General Method for the Preparation of Indole-2-Weinreb Amides

Glas, Carina und Bracher, Franz (2019): General Method for the Preparation of Indole-2-Weinreb Amides. In: Synthesis-Stuttgart, Bd. 51, Nr. 3, UNSP ss-2018-t0494-op: S. 757-768

Abstract

Indole-2-Weinreb amides are obtained via thermolysis of alpha-azidocinnamic acid Weinreb amides in a Hemetsberger-Knittel-type cyclization. The required vinyl azides are not accessible by Knoevenagel condensation, but are obtained by cerium(IV)-mediated oxidative azidation of the corresponding cinnamic Weinreb amides.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0039-7881
• Sprache: Englisch