeting the actin cytoskeleton: selective antitumor action via trapping PKCε. In: Cell Death & Disease, Vol. 5, e1398 [PDF, 3MB]

Grimm, Christian; Holdt, Lesca M.; Chen, Cheng-Chang; Hassan, Sami; Müller, Christoph; Jörs, Simone; Cuny, Hartmut; Kissing, Sandra; Schröder, Bernd; Butz, Elisabeth; Northoff, Bernd; Castonguay, Jan; Luber, Christian A.; Moser, Markus; Spahn, Saskia; Luellmann-Rauch, Renate; Fendel, Christina; Klugbauer, Norbert; Griesbeck, Oliver; Haas, Albert; Mann, Matthias; Bracher, Franz; Teupser, Daniel; Saftig, Paul; Biel, Martin and Wahl-Schott, Christian (2014): High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. In: Nature Communications, Vol. 5, 4699 [PDF, 3MB]

Kern, Selina; Agarwal, Shruti; Huber, Kilian; Gehring, André P.; Strödke, Benjamin; Wirth, Christine C.; Brügl, Thomas; Abodo, Liliane Onambele; Dandekar, Thomas; Doerig, Christian; Fischer, Rainer; Tobin, Andrew B.; Alam, Mahmood M.; Bracher, Franz and Pradel, Gabriele (2014): Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission.
In: PLOS ONE 9(9), e105732 [PDF, 3MB]

Kneidl, Barbara; Peller, Michael; Winter, Gerhard; Lindner, Lars H. and Hossann, Martin (2014): Thermosensitive liposomal drug delivery systems: state of the art review. In: International Journal of Nanomedicine, Vol. 9: pp. 4387-4398 [PDF, 4MB]

Kos, Petra; Lächelt, Ulrich; Herrmann, Annika; Mickler, Frauke M.; Krhač Levačić, Ana; Morys, Stephan; Bräuchle, Christoph and Wagner, Ernst (2014): Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer. In: Nanoscale, Vol. 7, No. 12: pp. 5350-5362 [PDF, 0B]

Neuner, Johanna; Filser, Severin; Michalakis, Stylianos; Biel, Martin and Herms, Jochen (2014): A30P alpha-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network. In: Scientific Reports, Vol. 4, 3931 [PDF, 11MB]

Soltysinska, Ewa; Bentzen, Bo Hjorth; Barthmes, Maria; Hattel, Helle; Thrush, A. Brianne; Harper, Mary-Ellen; Qvortrup, Klaus; Larsen, Filip J.; Schiffer, Tomas A.; Losa-Reyna, Jose; Straubinger, Julia; Kniess, Angelina; Thomsen, Morten Bækgaard; Brüggemann, Andrea; Fenske, Stefanie; Biel, Martin; Ruth, Peter; Wahl-Schott, Christian; Boushel, Robert Christopher; Olesen, Søren-Peter and Lukowski, Robert (2014): KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury.
In: PLOS ONE 9(7), e103402 [PDF, 1MB]

2012

Herrmann, Jennifer; Elnakady, Yasser A.; Wiedmann, Romina M.; Ullrich, Angelika; Rohde, Manfred; Kazmaier, Uli; Vollmar, Angelika M. and Müller, Rolf (2012): Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy.
In: PLOS ONE 7(5), e37416 [PDF, 1MB]

Kopp, Florian; Oak, Prajakta S.; Wagner, Ernst and Roidl, Andreas (2012): miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression.
In: PLOS ONE 7(11), e50469 [PDF, 700kB]

2011

Dussmann, Philipp; Pagel, Judith I.; Vogel, Sabina; Magnusson, Terese; Zimmermann, Rene; Wagner, Ernst; Schaper, Wolfgang; Ogris, Manfred and Deindl, Elisabeth (2011): Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing. In: BMC Developmental Biology 11:28 [PDF, 2MB]

1994

Maass, Gerd; Zatloukal, Kurt; Schmidt, Walter; Berger, M.; Cotten, Matt; Wagner, Ernst; Birnstiel, Max L. and Buschle, M. (1994): The generation of tumor vaccines by adenovirus-enhanced transfection of cytokine genes into tumor cells. In: Skouteris, George G. (ed.) : Liver carcinogenesis. Berlin u.a.: Springer. pp. 467-479 [PDF, 1MB]

This list was generated on Mon Nov 27 19:09:39 2023 CET.