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Schütz, Ramona; Müller, Martin; Gerndt, Susanne; Bartel, Karin; Bracher, Franz ORCID: 0000-0003-0009-8629 (2020): Racemic total synthesis and evaluation of the biological activities of the isoquinoline–benzylisoquinoline alkaloid muraricine. In: Archiv der Pharmazie, Vol. 353, No. 7, 2000106
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Abstract

The first racemic total synthesis of the isoquinoline–benzylisoquinoline alkaloid muraricine is reported herein. Pharmacological characterization identified muraricine as a moderate inhibitor of P‐glycoprotein, a crucial factor of multidrug resistance in cancer. When combined with vincristine, muraricine partly reversed the chemoresistance of vincristine‐resistant leukemia cells at a nontoxic concentration. Furthermore, no cytotoxic effects on noncancerous human cells in therapeutically relevant concentrations were observed.