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Jones, S. K.; Merkel, O. M. (2016): Tackling breast cancer chemoresistance with nano-formulated siRNA. In: Gene therapy, Vol. 23, No. 12: pp. 821-828
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Abstract

Breast cancer is the leading cancer diagnosed in women and the second leading cause of cancer-related deaths in women. Current limitations to standard chemotherapy in the clinic are extensively researched, including problems arising from repeated treatments with the same drugs. The phenomenon that cancer cells become resistant toward certain chemo drugs is called chemotherapy resistance. In this review, we are focusing on nanoformulation of siRNA for the fight against breast cancer chemoresistance.