Bornerie, Megane; Brion, Anais; Guichard, Gilles; Kichler, Antoine und Douat, Celine
(2021):
Delivery of siRNA by tailored cell-penetrating urea-based foldamers.
In: Chemical Communications, Vol. 57, No. 12: pp. 1458-1461
DOI: 10.1039/d0cc06285e
Abstract
Cell-penetrating foldamers (CPFs) have recently shown promise as efficient and safe nucleic acid delivery systems. However, the application of CPFs to siRNA transport remains scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n-octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA.
| Item Type: | Journal article |
|---|---|
| Faculties: | Chemistry and Pharmacy > Department of Pharmacy |
| Subjects: | 500 Science > 540 Chemistry |
| ISSN: | 1359-7345 |
| Language: | English |
| Item ID: | 97159 |
| Date Deposited: | 05. Jun 2023 15:25 |
| Last Modified: | 05. Jun 2023 15:25 |
Actions (login required)
- View Item
