Dimethylformamide Acetals and Bredereck's Reagent as Building Blocks in Natural Products Total Synthesis

Bracher, Franz (2020): Dimethylformamide Acetals and Bredereck's Reagent as Building Blocks in Natural Products Total Synthesis. In: Mini-Reviews in Organic Chemistry, Bd. 17, Nr. 1: S. 47-66

Abstract

Dimethylformamide acetals and Bredereck's reagent (tert-butoxy-bis(dimethylamino) methane) are versatile C-1 building blocks due to their ability to undergo condensation reactions with CH-acidic methyl and methylene moieties. Subsequent modulation of the resulting condensation products enables the preparation of open-chain products like aldehydes, ketones, enones, enol ethers, methyl groups, and, most important in alkaloid total synthesis, the annulation of heterocyclic rings like pyridines, pyridine-N-oxides, bromopyridines, aminopyridines, aminopyrimidines, pyrroles and chromenones. In certain cases, these reagents can act as alkylating agents. The applications of these building blocks in natural products total synthesis are reviewed here.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department für Pharmazie - Zentrum für Pharmaforschung
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1570-193X
• Sprache: Englisch