Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives

Ellwart, Mario; Höfner, Georg; Gerwien, Aaron; Wanner, Klaus T. und Knochel, Paul (2017): Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives. In: Synthesis-Stuttgart, Vol. 49, No. 23: pp. 5159-5166

Abstract

A range of N-benzylic and N-phenethylic ephedrine derivatives were prepared in a one-pot procedure starting from the two enantiomers of ephedrine using the Potier reagent, and a polyfunctional aryl-or benzylic organozinc halide. The biological activity in indatraline MS Binding Assays addressing hDAT, hNET and hSERT was determined and discussed.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry; Chemistry and Pharmacy > Department of Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 0039-7881
• Language: English