A short and divergent route to 2-alkenyl-4-quinolones

Lohrer, Bernhard und Bracher, Franz (2018): A short and divergent route to 2-alkenyl-4-quinolones. In: Tetrahedron Letters, Vol. 59, No. 40: pp. 3632-3635

Abstract

2-alkenyl-4-quinolones were accessed via a high-yielding, three-step synthesis starting from 2-methyl-4-quinolones using a one-pot phosphorylation-olefination sequence as the key step and SEM as a convenient protecting group. This protocol tolerates various functional groups and gives the target olefins with complete (E)-selectivity.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 0040-4039
• Language: English