Delivery of siRNA by tailored cell-penetrating urea-based foldamers

Bornerie, Megane; Brion, Anais; Guichard, Gilles; Kichler, Antoine und Douat, Celine (2021): Delivery of siRNA by tailored cell-penetrating urea-based foldamers. In: Chemical Communications, Bd. 57, Nr. 12: S. 1458-1461

Abstract

Cell-penetrating foldamers (CPFs) have recently shown promise as efficient and safe nucleic acid delivery systems. However, the application of CPFs to siRNA transport remains scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n-octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1359-7345
• Sprache: Englisch