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Lohrer, B.; Bracher, F. (2018): A convenient identification of carbamate-derived drug substances. In: Pharmazie, Vol. 73, No. 10: pp. 555-558
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The "second identification" of drugs in pharmacies and hospital pharmacies affords the availability of easy to perform and robust tests. Besides determination of melting points and simple chromatography (TLC), reliable color and precipitation reactions are common techniques for this purpose. Preferentially, these reactions allow for the identification of typical functional groups in the drugs. Here we present a reaction for identification of carbamate-type drugs, based on the precipitation of barium carbonate upon treating the analytes with barium hydroxide solution at 80 degrees C. This method works well for carbamate drugs with noteworthy water solubility like carbachol, neostigmine bromide, and pyridostigmine bromide, and could be considered as a method for second identification of these drugs in pharmacopoeias and in Deutscher Arzneimittel-Codex/Neues Rezeptur-Formularium (DAC-NRF).