Abstract
Uvinul (R) A plus (DHHB) is a synthetic benzophenone derivative mainly used in sunscreens, and also in other skin care products. The compound is authorized by the EU as UV filter and a maximum concentration of 10% in consumer products is permitted. Despite its high production volume and usage in consumer products,to date, no information about the systemic exposure to Uvinul (R) A plus in humans is available. Therefore, we developed a human biomonitoring method which allows the simultaneous determination of three major metabolites of Uvinul (R) A plus in human urine samples. Furthermore, three minor metabolites of Uvinul (R) A plus were identified by ion trap experiments. Urine samples were enzymatically hydrolyzed, extracted via liquid-liquid extraction with ethyl acetate, and analyzed by means of UPLC-MS/MS. The final method was validated according to FDA guidelines and applied to 58 urine samples retrieved from the general German population. The three major and specific metabolites of Uvinul (R) A plus were found in about 36% of the samples, proving the suitability of the method for future human biomonitoring studies.
| Item Type: | Journal article |
|---|---|
| Faculties: | Chemistry and Pharmacy > Department of Pharmacy |
| Subjects: | 500 Science > 540 Chemistry |
| ISSN: | 1618-2642 |
| Language: | English |
| Item ID: | 83580 |
| Date Deposited: | 15. Dec 2021 15:08 |
| Last Modified: | 15. Dec 2021 15:08 |
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