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Glas, Carina; Bracher, Franz (2019): General Method for the Preparation of Indole-2-Weinreb Amides. In: Synthesis-Stuttgart, Vol. 51, No. 3, UNSP ss-2018-t0494-op: pp. 757-768
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Indole-2-Weinreb amides are obtained via thermolysis of alpha-azidocinnamic acid Weinreb amides in a Hemetsberger-Knittel-type cyclization. The required vinyl azides are not accessible by Knoevenagel condensation, but are obtained by cerium(IV)-mediated oxidative azidation of the corresponding cinnamic Weinreb amides.