Abstract
Dimethylformamide acetals and Bredereck's reagent (tert-butoxy-bis(dimethylamino) methane) are versatile C-1 building blocks due to their ability to undergo condensation reactions with CH-acidic methyl and methylene moieties. Subsequent modulation of the resulting condensation products enables the preparation of open-chain products like aldehydes, ketones, enones, enol ethers, methyl groups, and, most important in alkaloid total synthesis, the annulation of heterocyclic rings like pyridines, pyridine-N-oxides, bromopyridines, aminopyridines, aminopyrimidines, pyrroles and chromenones. In certain cases, these reagents can act as alkylating agents. The applications of these building blocks in natural products total synthesis are reviewed here.
Item Type: | Journal article |
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Faculties: | Chemistry and Pharmacy > Department of Pharmacy |
Subjects: | 500 Science > 540 Chemistry |
ISSN: | 1570-193X |
Language: | English |
Item ID: | 89841 |
Date Deposited: | 25. Jan 2022, 09:32 |
Last Modified: | 25. Jan 2022, 09:32 |