Quantitative helix handedness bias through a single H vs. CH3 stereochemical differentiation

Bindl, Daniel; Heinemann, Elisabeth; Mandal, Pradeep K. und Huc, Ivan (2021): Quantitative helix handedness bias through a single H vs. CH3 stereochemical differentiation. In: Chemical Communications, Vol. 57, No. 46: pp. 5662-5665

Abstract

A novel chiral aromatic delta-amino acid building block was shown to fully induce handedness in quinoline oligoamide foldamers with the possibility of further increasing the bias by combining multiples of these units in the same sequence. Through its incorporation within the helix, both N- and C-termini are still accessible for further functionalisation.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Pharmacy
• Research Centers: Center for Integrated Protein Science Munich (CIPSM)
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Language: English