Inhibition of Phytosterol Biosynthesis by Azasterols

Darnet, Sylvain; Martin, Laetitia B. B.; Mercier, Pierre; Bracher, Franz; Geoffroy, Philippe und Schaller, Hubert (2020): Inhibition of Phytosterol Biosynthesis by Azasterols. In: Molecules, Vol. 25, No. 5, 1111

Abstract

Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Pharmacy
• Subjects: 500 Science > 540 Chemistry
• Language: English