Abstract
Background: The canthin-4-ones are a small, yet underexplored class of natural products from Apocynaceae plants. Efficient synthetic approaches are required for exploring this class of natural products for drug discovery. Objective: In this review, the synthetic approaches towards these alkaloids, as well as synthetic analogues are summarized comprehensively. Further, the applications of canthin-4-ones as building blocks for the synthesis of alkaloids and other polycyclic compounds of pharmaceutical interest are demonstrated. Conclusion: Meanwhile, efficient and flexible approaches to the canthin-4-one scaffold are available which should foster in-depth investigation of this chemotype for drug development.
| Item Type: | Journal article |
|---|---|
| Faculties: | Chemistry and Pharmacy > Department of Pharmacy |
| Subjects: | 500 Science > 540 Chemistry |
| ISSN: | 1570-193X |
| Language: | English |
| Item ID: | 55864 |
| Date Deposited: | 14. Jun 2018, 10:00 |
| Last Modified: | 15. Dec 2020, 09:44 |
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