Abstract
A hydrogen‐bonding interface between helical aromatic oligoamide foldamers has been designed to promote the folding of a helix‐turn‐helix motif with a head‐to‐tail arrangement of two helices of opposite handedness. This design complements an earlier helix‐turn‐helix motif with a head‐to‐head arrangement of two helices of identical handedness interface. The two motifs were shown to have comparable stability and were combined in a unimolecular tetra‐helix fold constituting the largest abiotic tertiary structure to date.
Item Type: | Journal article |
---|---|
Faculties: | Chemistry and Pharmacy > Department of Pharmacy |
Research Centers: | Center for Integrated Protein Science Munich (CIPSM) |
Subjects: | 500 Science > 540 Chemistry |
URN: | urn:nbn:de:bvb:19-epub-70507-0 |
ISSN: | 1433-7851 |
Language: | English |
Item ID: | 70507 |
Date Deposited: | 06. Feb 2020, 14:22 |
Last Modified: | 04. Nov 2020, 13:52 |