Abstract
Within the last two decades, a series of novel therapeutic nucleic acids entered research and clinical evaluation. Their differences both in biophysical properties as well as in mode and site of biological action provide polymer-based carriers with new delivery challenges. Recent tailor-made designs of polymeric carriers are reviewed that were optimized for nucleic acid cargos such as plasmid DNA, siRNA, and micro RNA, mRNA, or genome-modifying nucleic acids. The specific requirements for the various therapeutic cargos are discussed. Future directions include dynamic bioresponsive polymers as components of nanomachines, multifunctional sequence-defined carriers for evolution-based selective optimization, and organic inorganic multicomponent nanoassemblies.
Item Type: | Journal article |
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Faculties: | Chemistry and Pharmacy > Department of Pharmacy |
Research Centers: | Center for NanoScience (CENS) |
Subjects: | 500 Science > 540 Chemistry 500 Science > 500 Science |
ISSN: | 1525-7797 |
Language: | English |
Item ID: | 83570 |
Date Deposited: | 15. Dec 2021, 15:08 |
Last Modified: | 15. Dec 2021, 15:08 |