| Untergehrer, Martin; Bracher, Franz (2020): A short divergent approach to highly substituted carbazoles and beta-carbolines via in situ-generated diketoindoles. In: Tetrahedron Letters, Vol. 61, No. 12, 151597 |
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Abstract
Based on an aza-alkylation/Michael addition cascade reaction developed by Kim and co-workers we have developed divergent cascade reactions leading to either highly substituted 1-hydroxycarbazoles, 3-hydroxycarbazoles or beta-carbolines, starting from readily accessible ortho-arylsulfonylaminobenzaldehydes. Olefination of the aldehyde functionality by aldol condensation or Wittig olefination gave reactive enone intermediates, which underwent the cascade reactions, either in two steps or in one-pot conversions, to give hydroxycarbazoles or complex beta-carbolines. (C) 2020 Elsevier Ltd. All rights reserved.
| Item Type: | Journal article |
|---|---|
| Faculties: | Chemistry and Pharmacy > Department of Pharmacy |
| Subjects: | 500 Science > 540 Chemistry |
| ISSN: | 0040-4039 |
| Language: | English |
| ID Code: | 89803 |
| Deposited On: | 25. Jan 2022 09:32 |
| Last Modified: | 25. Jan 2022 09:32 |
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