Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages

Tsiamantas, Christos; Kwon, Sunbum; Rogers, Joseph M.; Douat, Céline; Huc, Ivan and Suga, Hiroaki (2020): Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages. In: Angewandte Chemie - International Edition, Vol. 59, No. 12: pp. 4860-4864

Abstract

Derivatives of 4‐aminomethyl‐l ‐phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C‐terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Pharmacy
• Subjects: 500 Science > 540 Chemistry; 600 Technology > 610 Medicine and health
• ISSN: 1433-7851
• Language: English