The Chemistry of the Canthin-4-ones

Bracher, Franz und Tremmel, Tim (2017): The Chemistry of the Canthin-4-ones. In: Mini-Reviews in Organic Chemistry, Vol. 14, No. 2: pp. 92-98

Abstract

Background: The canthin-4-ones are a small, yet underexplored class of natural products from Apocynaceae plants. Efficient synthetic approaches are required for exploring this class of natural products for drug discovery. Objective: In this review, the synthetic approaches towards these alkaloids, as well as synthetic analogues are summarized comprehensively. Further, the applications of canthin-4-ones as building blocks for the synthesis of alkaloids and other polycyclic compounds of pharmaceutical interest are demonstrated. Conclusion: Meanwhile, efficient and flexible approaches to the canthin-4-one scaffold are available which should foster in-depth investigation of this chemotype for drug development.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1570-193X
• Language: English